Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDF79Z)

• Drug Name: Acetylcholine Drug Info
• Synonyms: acetylcholine; Choline acetate; O-Acetylcholine; Acetyl choline ion; Acetylcholinum; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline cation; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ach; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; Bromoacetylcholine; EINECS 200-128-9; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; Miochol; Miochol-e

Indication

Disease Entry	ICD 11	Status	REF
Cataract	9B10	Approved	[1] , [2]

• Therapeutic Class: Cardiovascular Agents
• Cross-matching ID:
  PubChem CID: 187
  ChEBI ID: CHEBI:15355
  CAS Number: CAS 51-84-3
  TTD Drug ID: DMDF79Z
  VARIDT Drug ID: DR00070
  INTEDE Drug ID: DR0041

Molecule-Related Drug Atlas

Drug(s) Metabolized By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[9]

Drug(s) Transported By Organic cation transporter 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Migraine	8A80	Approved	[10]
Ergotidine	DM78IME	Respiratory allergy	4A80	Approved	[11]
Metformin	DM89QE1	Type-2 diabetes	5A11	Approved	[12]
Clonidine	DM6RZ9Q	Hypertension	BA00-BA04	Approved	[10]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[13]
Epinephrine	DM3KJBC	Allergy	4A80-4A85	Approved	[11]
Norepinephrine	DMOUC09	Sepsis	1G40-1G41	Approved	[11]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[15]
Etilefrine	DM67PWD	Cardiovascular disease	BA00-BE2Z	Withdrawn from market	[16]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[17]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Oxaliplatin	DMQNWRD	Colorectal cancer	2B91.Z	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[22]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[23]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[24]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[25]
Propranolol	DM79NTF	Migraine	8A80	Approved	[10]

Drug(s) Transported By Choline transporter-like protein 4 (SLC44A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin B1	DMZ1WXJ	Vitamin B1 deficiency	5B5A	Approved	[26]
Choline	DM5D9YK	Discovery agent	N.A.	Investigative	[27]

Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[28]
Darifenacin	DMWXLYZ	Overactive bladder	GC50.0	Approved	[29]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[30]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[31]
Oxybutynin hydrochloride	DMF2KLU	Urinary incontinence	MF50.2	Approved	[32]
Incruse ellipta	DM32GSJ	Chronic obstructive pulmonary disease	CA22	Approved	[33]
Revefenacin	DMMP5SI	Chronic obstructive pulmonary disease	CA22	Approved	[34]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[35]
Isopropamide iodide	DMQYV60	Allergic rhinitis	CA08.0	Approved	[36]
SUN-101	DMXNZQK	Chronic obstructive pulmonary disease	CA22	Phase 3	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor (CHRM)	TTOXS3C	NOUNIPROTAC	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Choline transporter-like protein 4 (SLC44A4)	DT8KXR9	CTL4_HUMAN	Substrate	[4]
Vesicular acetylcholine transporter (SLC18A3)	DT3T2K0	VACHT_HUMAN	Substrate	[5]
Organic cation transporter 3 (SLC22A3)	DT6201N	S22A3_HUMAN	Substrate	[6]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Acetylcholinesterase (ACHE) Main DME	DEQ2BAJ	ACES_HUMAN	Substrate	[8]

References

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