Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTEA9C)

Drug Name
ABBV-744 Drug Info
Synonyms
OEDSFMUSNZDJFD-UHFFFAOYSA-N; 2138861-99-9; N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; ABBV 744; SCHEMBL19463409; EX-A2713; ACN-054460; HY-112090; CS-0043318
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [1]
Prostate cancer 2C82.0 Phase 1 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Cross-matching ID
PubChem CID
132010322
CAS Number
CAS 2138861-99-9
TTD Drug ID
DMTEA9C

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CPI-0610 DMPXOYJ Myelofibrosis 2A20.2 Phase 3 [4]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [4]
PLX2853 DMX168L Acute myeloid leukaemia 2A60 Phase 1/2 [1]
RVX-208 DM1LO8K Alzheimer disease 8A20 Phase 1/2 [4]
INCB57643 DMBGU7V Advanced malignancy 2A00-2F9Z Phase 1/2 [1]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [5]
GSK525762 DMPAWBN Haematological malignancy 2B33.Y Phase 1 [4]
TEN010 DM4UOY5 Advanced solid tumour 2A00-2F9Z Phase 1 [4]
AZD5153 DMW4GM2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
PMID26924192-Compound-104 DM346EU N. A. N. A. Patented [6]
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Drug(s) Targeting Bromodomain-containing protein 3 (BRD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26924192-Compound-104 DM346EU N. A. N. A. Patented [6]
PMID26924192-Compound-102 DMEJ107 N. A. N. A. Patented [6]
PMID26924192-Compound-103 DMWOCP7 N. A. N. A. Patented [6]
PMID26924192-Compound-105 DMAWLGI N. A. N. A. Patented [6]
Pyrrolo-pyrrolone derivative 1 DMN4SE5 N. A. N. A. Patented [6]
XD14 DMUMACD Discovery agent N.A. Investigative [7]
GW841819X DMRL9IN Discovery agent N.A. Investigative [8]
PMID24000170C36 DMHUWZS Discovery agent N.A. Investigative [9]
PMID24000170C38 DMOLRIY Discovery agent N.A. Investigative [9]
I-BET151 DMYRUH2 Discovery agent N.A. Investigative [10]
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Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [4]
PMID26924192-Compound-104 DM346EU N. A. N. A. Patented [6]
PMID26924192-Compound-102 DMEJ107 N. A. N. A. Patented [6]
PMID26924192-Compound-103 DMWOCP7 N. A. N. A. Patented [6]
PMID26924192-Compound-105 DMAWLGI N. A. N. A. Patented [6]
Pyrrolo-pyrrolone derivative 1 DMN4SE5 N. A. N. A. Patented [6]
PMID26924192-Compound-106 DM9HRZJ N. A. N. A. Patented [6]
XD14 DMUMACD Discovery agent N.A. Investigative [7]
GW841819X DMRL9IN Discovery agent N.A. Investigative [8]
PMID24000170C36 DMHUWZS Discovery agent N.A. Investigative [9]
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Drug(s) Targeting HUMAN bromodomain-containing protein 2 (BRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
JQ1 DM3XQDH Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [15]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [15]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [20]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [26]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [28]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Etretinate DM2CZFA Keratosis ED56 Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [33]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [35]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [38]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [52]
Etretinate DM2CZFA Keratosis ED56 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [51]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [41]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [82]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [74]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [83]
Paclitaxel DMLB81S Breast carcinoma Approved [84]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [76]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [87]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [28]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [51]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [102]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [105]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [106]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [107]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [108]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [109]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [110]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [111]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [112]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [119]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [120]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [117]
Ethacrynic acid DM60QMR Edema MG29 Approved [121]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
Quercetin DM3NC4M Obesity 5B81 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [126]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [129]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [133]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [134]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [135]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [136]
Testosterone DM7HUNW Hot flushes GA30 Approved [137]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [138]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [140]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [141]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [144]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [145]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [20]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [146]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [141]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Meloxicam DM2AR7L Arthritis FA20 Approved [148]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [51]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [151]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [154]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Etretinate DM2CZFA Keratosis ED56 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [126]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [160]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [162]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [165]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
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Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [160]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [170]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [173]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [174]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [178]
Testosterone DM7HUNW Hot flushes GA30 Approved [137]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [179]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [182]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [184]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [185]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [102]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 2 (BRD2) TTDP48B BRD2_HUMAN Inhibitor [1]
Bromodomain-containing protein 3 (BRD3) TTHE657 BRD3_HUMAN Inhibitor [1]
Bromodomain-containing protein 4 (BRD4) TTRA6BO BRD4_HUMAN Inhibitor [1]
HUMAN bromodomain-containing protein 2 (BRD2) TTNISW6 BRD2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [3]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [3]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [3]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [3]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]

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