Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLRNV2)

Drug Name
AMENTOFLAVONE Drug Info
Synonyms
Amentoflavone; 1617-53-4; 3',8''-Biapigenin; Didemethyl-ginkgetin; Amenthoflavone; UNII-9I1VC79L77; MLS000574827; CHEBI:2631; 9I1VC79L77; SMR000156235; Q-100192; 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281600
ChEBI ID
CHEBI:2631
CAS Number
CAS 1617-53-4
TTD Drug ID
DMLRNV2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [10]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [11]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [12]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [11]
ELTANOLONE DM38CIV Premenstrual syndrome GA34.40 Discontinued in Phase 3 [10]
U-78875 DM2WOPX Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [13]
CGS-9896 DM39PQI N. A. N. A. Terminated [14]
CGS-17867A DMMZJY3 Alcohol dependence 6C40.2 Terminated [15]
TBPS DMFC3XP Discovery agent N.A. Investigative [16]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [17]
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Drug(s) Targeting Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
AZD5991 DM7QGHO Haematological malignancy 2B33.Y Phase 1 [19]
AMG 176 DM0Q7NO Acute myeloid leukaemia 2A60 Phase 1 [19]
PRT1419 DMIKE0O Melanoma 2C30 Phase 1 [20]
ABBV-467 DM87SM9 Multiple myeloma 2A83 Phase 1 [21]
MIK665 DMTUVCG Acute myeloid leukaemia 2A60 Phase 1 [22]
AMG 397 DM7CNTG Refractory hematologic malignancy 2A85.5 Phase 1 [23]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [24]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [24]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [24]
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Drug(s) Targeting GABA(A) receptor alpha-5 (GABRA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [25]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [26]
Basmisanil DMQ8J0U Alzheimer disease 8A20 Phase 2 [27]
RG-7816 DMD16JK Autism spectrum disorder 6A02 Phase 1 [28]
TBPS DMFC3XP Discovery agent N.A. Investigative [25]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [29]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [25]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [30]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [25]
CI-218872 DM0RH3S Discovery agent N.A. Investigative [31]
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Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopurinol DMLPAOB Gout FA25 Approved [32]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [33]
Fosdenopterin DMR0TYK Molybdenum cofactor deficiency 5B5K.A Approved [34]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [35]
Oxypurinol DMURH4X Heart failure BD10-BD13 Phase 2/3 [36]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [3]
Topiroxostat DMA04DE Gout FA25 Phase 2 [37]
TMX-049 DME8PFQ Diabetic nephropathy GB61.Z Phase 2 [38]
LC-350189 DMHT3CB Gout FA25 Phase 1 [39]
Azaindole derivative 5 DMD2BL3 N. A. N. A. Patented [40]
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Drug(s) Targeting GABA(A) receptor alpha-2 (GABRA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [41]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [26]
PF-4480682 DMWYJHC Neuropathic pain 8E43.0 Discontinued in Phase 2 [42]
CGS-17867A DMMZJY3 Alcohol dependence 6C40.2 Terminated [15]
TBPS DMFC3XP Discovery agent N.A. Investigative [41]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [29]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [41]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [30]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [41]
CI-218872 DM0RH3S Discovery agent N.A. Investigative [31]
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Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [43]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [44]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [43]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [43]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [10]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [43]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [43]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [11]
Meprobamate DMHM93Y Anxiety Approved [43]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [45]
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Drug(s) Targeting GABA(A) receptor alpha-3 (GABRA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [46]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [26]
Adipiplon DM821BS Sleep-wake disorder 7A00-7B2Z Phase 2 [47]
NS-2710 DMMUR6V Anxiety disorder 6B00-6B0Z Phase 2 [48]
AZD6280 DMFAZLU Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [49]
TBPS DMFC3XP Discovery agent N.A. Investigative [46]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [29]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [46]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [30]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [46]
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Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [43]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [50]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [11]
Clonazepam DMTO13J Absence epilepsy Approved [51]
Piperazine DMTY9LU Ascariasis 1F62 Approved [52]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [53]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [54]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [55]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [50]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [12]
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Drug(s) Targeting GABA(A) receptor beta-2 (GABRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [10]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [11]
Ethchlorvynol DM53IP1 Insomnia 7A00-7A0Z Approved [43]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [12]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [11]
ELTANOLONE DM38CIV Premenstrual syndrome GA34.40 Discontinued in Phase 3 [10]
U-78875 DM2WOPX Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [56]
CGS-9896 DM39PQI N. A. N. A. Terminated [14]
TBPS DMFC3XP Discovery agent N.A. Investigative [57]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [17]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [58]
Indomethacin DMSC4A7 Bursitis Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [66]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [67]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [68]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [69]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [72]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [80]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [81]
Estrone DM5T6US Acne vulgaris ED80 Approved [82]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [83]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [84]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [85]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [86]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [87]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
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Drug(s) Affected By L-dopachrome tautomerase (DCT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [100]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [103]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [102]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [89]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [104]
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Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [106]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [110]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [111]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [112]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [58]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [113]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [1]
GABA(A) receptor alpha-2 (GABRA2) TTBMV1G GBRA2_HUMAN Inhibitor [1]
GABA(A) receptor alpha-3 (GABRA3) TT37EDJ GBRA3_HUMAN Inhibitor [1]
GABA(A) receptor alpha-5 (GABRA5) TTNZPQ1 GBRA5_HUMAN Inhibitor [1]
GABA(A) receptor beta-2 (GABRB2) TTZA1NY GBRB2_HUMAN Inhibitor [1]
GABA(A) receptor gamma-2 (GABRG2) TT06RH5 GBRG2_HUMAN Inhibitor [1]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [2]
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [4]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Gene/Protein Processing [5]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Gene/Protein Processing [6]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [6]
Prostaglandin-H2 D-isomerase (PTGDS) OT71NN7C PTGDS_HUMAN Protein Interaction/Cellular Processes [7]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Gene/Protein Processing [8]
Tyrosinase OTX54MAA TYRO_HUMAN Gene/Protein Processing [5]
UDP-glucuronosyltransferase 1-6 OTGTQ2C9 UD16_HUMAN Gene/Protein Processing [9]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Gene/Protein Processing [9]
UDP-glucuronosyltransferase 1A10 OTOTZVEY UD110_HUMAN Gene/Protein Processing [9]

References

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8 Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPAR/CD36 signal pathway. Toxicol Appl Pharmacol. 2021 Nov 15;431:115733. doi: 10.1016/j.taap.2021.115733. Epub 2021 Sep 29.
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49 AZD6280, a novel partial -aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.J Clin Psychopharmacol.2015 Feb;35(1):22-33.
50 Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
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