Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4LSNE)

Drug Name
Procaine Drug Info
Synonyms
Allocaine; Anticort; Anuject; Duracaine; Gerokit; Gerovital; Jenacain; Jenacaine; Nissocaine; Norocaine; Novocain; Novocaine; Procain; Procaina; Procainum; Scurocaine; Spinocaine; Solution of novocain; Factor H3; SP01; SP01A; Stoff H3; Vitamin H3; Anticort (TM); Diethylaminoethyl p-aminobenzoate; Gerovital H-3; Novocain (TN); P-Aminobenzoyldiethylaminoethanol; P-Aminobenzyoyldiethylaminoethanol; Procaina [INN-Spanish]; Procaine (INN); Procaine [INN:BAN]; Procaine, base; Procainum [INN-Latin]; SP-01A; Solution of novocain (TN); Beta-Diethylaminoethyl 4-aminobenzoate; P-Aminobenzoic acid 2-diethylaminoethyl ester; Beta-(Diethylamino)ethyl 4-aminobenzoate; Beta-(Diethylamino)ethyl p-aminobenzoate; BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester; Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester; 2-(Diethylamino)ethyl 4-aminobenzoate; 2-(Diethylamino)ethyl p-aminobenzoate; 2-(Diethylamino)ethyl-4-aminobenzoate; 2-Diethylaminoethyl 4-aminobenzoate; 2-Diethylaminoethyl p-aminobenzoate; 2-Diethylaminoethylester kyseliny p-aminobenzoove; 2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]; 4-Aminobenzoesaeure-beta-diethylaminoethylester; 4-Aminobenzoic acid 2-(diethylamino) ethyl ester; 4-Aminobenzoic acid diethylaminoethyl ester
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
4914
ChEBI ID
CHEBI:8430
CAS Number
CAS 59-46-1
TTD Drug ID
DM4LSNE
ACDINA Drug ID
D01361

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 3A receptor (HTR3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dolasetron DMMG26Z Nausea MD90 Approved [7]
Alosetron DML2A03 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [8]
Tropisetron DMNSJ7V Fibromyalgia MG30.01 Approved [9]
Palonosetron DMBHMOX Nausea MD90 Approved [10]
Levetiracetam DMTGDN8 Epilepsy 8A60-8A68 Approved [9]
Cilansetron DMP0NGX Irritable bowel syndrome DD91.0 Phase 3 [11]
BEMESETRON DMSPJX9 N. A. N. A. Discontinued in Phase 3 [12]
Norcisapride DMJSKUI Gastroesophageal reflux disease DA22.Z Discontinued in Phase 2 [13]
YM-114 DML2IXO Nausea MD90 Discontinued in Phase 2 [14]
ATI-17000 DMZJVR5 Irritable bowel syndrome DD91.0 Preclinical [15]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Gefitinib DM15F0X Colon adenocarcinoma Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [19]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Estrone DM5T6US Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
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Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [32]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [6]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [6]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [37]
Etidronic acid DM1XHYJ Bone Paget disease Approved [6]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [6]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [39]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [44]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [45]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Arsenic DMTL2Y1 N. A. N. A. Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [45]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [59]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [60]
Paclitaxel DMLB81S Breast carcinoma Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [64]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [71]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [72]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [73]
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Drug(s) Affected By Cadherin-5 (CDH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ethanol DMDRQZU Chronic pain MG30 Approved [78]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [80]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [81]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [82]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [83]
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Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [90]
Ethanol DMDRQZU Chronic pain MG30 Approved [91]
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Drug(s) Affected By Histamine H1 receptor (HRH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [92]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [92]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Clozapine DMFC71L Schizophrenia 6A20 Approved [96]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [97]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [98]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [99]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [102]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Testosterone enanthate DMB6871 N. A. N. A. Approved [104]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [105]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 3A receptor (HTR3A) TTPC4TU 5HT3A_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Post-Translational Modifications [3]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Gene/Protein Processing [4]
Cadherin-5 (CDH5) OTVX0E1Q CADH5_HUMAN Gene/Protein Processing [3]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Biotransformations [5]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [4]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Drug Response [3]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) OTX7MWW1 ITPR1_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [6]

References

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58 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
59 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
60 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
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