Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7ICNU)

• Drug Name: Doxycycline Drug Info
• Synonyms: Atridox; Azudoxat; DOXY; Deoxymykoin; Dossiciclina; Doxiciclina; Doxitard; Doxivetin; Doxycen; Doxychel; Doxycin; Doxycyclin; Doxycyclinum; Doxysol; Doxytec; Doxytetracycline; Hydramycin; Investin; Jenacyclin; Liviatin; Monodox; Oracea; Ronaxan; Spanor; Supracyclin; Vibramycin; Vibramycine; Vibravenos; DOXCYCLINE ANHYDROUS; DOXYCYCLINE CALCIUM; DOXYCYCLINE MONOHYDRATE; Dossiciclina [DCIT]; Doxiciclina [Italian]; Doxycycline anhydrous; Doxycycline hyclate; Vibramycin Novum; Alpha-Doxycycline; Alti-Doxycycline; Apo-Doxy; BMY-28689; BU-3839T; Doxiciclina [INN-Spanish]; Doxy-Caps; Doxy-Puren; Doxy-Tabs; Doxychel (TN); Doxycycline (INN); Doxycycline (TN); Doxycycline (anhydrous); Doxycycline (internal use); Doxycycline-Chinoin; Doxycyclinum [INN-Latin]; Novo-Doxylin; Nu-Doxycycline; Periostat (TN); Vibra-tabs; Alpha-6-Deoxyoxytetracycline; DMSC (*Fosfatex); Doxycycline (200mg/day) or Placebo; Monodox (*monohydrate); Vibramycin (*monohydrate); Vivox (*Hyclate); GS-3065 (*monohydrate); Alpha-6-Deoxy-5-hydroxytetracycline; (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS); 5-Hydroxy-alpha-6-deoxytetracycline; 6-Deoxyoxytetracycline; 6-Deoxytetracycline; 6-alpha-Deoxy-5-oxytetracycline; 6alpha-Deoxy-5-oxytetracycline

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Actinomycosis		Approved	[1]
Acute gonococcal cervicitis		Approved	[1]
Acute gonococcal epididymo-orchitis		Approved	[1]
Advanced gum disease	DA0D	Approved	[2]
Anthrax	1B97	Approved	[1]
Bartonellosis		Approved	[1]
Boutonneuse fever		Approved	[1]
Brill-Zinsser disease		Approved	[1]
Bronchitis	CA20	Approved	[1]
Brucellosis		Approved	[1]
Chancroid		Approved	[1]
Chlamydiaceae infections		Approved	[1]
Chronic periodontitis	DA0C.Y	Approved	[2]
Colorectal carcinoma		Approved	[1]
Cutaneous anthrax		Approved	[1]
Endemic typhus		Approved	[1]
Epidemic louse-borne typhus		Approved	[1]
Gastrointestinal anthrax		Approved	[1]
Inhalational anthrax		Approved	[1]
Listeriosis		Approved	[1]
Lymphogranuloma venereum		Approved	[1]
Mycoplasma pneumoniae pneumonia		Approved	[1]
Ornithosis		Approved	[1]
Q fever		Approved	[1]
Relapsing fever		Approved	[1]
Rickettsialpox		Approved	[1]
Rickettsiosis		Approved	[1]
Rocky mountain spotted fever		Approved	[1]
Syphilis		Approved	[1]
Trachoma		Approved	[1]
Tularemia	1B94	Approved	[1]
Typhus		Approved	[1]
Yaws		Approved	[1]
Diabetic foot ulcer	BD54	Phase 2	[3]
Sinusitis	CA0A.Z	Investigative	[1]
Vibrio cholerae infection	1A00	Investigative	[1]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 54671203
  ChEBI ID: CHEBI:50845
  CAS Number: CAS 564-25-0
  TTD Drug ID: DM7ICNU
  VARIDT Drug ID: DR00666
  INTEDE Drug ID: DR0547
  ACDINA Drug ID: D00215

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[13]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[4]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[14]
TP-434	DM5A31S	Intra-abdominal infection	1A40	Approved	[15]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[16]
Sarecycline	DMLZNIQ	Acne vulgaris	ED80	Approved	[17]
ME1100	DM39PSZ	Bacterial pneumonia	CA40.0	Phase 1	[18]
TP-6076	DM5RIT8	Enterobacteriaceae infection	MG50.C	Phase 1	[19]
TP-271	DM3PJSE	Pneumonia	CA40	Phase 1	[20]
TP 6076	DMD0NA1	Multidrug resistant infection	MG51	Phase 1	[19]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[23]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[5]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[36]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[38]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[39]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[40]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[42]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[43]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[44]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[42]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[49]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[50]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[51]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[52]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[53]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[54]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[57]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[65]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[66]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[70]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[11]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[71]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[83]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[84]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[84]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[90]

Drug(s) Affected By Neutrophil collagenase (MMP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[7]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[7]
Edetic acid	DM10D85	Hypercalcaemia	5B91.0	Investigative	[93]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[95]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[10]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[97]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[7]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[110]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[111]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[7]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[8]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[9]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Gene/Protein Processing	[10]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[8]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Gene/Protein Processing	[11]
Neutrophil collagenase (MMP8)	OTZXH19L	MMP8_HUMAN	Gene/Protein Processing	[7]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Gene/Protein Processing	[7]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Gene/Protein Processing	[12]
UDP-glucuronosyltransferase 1A10	OTOTZVEY	UD110_HUMAN	Gene/Protein Processing	[8]

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