Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8YMWE)

Drug Name
Riboflavin Drug Info
Synonyms
riboflavin; vitamin B2; Lactoflavin; Riboflavine; Vitamin G; 83-88-5; Lactoflavine; (-)-riboflavin; Beflavine; Beflavin; Riboflavina; Flavaxin; Vitaflavine; Riboflavinum; Ribocrisina; Ribovel; Lactobene; Ribotone; Flaxain; Ribosyn; Riboderm; Ribipca; Flavin BB; Vitasan B2; Fiboflavin; Dermadram; Hyflavin; HYRE; Vitamin Bi; Aqua-Flave; 7,8-Dimethyl-10-ribitylisoalloxazine; Russupteridine Yellow III; 6,7-Dimethyl-9-D-ribitylisoalloxazine; Riboflavinequinone; Riboflavinum [INN-Latin]; Riboflavine [INN-French]; Riboflavina [INN-Spanish]
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Vitamin deficiency 5B55-5B71 Approved [2]
Cross-matching ID
PubChem CID
493570
ChEBI ID
CHEBI:17015
CAS Number
CAS 83-88-5
TTD Drug ID
DM8YMWE
VARIDT Drug ID
DR00079
INTEDE Drug ID
DR1416

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [29]
Estrone DM5T6US Acne vulgaris ED80 Approved [30]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [31]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [32]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [33]
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Drug(s) Metabolized By NADPH-dependent oxidoreductase (nfrA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [7]
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [7]
Drug(s) Metabolized By NADPH-dependent nitroreductase (nfrA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [8]
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [8]
Drug(s) Metabolized By Nitroreductase (NTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [9]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [34]
Mononitrophenol DM4QO9G N. A. N. A. Investigative [9] , [10]
Nitrobenzoate DM6FVHC N. A. N. A. Investigative [9] , [10]
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [38]
Etretinate DM2CZFA Keratosis ED56 Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
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Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Ketoprofen DMRKXPT Bursitis Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Selenium DM25CGV N. A. N. A. Approved [60]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [61]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [67]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [68]
Paclitaxel DMLB81S Breast carcinoma Approved [69]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [74]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [77]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [79]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [82]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [60]
Etretinate DM2CZFA Keratosis ED56 Approved [39]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [92]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
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Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Testosterone DM7HUNW Hot flushes GA30 Approved [101]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [101]
Leflunomide DMR8ONJ Arthritis FA20 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [74]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [105]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [107]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Meloxicam DM2AR7L Arthritis FA20 Approved [110]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
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Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [101]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [101]
Leflunomide DMR8ONJ Arthritis FA20 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Fructose DM43AN2 Vomiting MD90 Approved [114]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [115]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [117]
Leflunomide DMR8ONJ Arthritis FA20 Approved [102]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
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Drug(s) Affected By Zinc finger protein PLAGL1 (PLAGL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [123]
Arsenic DMTL2Y1 N. A. N. A. Approved [124]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [125]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [126]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [127]
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Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [128]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [129]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [101]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [133]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [134]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Riboflavin transporter 2 (SLC52A3) DTBVQIO S52A3_HUMAN Substrate [3]
Riboflavin transporter 3 (SLC52A2) DTAVOS6 S52A2_HUMAN Substrate [3]
Riboflavin transporter 1 (SLC52A1) DT7NOKR S52A1_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [5]
Eosinophil peroxidase (EPX) DETE84Z PERE_HUMAN Substrate [6]
Tartrate-resistant acid ATPase (ACP5) DESITDW PPA5_HUMAN Substrate [6]
Xylosyl phosphatase (PXYLP1) DEGSUI0 PXYP1_HUMAN Substrate [6]
Prostatic acid phosphatase (ACP3) DEDW5H6 PPAP_HUMAN Substrate [6]
Acid phosphatase-like protein 1 (ACP6) DER6BCE PPA6_HUMAN Substrate [6]
NADPH-dependent oxidoreductase (nfrA) DE82GV7 NRFA_STAA8 Substrate [7]
NADPH-dependent nitroreductase (nfrA1) DE21PLI NFRA1_BACSU Substrate [8]
Nitroreductase (NTR) DE0K82S A0A5K1UB29_SALTM Substrate [9] , [10]
Testicular acid phosphatase (ACP4) DE3OZT4 PPAT_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Gene/Protein Processing [11]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [12]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [12]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [12]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [13]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [11]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Gene/Protein Processing [13]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Gene/Protein Processing [11]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Drug Response [14]

References

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2 Riboflavin FDA Label
3 An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188.
4 Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. Mol Cell Biol. 2007 Feb;27(4):1247-53.
5 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
6 An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507)
7 Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500.
8 Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5.
9 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
10 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter
11 Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
12 [Apoptosis of human gastric cancer cell induced by photochemical riboflavin]. Ai Zheng. 2003 Mar;22(3):253-6.
13 Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J Nutr Biochem. 2006 Apr;17(4):250-6. doi: 10.1016/j.jnutbio.2005.05.004. Epub 2005 Jun 13.
14 Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status. Nutrition. 2007 Mar;23(3):229-35. doi: 10.1016/j.nut.2006.12.006. Epub 2007 Feb 14.
15 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
16 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
17 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
18 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
19 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
20 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
21 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
22 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
23 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
24 Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
25 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
26 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
27 Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
28 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
29 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
30 A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
31 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
32 Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
33 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
34 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
35 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
36 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
37 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
38 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
39 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
40 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
41 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
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