Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9SCME)

Drug Name
IRX4204 Drug Info
Synonyms
220619-73-8; CHEMBL75133; UNII-877M97Z38Y; VTP-194204; 877M97Z38Y; KB-145960; SCHEMBL3437269; MolPort-042-665-869; ZINC1550770; IRX-4204; 3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid; BDBM50101445; DB11806; VTP 194204; (+)-VTP-194204; AGN 4204; (2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1 [1]
Non-small-cell lung cancer 2C25.Y Phase 1 [1]
Pancreatic cancer 2C10 Phase 1 [1]
Prostate cancer 2C82.0 Phase 1 [2]
Cross-matching ID
PubChem CID
9863341
CAS Number
CAS 220619-73-8
TTD Drug ID
DM9SCME

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor RXR-gamma (RXRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [8]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [9]
NRX-4204 DMYXOU2 Diabetic complication 5A2Y Phase 2 [10]
9cUAB-30 DMYKPXJ Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
SR-11237 DMQG3CK Solid tumour/cancer 2A00-2F9Z Terminated [12]
AGN-34 DM5ECDM Discovery agent N.A. Investigative [13]
LG100754 DMEK4FY Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Retinoic acid receptor RXR (RXR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IRX-5183 DMCED9U Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [15]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [19]
Fluoxetine DM3PD2C Bipolar depression Approved [16]
Fructose DM43AN2 Vomiting MD90 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [16]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [24]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [25]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [31]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Gefitinib DM15F0X Colon adenocarcinoma Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [37]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [36]
Etretinate DM2CZFA Keratosis ED56 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [49]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [50]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [51]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [51]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [52]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [36]
Etretinate DM2CZFA Keratosis ED56 Approved [44]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [62]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [67]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [80]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Fluoxetine DM3PD2C Bipolar depression Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [95]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [97]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [98]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [101]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
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Drug(s) Affected By Mitogen-activated protein kinase 4 (MAPK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [107]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [108]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [109]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [110]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [111]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [112]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [115]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [116]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [117]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [118]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [120]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [121]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [122]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Prednisone DM2HG4X Acute asthma CA23 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Fluoxetine DM3PD2C Bipolar depression Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [132]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [133]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Gefitinib DM15F0X Colon adenocarcinoma Approved [138]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [140]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [141]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
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Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [147]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [148]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [150]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [151]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [152]
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Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
Testosterone DM7HUNW Hot flushes GA30 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [157]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [158]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [159]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [160]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor RXR (RXR) TTP7WQM NOUNIPROTAC Agonist [1]
Retinoic acid receptor RXR-gamma (RXRG) TTH029C RXRG_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [4]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Drug Response [5]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Protein Interaction/Cellular Processes [7]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [6]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Gene/Protein Processing [6]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02438215) Study of IRX4204 for Treatment of Early Parkinson's Disease. U.S. National Institutes of Health.
3 Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease.Oncotarget.2016 Feb 16;7(7):7469-79.
4 Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clin Cancer Res. 2005 Jul 1;11(13):4851-6. doi: 10.1158/1078-0432.CCR-04-2160.
5 Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands. BMC Cancer. 2010 Nov 16;10:629. doi: 10.1186/1471-2407-10-629.
6 A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. Breast Cancer Res. 2004;6(5):R546-55. doi: 10.1186/bcr913. Epub 2004 Jul 23.
7 Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators. Arterioscler Thromb Vasc Biol. 2001 May;21(5):746-51. doi: 10.1161/01.atv.21.5.746.
8 Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
9 Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
10 DOI: 10.1038/scibx.2010.766
11 In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metab Dispos. 2007 Jul;35(7):1157-64.
12 Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem. 2009 Jul;4(7):1143-52.
13 Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403.
14 Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 Oct 3;383(6599):450-3.
15 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
16 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
17 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
18 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
19 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
20 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
21 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
22 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
23 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
24 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
25 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
26 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
27 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
28 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
29 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
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