Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ6SJT)

Drug Name
ROSMARINIC ACID Drug Info
Synonyms
rosmarinic acid; 20283-92-5; Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Investigative [1]
Cross-matching ID
PubChem CID
5281792
ChEBI ID
CHEBI:50371
CAS Number
CAS 20283-92-5
TTD Drug ID
DMQ6SJT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [9]
AZD5991 DM7QGHO Haematological malignancy 2B33.Y Phase 1 [10]
AMG 176 DM0Q7NO Acute myeloid leukaemia 2A60 Phase 1 [10]
PRT1419 DMIKE0O Melanoma 2C30 Phase 1 [11]
ABBV-467 DM87SM9 Multiple myeloma 2A83 Phase 1 [12]
MIK665 DMTUVCG Acute myeloid leukaemia 2A60 Phase 1 [13]
AMG 397 DM7CNTG Refractory hematologic malignancy 2A85.5 Phase 1 [14]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [15]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [15]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [15]
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Drug(s) Targeting Tyrosinase (TYR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [16]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [16]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [17]
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [18]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [19]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [20]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [21]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [22]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [23]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [23]
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Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [38]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [3]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [46]
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Drug(s) Affected By Potassium channel subfamily U member 1 (KCNU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [48]
NAPQI DM8F5LR Autoimmune disease 4A40-4A45 Investigative [49]
Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Haloperidol DM96SE0 Delirium Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [55]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Epinephrine DM3KJBC Acute asthma CA23 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Diazepam DM08E9O Alcohol withdrawal Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [64]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Haloperidol DM96SE0 Delirium Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [70]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [71]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [78]
Epinephrine DM3KJBC Acute asthma CA23 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [80]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
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Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [102]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [105]
Verapamil DMA7PEW Angina pectoris BA40 Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [108]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [111]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [116]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [80]
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Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [123]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [126]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [129]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [130]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [131]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [133]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [134]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [136]
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Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Menthol DMG2KW7 Back pain ME84.Z Approved [140]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [30]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [31]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [142]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Menthol DMG2KW7 Back pain ME84.Z Approved [140]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [144]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [145]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Arsenic DMTL2Y1 N. A. N. A. Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [148]
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Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [149]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [111]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [111]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [156]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [158]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Gefitinib DM15F0X Colon adenocarcinoma Approved [160]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [162]
Selenium DM25CGV N. A. N. A. Approved [151]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Verapamil DMA7PEW Angina pectoris BA40 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [151]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [166]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [116]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [167]
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Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Selenium DM25CGV N. A. N. A. Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [171]
Ethanol DMDRQZU Chronic pain MG30 Approved [172]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [173]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [2]
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [3]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [4]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [5]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [6]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Gene/Protein Processing [7]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Gene/Protein Processing [8]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Gene/Protein Processing [5]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Gene/Protein Processing [5]

References

1 A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antio... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7393-6.
2 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
3 Combining initro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.
4 Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells. Chem Biol Interact. 2023 Apr 25;375:110427. doi: 10.1016/j.cbi.2023.110427. Epub 2023 Feb 28.
5 Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway. Chem Biol Interact. 2019 Dec 1;314:108847. doi: 10.1016/j.cbi.2019.108847. Epub 2019 Oct 11.
6 Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis. Toxicol In Vitro. 2016 Sep;35:77-85. doi: 10.1016/j.tiv.2016.05.012. Epub 2016 May 26.
7 Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo. Food Chem Toxicol. 2013 Sep;59:311-5. doi: 10.1016/j.fct.2013.06.003. Epub 2013 Jun 14.
8 Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols. Toxicol In Vitro. 2011 Feb;25(1):213-21. doi: 10.1016/j.tiv.2010.11.003. Epub 2010 Nov 13.
9 Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 Clinical pipeline report, company report or official report of Prelude Therapeutics.
12 Clinical pipeline report, company report or official report of AbbVie.
13 MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443.
14 Clinical pipeline report, company report or official report of Amgen.
15 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.
16 Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5.
17 Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650.
18 National Cancer Institute Drug Dictionary (drug id 685201).
19 An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015.
20 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
21 ClinicalTrials.gov (NCT00003362) Vaccine Therapy Plus Immune Adjuvants in Treating Patients With Advanced Melanoma. U.S. National Institutes of Health.
22 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.
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