Details of the Drug Combination

General Information of Drug Combination (ID: DCRAVTW)

Drug Combination Name
AHPN Mitomycin
Indication
Disease Entry Status REF
Diffuse large B cell lymphoma Investigative [1]
Component Drugs AHPN   DM8G6O4 Mitomycin   DMH0ZJE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL
High-throughput Screening Result Testing Cell Line: TMD8
Zero Interaction Potency (ZIP) Score: 2.599
Bliss Independence Score: 2.609
Loewe Additivity Score: 4.485
LHighest Single Agent (HSA) Score: 7.151

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of AHPN
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [2]
AHPN Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Agonist [7]
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AHPN Interacts with 193 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Increases Expression [8]
Menin (MEN1) OTN6U6V0 MEN1_HUMAN Decreases Expression [6]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Expression [6]
Histone deacetylase complex subunit SAP18 (SAP18) OTJAZWOL SAP18_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) OTY21FKV COX7R_HUMAN Decreases Expression [6]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Decreases Expression [6]
Actin-related protein 2/3 complex subunit 2 (ARPC2) OTSOKOMY ARPC2_HUMAN Decreases Expression [6]
Actin-related protein 2/3 complex subunit 3 (ARPC3) OTKWVF8P ARPC3_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 3 subunit D (EIF3D) OTDOMP80 EIF3D_HUMAN Decreases Expression [6]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) OT585WY8 PSMD3_HUMAN Decreases Expression [6]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [6]
NADH dehydrogenase iron-sulfur protein 5 (NDUFS5) OTF40UYJ NDUS5_HUMAN Decreases Expression [6]
Selenoprotein F (SELENOF) OT2JFB3S SEP15_HUMAN Decreases Expression [6]
Barrier-to-autointegration factor (BANF1) OTP7Z38L BAF_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 3 subunit G (EIF3G) OT5L1SRY EIF3G_HUMAN Decreases Expression [6]
ATP synthase subunit g, mitochondrial (ATP5MG) OTD569IJ ATP5L_HUMAN Decreases Expression [6]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [6]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Decreases Expression [6]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [6]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [6]
Muellerian-inhibiting factor (AMH) OT5FH4BD MIS_HUMAN Decreases Expression [6]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [6]
ADP/ATP translocase 2 (SLC25A5) OT1XIBMN ADT2_HUMAN Decreases Expression [6]
Large ribosomal subunit protein P1 (RPLP1) OT7B0SIB RLA1_HUMAN Decreases Expression [6]
Large ribosomal subunit protein P2 (RPLP2) OT2YBK3W RLA2_HUMAN Decreases Expression [6]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Decreases Expression [6]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [6]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Expression [6]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [6]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [6]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Decreases Expression [6]
Small ribosomal subunit protein eS17 (RPS17) OTWHZ2JQ RS17_HUMAN Decreases Expression [6]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Decreases Expression [6]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Decreases Expression [6]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Decreases Expression [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [6]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Decreases Expression [6]
Microsomal glutathione S-transferase 1 (MGST1) OTGN1KVZ MGST1_HUMAN Decreases Expression [6]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [6]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Decreases Expression [6]
Polyadenylate-binding protein 1 (PABPC1) OT54LG0P PABP1_HUMAN Decreases Expression [6]
ADP/ATP translocase 3 (SLC25A6) OT9KAJP7 ADT3_HUMAN Decreases Expression [6]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [6]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) OTVT146E CX7A2_HUMAN Decreases Expression [6]
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) OT3UJ4ZU RSMB_HUMAN Decreases Expression [6]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Decreases Expression [6]
Arylsulfatase A (ARSA) OT1CU8VR ARSA_HUMAN Decreases Expression [6]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS5 (RPS2) OTSMTZVB RS2_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Decreases Expression [6]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [6]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Decreases Expression [6]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Decreases Expression [6]
Proteasome subunit beta type-1 (PSMB1) OTYRFBAH PSB1_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 4B (EIF4B) OTE8TXA8 IF4B_HUMAN Decreases Expression [6]
Cytochrome c oxidase subunit 7B, mitochondrial (COX7B) OT67PIDP COX7B_HUMAN Decreases Expression [6]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Decreases Expression [6]
Proteasome subunit alpha type-4 (PSMA4) OTAD2XXI PSA4_HUMAN Decreases Expression [6]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL13 (RPL13) OTFKNTD6 RL13_HUMAN Decreases Expression [6]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL16 (RPL10) OTBHOZGC RL10_HUMAN Decreases Expression [6]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Decreases Expression [6]
Coronin-1A (CORO1A) OTVAZOHC COR1A_HUMAN Increases Expression [6]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Decreases Expression [6]
Transcription factor SOX-11 (SOX11) OT4LG7LA SOX11_HUMAN Decreases Expression [6]
ADP-ribosylation factor-like protein 2 (ARL2) OTICNK0O ARL2_HUMAN Decreases Expression [6]
ATP synthase subunit gamma, mitochondrial (ATP5F1C) OTV5GZK5 ATPG_HUMAN Decreases Expression [6]
RNA-binding motif protein, X chromosome (RBMX) OTFZN66E RBMX_HUMAN Decreases Expression [6]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL13 (RPL13A) OTME3VXN RL13A_HUMAN Decreases Expression [6]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Decreases Expression [6]
Small ribosomal subunit protein eS27 (RPS27) OTFXKY7P RS27_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL29 (RPL35) OTFZX52Q RL35_HUMAN Increases Expression [6]
Translocon-associated protein subunit beta (SSR2) OTQJSL7M SSRB_HUMAN Decreases Expression [6]
G-protein coupled receptor 6 (GPR6) OTBF9YGT GPR6_HUMAN Decreases Expression [6]
Small ribosomal subunit protein eS10 (RPS10) OTE3VSAH RS10_HUMAN Decreases Expression [6]
ATP synthase subunit O, mitochondrial (ATP5PO) OTU3MCTN ATPO_HUMAN Decreases Expression [6]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [6]
T-complex protein 1 subunit gamma (CCT3) OTL6EOS1 TCPG_HUMAN Decreases Expression [6]
Fms-related tyrosine kinase 3 ligand (FLT3LG) OTU0YGC4 FLT3L_HUMAN Decreases Expression [6]
Hsc70-interacting protein (ST13) OTNML6UP F10A1_HUMAN Decreases Expression [6]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [6]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Decreases Expression [6]
Homeobox protein Nkx-2.5 (NKX2-5) OTS1SAWM NKX25_HUMAN Decreases Expression [6]
AP-2 complex subunit sigma (AP2S1) OTEV2XGW AP2S1_HUMAN Decreases Expression [6]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) OTK71JYU TCP4_HUMAN Increases Expression [6]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Decreases Expression [6]
Eukaryotic initiation factor 4A-I (EIF4A1) OTMTBX6N IF4A1_HUMAN Decreases Expression [6]
26S proteasome complex subunit SEM1 (SEM1) OTASLBM1 SEM1_HUMAN Decreases Expression [6]
Transmembrane protein 258 (TMEM258) OTXSDU14 TM258_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Decreases Expression [6]
Small nuclear ribonucleoprotein F (SNRPF) OTZE5W6G RUXF_HUMAN Decreases Expression [6]
Small nuclear ribonucleoprotein G (SNRPG) OTWX4XK1 RUXG_HUMAN Decreases Expression [6]
U6 snRNA-associated Sm-like protein LSm3 (LSM3) OTBHPD8H LSM3_HUMAN Decreases Expression [6]
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) OT5ZGKU5 SMD2_HUMAN Decreases Expression [6]
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) OTVYWCGN RPB7_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS19 (RPS15) OT0WYZYG RS15_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase RBX1 (RBX1) OTYA1UIO RBX1_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL39 (RPL39) OTL8TZHQ RL39_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL5 (RPL11) OT3VZ6OE RL11_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL2 (RPL8) OTHMZ1R9 RL8_HUMAN Decreases Expression [6]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Decreases Expression [6]
S-phase kinase-associated protein 1 (SKP1) OT5BPAZ4 SKP1_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [6]
Thymosin beta-10 (TMSB10) OTLVZ13T TYB10_HUMAN Decreases Expression [6]
T-complex protein 1 subunit beta (CCT2) OTW1VV4E TCPB_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL24 (RPL24) OTCY9DEB RL24_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL42 (RPL36A) OT1LYV85 RL36A_HUMAN Decreases Expression [6]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [6]
Enhancer of rudimentary homolog (ERH) OTJDWX99 ERH_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL19 (RPL19) OT33LM66 RL19_HUMAN Decreases Expression [6]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Decreases Expression [6]
Solute carrier family 25 member 3 (SLC25A3) OTAWGR4K S25A3_HUMAN Decreases Expression [6]
Protein SET (SET) OTGYYQJO SET_HUMAN Decreases Expression [6]
POU domain, class 3, transcription factor 1 (POU3F1) OTYARA94 PO3F1_HUMAN Decreases Expression [6]
Single-stranded DNA-binding protein, mitochondrial (SSBP1) OTH2PZWH SSBP_HUMAN Decreases Expression [6]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Decreases Expression [6]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [6]
Interleukin enhancer-binding factor 2 (ILF2) OTWWVM9X ILF2_HUMAN Decreases Expression [6]
Peroxiredoxin-4 (PRDX4) OTT4OR8G PRDX4_HUMAN Increases Expression [6]
Serine/threonine-protein kinase 3 (STK3) OTLNSCQD STK3_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 3 subunit I (EIF3I) OTE07WND EIF3I_HUMAN Decreases Expression [6]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [6]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) OTDS5WAU PIN1_HUMAN Decreases Expression [6]
Nascent polypeptide-associated complex subunit alpha (NACA) OTLP1KR3 NACA_HUMAN Decreases Expression [6]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Decreases Expression [6]
Hypermethylated in cancer 1 protein (HIC1) OTI9TWY4 HIC1_HUMAN Decreases Expression [6]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [6]
Lysine--tRNA ligase (KARS1) OT0EU4SV SYK_HUMAN Decreases Expression [6]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [6]
Poly(rC)-binding protein 2 (PCBP2) OTXCN9CG PCBP2_HUMAN Decreases Expression [6]
Septin-7 (SEPTIN7) OTJI08YX SEPT7_HUMAN Decreases Expression [6]
Fascin (FSCN1) OTTGIHTM FSCN1_HUMAN Decreases Expression [6]
Prickle-like protein 4 (PRICKLE4) OT19NLJR PRIC4_HUMAN Decreases Expression [6]
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) OTT5T45Q PLPL6_HUMAN Decreases Expression [6]
RING1 and YY1-binding protein (RYBP) OTZZ4P2Z RYBP_HUMAN Decreases Expression [6]
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) OTOWD75R ZNT5_HUMAN Decreases Expression [6]
Roundabout homolog 4 (ROBO4) OT2Q29L9 ROBO4_HUMAN Decreases Expression [6]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [6]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Decreases Expression [6]
Growth hormone secretagogue receptor type 1 (GHSR) OT1Y8ARK GHSR_HUMAN Decreases Expression [6]
Ribosomal protein eL42-like (RPL36AL) OTH8NHO7 RL36L_HUMAN Decreases Expression [6]
AP-2 complex subunit mu (AP2M1) OTQCOSFN AP2M1_HUMAN Decreases Expression [6]
Transcriptional regulator protein Pur-beta (PURB) OTCDDKYB PURB_HUMAN Decreases Expression [6]
Ras-like protein family member 10B (RASL10B) OT0A5YKR RSLAB_HUMAN Decreases Expression [6]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [6]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Decreases Expression [6]
Apoptosis inhibitor 5 (API5) OTYX9YCZ API5_HUMAN Decreases Expression [6]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [6]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Increases Expression [6]
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) OT2M7VH6 SLIRP_HUMAN Decreases Expression [6]
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) OTKMW34I SH3L3_HUMAN Decreases Expression [6]
MOB kinase activator 1A (MOB1A) OTSPBZ4Z MOB1A_HUMAN Decreases Expression [6]
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) OTHN25MF IMP3_HUMAN Decreases Expression [6]
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) OT9ZAY6U S38A7_HUMAN Decreases Expression [6]
Mitoferrin-1 (SLC25A37) OTJ9F01S MFRN1_HUMAN Decreases Expression [6]
Transmembrane protein 14C (TMEM14C) OTHYTMLC TM14C_HUMAN Decreases Expression [6]
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) OTJJOI2B TOM7_HUMAN Decreases Expression [6]
Stomatin-like protein 2, mitochondrial (STOML2) OTJ55M30 STML2_HUMAN Decreases Expression [6]
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) OTI780UB MA1B1_HUMAN Decreases Expression [6]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Decreases Expression [6]
Integral membrane protein 2B (ITM2B) OTMXEPXB ITM2B_HUMAN Decreases Expression [6]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Decreases Expression [6]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) OTGZO1MT TIM8B_HUMAN Decreases Expression [6]
Mitochondrial carrier homolog 2 (MTCH2) OTV3E4GU MTCH2_HUMAN Decreases Expression [6]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) OTO3WI7S NDUB9_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [9]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [10]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Affects Expression [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Expression [11]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [12]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Localization [13]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Decreases Expression [12]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Expression [12]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [14]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [12]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Decreases Activity [15]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [10]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [16]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [14]
Double-strand break repair protein MRE11 (MRE11) OTGU8TZM MRE11_HUMAN Decreases Expression [12]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [16]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [16]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Increases Expression [12]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [16]
Syntaxin-binding protein 5 (STXBP5) OTE3M7QB STXB5_HUMAN Increases Expression [12]
ADP/ATP translocase 4 (SLC25A31) OTX8N6YO ADT4_HUMAN Decreases Activity [15]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [12]
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⏷ Show the Full List of 193 DOT(s)
Indication(s) of Mitomycin
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [3]
Gastrointestinal cancer 2C11 Approved [3]
Pancreatic adenocarcinoma N.A. Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Urinary bladder cancer N.A. Approved [4]
Urinary bladder neoplasm N.A. Approved [4]
Urinary system neoplasm N.A. Approved [4]
Urinary tract disease GC2Z Approved [4]
Bladder disease DC11-DC1Z Investigative [4]
Colon cancer 2B90.Z Investigative [4]
Mitomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Binder [23]
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Mitomycin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [24]
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Mitomycin Interacts with 274 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [25]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [26]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Expression [26]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Decreases Expression [26]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Decreases Expression [26]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [26]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [26]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [26]
DNA ligase 1 (LIG1) OTEEQS43 DNLI1_HUMAN Decreases Expression [26]
Nuclear transcription factor Y subunit alpha (NFYA) OTWFFOVH NFYA_HUMAN Increases Expression [26]
Ephrin type-A receptor 2 (EPHA2) OTI6QNX2 EPHA2_HUMAN Decreases Expression [26]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [26]
Matrix metalloproteinase-14 (MMP14) OT9C197Z MMP14_HUMAN Decreases Expression [26]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) OTK71JYU TCP4_HUMAN Increases Expression [26]
Small ribosomal subunit protein eS1 (RPS3A) OTUEP7CL RS3A_HUMAN Increases Expression [26]
Microtubule-associated protein RP/EB family member 1 (MAPRE1) OTCVQD60 MARE1_HUMAN Increases Expression [26]
Histone-binding protein RBBP7 (RBBP7) OTLB56HX RBBP7_HUMAN Increases Expression [26]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [27]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Increases Expression [28]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [28]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [28]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Increases Expression [28]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [28]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [28]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [28]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [28]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [28]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [29]
Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1) OTDG5VW7 SDHF1_HUMAN Decreases Expression [18]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [18]
E3 ubiquitin-protein ligase TRIM38 (TRIM38) OT6SP1M9 TRI38_HUMAN Decreases Expression [18]
Torsin-1A (TOR1A) OTYCLGJU TOR1A_HUMAN Decreases Expression [18]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [30]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Phosphorylation [31]
Transcription factor EC (TFEC) OTUST8MR TFEC_HUMAN Decreases Expression [18]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Decreases Expression [18]
E3 ubiquitin-protein ligase RNF113A (RNF113A) OTR6N7HU R113A_HUMAN Decreases Expression [18]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Decreases Expression [18]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [18]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [18]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [31]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [32]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [33]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Increases Mutagenesis [34]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [33]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [33]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [35]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [32]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Activity [36]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [37]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [38]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [37]
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Increases Mutagenesis [39]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [40]
Beta-galactosidase (GLB1) OTB0TKAG BGAL_HUMAN Increases Activity [33]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [41]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Decreases Expression [18]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [42]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [43]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [43]
GTP cyclohydrolase 1 (GCH1) OTOZ6NSL GCH1_HUMAN Decreases Expression [18]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [44]
Replication factor C subunit 1 (RFC1) OT3L5PK3 RFC1_HUMAN Decreases Expression [18]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [45]
RNA-binding protein 34 (RBM34) OTX3LUGI RBM34_HUMAN Decreases Expression [18]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [42]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [33]
LIM/homeobox protein Lhx2 (LHX2) OTK61NP8 LHX2_HUMAN Decreases Expression [18]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [18]
RecQ-like DNA helicase BLM (BLM) OTEJOAJX BLM_HUMAN Decreases Expression [18]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Decreases Expression [18]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [44]
Ras-related protein Rap-2b (RAP2B) OTD2NDQP RAP2B_HUMAN Decreases Expression [18]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Secretion [45]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [46]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [18]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [47]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Increases Cleavage [45]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [43]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [38]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [48]
Tripartite motif-containing protein 26 (TRIM26) OTS0DJIP TRI26_HUMAN Decreases Expression [18]
E3 ubiquitin-protein ligase TRIM32 (TRIM32) OTJOV0PG TRI32_HUMAN Decreases Expression [18]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [18]
Chromatin assembly factor 1 subunit B (CHAF1B) OTOMK4KH CAF1B_HUMAN Decreases Expression [18]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Decreases Expression [47]
Protein BTG3 (BTG3) OT9ANHVT BTG3_HUMAN Decreases Expression [18]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [18]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [45]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [48]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Decreases Expression [18]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [18]
Partner and localizer of BRCA2 (PALB2) OT6DNDBG PALB2_HUMAN Decreases Expression [18]
Leucine-rich repeat-containing protein 47 (LRRC47) OTSE8NAO LRC47_HUMAN Decreases Expression [18]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [44]
Cytochrome c oxidase assembly factor 7 (COA7) OTRQJYL6 COA7_HUMAN Decreases Expression [18]
Mitochondrial potassium channel (CCDC51) OTOJNHNA MITOK_HUMAN Decreases Expression [18]
Integrator complex subunit 15 (INTS15) OT3O4INM INT15_HUMAN Decreases Expression [18]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Decreases Expression [18]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [18]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [18]
Protein orai-3 (ORAI3) OTUP3OH3 ORAI3_HUMAN Decreases Expression [18]
Protein pelota homolog (PELO) OTF3WLIM PELO_HUMAN Decreases Expression [18]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [18]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Increases Ubiquitination [31]
tRNA pseudouridine(38/39) synthase (PUS3) OT6WG6M2 PUS3_HUMAN Decreases Expression [18]
Transmembrane protein 185B (TMEM185B) OTGNYS0J T185B_HUMAN Decreases Expression [18]
Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2) OT3Q11WQ I20L2_HUMAN Decreases Expression [18]
GrpE protein homolog 1, mitochondrial (GRPEL1) OT8O00YJ GRPE1_HUMAN Decreases Expression [18]
Forkhead box protein J2 (FOXJ2) OTPT639J FOXJ2_HUMAN Decreases Expression [18]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [18]
rRNA methyltransferase 2, mitochondrial (MRM2) OTRYA1HU MRM2_HUMAN Decreases Expression [18]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Decreases Expression [18]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Affects Response To Substance [21]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [21]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Affects Response To Substance [21]
Fanconi-associated nuclease 1 (FAN1) OT1LM1HZ FAN1_HUMAN Increases Response To Substance [49]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Affects Response To Substance [21]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Affects Response To Substance [21]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1) OT2E7A6W KANK1_HUMAN Affects Response To Substance [21]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Affects Response To Substance [21]
Mitochondrial fission 1 protein (FIS1) OT2HL10J FIS1_HUMAN Affects Response To Substance [21]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Affects Response To Substance [21]
Syncytin-2 (ERVFRD-1) OT3064D7 SYCY2_HUMAN Affects Response To Substance [21]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [21]
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) OT34P56Z PDS5A_HUMAN Affects Response To Substance [21]
Excitatory amino acid transporter 3 (SLC1A1) OT3B9M6W EAA3_HUMAN Affects Response To Substance [21]
Syntabulin (SYBU) OT3FQV7N SYBU_HUMAN Affects Response To Substance [21]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Affects Response To Substance [21]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Affects Response To Substance [21]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Response To Substance [50]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Affects Response To Substance [21]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Affects Response To Substance [21]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Affects Response To Substance [21]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Increases Response To Substance [51]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Affects Response To Substance [21]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Affects Response To Substance [21]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) OT6MFOWF TGM2_HUMAN Affects Response To Substance [21]
G-protein-signaling modulator 2 (GPSM2) OT6RPMRM GPSM2_HUMAN Affects Response To Substance [21]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Affects Response To Substance [21]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Increases Response To Substance [52]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Affects Response To Substance [21]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Affects Response To Substance [21]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Affects Response To Substance [21]
Ras-related protein Rab-17 (RAB17) OT7NBUGQ RAB17_HUMAN Affects Response To Substance [21]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Affects Response To Substance [21]
Pirin (PIR) OT8ALXHU PIR_HUMAN Affects Response To Substance [21]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Affects Response To Substance [21]
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) OT8CNKBO ICMT_HUMAN Affects Response To Substance [21]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Affects Response To Substance [21]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) OT8GPFT5 2A5E_HUMAN Decreases Response To Substance [53]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Affects Response To Substance [21]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Affects Response To Substance [21]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Decreases Response To Substance [53]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Affects Response To Substance [21]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2) OTAKUO27 ACOT2_HUMAN Affects Response To Substance [21]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Affects Response To Substance [54]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Affects Response To Substance [21]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Affects Response To Substance [21]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [21]
ETS domain-containing protein Elk-3 (ELK3) OTBM9BHT ELK3_HUMAN Affects Response To Substance [21]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Affects Response To Substance [21]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Affects Response To Substance [21]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Affects Response To Substance [21]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Affects Response To Substance [21]
Creatine kinase U-type, mitochondrial (CKMT1A) OTCINHH5 KCRU_HUMAN Affects Response To Substance [21]
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) OTCJ458Q AT1A1_HUMAN Affects Response To Substance [21]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Affects Response To Substance [21]
Cytochrome c oxidase copper chaperone (COX17) OTCP4LH2 COX17_HUMAN Affects Response To Substance [21]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Decreases Response To Substance [55]
Collagen alpha-3(IX) chain (COL9A3) OTCUJOEK CO9A3_HUMAN Affects Response To Substance [21]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Affects Response To Substance [21]
Dystrophin (DMD) OTD21T5J DMD_HUMAN Affects Response To Substance [21]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Affects Response To Substance [21]
dTDP-D-glucose 4,6-dehydratase (TGDS) OTEOFLOS TGDS_HUMAN Affects Response To Substance [21]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Affects Response To Substance [21]
Ras association domain-containing protein 1 (RASSF1) OTEZIPB7 RASF1_HUMAN Increases Response To Substance [56]
Protocadherin Fat 1 (FAT1) OTF174DH FAT1_HUMAN Affects Response To Substance [21]
Midkine (MDK) OTF24HKC MK_HUMAN Affects Response To Substance [21]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Affects Response To Substance [21]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) OTF7CGO2 2A5G_HUMAN Increases Response To Substance [53]
G antigen 7 (GAGE7) OTF8BTR9 GAGE7_HUMAN Affects Response To Substance [21]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Affects Response To Substance [21]
Catenin alpha-1 (CTNNA1) OTFC725Z CTNA1_HUMAN Affects Response To Substance [21]
Sortilin (SORT1) OTFCQ4B1 SORT_HUMAN Affects Response To Substance [21]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Affects Response To Substance [21]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Affects Response To Substance [21]
Tudor domain-containing protein 3 (TDRD3) OTG83E2C TDRD3_HUMAN Affects Response To Substance [21]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Affects Response To Substance [21]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Affects Response To Substance [21]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [57]
Sigma intracellular receptor 2 (TMEM97) OTH76ZWK SGMR2_HUMAN Affects Response To Substance [21]
Transmembrane protein 156 (TMEM156) OTH7YJID TM156_HUMAN Affects Response To Substance [21]
Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) OTHAWK8C JHD2C_HUMAN Affects Response To Substance [21]
Unconventional myosin-X (MYO10) OTHB78ZQ MYO10_HUMAN Affects Response To Substance [21]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Affects Response To Substance [21]
Actin-binding LIM protein 1 (ABLIM1) OTHXEK3E ABLM1_HUMAN Affects Response To Substance [21]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Response To Substance [21]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Affects Response To Substance [21]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Affects Response To Substance [21]
Melanoma-associated antigen 6 (MAGEA6) OTI8S0O2 MAGA6_HUMAN Affects Response To Substance [21]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Increases Response To Substance [58]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Affects Response To Substance [21]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Affects Response To Substance [21]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Affects Response To Substance [21]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Affects Response To Substance [21]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Affects Response To Substance [21]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Affects Response To Substance [21]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Affects Response To Substance [21]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Affects Response To Substance [21]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) OTLNA39Z NMT2_HUMAN Affects Response To Substance [21]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Response To Substance [59]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Affects Response To Substance [21]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [21]
Bridging integrator 3 (BIN3) OTMIWWDW BIN3_HUMAN Affects Response To Substance [21]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Affects Response To Substance [21]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Affects Response To Substance [21]
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) OTNE3T6Z CHIC2_HUMAN Affects Response To Substance [21]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Affects Response To Substance [21]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Affects Response To Substance [21]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Affects Response To Substance [60]
Kynurenine--oxoglutarate transaminase 3 (KYAT3) OTO4U2QK KAT3_HUMAN Affects Response To Substance [21]
Beta-secretase 2 (BACE2) OTO5YQVK BACE2_HUMAN Affects Response To Substance [21]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Affects Response To Substance [21]
SH3 domain-binding protein 5 (SH3BP5) OTOOEGUJ 3BP5_HUMAN Affects Response To Substance [21]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Affects Response To Substance [21]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Affects Response To Substance [21]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Affects Response To Substance [21]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Affects Response To Substance [21]
Kazrin (KAZN) OTPM7BYM KAZRN_HUMAN Affects Response To Substance [21]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Affects Response To Substance [21]
Centrosomal protein of 57 kDa (CEP57) OTPOHLIX CEP57_HUMAN Affects Response To Substance [21]
Epithelial membrane protein 2 (EMP2) OTPS2H0L EMP2_HUMAN Affects Response To Substance [21]
Dermatan-sulfate epimerase (DSE) OTQ108VJ DSE_HUMAN Affects Response To Substance [21]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Affects Response To Substance [21]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) OTQDYH8E ASM3A_HUMAN Affects Response To Substance [21]
MAPK/MAK/MRK overlapping kinase (MOK) OTQK7M9V MOK_HUMAN Affects Response To Substance [21]
High mobility group protein HMG-I/HMG-Y (HMGA1) OTQUSHPX HMGA1_HUMAN Affects Response To Substance [21]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Affects Response To Substance [21]
Dr1-associated corepressor (DRAP1) OTRWLF6D NC2A_HUMAN Affects Response To Substance [21]
Latent-transforming growth factor beta-binding protein 2 (LTBP2) OTS88GSD LTBP2_HUMAN Affects Response To Substance [21]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Affects Response To Substance [21]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Affects Response To Substance [21]
DNA repair protein RAD51 homolog 3 (RAD51C) OTUD6SY5 RA51C_HUMAN Increases Response To Substance [61]
Calcium-dependent secretion activator 2 (CADPS2) OTV1FW0M CAPS2_HUMAN Affects Response To Substance [21]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Affects Response To Substance [21]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Response To Substance [59]
Ensconsin (MAP7) OTVSSJ33 MAP7_HUMAN Affects Response To Substance [21]
Protein artemis (DCLRE1C) OTW3KB1I DCR1C_HUMAN Decreases Response To Substance [22]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Affects Response To Substance [21]
Protein mago nashi homolog (MAGOH) OTWRYTOX MGN_HUMAN Affects Response To Substance [21]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Affects Response To Substance [21]
Acylamino-acid-releasing enzyme (APEH) OTX258QE ACPH_HUMAN Affects Response To Substance [21]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Affects Response To Substance [21]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Response To Substance [21]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Affects Response To Substance [21]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Affects Response To Substance [21]
Arginine vasopressin-induced protein 1 (AVPI1) OTXSBR60 AVPI1_HUMAN Affects Response To Substance [21]
Neuroendocrine protein 7B2 (SCG5) OTXSJMT1 7B2_HUMAN Affects Response To Substance [21]
Carbamoyl-phosphate synthase , mitochondrial (CPS1) OTXV8NSR CPSM_HUMAN Affects Response To Substance [21]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Affects Response To Substance [21]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Affects Response To Substance [21]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Affects Response To Substance [21]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Affects Response To Substance [21]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Affects Response To Substance [21]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Affects Response To Substance [21]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Affects Response To Substance [21]
Epithelial discoidin domain-containing receptor 1 (DDR1) OTYW1SH8 DDR1_HUMAN Affects Response To Substance [21]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [21]
Suppressor of tumorigenicity 7 protein (ST7) OTZG8RC6 ST7_HUMAN Affects Response To Substance [21]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Response To Substance [59]
CTD small phosphatase-like protein (CTDSPL) OTZJ0CZK CTDSL_HUMAN Affects Response To Substance [21]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Affects Response To Substance [21]
Eukaryotic translation initiation factor 5B (EIF5B) OTZTT22W IF2P_HUMAN Affects Response To Substance [21]
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⏷ Show the Full List of 274 DOT(s)

References

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