Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKYQWG)

Drug Name
NORHARMANE Drug Info
Synonyms
9H-Pyrido[3,4-B]indole; Norharman; Norharmane; 244-63-3; beta-Carboline; 2,9-Diazafluorene; Carbazoline; 9H-Beta-carboline; 2-Azacarbazole; 9H-Pyrido(3,4-B)indole; .beta.-Carboline; Carbazoline (VAN); b-carboline; beta Carboline; 2H-Pyrido[3,4-b]indole; UNII-94HMA1I78O; CCRIS 6915; CHEBI:109895; EINECS 205-959-0; NSC 84417; BRN 0128414; MLS000069651; 94HMA1I78O; CHEMBL275224; AIFRHYZBTHREPW-UHFFFAOYSA-N; Norharman, 98%; SMR000058207; AK-25655; N-8720; N-8700; 244-66-6; SR-01000000213; 9h-; Prestwick_363; Norharmane, 98%; zlchem 7
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
64961
ChEBI ID
CHEBI:109895
CAS Number
CAS 244-63-3
TTD Drug ID
DMKYQWG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [7]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [8]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [7]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [7]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [9]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [7]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [7]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [10]
Meprobamate DMHM93Y Anxiety Approved [7]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [11]
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Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [7]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [12]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [10]
Clonazepam DMTO13J Absence epilepsy Approved [13]
Piperazine DMTY9LU Ascariasis 1F62 Approved [14]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [15]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [16]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [17]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [12]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [18]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [27]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [28]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [31]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
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Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [35]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [37]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [38]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Trospium chloride DM32XZT Discovery agent N.A. Approved [40]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [41]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [35]
Trospium chloride DM32XZT Discovery agent N.A. Approved [40]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [43]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [46]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [39]
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Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [47]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [47]
Norepinephrine DMOUC09 Alopecia ED70 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [49]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [50]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Haloperidol DM96SE0 Delirium Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [55]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [63]
Paclitaxel DMLB81S Breast carcinoma Approved [64]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [86]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [89]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [63]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [90]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [93]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [94]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [95]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [99]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [100]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [103]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [104]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [105]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [106]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Meloxicam DM2AR7L Arthritis FA20 Approved [109]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [110]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [111]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Verapamil DMA7PEW Angina pectoris BA40 Approved [113]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [114]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [115]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [116]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [2]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [3]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [5]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [6]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Gene/Protein Processing [5]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [5]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [5]

References

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