General Information of Drug (ID: DM6A0X7)

Drug Name
Pravastatin Drug Info
Synonyms
Eptastatin; Oliprevin; Pravastatina; Pravastatine; Pravastatinum; Pravator; Vasten; Pravastatin Sodium Salt; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; KS-5015; Pravachol (TN); Pravastatin (INN); Pravastatin [INN:BAN]; Pravastatin tert-Octylamine Salt; Pravator (TN); RMS-431; Selektine (TN); SQ-31,000; (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid; 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid
Indication
Disease Entry ICD 11 Status REF
Adult acute monocytic leukemia Approved [1]
Arteriosclerosis BD40 Approved [1]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia, familial combined, LPL related Approved [1]
Hypertriglyceridemia 5C80.1 Approved [1]
Stroke 8B20 Investigative [1]
Therapeutic Class
Anticholesteremic Agents
Cross-matching ID
PubChem CID
54687
ChEBI ID
CHEBI:63618
CAS Number
CAS 81093-37-0
TTD Drug ID
DM6A0X7
VARIDT Drug ID
DR00045
INTEDE Drug ID
DR1327
ACDINA Drug ID
D00548

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting HMG-CoA reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [21]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [22]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [23]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [24]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [21]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [26]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [25]
TOCOTRIENOL DM1UE67 Hyperlipidaemia 5C80 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [10]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [10]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [10]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Folic Acid DMEMBJC Colorectal carcinoma Approved [46]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [51]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [52]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [54]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [55]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [57]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [58]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [59]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [11]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [60]
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Drug(s) Transported By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [61]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [61]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [61]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [62]
Sodium taurocholate DM3GO0J Type-2 diabetes 5A11 Phase 1/2 [6]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [66]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [67]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [68]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [69]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [70]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [71]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [72]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [64]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [74]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [75]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [76]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [77]
Levocetirizine DMQYLGP Allergic rhinitis CA08.0 Approved [78]
PGF2alpha DM4XAU7 Solid tumour/cancer 2A00-2F9Z Clinical trial [64]
uric acid DMA1MKT Discovery agent N.A. Investigative [79]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [81]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [82]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [55]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [57]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [59]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [83]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [59]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [85]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [86]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [87]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [88]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [89]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [90]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [91]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [60]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Phosphate DMUXQG7 Constipation DD91.1 Approved [4]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [93]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [94]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [95]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [96]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [98]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [94]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [104]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [105]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [106]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [107]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [108]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [110]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [105]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [111]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [112]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [114]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [115]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [114]
Verapamil DMA7PEW Angina pectoris BA40 Approved [116]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [117]
Estrone DM5T6US Acne vulgaris ED80 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
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Drug(s) Affected By Stromelysin-1 (MMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [19]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
Quercetin DM3NC4M Obesity 5B81 Approved [124]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [127]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [129]
Selenium DM25CGV N. A. N. A. Approved [130]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [133]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [134]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Arsenic DMTL2Y1 N. A. N. A. Approved [139]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [141]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [142]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [143]
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Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [144]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [147]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [153]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Fluoxetine DM3PD2C Bipolar depression Approved [158]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [147]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [4]
Organic anion transporter 7 (SLC22A9) DTDI5S3 S22A9_HUMAN Substrate [5]
Bile salt export pump (ABCB11) DTJ0EW4 ABCBB_HUMAN Substrate [6]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [7]
Organic anion transporter 4 (SLC22A11) DT06JWZ S22AB_HUMAN Substrate [8]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [9]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [13]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [15]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [16]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [17]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Drug Response [18]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Drug Response [19]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Drug Response [20]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Drug Response [19]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Drug Response [19]

References

1 Pravastatin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2953).
3 A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis. 2002 Jun;162(2):373-9.
4 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
5 Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors. Pharmacogenomics J. 2016 Aug;16(4):341-51.
6 Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82.
7 Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release. 2002 Jan 17;78(1-3):43-54.
8 Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007 Apr;37(4):416-26.
9 Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45.
10 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
11 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
12 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
13 Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8.
14 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
15 Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events. Clin Pharmacokinet. 2000 Dec;39(6):397-412.
16 In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors. Eur J Clin Pharmacol. 1996;50(3):209-15.
17 Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9.
18 Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. doi: 10.1001/jama.291.23.2821.
19 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
20 Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057.
21 Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64.
22 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
23 Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203.
24 New dimension of statin action on ApoB atherogenicity. Clin Cardiol. 2003 Jan;26(1 Suppl 1):I7-10.
25 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
26 Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46.
27 Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48(5):332-7.
28 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
29 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
30 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
31 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
32 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
33 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
34 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
35 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
36 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
37 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
38 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
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