General Information of Drug (ID: DMNWIYM)

Drug Name
Flavanone Drug Info
Synonyms
FLAVANONE; 487-26-3; 2-Phenylchroman-4-one; 2,3-Dihydroflavone; 2-Phenyl-4-chromanone; 4-Flavanone; 2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-2-phenyl-; 2-Phenyl-2,3-dihydro-4H-chromen-4-one; NSC-50393; 2,3-Dihydro-2-phenyl-4H-benzopyran-4-one; 2-Phenyl-chroman-4-one; 2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one; EINECS 207-654-8; NSC 50393; BRN 0183227; MLS002667384; CHEMBL274318; CHEBI:5070; ZONYXWQDUYMKFB-UHFFFAOYSA-N; NSC50393; 2-phenyl-2,3-dihydrochromen-4-one; MFCD00006841; (-)-Flavanone
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10251
ChEBI ID
CHEBI:5070
CAS Number
CAS 487-26-3
TTD Drug ID
DMNWIYM
INTEDE Drug ID
DR2357

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [8]
BVT.2733 DM6RUKX Lupus 4A40 Phase 3 [9]
INCB13739 DMLQ3PO Type-2 diabetes 5A11 Phase 2a [10]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [11]
JTT-654 DM50M2R Type-2 diabetes 5A11 Phase 2 [12]
RG-4929 DMT4QRD Metabolic disorder 5C50-5D2Z Phase 2 [12]
BMS-770767 DMTVGY7 Hypercholesterolaemia 5C80.0 Phase 2 [12]
UE-2343 DMIERPK Alzheimer disease 8A20 Phase 2 [13]
AZD-4017 DML9M5S Ocular hypertension 9C61.01 Phase 2 [12]
Xanamem DM580GT Alzheimer disease 8A20 Phase 1/2 [14]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [15]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [16]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [17]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [18]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [19]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [20]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [21]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [22]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [23]
Budipine DMODHQI Migraine 8A80 Approved [24]
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Drug(s) Metabolized By Biphenyl dioxygenase (bphC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoflavone DM7U58J N. A. N. A. Phase 4 [3]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [3]
flavone DMEQH6J Discovery agent N.A. Investigative [3]
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [25]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [26]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [27]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Ethacrynic acid DM60QMR Edema MG29 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [32]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [33]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [34]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [35]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [35]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [36]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [37]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [38]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [39]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [41]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [42]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [46]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [48]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [49]
Capsaicin DMGMF6V Back pain ME84.Z Approved [50]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [51]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [56]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Fructose DM43AN2 Vomiting MD90 Approved [63]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [64]
Estrone DM5T6US Acne vulgaris ED80 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [65]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [65]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [65]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [82]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Epinephrine DM3KJBC Acute asthma CA23 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Fructose DM43AN2 Vomiting MD90 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [100]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [103]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Etretinate DM2CZFA Keratosis ED56 Approved [108]
Prednisone DM2HG4X Acute asthma CA23 Approved [109]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Prednisone DM2HG4X Acute asthma CA23 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Fluoxetine DM3PD2C Bipolar depression Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Epinephrine DM3KJBC Acute asthma CA23 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Fructose DM43AN2 Vomiting MD90 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [124]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [129]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [133]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [134]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [135]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [139]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [140]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [141]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [142]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [143]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [136]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Meloxicam DM2AR7L Arthritis FA20 Approved [144]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [147]
Artemether DM48QOT Malaria 1F40-1F45 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [150]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [151]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [2]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Biphenyl dioxygenase (bphC) Main DME DEUX61H BPHC_PSEFK Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [5]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [5]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [6]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [6]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Gene/Protein Processing [7]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Gene/Protein Processing [5]

References

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27 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
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