Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH6LD0)

Drug Name
7alpha-hydroxycholesterol Drug Info
Synonyms 7-alpha-OHC
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
107722
ChEBI ID
CHEBI:17500
CAS Number
CAS 566-26-7
TTD Drug ID
DMH6LD0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting EBV-induced G-protein coupled receptor 2 (GPR183)
Drug Name Drug ID Indication ICD 11 Highest Status REF
27-hydroxycholesterol DM2L6OZ Discovery agent N.A. Investigative [2]
25-hydroxycholesterol DMCHAQ7 Discovery agent N.A. Investigative [2]
7alpha,25-dihydroxycholesterol DM2N8TW Discovery agent N.A. Investigative [10]
7alpha,27-dihydroxycholesterol DM52UOM Discovery agent N.A. Investigative [2]
7beta-hydroxycholesterol DMPHJZU Discovery agent N.A. Investigative [2]
7beta, 27-dihydroxycholesterol DMSDINR Discovery agent N.A. Investigative [2]
7beta, 25-dihydroxycholesterol DMYKXWE Discovery agent N.A. Investigative [2]
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Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [15]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [16]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [19]
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Drug(s) Affected By Prostaglandin E synthase (PTGES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Menthol DMG2KW7 Back pain ME84.Z Approved [25]
Mestranol DMG3F94 Contraception QA21 Approved [20]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [26]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [27]
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Drug(s) Affected By Integrin beta-1 (ITGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [33]
Fructose DM43AN2 Vomiting MD90 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [42]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [43]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [49]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [50]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [58]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [59]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [64]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [69]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [79]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [78]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [80]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [87]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [72]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [92]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [92]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [38]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [92]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [96]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [104]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [108]
Paclitaxel DMLB81S Breast carcinoma Approved [109]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [110]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [113]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [114]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [115]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [116]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [117]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [118]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [120]
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Drug(s) Affected By Cholesterol 24-hydroxylase (CYP46A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [6]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [6]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Arsenic DMTL2Y1 N. A. N. A. Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [6]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [124]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [6]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [125]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
EBV-induced G-protein coupled receptor 2 (GPR183) TTME5YJ GP183_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Cholesterol 24-hydroxylase (CYP46A1) OTJ27FOX CP46A_HUMAN Biotransformations [6]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Gene/Protein Processing [8]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [9]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4351).
2 Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.
3 Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. PLoS One. 2014 May 6;9(5):e96795.
4 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):462-70. doi: 10.1016/j.taap.2013.12.007. Epub 2013 Dec 24.
5 Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. Eur J Pharmacol. 2002 Dec 5;456(1-3):29-37. doi: 10.1016/s0014-2999(02)02639-0.
6 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
7 Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. doi: 10.1007/s10565-005-0141-2.
8 Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. J Clin Invest. 1996 Jan 15;97(2):461-8. doi: 10.1172/JCI118436.
9 7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. Atherosclerosis. 2000 Nov;153(1):23-35. doi: 10.1016/s0021-9150(00)00380-4.
10 Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.
11 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
12 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
13 Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-B signaling pathway. Immunobiology. 2011 Mar;216(3):367-73. doi: 10.1016/j.imbio.2010.07.011. Epub 2010 Aug 19.
14 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
15 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
16 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
17 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
18 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
19 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
20 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
21 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
22 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
23 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
24 Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
25 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
26 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
27 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
28 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
29 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
30 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
31 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
32 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
33 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
34 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
35 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
36 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
37 Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
38 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
39 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
40 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
41 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
42 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
43 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
44 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
45 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
46 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
47 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
48 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
49 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
50 Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
51 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
52 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
53 Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
54 Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
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