Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOGFVH)

Drug Name
lysophosphatidylcholine Drug Info
Synonyms
Lysophosphatidylcholine; 1-acetyl-sn-glycero-3-phosphocholine; AC1NSKBT; GTPL2508; SCHEMBL19821626; CHEBI:138424; LMGP01050043; [(2R)-3-acetyloxy-2-hydroxypropyl] 2-trimethylazaniumylethyl phosphate; [(2R)-3-acetyloxy-2-hydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate; 3,5,9-Trioxa-4-phosphaundecan-1-aminium, 4,7-dihydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (R)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5311264
ChEBI ID
CHEBI:138424
CAS Number
CAS 9008-30-4
TTD Drug ID
DMOGFVH
VARIDT Drug ID
DR00231

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Short transient receptor potential channel 5 (TRPC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BI 1358894 DM740BS Depression 6A70-6A7Z Phase 2 [11]
GFB-887 DM2IJWG Diabetic nephropathy GB61.Z Phase 2 [12]
2-APB DM9AKVR Discovery agent N.A. Investigative [13]
daidzein DMRFTJX Discovery agent N.A. Investigative [2]
KB-R7943 DMMD5W3 Discovery agent N.A. Investigative [14]
BTP2 DMNM63G Discovery agent N.A. Investigative [2]
bromoenol lactone DMKQ0CA Discovery agent N.A. Investigative [15]
ML204 DM15YL0 Discovery agent N.A. Investigative [16]
(-)-englerin A DMPQBWY Discovery agent N.A. Investigative [17]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [3]
ACAA DMACYPW Discovery agent N.A. Investigative [3]
OAG DMOP8IJ Discovery agent N.A. Investigative [18]
KB-R7943 DMMD5W3 Discovery agent N.A. Investigative [3]
flufenamate DMN8AP0 Discovery agent N.A. Investigative [3]
SAG DMHOG7W Discovery agent N.A. Investigative [18]
ML9 DMP13VE Discovery agent N.A. Investigative [3]
hyp 9 DM0U8IV Discovery agent N.A. Investigative [19]
SLG DMEBPCO Discovery agent N.A. Investigative [18]
20-HETE DM5BAJ9 Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Transient receptor potential cation channel V2 (TRPV2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [20]
2-APB DM9AKVR Discovery agent N.A. Investigative [20]
diphenylboronic anhydride DMRQZTS Discovery agent N.A. Investigative [20]
lysophosphatidylinositol DMETM3R Discovery agent N.A. Investigative [4]
citral DM53ZGY Discovery agent N.A. Investigative [21]
cannabinol DMM6A7P Discovery agent N.A. Investigative [22]
TRIM DMNHU4M Discovery agent N.A. Investigative [20]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Transported By Major facilitator superfamily domain-containing protein 2A (SLC59A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [23]
Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [30]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [30]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [31]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-33 (IL33)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [36]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [37]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [46]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [52]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [52]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [55]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [58]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [59]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [63]
Verapamil DMA7PEW Angina pectoris BA40 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [66]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [71]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [72]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [73]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [74]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [76]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [77]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G-protein coupled receptor 4 (GPR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [80]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [81]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [82]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [83]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Gefitinib DM15F0X Colon adenocarcinoma Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit beta-3 (LAMB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Selenium DM25CGV N. A. N. A. Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [97]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [103]
Panobinostat DM58WKG Chronic graft versus host disease Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [110]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [112]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [113]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [116]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [116]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [110]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Ethanol DMDRQZU Chronic pain MG30 Approved [121]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [116]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [116]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [126]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [127]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [81]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Short transient receptor potential channel 5 (TRPC5) TT32NQ1 TRPC5_HUMAN Activator [2]
Short transient receptor potential channel 6 (TRPC6) TTRBT3W TRPC6_HUMAN Activator [3]
Transient receptor potential cation channel V2 (TRPV2) TTBECWA TRPV2_HUMAN Activator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Major facilitator superfamily domain-containing protein 2A (SLC59A1) DT5G94L NLS1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Gene/Protein Processing [7]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7) OTWOBMQ9 ENPP7_HUMAN Biotransformations [8]
G-protein coupled receptor 4 (GPR4) OTIBF32I GPR4_HUMAN Gene/Protein Processing [6]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [9]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [7]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [6]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Gene/Protein Processing [6]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Gene/Protein Processing [6]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Gene/Protein Processing [10]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2508).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
4 Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39.
5 Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 22;509(7501):503-6.
6 Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation. Toxicol In Vitro. 2021 Dec;77:105227. doi: 10.1016/j.tiv.2021.105227. Epub 2021 Jul 20.
7 Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells. J Clin Biochem Nutr. 2016 May;58(3):193-201. doi: 10.3164/jcbn.16-2. Epub 2016 Apr 16.
8 Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem. 2003 Oct 3;278(40):38528-36. doi: 10.1074/jbc.M305437200. Epub 2003 Jul 28.
9 Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J Am Soc Nephrol. 1998 Nov;9(11):1990-7. doi: 10.1681/ASN.V9111990.
10 Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. Br J Dermatol. 2004 Nov;151(5):961-70. doi: 10.1111/j.1365-2133.2004.06175.x.
11 Clinical pipeline report, company report or official report of Boehringer Ingelheim.
12 Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design. Kidney Int Rep. 2021 Jul 23;6(10):2575-2584.
13 Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol. 2005 Jun;145(4):405-14.
14 The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6.
15 Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels. J Pharmacol Exp Ther. 2011 Nov;339(2):329-40.
16 Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.
17 (-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.
18 Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
19 Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.
20 Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68.
21 Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
22 TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
23 Mfsd2a Is a Transporter for the Essential -3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14.
24 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
25 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
26 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
27 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
28 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
29 In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
30 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
31 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
32 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
33 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
34 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
35 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
36 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
37 The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue. Toxicology. 2020 Dec 1;445:152600. doi: 10.1016/j.tox.2020.152600. Epub 2020 Sep 22.
38 The PPAR-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells. Chem Biol Interact. 2022 Jan 5;351:109712. doi: 10.1016/j.cbi.2021.109712. Epub 2021 Oct 23.
39 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
40 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
41 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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