General Information of Drug Combination (ID: DCA09QP)

Drug Combination Name
Dexamethasone Bortezomib
Indication
Disease Entry Status REF
Multiple Myeloma Phase 1 [1]
Component Drugs Dexamethasone   DMMWZET Bortezomib   DMNO38U
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Dexamethasone
Disease Entry ICD 11 Status REF
Acute adrenal insufficiency N.A. Approved [2]
Acute asthma CA23 Approved [2]
Addison disease 5A74.0 Approved [2]
Allergic otitis media N.A. Approved [2]
Allergic rhinitis CA08.0 Approved [2]
Angioedema 4A00.15 Approved [2]
Articular cartilage disorder FA34.Y Approved [2]
Autoimmune haemolytic anaemia 3A20 Approved [2]
Blepharoconjunctivitis N.A. Approved [2]
Burkitt lymphoma N.A. Approved [2]
Bursitis N.A. Approved [2]
Central retinal vein occlusion with macular edema N.A. Approved [2]
Cerebral edema 8D60.1 Approved [2]
Congenital adrenal hyperplasia 5A71.01 Approved [2]
Corneal abrasion NA06.4 Approved [2]
Corneal ulcer 9A76 Approved [2]
Crohn disease DD70 Approved [2]
Dermatitis herpetiformis EB44 Approved [2]
Diamond-Blackfan anemia N.A. Approved [2]
Disorder of orbital region N.A. Approved [2]
Epicondylitis N.A. Approved [2]
Erythema multiforme N.A. Approved [2]
Exanthem N.A. Approved [2]
Granuloma annulare N.A. Approved [2]
Inflammatory bowel disease DD72 Approved [2]
Keratitis N.A. Approved [2]
Liver cirrhosis DB93.1 Approved [2]
Lung cancer 2C25.0 Approved [2]
Malignant otitis externa caused by Pseudomonas aeruginosa N.A. Approved [2]
Miliary tuberculosis N.A. Approved [2]
Multiple sclerosis 8A40 Approved [2]
Mycosis fungoides 2B01 Approved [2]
Nausea MD90 Approved [2]
Plasma cell myeloma 2A83.1 Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Psoriasis EA90 Approved [2]
Psoriatic arthritis FA21 Approved [2]
Rheumatic heart disease N.A. Approved [2]
Rheumatoid arthritis FA20 Approved [3]
Rosacea ED90.0 Approved [2]
Sarcoidosis 4B20.5 Approved [2]
Serum sickness N.A. Approved [2]
Skin disease EA00-EM0Z Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [2]
Vomiting MD90 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [4]
Acquired thrombocytopenia N.A. Investigative [2]
Asthma CA23 Investigative [2]
B-cell neoplasm N.A. Investigative [2]
Beta-thalassemia major N.A. Investigative [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Iridocyclitis N.A. Investigative [2]
Keloid EE60 Investigative [2]
Trichinellosis N.A. Investigative [2]
Uveitis 9A96.Z Investigative [2]
Dexamethasone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Agonist [17]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [18]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [19]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [20]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [21]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [22]
Carboxylesterase 2 (CES2) DETHCPD EST2_HUMAN Metabolism [23]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DEDH7FP DHI2_HUMAN Metabolism [24]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 979 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [25]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Increases Expression [26]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Expression [27]
Cytochrome P450 3A7 (CYP3A7) OTTCDHHM CP3A7_HUMAN Increases Expression [28]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [29]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [30]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [10]
Haptoglobin (HP) OTGUGAF9 HPT_HUMAN Increases Expression [10]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [10]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Decreases Expression [11]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [31]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Affects Expression [32]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [33]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [34]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases ADR [35]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) OTDAWAUZ JIP1_HUMAN Increases ADR [35]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Response To Substance [36]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [37]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Expression [37]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [8]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Increases Expression [8]
Protein arginine N-methyltransferase 3 (PRMT3) OTH2KILE ANM3_HUMAN Decreases Expression [8]
GRB2-related adapter protein 2 (GRAP2) OTS5NIZ3 GRAP2_HUMAN Increases Expression [8]
AP-1 complex subunit gamma-like 2 (AP1G2) OTTJ7NXL AP1G2_HUMAN Increases Expression [8]
Cell cycle checkpoint protein RAD17 (RAD17) OT1I93DT RAD17_HUMAN Decreases Expression [8]
Endonuclease domain-containing 1 protein (ENDOD1) OTME0ZW5 ENDD1_HUMAN Decreases Expression [8]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Increases Expression [8]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [8]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Increases Expression [8]
Integrin alpha-4 (ITGA4) OTSCAL0V ITA4_HUMAN Decreases Expression [8]
V(D)J recombination-activating protein 1 (RAG1) OTV131E4 RAG1_HUMAN Decreases Expression [8]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) OTEGNEHW PP2BB_HUMAN Decreases Expression [8]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [8]
Leukocyte surface antigen CD53 (CD53) OT9U5OXJ CD53_HUMAN Increases Expression [8]
Receptor-type tyrosine-protein phosphatase mu (PTPRM) OTCEL6PN PTPRM_HUMAN Increases Expression [8]
Inositol polyphosphate 1-phosphatase (INPP1) OTHSJCRQ INPP_HUMAN Increases Expression [8]
C-C chemokine receptor type 4 (CCR4) OT68KZ9B CCR4_HUMAN Increases Expression [8]
Calcipressin-1 (RCAN1) OT1MVXC7 RCAN1_HUMAN Increases Expression [8]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [8]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [8]
Microtubule-associated protein 1A (MAP1A) OTHO8K43 MAP1A_HUMAN Increases Expression [8]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [8]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Decreases Expression [8]
Synaptic vesicular amine transporter (SLC18A2) OTUOMMM6 VMAT2_HUMAN Increases Expression [8]
Amidophosphoribosyltransferase (PPAT) OTXK12ZB PUR1_HUMAN Decreases Expression [8]
Lymphotoxin-beta (LTB) OTUFS8CF TNFC_HUMAN Decreases Expression [8]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [8]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [8]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [8]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [8]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Expression [8]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Decreases Expression [8]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [8]
Pre-rRNA-processing protein TSR1 homolog (TSR1) OTCVZFL9 TSR1_HUMAN Decreases Expression [8]
Neurobeachin-like protein 2 (NBEAL2) OTMCAXWR NBEL2_HUMAN Increases Expression [8]
Protein FAM216A (FAM216A) OTL6I6AI F216A_HUMAN Decreases Expression [8]
Junctional adhesion molecule C (JAM3) OTX0F9QL JAM3_HUMAN Increases Expression [8]
Coiled-coil domain-containing protein 86 (CCDC86) OT5YQ0R0 CCD86_HUMAN Decreases Expression [8]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Increases Expression [8]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) OT8P6QNJ CELR3_HUMAN Decreases Expression [8]
PALM2-AKAP2 fusion protein (PALM2AKAP2) OTI618VF PLAK2_HUMAN Increases Expression [8]
Nucleolar protein 16 (NOP16) OT2829ZC NOP16_HUMAN Decreases Expression [8]
Nucleolar complex protein 2 homolog (NOC2L) OTNT7R33 NOC2L_HUMAN Decreases Expression [8]
Plexin-D1 (PLXND1) OTNK9ALK PLXD1_HUMAN Increases Expression [8]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Increases Expression [8]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Increases Expression [8]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [38]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [26]
Period circadian protein homolog 1 (PER1) OTVQF3WX PER1_HUMAN Increases Expression [26]
Macrophage colony-stimulating factor 1 receptor (CSF1R) OTDYTB9C CSF1R_HUMAN Increases Expression [26]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Increases Expression [26]
Olfactomedin-4 (OLFM4) OTELHN9L OLFM4_HUMAN Increases Expression [26]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Expression [39]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [39]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Increases Expression [40]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [41]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [42]
Pulmonary surfactant-associated protein B (SFTPB) OTOHS07E PSPB_HUMAN Increases Expression [43]
Pulmonary surfactant-associated protein A1 (SFTPA1) OT87XL1U SFTA1_HUMAN Decreases Expression [43]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Decreases Expression [44]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Increases Expression [45]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Increases Expression [45]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [46]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [47]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [47]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Activity [47]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Increases Expression [47]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Increases Expression [47]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Increases Expression [47]
Tyrosine aminotransferase (TAT) OT2CJ91O ATTY_HUMAN Increases Expression [47]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Increases Expression [47]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Increases Expression [47]
Nuclear receptor subfamily 2 group C member 2 (NR2C2) OTDZWVOJ NR2C2_HUMAN Increases Expression [47]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Expression [47]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Increases Expression [47]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [47]
Nuclear receptor subfamily 6 group A member 1 (NR6A1) OTFZOOQ9 NR6A1_HUMAN Increases Expression [47]
Nuclear receptor coactivator 2 (NCOA2) OTMQFPBB NCOA2_HUMAN Increases Expression [47]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [47]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Increases Expression [47]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Increases Expression [47]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Affects Expression [48]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [48]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [10]
Aquaporin-7 (AQP7) OTSOSZEE AQP7_HUMAN Increases Expression [10]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Increases Expression [10]
Renin receptor (ATP6AP2) OT0IABVV RENR_HUMAN Decreases Expression [10]
Complement factor D (CFD) OTLNRXB6 CFAD_HUMAN Increases Expression [10]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Increases Expression [10]
Beta-nerve growth factor (NGF) OTOLABJT NGF_HUMAN Decreases Expression [10]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [10]
Retinol-binding protein 4 (RBP4) OTL9RBH5 RET4_HUMAN Increases Expression [10]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [10]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [10]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [10]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [10]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Increases Expression [10]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [10]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Increases Expression [10]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [10]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [10]
Zinc-alpha-2-glycoprotein (AZGP1) OTPD9TDR ZA2G_HUMAN Increases Expression [10]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Increases Expression [10]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [10]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [10]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [10]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [10]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Expression [10]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [10]
Lipid transferase CIDEC (CIDEC) OTMDZ56K CIDEC_HUMAN Increases Expression [10]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Increases Expression [10]
Histone-lysine N-methyltransferase PRDM16 (PRDM16) OT0BGA27 PRD16_HUMAN Decreases Expression [10]
Apelin (APLN) OTSWJD7B APEL_HUMAN Decreases Expression [10]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Increases Expression [49]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Increases Expression [50]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [50]
Cytochrome P450 2S1 (CYP2S1) OTKHX4RF CP2S1_HUMAN Decreases Expression [51]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Increases Expression [52]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [53]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [54]
Glucoside xylosyltransferase 2 (GXYLT2) OTMLQQKP GXLT2_HUMAN Decreases Expression [11]
Tetraspanin-11 (TSPAN11) OT3GJF1N TSN11_HUMAN Decreases Expression [11]
Glutamate-rich protein 2 (ERICH2) OT0QA5Z1 ERIC2_HUMAN Decreases Expression [11]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3) OTF6I8RV PKHG3_HUMAN Increases Expression [11]
Coiled-coil domain-containing protein 69 (CCDC69) OT43MI0R CCD69_HUMAN Increases Expression [11]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Increases Expression [11]
Isthmin-1 (ISM1) OTZTK2TV ISM1_HUMAN Increases Expression [11]
Transmembrane protein 233 (TMEM233) OT9J7BRF TM233_HUMAN Decreases Expression [11]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [11]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [11]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Decreases Expression [11]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) OTY2PROB P3C2B_HUMAN Increases Expression [11]
Acetyl-CoA carboxylase 2 (ACACB) OT96UIP1 ACACB_HUMAN Increases Expression [11]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Decreases Expression [11]
Cdc42 effector protein 2 (CDC42EP2) OTX3YDPN BORG1_HUMAN Increases Expression [11]
Glutathione S-transferase 3, mitochondrial (MGST3) OTYK80JA MGST3_HUMAN Increases Expression [11]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [11]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Expression [11]
Synaptojanin-2 (SYNJ2) OTLRHXP1 SYNJ2_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase DCLK1 (DCLK1) OTVSPS98 DCLK1_HUMAN Increases Expression [11]
Mothers against decapentaplegic homolog 7 (SMAD7) OTSLHWF4 SMAD7_HUMAN Decreases Expression [11]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Increases Expression [11]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4) OTQUX50Z LRAD4_HUMAN Decreases Expression [11]
Membrane-associated progesterone receptor component 2 (PGRMC2) OTH6G1CV PGRC2_HUMAN Increases Expression [11]
Protein SLC31A2 (SLC31A2) OTQC136Q COPT2_HUMAN Decreases Expression [11]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Decreases Expression [11]
Glycogenin-2 (GYG2) OTAJ7YEW GLYG2_HUMAN Increases Expression [11]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [11]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [11]
Rho GTPase-activating protein 6 (ARHGAP6) OTNVXXFX RHG06_HUMAN Increases Expression [11]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Increases Expression [11]
Perilipin-1 (PLIN1) OT3OAAZ4 PLIN1_HUMAN Increases Expression [11]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Increases Expression [11]
Protein-tyrosine sulfotransferase 1 (TPST1) OTDPQKEA TPST1_HUMAN Decreases Expression [11]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Increases Expression [11]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [11]
Thiamine transporter 1 (SLC19A2) OTH5SB0M S19A2_HUMAN Increases Expression [11]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Increases Expression [11]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Decreases Expression [11]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Decreases Expression [11]
Rho-associated protein kinase 2 (ROCK2) OTVYN14T ROCK2_HUMAN Increases Expression [11]
Cartilage intermediate layer protein 1 (CILP) OTKEY2NJ CILP1_HUMAN Increases Expression [11]
Citrate synthase, mitochondrial (CS) OTYLYXMO CISY_HUMAN Increases Expression [11]
Sperm-associated antigen 7 (SPAG7) OTSDFA2D SPAG7_HUMAN Decreases Expression [11]
Claudin-11 (CLDN11) OTNN6UTL CLD11_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) OTHODA1F MYCB2_HUMAN Increases Expression [11]
Protein phosphatase 1B (PPM1B) OTZMH6V3 PPM1B_HUMAN Increases Expression [11]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) OT15HOJX AL1L1_HUMAN Increases Expression [11]
Diacylglycerol O-acyltransferase 1 (DGAT1) OTL104WL DGAT1_HUMAN Increases Expression [11]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1) OT1U2GWG DDAH1_HUMAN Increases Expression [11]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Increases Expression [11]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Decreases Expression [11]
Indolethylamine N-methyltransferase (INMT) OT5NWOZH INMT_HUMAN Increases Expression [11]
Neurexophilin-4 (NXPH4) OTV057AG NXPH4_HUMAN Decreases Expression [11]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B) OT4217NK PDE8B_HUMAN Increases Expression [11]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Expression [11]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Increases Expression [11]
Angiopoietin-related protein 1 (ANGPTL1) OTXIN6V5 ANGL1_HUMAN Increases Expression [11]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Decreases Expression [11]
Cholesterol 25-hydroxylase (CH25H) OT9S2BSW CH25H_HUMAN Decreases Expression [11]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Increases Expression [11]
All-trans-retinol dehydrogenase ADH1B (ADH1B) OTV3TB81 ADH1B_HUMAN Increases Expression [11]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Increases Expression [11]
Haptoglobin-related protein (HPR) OTXSC9UB HPTR_HUMAN Increases Expression [11]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [11]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [11]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Increases Expression [11]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Increases Expression [11]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [11]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [11]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [11]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [11]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Expression [11]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Increases Expression [11]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [11]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Expression [11]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Decreases Expression [11]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Increases Expression [11]
Fatty acid-binding protein, heart (FABP3) OT562DA1 FABPH_HUMAN Increases Expression [11]
Tetranectin (CLEC3B) OTFD29NF TETN_HUMAN Increases Expression [11]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [11]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Increases Expression [11]
Glycogen phosphorylase, liver form (PYGL) OTS1YFGR PYGL_HUMAN Increases Expression [11]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Increases Expression [11]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Decreases Expression [11]
Acyl-CoA-binding protein (DBI) OT884QY9 ACBP_HUMAN Increases Expression [11]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Increases Expression [11]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [11]
Alcohol dehydrogenase 1A (ADH1A) OTTS983E ADH1A_HUMAN Increases Expression [11]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [11]
Metallothionein-1B (MT1B) OTUA4FFH MT1B_HUMAN Increases Expression [11]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Increases Expression [11]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [11]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Decreases Expression [11]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Increases Expression [11]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Decreases Expression [11]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [11]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [11]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Decreases Expression [11]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) OTGEU8IK ODPA_HUMAN Increases Expression [11]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [11]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Decreases Expression [11]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [11]
Inhibin beta B chain (INHBB) OT2QLD11 INHBB_HUMAN Increases Expression [11]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [11]
Protein ELFN1 (ELFN1) OTM7M52U ELFN1_HUMAN Decreases Expression [11]
Serum amyloid A-1 protein (SAA1) OTO2D8S0 SAA1_HUMAN Increases Expression [11]
Zinc finger protein GLI2 (GLI2) OTIRV97L GLI2_HUMAN Decreases Expression [11]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Decreases Expression [11]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) OT9LBJVN ODP2_HUMAN Increases Expression [11]
Microsomal glutathione S-transferase 1 (MGST1) OTGN1KVZ MGST1_HUMAN Increases Expression [11]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Increases Expression [11]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Decreases Expression [11]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Decreases Expression [11]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [11]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Decreases Expression [11]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [11]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [11]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [11]
Myosin light chain 6B (MYL6B) OTWTRGT7 MYL6B_HUMAN Decreases Expression [11]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [11]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Decreases Expression [11]
Glutamine synthetase (GLUL) OTYGTCGF GLNA_HUMAN Increases Expression [11]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Decreases Expression [11]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Increases Expression [11]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [11]
Rho-related GTP-binding protein RhoQ (RHOQ) OTUBTU57 RHOQ_HUMAN Increases Expression [11]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Decreases Expression [11]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [11]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Increases Expression [11]
Alpha-2C adrenergic receptor (ADRA2C) OT5B9RKP ADA2C_HUMAN Increases Expression [11]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [11]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Decreases Expression [11]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Decreases Expression [11]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Increases Expression [11]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [11]
Interleukin-11 (IL11) OTXHN86R IL11_HUMAN Decreases Expression [11]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Decreases Expression [11]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Increases Expression [11]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [11]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1) OTQW7TMB GPDA_HUMAN Increases Expression [11]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [11]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Decreases Expression [11]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [11]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Increases Expression [11]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Increases Expression [11]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Decreases Expression [11]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [11]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1) OTHV25GG CX7A1_HUMAN Increases Expression [11]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [11]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [11]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Increases Expression [11]
Metallothionein-3 (MT3) OTVCZ7HI MT3_HUMAN Increases Expression [11]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [11]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [11]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [11]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Increases Expression [11]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [11]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [11]
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1) OT25Z6XH AL4A1_HUMAN Increases Expression [11]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Increases Expression [11]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases Expression [11]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Decreases Expression [11]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) OTQHB52T P5CR1_HUMAN Decreases Expression [11]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [11]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Decreases Expression [11]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [11]
G protein-coupled receptor kinase 5 (GRK5) OTJK79EK GRK5_HUMAN Increases Expression [11]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Decreases Expression [11]
Fibrillin-2 (FBN2) OT3KYJQL FBN2_HUMAN Increases Expression [11]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [11]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [11]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Expression [11]
Serine/threonine-protein kinase receptor R3 (ACVRL1) OT1HQR88 ACVL1_HUMAN Increases Expression [11]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) OTIOLNHE LICH_HUMAN Increases Expression [11]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Decreases Expression [11]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Increases Expression [11]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [11]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [11]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [11]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Increases Expression [11]
Excitatory amino acid transporter 1 (SLC1A3) OTILR60R EAA1_HUMAN Decreases Expression [11]
Prostaglandin F2-alpha receptor (PTGFR) OTUI456H PF2R_HUMAN Decreases Expression [11]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Increases Expression [11]
Cathepsin K (CTSK) OTT3YX5O CATK_HUMAN Increases Expression [11]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Decreases Expression [11]
Aspartoacylase (ASPA) OTR2MWS4 ACY2_HUMAN Increases Expression [11]
Large proline-rich protein BAG6 (BAG6) OT4Z0S2U BAG6_HUMAN Decreases Expression [11]
B1 bradykinin receptor (BDKRB1) OT1DHSVQ BKRB1_HUMAN Decreases Expression [11]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [11]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [11]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Decreases Expression [11]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Decreases Expression [11]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [11]
Amphiphysin (AMPH) OTWPGWZX AMPH_HUMAN Increases Expression [11]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Decreases Expression [11]
Placenta growth factor (PGF) OT5MF5DJ PLGF_HUMAN Decreases Expression [11]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Decreases Expression [11]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [11]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Decreases Expression [11]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [11]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Increases Expression [11]
Glypican-3 (GPC3) OTWS8WSW GPC3_HUMAN Increases Expression [11]
Lumican (LUM) OTSRC874 LUM_HUMAN Decreases Expression [11]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Increases Expression [11]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [11]
Sodium/myo-inositol cotransporter (SLC5A3) OT6FY2KA SC5A3_HUMAN Decreases Expression [11]
Phospholipase A and acyltransferase 3 (PLAAT3) OTVXXJ5K PLAT3_HUMAN Increases Expression [11]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [11]
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) OTOFL24U AT1B3_HUMAN Increases Expression [11]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [11]
Microfibrillar-associated protein 2 (MFAP2) OTMHVBTV MFAP2_HUMAN Decreases Expression [11]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Decreases Expression [11]
Growth/differentiation factor 10 (GDF10) OTEVXGJ7 GDF10_HUMAN Decreases Expression [11]
Laminin subunit beta-2 (LAMB2) OT71OI2Y LAMB2_HUMAN Decreases Expression [11]
GDNF family receptor alpha-1 (GFRA1) OT3WBVYB GFRA1_HUMAN Increases Expression [11]
Homeobox protein DLX-5 (DLX5) OTEEFBEU DLX5_HUMAN Decreases Expression [11]
Junctional adhesion molecule B (JAM2) OTHVJJRJ JAM2_HUMAN Decreases Expression [11]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Decreases Expression [11]
Protein eva-1 homolog C (EVA1C) OT18YR25 EVA1C_HUMAN Increases Expression [11]
Reactive oxygen species modulator 1 (ROMO1) OTIEYVBW ROMO1_HUMAN Increases Expression [11]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [11]
Somatostatin (SST) OTY75GQH SMS_HUMAN Decreases Expression [11]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [11]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [11]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [11]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) OTSSOMUP RPAB5_HUMAN Increases Expression [11]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE) OTXF5ICU GBRE_HUMAN Decreases Expression [11]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Increases Expression [11]
C-X-C motif chemokine 6 (CXCL6) OTFTCQ4O CXCL6_HUMAN Decreases Expression [11]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Increases Expression [11]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [11]
Nucleobindin-2 (NUCB2) OTHO6JWN NUCB2_HUMAN Decreases Expression [11]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Increases Expression [11]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [11]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [11]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Increases Expression [11]
Fatty acid-binding protein 5 (FABP5) OTNM186C FABP5_HUMAN Increases Expression [11]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [11]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [11]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Increases Expression [11]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [11]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [11]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) OTF6OC66 GCNT1_HUMAN Increases Expression [11]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [11]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Increases Expression [11]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Decreases Expression [11]
Mevalonate kinase (MVK) OTHJCUKT KIME_HUMAN Increases Expression [11]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [11]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [11]
Hormone-sensitive lipase (LIPE) OTMMVJ8A LIPS_HUMAN Increases Expression [11]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Decreases Expression [11]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Increases Expression [11]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Decreases Expression [11]
Nexilin (NEXN) OTKB0B0H NEXN_HUMAN Increases Expression [11]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Increases Expression [11]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Decreases Expression [11]
Trophinin (TRO) OTRZQMU8 TROP_HUMAN Decreases Expression [11]
Epidermal growth factor receptor kinase substrate 8 (EPS8) OTZ6ES6V EPS8_HUMAN Increases Expression [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [11]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [11]
Methanethiol oxidase (SELENBP1) OT3NZNTR SBP1_HUMAN Increases Expression [11]
Beta-2-syntrophin (SNTB2) OTIVMQ2S SNTB2_HUMAN Increases Expression [11]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) OTGTAGCV PPR1A_HUMAN Increases Expression [11]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [11]
Integrin alpha-7 (ITGA7) OTTBTAYW ITA7_HUMAN Increases Expression [11]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [11]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Decreases Expression [11]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [11]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Decreases Expression [11]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Decreases Expression [11]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [11]
Transforming growth factor beta activator LRRC32 (LRRC32) OTG7EDZL LRC32_HUMAN Decreases Expression [11]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Increases Expression [11]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1) OT2E7A6W KANK1_HUMAN Increases Expression [11]
Neutral alpha-glucosidase AB (GANAB) OTYLXY4M GANAB_HUMAN Decreases Expression [11]
Potassium voltage-gated channel subfamily B member 1 (KCNB1) OTLCU4FR KCNB1_HUMAN Increases Expression [11]
Delta(14)-sterol reductase LBR (LBR) OT1HG3HG LBR_HUMAN Increases Expression [11]
Latent-transforming growth factor beta-binding protein 2 (LTBP2) OTS88GSD LTBP2_HUMAN Decreases Expression [11]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Expression [11]
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) OT6A9JT8 PA1B3_HUMAN Decreases Expression [11]
Inorganic pyrophosphatase (PPA1) OTHZK1QB IPYR_HUMAN Increases Expression [11]
Platelet-derived growth factor receptor-like protein (PDGFRL) OTJPRECT PGFRL_HUMAN Decreases Expression [11]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [11]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [11]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Increases Expression [11]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Increases Expression [11]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [11]
Ovarian cancer G-protein coupled receptor 1 (GPR68) OT1NXSMN OGR1_HUMAN Decreases Expression [11]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [11]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Increases Expression [11]
Neuronatin (NNAT) OTNRLO7G NNAT_HUMAN Increases Expression [11]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Decreases Expression [11]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [11]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [11]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Increases Expression [11]
NADP-dependent malic enzyme, mitochondrial (ME3) OT3XMLYG MAON_HUMAN Increases Expression [11]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Increases Expression [11]
Amine oxidase 3 (AOC3) OT30YKV0 AOC3_HUMAN Increases Expression [11]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Decreases Expression [11]
Cysteine dioxygenase type 1 (CDO1) OTLG1P77 CDO1_HUMAN Increases Expression [11]
Transmembrane protein 132A (TMEM132A) OTNUI7O1 T132A_HUMAN Decreases Expression [11]
Kinesin-like protein KIF26B (KIF26B) OTVHWIKR KI26B_HUMAN Decreases Expression [11]
Transmembrane protein 44 (TMEM44) OTRUF467 TMM44_HUMAN Decreases Expression [11]
PWWP domain-containing DNA repair factor 3A (PWWP3A) OTXQVL4U PWP3A_HUMAN Decreases Expression [11]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [11]
Fibronectin type III domain-containing protein 1 (FNDC1) OTU2BA12 FNDC1_HUMAN Decreases Expression [11]
BolA-like protein 3 (BOLA3) OTDEDY0S BOLA3_HUMAN Increases Expression [11]
Cordon-bleu protein-like 1 (COBLL1) OTQFN1TC COBL1_HUMAN Increases Expression [11]
Mesoderm-specific transcript homolog protein (MEST) OT8Q4U8Y MEST_HUMAN Increases Expression [11]
Proline-rich transmembrane protein 3 (PRRT3) OT231D18 PRRT3_HUMAN Increases Expression [11]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Expression [11]
Dedicator of cytokinesis protein 11 (DOCK11) OTFSTN6A DOC11_HUMAN Increases Expression [11]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Increases Expression [11]
Transcription factor HIVEP3 (HIVEP3) OTM3QT3L ZEP3_HUMAN Increases Expression [11]
Transmembrane protein 170B (TMEM170B) OT4AS8RJ T170B_HUMAN Increases Expression [11]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase RNF187 (RNF187) OTXTN1HP RN187_HUMAN Decreases Expression [11]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Expression [11]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Increases Expression [11]
Synaptophysin-like protein 2 (SYPL2) OT6CV0CA SYPL2_HUMAN Increases Expression [11]
Phospholipid phosphatase 4 (PLPP4) OTH5EXZC PLPP4_HUMAN Decreases Expression [11]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases Expression [11]
Tensin-2 (TNS2) OTP72P0F TENS2_HUMAN Increases Expression [11]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Decreases Expression [11]
La-related protein 1B (LARP1B) OT9JZ7K5 LAR1B_HUMAN Increases Expression [11]
Protein sel-1 homolog 3 (SEL1L3) OT10N6Z2 SE1L3_HUMAN Decreases Expression [11]
Scavenger receptor class A member 3 (SCARA3) OT46I38Y SCAR3_HUMAN Decreases Expression [11]
Dermokine (DMKN) OTRIGZMK DMKN_HUMAN Increases Expression [11]
Protein Jade-1 (JADE1) OTBPJIRI JADE1_HUMAN Increases Expression [11]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [11]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Increases Expression [11]
Lysophospholipid acyltransferase 5 (LPCAT3) OTWI96P4 MBOA5_HUMAN Increases Expression [11]
F-box only protein 42 (FBXO42) OTHPN53C FBX42_HUMAN Decreases Expression [11]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) OTXP4QH8 CNKR3_HUMAN Increases Expression [11]
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2) OTKH0NVX DR4L2_HUMAN Increases Expression [11]
Ras-like protein family member 11A (RASL11A) OTDO6CMY RSLBA_HUMAN Increases Expression [11]
Kelch-like protein 17 (KLHL17) OTUWIJIQ KLH17_HUMAN Decreases Expression [11]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [11]
Sushi domain-containing protein 1 (SUSD1) OTR3UGLY SUSD1_HUMAN Increases Expression [11]
Suprabasin (SBSN) OT89RKJH SBSN_HUMAN Increases Expression [11]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Decreases Expression [11]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Decreases Expression [11]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Decreases Expression [11]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Increases Expression [11]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Increases Expression [11]
Scavenger receptor class A member 5 (SCARA5) OTOVA96E SCAR5_HUMAN Increases Expression [11]
SPOC domain-containing protein 1 (SPOCD1) OTF4K46N SPOC1_HUMAN Increases Expression [11]
Nesprin-3 (SYNE3) OTEOJBYB SYNE3_HUMAN Increases Expression [11]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Decreases Expression [11]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [11]
TOM1-like protein 2 (TOM1L2) OTUXXUH8 TM1L2_HUMAN Increases Expression [11]
Protein phosphatase Slingshot homolog 2 (SSH2) OT8NCK82 SSH2_HUMAN Increases Expression [11]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1) OTTOGO05 EEPD1_HUMAN Increases Expression [11]
Peroxiredoxin-like 2C (PRXL2C) OTI8ZAK8 PXL2C_HUMAN Increases Expression [11]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [11]
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) OTZ7IIPM LIMS2_HUMAN Increases Expression [11]
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Increases Expression [11]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [11]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Decreases Expression [11]
Disheveled-associated activator of morphogenesis 2 (DAAM2) OTC1WVZT DAAM2_HUMAN Increases Expression [11]
Acyl-coenzyme A thioesterase 1 (ACOT1) OTXFL7WM ACOT1_HUMAN Increases Expression [11]
Regulating synaptic membrane exocytosis protein 1 (RIMS1) OT10T7CK RIMS1_HUMAN Increases Expression [11]
Metalloprotease TIKI1 (TRABD2A) OTVMA26J TIKI1_HUMAN Increases Expression [11]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Decreases Expression [11]
Chondroitin sulfate synthase 1 (CHSY1) OTB1XSSF CHSS1_HUMAN Decreases Expression [11]
Extracellular matrix organizing protein FRAS1 (FRAS1) OTLPESF3 FRAS1_HUMAN Increases Expression [11]
Beta-klotho (KLB) OTTKKFS8 KLOTB_HUMAN Increases Expression [11]
Protein O-mannosyl-transferase TMTC1 (TMTC1) OTZ7NW96 TMTC1_HUMAN Increases Expression [11]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Decreases Expression [11]
Sodium/hydrogen exchanger 9 (SLC9A9) OT00PCW3 SL9A9_HUMAN Increases Expression [11]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Increases Expression [11]
Prolyl 3-hydroxylase 2 (P3H2) OTY84H6U P3H2_HUMAN Decreases Expression [11]
DCN1-like protein 3 (DCUN1D3) OTG20VWE DCNL3_HUMAN Increases Expression [11]
Cullin-9 (CUL9) OTPUCLZT CUL9_HUMAN Decreases Expression [11]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Decreases Expression [11]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [11]
Trafficking regulator of GLUT4 1 (TRARG1) OTQ1R3JD TARG1_HUMAN Increases Expression [11]
Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12) OTVIBUST GLT12_HUMAN Decreases Expression [11]
Solute carrier family 22 member 15 (SLC22A15) OT60WAAI S22AF_HUMAN Decreases Expression [11]
Protein APCDD1 (APCDD1) OTV9AD0L APCD1_HUMAN Increases Expression [11]
Cell cycle exit and neuronal differentiation protein 1 (CEND1) OTPHOC22 CEND_HUMAN Increases Expression [11]
ATP-binding cassette sub-family A member 6 (ABCA6) OTJJELUF ABCA6_HUMAN Increases Expression [11]
Glypican-2 (GPC2) OT3WSQE1 GPC2_HUMAN Decreases Expression [11]
Protein odd-skipped-related 2 (OSR2) OTYG371T OSR2_HUMAN Increases Expression [11]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [11]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) OTVLWW9T GPD1L_HUMAN Increases Expression [11]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [11]
Maturin (MTURN) OTEBJNVG MTURN_HUMAN Increases Expression [11]
GTP-binding protein 8 (GTPBP8) OTI8X03A GTPB8_HUMAN Increases Expression [11]
Tetratricopeptide repeat protein 39C (TTC39C) OTKKI81C TT39C_HUMAN Increases Expression [11]
Refilin-B (RFLNB) OTI7ZM75 RFLB_HUMAN Decreases Expression [11]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) OT2SH7HJ CGAT2_HUMAN Decreases Expression [11]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Increases Expression [11]
Interleukin-17 receptor C (IL17RC) OTEFOBSS I17RC_HUMAN Increases Expression [11]
Protein APCDD1-like (APCDD1L) OTP7CAV5 APCDL_HUMAN Decreases Expression [11]
LRRN4 C-terminal-like protein (LRRN4CL) OTJFDTVR LRN4L_HUMAN Increases Expression [11]
Phospholipid phosphatase 5 (PLPP5) OTHT51D6 PLPP5_HUMAN Decreases Expression [11]
Activin receptor type-1C (ACVR1C) OTOTYERF ACV1C_HUMAN Increases Expression [11]
Neuron navigator 1 (NAV1) OT667KTL NAV1_HUMAN Decreases Expression [11]
Nesprin-1 (SYNE1) OTSBSLUH SYNE1_HUMAN Decreases Expression [11]
Interleukin-17 receptor E (IL17RE) OTMFTNLS I17RE_HUMAN Increases Expression [11]
Neuroligin-2 (NLGN2) OTHDYL3H NLGN2_HUMAN Decreases Expression [11]
Tetraspanin-14 (TSPAN14) OT29167O TSN14_HUMAN Increases Expression [11]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Increases Expression [11]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [11]
Protein cornichon homolog 3 (CNIH3) OTNLZ2QS CNIH3_HUMAN Decreases Expression [11]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) OT4WOLA8 ENOX1_HUMAN Decreases Expression [11]
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) OTN3D4ZM PHOP2_HUMAN Increases Expression [11]
Melanocortin-2 receptor accessory protein (MRAP) OTLBWM7X MRAP_HUMAN Increases Expression [11]
Pleckstrin homology domain-containing family O member 2 (PLEKHO2) OT2FTK68 PKHO2_HUMAN Increases Expression [11]
G-protein coupled bile acid receptor 1 (GPBAR1) OT4BKEJ9 GPBAR_HUMAN Increases Expression [11]
Actin filament-associated protein 1-like 1 (AFAP1L1) OTWNTNDB AF1L1_HUMAN Increases Expression [11]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) OTY829Z3 ABHD5_HUMAN Increases Expression [11]
Cell migration-inducing and hyaluronan-binding protein (CEMIP) OTK80FYN CEMIP_HUMAN Decreases Expression [11]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5) OTX4Q83J S38A5_HUMAN Decreases Expression [11]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Increases Expression [11]
Coiled-coil domain-containing protein 107 (CCDC107) OTF1H2TM CC107_HUMAN Increases Expression [11]
RING finger protein 141 (RNF141) OT07ANSG RN141_HUMAN Increases Expression [11]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [11]
Gem-associated protein 6 (GEMIN6) OTE262KF GEMI6_HUMAN Increases Expression [11]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Increases Expression [11]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10) OTCDHAM6 CHC10_HUMAN Increases Expression [11]
SHC-transforming protein 3 (SHC3) OT305NPA SHC3_HUMAN Increases Expression [11]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [11]
Receptor-type tyrosine-protein phosphatase U (PTPRU) OTHDO0QG PTPRU_HUMAN Decreases Expression [11]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Increases Expression [11]
Retinol dehydrogenase 5 (RDH5) OTYBZHCC RDH5_HUMAN Increases Expression [11]
NEDD4-binding protein 2-like 2 (N4BP2L2) OTV2F04G N42L2_HUMAN Decreases Expression [11]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Increases Expression [11]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Decreases Expression [11]
Ribonuclease P/MRP protein subunit POP5 (POP5) OTCZTDJC POP5_HUMAN Increases Expression [11]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Decreases Expression [11]
Protein lifeguard 3 (TMBIM1) OTE47B57 LFG3_HUMAN Increases Expression [11]
Antizyme inhibitor 2 (AZIN2) OT8OB7CG AZIN2_HUMAN Decreases Expression [11]
Fermitin family homolog 2 (FERMT2) OTZNPWWX FERM2_HUMAN Increases Expression [11]
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) OTR3ERMR PLPL2_HUMAN Increases Expression [11]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [11]
Mas-related G-protein coupled receptor member F (MRGPRF) OT74OZ2Z MRGRF_HUMAN Increases Expression [11]
Dapper homolog 3 (DACT3) OTSNQ55G DACT3_HUMAN Decreases Expression [11]
Inactive rhomboid protein 1 (RHBDF1) OTCQ7UDS RHDF1_HUMAN Decreases Expression [11]
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) OTBB799S ACSF2_HUMAN Increases Expression [11]
Isochorismatase domain-containing protein 1 (ISOC1) OTAO7Z87 ISOC1_HUMAN Increases Expression [11]
Galectin-12 (LGALS12) OTNTQULB LEG12_HUMAN Increases Expression [11]
Transcription elongation factor A protein-like 4 (TCEAL4) OTX24CQI TCAL4_HUMAN Increases Expression [11]
C1GALT1-specific chaperone 1 (C1GALT1C1) OTRTZUF5 C1GLC_HUMAN Increases Expression [11]
Small integral membrane protein 12 (SMIM12) OTMOQSL4 SIM12_HUMAN Increases Expression [11]
Intraflagellar transport protein 43 homolog (IFT43) OTKWYQ5C IFT43_HUMAN Decreases Expression [11]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Decreases Expression [11]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [11]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [11]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2) OT0KHLY2 SUCB2_HUMAN Increases Expression [11]
Calmin (CLMN) OT7U5J3T CLMN_HUMAN Increases Expression [11]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Decreases Expression [11]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) OTYXJQCW FGD4_HUMAN Increases Expression [11]
RIPOR family member 3 (RIPOR3) OTHZ4RKK RIPR3_HUMAN Increases Expression [11]
Pseudokinase FAM20A (FAM20A) OT5Z5IW8 FA20A_HUMAN Decreases Expression [11]
Prickle-like protein 1 (PRICKLE1) OT9HHEM9 PRIC1_HUMAN Decreases Expression [11]
Sterile alpha motif domain-containing protein 11 (SAMD11) OT6WRQOX SAM11_HUMAN Decreases Expression [11]
Diacylglycerol O-acyltransferase 2 (DGAT2) OTE5PDD0 DGAT2_HUMAN Increases Expression [11]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Decreases Expression [11]
Coiled-coil domain-containing protein 85A (CCDC85A) OT2GLF5Z CC85A_HUMAN Increases Expression [11]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [11]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Decreases Expression [11]
Ethanolamine-phosphate cytidylyltransferase (PCYT2) OTT8TAEA PCY2_HUMAN Increases Expression [11]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Increases Expression [11]
Sortilin (SORT1) OTFCQ4B1 SORT_HUMAN Increases Expression [11]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [11]
Monoglyceride lipase (MGLL) OT5ES4IE MGLL_HUMAN Increases Expression [11]
Collagen alpha-1(XII) chain (COL12A1) OTHLTV53 COCA1_HUMAN Decreases Expression [11]
Metalloproteinase inhibitor 4 (TIMP4) OT8A68SW TIMP4_HUMAN Increases Expression [11]
MyoD family inhibitor (MDFI) OTIA6YUG MDFI_HUMAN Decreases Expression [11]
Paired mesoderm homeobox protein 2 (PRRX2) OT8UR4AU PRRX2_HUMAN Decreases Expression [11]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [11]
Histone H2A type 1-J (H2AC14) OT5Y4MMC H2A1J_HUMAN Increases Expression [11]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [11]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Decreases Expression [11]
FYVE and coiled-coil domain-containing protein 1 (FYCO1) OTKZHTZ5 FYCO1_HUMAN Increases Expression [11]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Decreases Expression [11]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [11]
La-related protein 6 (LARP6) OTUQ9QS9 LARP6_HUMAN Decreases Expression [11]
Peroxiredoxin-like 2A (PRXL2A) OTR4X7UH PXL2A_HUMAN Increases Expression [11]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Decreases Expression [11]
Transmembrane protein 204 (TMEM204) OT7X11D9 TM204_HUMAN Decreases Expression [11]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Increases Expression [11]
Chordin-like protein 1 (CHRDL1) OTGMWVVA CRDL1_HUMAN Increases Expression [11]
Protein ABHD14A (ABHD14A) OT94GKE1 ABHEA_HUMAN Increases Expression [11]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (CHCHD7) OTHHROAQ CHCH7_HUMAN Increases Expression [11]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Decreases Expression [11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Increases Expression [11]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Increases Expression [11]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Decreases Expression [11]
EMILIN-2 (EMILIN2) OTOYK5A8 EMIL2_HUMAN Increases Expression [11]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) OTOOXC7B HOIL1_HUMAN Decreases Expression [11]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Decreases Expression [11]
Forkhead box protein Q1 (FOXQ1) OT6S3EB0 FOXQ1_HUMAN Decreases Expression [11]
Carbohydrate sulfotransferase 6 (CHST6) OTXD2IWK CHST6_HUMAN Decreases Expression [11]
N-alpha-acetyltransferase 50 (NAA50) OTFJ8S47 NAA50_HUMAN Increases Expression [11]
Serine/threonine-protein kinase SIK2 (SIK2) OTODY7XG SIK2_HUMAN Increases Expression [11]
Uncharacterized protein C1orf21 (C1ORF21) OTMD7O88 CA021_HUMAN Increases Expression [11]
Solute carrier family 25 member 32 (SLC25A32) OTPP3NWG S2532_HUMAN Increases Expression [11]
Ras association domain-containing protein 4 (RASSF4) OT7YLOFH RASF4_HUMAN Increases Expression [11]
Forkhead box protein P1 (FOXP1) OTSG6XGF FOXP1_HUMAN Decreases Expression [11]
SPARC-related modular calcium-binding protein 2 (SMOC2) OTK1EQ49 SMOC2_HUMAN Increases Expression [11]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Decreases Expression [11]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Increases Expression [11]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Increases Expression [11]
IGF-like family receptor 1 (IGFLR1) OTPUCWQR IGFR1_HUMAN Increases Expression [11]
Reticulophagy regulator 1 (RETREG1) OTYOSLZX RETR1_HUMAN Increases Expression [11]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Decreases Expression [11]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Decreases Expression [11]
Protein eva-1 homolog A (EVA1A) OTCY3Q2M EVA1A_HUMAN Decreases Expression [11]
RING finger protein 122 (RNF122) OT8RE3IM RN122_HUMAN Decreases Expression [11]
Interleukin-21 receptor (IL21R) OTDIOB63 IL21R_HUMAN Decreases Expression [11]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) OTNA9G8V MKNK2_HUMAN Increases Expression [11]
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) OT157TY3 TPC_HUMAN Increases Expression [11]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Increases Expression [11]
Plexin-A4 (PLXNA4) OT5XKB3Q PLXA4_HUMAN Increases Expression [11]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [11]
Carbohydrate-responsive element-binding protein (MLXIPL) OTR9MLLW MLXPL_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Decreases Expression [11]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Decreases Expression [11]
Omega-amidase NIT2 (NIT2) OTC1RAH3 NIT2_HUMAN Increases Expression [11]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [11]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Increases Expression [11]
Sialin (SLC17A5) OTM5EC0O S17A5_HUMAN Increases Expression [11]
Teashirt homolog 2 (TSHZ2) OTZWBXXY TSH2_HUMAN Decreases Expression [11]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [11]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) OT5CTQKO PLCD_HUMAN Decreases Expression [11]
Semaphorin-3G (SEMA3G) OTBLVF8V SEM3G_HUMAN Increases Expression [11]
Protein C19orf12 (C19ORF12) OTVSJ1AR CS012_HUMAN Increases Expression [11]
Teneurin-2 (TENM2) OTPLUYEF TEN2_HUMAN Decreases Expression [11]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [11]
Copper homeostasis protein cutC homolog (CUTC) OTOVHLU9 CUTC_HUMAN Increases Expression [11]
PI-PLC X domain-containing protein 1 (PLCXD1) OTU7KCQL PLCX1_HUMAN Increases Expression [11]
Fas apoptotic inhibitory molecule 1 (FAIM) OTR67PGU FAIM1_HUMAN Increases Expression [11]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Decreases Expression [11]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Decreases Expression [11]
Myotubularin-related protein 10 (MTMR10) OTF6DB4O MTMRA_HUMAN Increases Expression [11]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Decreases Expression [11]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Increases Expression [11]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Decreases Expression [11]
Potassium voltage-gated channel subfamily D member 2 (KCND2) OTIFUVV7 KCND2_HUMAN Decreases Expression [11]
Ankycorbin (RAI14) OT6USGBK RAI14_HUMAN Decreases Expression [11]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Expression [11]
Rho GTPase-activating protein 20 (ARHGAP20) OTG1STV8 RHG20_HUMAN Increases Expression [11]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Decreases Expression [11]
]-phosphatase 2, mitochondrial (PDP2) OTADNMGK PDP2_HUMAN Increases Expression [11]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Increases Expression [11]
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) OTSB4XO0 DPM3_HUMAN Increases Expression [11]
SUMO-activating enzyme subunit 1 (SAE1) OT18HFX5 SAE1_HUMAN Decreases Expression [11]
C-type mannose receptor 2 (MRC2) OTLWQAX1 MRC2_HUMAN Decreases Expression [11]
ATP-binding cassette sub-family D member 2 (ABCD2) OT8RGNH8 ABCD2_HUMAN Increases Expression [11]
Copine-7 (CPNE7) OTR0FJ8A CPNE7_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Decreases Expression [11]
Heat shock protein beta-7 (HSPB7) OTLATAOV HSPB7_HUMAN Increases Expression [11]
Tight junction protein ZO-2 (TJP2) OTQUY6BV ZO2_HUMAN Increases Expression [11]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Increases Expression [11]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) OTHTAM54 AAKG2_HUMAN Increases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Increases Expression [11]
Sushi domain-containing protein 2 (SUSD2) OTSJTAZP SUSD2_HUMAN Increases Expression [11]
Zinc finger transcription factor Trps1 (TRPS1) OT7XPPEL TRPS1_HUMAN Decreases Expression [11]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Increases Expression [11]
Potassium voltage-gated channel subfamily G member 1 (KCNG1) OTZ9ZRG8 KCNG1_HUMAN Decreases Expression [11]
ERBB receptor feedback inhibitor 1 (ERRFI1) OT7VZ2IZ ERRFI_HUMAN Increases Expression [11]
A-kinase anchor protein 11 (AKAP11) OT7E2FVD AKA11_HUMAN Decreases Expression [11]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) OTSZE6L4 ATS6_HUMAN Decreases Expression [11]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Decreases Expression [11]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [11]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Increases Expression [11]
RING finger protein 112 (RNF112) OT0Q9OUQ RN112_HUMAN Decreases Expression [11]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [11]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Increases Expression [11]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [11]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [11]
HIG1 domain family member 1A, mitochondrial (HIGD1A) OTS351DV HIG1A_HUMAN Increases Expression [11]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Decreases Expression [11]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [11]
Calcium-regulated heat-stable protein 1 (CARHSP1) OTAUG6Y9 CHSP1_HUMAN Decreases Expression [11]
Deoxyribose-phosphate aldolase (DERA) OT8SMO3N DEOC_HUMAN Increases Expression [11]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Increases Expression [11]
C2 domain-containing protein 2 (C2CD2) OTL1K0OB C2CD2_HUMAN Increases Expression [11]
Lysyl oxidase homolog 2 (LOXL2) OTRT46B5 LOXL2_HUMAN Decreases Expression [11]
ADP-ribose glycohydrolase OARD1 (OARD1) OTNNWATS OARD1_HUMAN Decreases Expression [11]
Ankyrin repeat and SOCS box protein 1 (ASB1) OT0NZGEI ASB1_HUMAN Decreases Expression [11]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) OTGZO1MT TIM8B_HUMAN Increases Expression [11]
Retinoic acid-induced protein 2 (RAI2) OTR8LX4J RAI2_HUMAN Increases Expression [11]
Mitochondrial pyruvate carrier 1 (MPC1) OT6DYFUO MPC1_HUMAN Increases Expression [11]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Decreases Expression [11]
Cysteine sulfinic acid decarboxylase (CSAD) OT3I2G0A CSAD_HUMAN Increases Expression [11]
Glypican-6 (GPC6) OTNJBESF GPC6_HUMAN Decreases Expression [11]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [11]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) OTTLD0KB SQOR_HUMAN Increases Expression [11]
SET-binding protein (SETBP1) OTKGCOSR SETBP_HUMAN Decreases Expression [11]
Tryptophan 2,3-dioxygenase (TDO2) OTV5HKJ4 T23O_HUMAN Increases Expression [55]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [56]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [57]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Increases Expression [57]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Decreases Expression [57]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Decreases Expression [57]
Collagen alpha-1(X) chain (COL10A1) OTC4G2YC COAA1_HUMAN Increases Expression [57]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Increases Expression [57]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Increases Expression [58]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [59]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) OTMI12L2 BMAL1_HUMAN Affects Expression [60]
Syntenin-1 (SDCBP) OTS3NCC5 SDCB1_HUMAN Increases Expression [15]
Transcription factor SOX-1 (SOX1) OTVI1RAR SOX1_HUMAN Increases Expression [61]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [62]
Calsequestrin-2 (CASQ2) OT09MNQ8 CASQ2_HUMAN Affects Expression [61]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Affects Expression [60]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Increases Expression [63]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Affects Expression [64]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [65]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [66]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Decreases Expression [67]
Circadian locomoter output cycles protein kaput (CLOCK) OTNEOJY7 CLOCK_HUMAN Affects Expression [60]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Increases Expression [67]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3) OT9ZS72C SRGP3_HUMAN Increases Expression [68]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Increases Expression [16]
Neuronal migration protein doublecortin (DCX) OTISR7K3 DCX_HUMAN Increases Expression [61]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) OTLCYA32 G6PT1_HUMAN Increases Expression [69]
Left-right determination factor 1 (LEFTY1) OT51HVC4 LFTY1_HUMAN Increases Expression [16]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Increases Expression [70]
Sciellin (SCEL) OT46SDNQ SCEL_HUMAN Increases Expression [15]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Increases Expression [61]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Increases Expression [71]
Eyes absent homolog 4 (EYA4) OTINGR3Z EYA4_HUMAN Affects Expression [61]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Decreases Expression [72]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [12]
Eomesodermin homolog (EOMES) OTB9VQFA EOMES_HUMAN Increases Expression [61]
T-box transcription factor TBX6 (TBX6) OTW1Q8RM TBX6_HUMAN Affects Expression [61]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Expression [61]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [73]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [74]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Decreases Expression [75]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [76]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [77]
Pro-opiomelanocortin (POMC) OTV41F7T COLI_HUMAN Decreases Expression [73]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [78]
Insulin (INS) OTZ85PDU INS_HUMAN Decreases Response To Substance [79]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [80]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [31]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [81]
T-cell surface glycoprotein CD4 (CD4) OT7Z5LNF CD4_HUMAN Decreases Expression [82]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Increases Expression [67]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases Expression [67]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Decreases Expression [83]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [67]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [84]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [75]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [85]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [31]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases Expression [67]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [86]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [15]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [87]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [88]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [31]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [89]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Affects Expression [61]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [14]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [90]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [68]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [88]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [91]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [84]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Affects Expression [67]
Beta-microseminoprotein (MSMB) OTYORAJC MSMB_HUMAN Increases Expression [16]
Corticosteroid-binding globulin (SERPINA6) OTOIBEW7 CBG_HUMAN Increases Expression [92]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [12]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Increases Expression [93]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Affects Expression [61]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [31]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [94]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [95]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Increases Expression [15]
Transmembrane protein 191B (TMEM191B) OTDKHB0K T191B_HUMAN Decreases Expression [16]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [96]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Expression [15]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [87]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Increases Expression [15]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Increases Expression [16]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Increases Expression [68]
Pulmonary surfactant-associated protein C (SFTPC) OTIZJD09 PSPC_HUMAN Increases Expression [97]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [98]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [99]
Myosin-7 (MYH7) OT4Z9T8N MYH7_HUMAN Increases Expression [61]
Myosin-6 (MYH6) OT3YNCH1 MYH6_HUMAN Affects Expression [61]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [15]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [100]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Increases Expression [70]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Decreases Expression [101]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [68]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Decreases Expression [81]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Increases Expression [67]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Increases Expression [102]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases Phosphorylation [103]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Expression [104]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Affects Expression [67]
Syndecan-1 (SDC1) OTWKRVZC SDC1_HUMAN Decreases Expression [105]
Transcobalamin-2 (TCN2) OT41D0L3 TCO2_HUMAN Decreases Expression [67]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Increases Expression [68]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Decreases Expression [106]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Increases Expression [86]
C-type natriuretic peptide (NPPC) OTYJ0LMA ANFC_HUMAN Increases Expression [16]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Affects Expression [61]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [70]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [107]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Increases Expression [108]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Increases Expression [109]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [110]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [67]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [61]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [111]
Interleukin-1 receptor type 2 (IL1R2) OT0G7E35 IL1R2_HUMAN Increases Expression [83]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Decreases Expression [74]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [112]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [111]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [15]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [113]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [114]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Increases Expression [93]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Increases Expression [108]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [72]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [92]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Decreases Expression [115]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Affects Expression [61]
GMP reductase 1 (GMPR) OTERWHYM GMPR1_HUMAN Increases Expression [16]
TGF-beta receptor type-2 (TGFBR2) OT3P7GZP TGFR2_HUMAN Increases Expression [67]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [116]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [78]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [15]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Increases Expression [117]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Affects Activity [118]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Affects Expression [32]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Activity [119]
Interleukin-12 receptor subunit beta-1 (IL12RB1) OTM1IJO2 I12R1_HUMAN Decreases Expression [120]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Increases Expression [61]
Transcription factor GATA-4 (GATA4) OTQHWAZG GATA4_HUMAN Increases Expression [61]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Affects Expression [32]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [70]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Decreases Activity [121]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [122]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Expression [123]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Expression [124]
G protein-activated inward rectifier potassium channel 4 (KCNJ5) OTA2MBIE KCNJ5_HUMAN Affects Expression [61]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Increases Expression [61]
Sodium/hydrogen exchanger 3 (SLC9A3) OTZ7PFVT SL9A3_HUMAN Increases Expression [125]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [126]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [127]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [78]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Increases Expression [128]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G) OTSJYQVQ SCNNG_HUMAN Increases Expression [128]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Decreases Expression [129]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Increases Activity [118]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX) OTDAC6Z0 PRKX_HUMAN Increases Expression [15]
Thyroxine 5-deiodinase (DIO3) OTNTITOT IOD3_HUMAN Decreases Activity [130]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [131]
Transcription factor SOX-10 (SOX10) OTF25ULQ SOX10_HUMAN Increases Expression [61]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Decreases Expression [122]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [132]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [133]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Decreases Expression [134]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [77]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [68]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [135]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Affects Localization [136]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [70]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Affects Expression [61]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Decreases Expression [67]
Elongation factor 1-alpha 2 (EEF1A2) OT9Z23K5 EF1A2_HUMAN Increases Expression [15]
Homeobox protein engrailed-1 (EN1) OT2DKIDK HME1_HUMAN Increases Expression [61]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [137]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Expression [15]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Decreases Expression [126]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Increases Expression [67]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [98]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Cleavage [114]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) OTX7MWW1 ITPR1_HUMAN Increases Expression [68]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Increases Expression [15]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Activity [138]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [113]
Leukotriene C4 synthase (LTC4S) OT3XNFJZ LTC4S_HUMAN Increases Expression [139]
Protein Largen (PRR16) OTG4TEGR LARGN_HUMAN Increases Expression [16]
Zinc finger protein PLAG1 (PLAG1) OTT9AJQY PLAG1_HUMAN Increases Expression [15]
Beclin 1-associated autophagy-related key regulator (ATG14) OTPZDKI0 BAKOR_HUMAN Increases Expression [98]
Histone H3.2 (H3C13) OT97FS6C H32_HUMAN Increases Expression [68]
Cytochrome P450 4Z1 (CYP4Z1) OTKRGJBG CP4Z1_HUMAN Increases Expression [140]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [15]
ATP-dependent RNA helicase TDRD9 (TDRD9) OTS4UBI8 TDRD9_HUMAN Increases Expression [16]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Increases Expression [76]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [141]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Expression [72]
Ras-responsive element-binding protein 1 (RREB1) OT62460U RREB1_HUMAN Increases Expression [15]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [142]
Neurogenin-1 (NEUROG1) OTMJZP9G NGN1_HUMAN Decreases Expression [16]
Paired mesoderm homeobox protein 2B (PHOX2B) OT3SFR2O PHX2B_HUMAN Affects Expression [61]
Interleukin-12 receptor subunit beta-2 (IL12RB2) OTDLV8H8 I12R2_HUMAN Decreases Expression [120]
Cbp/p300-interacting transactivator 1 (CITED1) OTUJQ3VL CITE1_HUMAN Decreases Expression [61]
Myocilin (MYOC) OT6DAHNF MYOC_HUMAN Increases Expression [84]
Mesoderm posterior protein 1 (MESP1) OTY5QDBN MESP1_HUMAN Decreases Expression [61]
Chitinase domain-containing protein 1 (CHID1) OT4DIUKC CHID1_HUMAN Increases Expression [115]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [65]
Negative elongation factor A (NELFA) OT7O6E84 NELFA_HUMAN Increases Expression [15]
Rho-related GTP-binding protein RhoJ (RHOJ) OTWI65OA RHOJ_HUMAN Increases Expression [68]
Glucose-6-phosphatase 2 (G6PC2) OTET1IKU G6PC2_HUMAN Increases Expression [69]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [143]
Fibroblast growth factor 21 (FGF21) OT3RXVRD FGF21_HUMAN Increases Expression [144]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Increases Expression [68]
FERM domain-containing protein 4A (FRMD4A) OTJDTIK2 FRM4A_HUMAN Decreases Expression [16]
Vesicular glutamate transporter 2 (SLC17A6) OTP1MJGP VGLU2_HUMAN Increases Expression [61]
ETS-related transcription factor Elf-5 (ELF5) OTLRU8YF ELF5_HUMAN Decreases Expression [16]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Increases Expression [76]
Histone deacetylase 5 (HDAC5) OTWG387P HDAC5_HUMAN Increases Expression [126]
Hepatocyte nuclear factor 3-beta (FOXA2) OTJOCVOY FOXA2_HUMAN Decreases Expression [61]
Potassium voltage-gated channel subfamily E member 2 (KCNE2) OTUO214Y KCNE2_HUMAN Affects Expression [61]
Mitogen-activated protein kinase 11 (MAPK11) OT0AS010 MK11_HUMAN Increases ADR [35]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Increases ADR [35]
Islet amyloid polypeptide (IAPP) OT5Z8ERW IAPP_HUMAN Increases ADR [35]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Increases Response To Substance [145]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Increases ADR [35]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Response To Substance [146]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Response To Substance [147]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Response To Substance [148]
Gastrin (GAST) OTD0IP9N GAST_HUMAN Increases ADR [35]
Cadherin-12 (CDH12) OTF2HCGA CAD12_HUMAN Increases ADR [35]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [143]
Poly polymerase 1 (PARP1) OTIESHK4 PARP1_ARATH Increases ADR [35]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Increases ADR [35]
Histidine decarboxylase (hdc) OTM3771T DCHS_RAOOR Increases ADR [35]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases ADR [35]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Response To Substance [149]
Interferon alpha-7 (IFNA7) OTSQ6R46 IFNA7_HUMAN Increases ADR [35]
Polymerase delta-interacting protein 3 (POLDIP3) OTTB5SV7 PDIP3_HUMAN Increases Response To Substance [36]
Alpha-2-HS-glycoprotein (AHSG) OTUG0LEA FETUA_HUMAN Increases Response To Substance [36]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Decreases Response To Substance [150]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Decreases Response To Substance [151]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Increases ADR [35]
------------------------------------------------------------------------------------
⏷ Show the Full List of 979 DOT(s)
Indication(s) of Bortezomib
Disease Entry ICD 11 Status REF
Leukemia N.A. Approved [5]
Lung cancer 2C25.0 Approved [5]
Lymphoproliferative syndrome N.A. Approved [5]
MALT lymphoma N.A. Approved [5]
Mantle cell lymphoma 2A85.5 Approved [6]
Minimally invasive lung adenocarcinoma N.A. Approved [5]
Multiple myeloma 2A83 Approved [7]
Nodal marginal zone lymphoma 2A85.0 Approved [5]
Plasma cell myeloma 2A83.1 Approved [5]
Recurrent adult burkitt lymphoma 2A85.6 Approved [5]
Non-hodgkin lymphoma 2B33.5 Phase 3 [7]
B-cell neoplasm N.A. Investigative [5]
Colon cancer 2B90.Z Investigative [5]
Gastric cancer 2B72 Investigative [5]
Bortezomib Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Inhibitor [158]
Kallikrein-related peptidase (KLK) TT5L2VC NOUNIPROTAC Inhibitor [158]
Proteasome (PS) TTU7ZMG NOUNIPROTAC Modulator [159]
------------------------------------------------------------------------------------
Bortezomib Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [160]
------------------------------------------------------------------------------------
Bortezomib Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [161]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [162]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [163]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [164]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [163]
------------------------------------------------------------------------------------
Bortezomib Interacts with 686 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [165]
Extended synaptotagmin-2 (ESYT2) OTWCXTX3 ESYT2_HUMAN Decreases Expression [152]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [152]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [152]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Decreases Expression [152]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Decreases Expression [152]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Increases Expression [152]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [152]
Leukocyte-specific transcript 1 protein (LST1) OTUVG424 LST1_HUMAN Decreases Expression [152]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [152]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Increases Expression [152]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [152]
Pirin (PIR) OT8ALXHU PIR_HUMAN Increases Expression [152]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Increases Expression [152]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [152]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [152]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) OT7AU2R3 TRAD1_HUMAN Increases Expression [152]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Increases Expression [152]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [152]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Increases Expression [152]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) OTOKUXUH ADA10_HUMAN Decreases Expression [152]
Apolipoprotein L1 (APOL1) OT8QBVTY APOL1_HUMAN Increases Expression [152]
Interferon-inducible protein AIM2 (AIM2) OT86QUI8 AIM2_HUMAN Increases Expression [152]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [152]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Increases Expression [152]
Small ribosomal subunit protein uS12m (MRPS12) OTGY4GIX RT12_HUMAN Decreases Expression [152]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [152]
V-type proton ATPase subunit e 1 (ATP6V0E1) OTZZIUYY VA0E1_HUMAN Increases Expression [152]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Decreases Expression [152]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [152]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [152]
PHD finger protein 1 (PHF1) OTW2PSIR PHF1_HUMAN Increases Expression [152]
Synaptogyrin-2 (SYNGR2) OTJX84RI SNG2_HUMAN Decreases Expression [152]
Cytohesin-interacting protein (CYTIP) OTRJ3ZC5 CYTIP_HUMAN Increases Expression [152]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Decreases Expression [152]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Increases Expression [152]
Glycosaminoglycan xylosylkinase (FAM20B) OTOA0UYT XYLK_HUMAN Decreases Expression [152]
Suppressor of cytokine signaling 5 (SOCS5) OTN1ABYR SOCS5_HUMAN Increases Expression [152]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [152]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Decreases Expression [152]
Calpain-15 (CAPN15) OT0WE161 CAN15_HUMAN Decreases Expression [152]
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Increases Expression [152]
Triple functional domain protein (TRIO) OT71X1AK TRIO_HUMAN Decreases Expression [152]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Increases Expression [152]
ATP-dependent DNA helicase Q4 (RECQL4) OT59LSW7 RECQ4_HUMAN Increases Expression [152]
Erlin-2 (ERLIN2) OT551BVG ERLN2_HUMAN Decreases Expression [152]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Decreases Expression [152]
Lysine-specific demethylase 4B (KDM4B) OT5P1UPY KDM4B_HUMAN Decreases Expression [152]
Methyl-CpG-binding domain protein 4 (MBD4) OTWR9YXE MBD4_HUMAN Increases Expression [152]
Arginyl-tRNA--protein transferase 1 (ATE1) OT3QNM39 ATE1_HUMAN Increases Expression [152]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Decreases Expression [152]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Decreases Expression [152]
AP-2 complex subunit alpha-1 (AP2A1) OTEFZB21 AP2A1_HUMAN Decreases Expression [152]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Increases Expression [152]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [152]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Expression [152]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) OT1TN2KT GPAN1_HUMAN Increases Expression [152]
Putative lipid scramblase CLPTM1 (CLPTM1) OT14QP7N CLPT1_HUMAN Decreases Expression [152]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [152]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [152]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [152]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [152]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Decreases Expression [152]
T-cell surface glycoprotein CD5 (CD5) OTC5JEG5 CD5_HUMAN Decreases Expression [152]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Increases Expression [152]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Decreases Expression [152]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [152]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Decreases Expression [152]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Increases Expression [152]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) OT89UWAR GNAI3_HUMAN Increases Expression [152]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Decreases Expression [152]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Increases Expression [152]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [152]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Increases Expression [152]
Cancer/testis antigen family 45 member A6 (CT45A5) OTIFETOM CT456_HUMAN Increases Expression [152]
Schwannomin-interacting protein 1 (SCHIP1) OTF3FR4A SCHI1_HUMAN Decreases Expression [152]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Increases Expression [152]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [152]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [152]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Decreases Expression [152]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [152]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [152]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [152]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [152]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Decreases Expression [152]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [152]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [152]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [152]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [152]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [152]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [152]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Decreases Expression [152]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) OT18H1B0 ERF3A_HUMAN Decreases Expression [152]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [152]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Expression [152]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [152]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [152]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [152]
Ribosyldihydronicotinamide dehydrogenase (NQO2) OTGDAJRZ NQO2_HUMAN Increases Expression [152]
Leukosialin (SPN) OTFW338K LEUK_HUMAN Decreases Expression [152]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [152]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Increases Expression [152]
Ras-related protein Rab-5A (RAB5A) OTFR2KM4 RAB5A_HUMAN Decreases Expression [152]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [152]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [152]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Decreases Expression [152]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Decreases Expression [152]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [152]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [152]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Expression [152]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Decreases Expression [152]
ER lumen protein-retaining receptor 1 (KDELR1) OT8YBS5G ERD21_HUMAN Decreases Expression [152]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [152]
Polypyrimidine tract-binding protein 1 (PTBP1) OT2OBJUK PTBP1_HUMAN Decreases Expression [152]
NKG2-D type II integral membrane protein (KLRK1) OTQWXK71 NKG2D_HUMAN Decreases Expression [152]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Decreases Expression [152]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [152]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [152]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [152]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Increases Expression [152]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [152]
Homeobox protein Hox-A11 (HOXA11) OT42C4HF HXA11_HUMAN Decreases Expression [152]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [152]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [152]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Increases Expression [152]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [152]
Protein phosphatase 1A (PPM1A) OT1U770U PPM1A_HUMAN Increases Expression [152]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [152]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [152]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [152]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [152]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [152]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [152]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Decreases Expression [152]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [152]
Lysine-specific demethylase 5C (KDM5C) OTZ6E0HY KDM5C_HUMAN Decreases Expression [152]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [152]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Decreases Expression [152]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [152]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Decreases Expression [152]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Decreases Expression [152]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [152]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [152]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [152]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [152]
MAP kinase-activated protein kinase 2 (MAPKAPK2) OT460SBO MAPK2_HUMAN Decreases Expression [152]
Large ribosomal subunit protein bL19m (MRPL19) OTRBKF6R RM19_HUMAN Increases Expression [152]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Decreases Expression [152]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Increases Expression [152]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Increases Expression [152]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Expression [152]
Protein numb homolog (NUMB) OTMB586Q NUMB_HUMAN Increases Expression [152]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [152]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [152]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [152]
Dynamin-2 (DNM2) OTUYU2U3 DYN2_HUMAN Decreases Expression [152]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Decreases Expression [152]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [152]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Decreases Expression [152]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [152]
N-sulphoglucosamine sulphohydrolase (SGSH) OTLSSEOS SPHM_HUMAN Increases Expression [152]
AF4/FMR2 family member 1 (AFF1) OTT2C78E AFF1_HUMAN Increases Expression [152]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Increases Expression [152]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Decreases Expression [152]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [152]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Decreases Expression [152]
Cysteine-rich protein 2 (CRIP2) OTVVJSYX CRIP2_HUMAN Decreases Expression [152]
Serine/threonine-protein phosphatase 5 (PPP5C) OTC3HT6Y PPP5_HUMAN Decreases Expression [152]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [152]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [152]
Myc-associated zinc finger protein (MAZ) OTEHKN1M MAZ_HUMAN Decreases Expression [152]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Decreases Expression [152]
Small integral membrane protein 11 (SMIM11) OTZPLVUC SIM11_HUMAN Decreases Expression [152]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [152]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [152]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [152]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Increases Expression [152]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Increases Expression [152]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [152]
Small ribosomal subunit protein uS17 (RPS11) OTILZE44 RS11_HUMAN Increases Expression [152]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Increases Expression [152]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [152]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Decreases Expression [152]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Expression [152]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Increases Expression [152]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [152]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [152]
Small ribosomal subunit protein uS5m (MRPS5) OTZZR208 RT05_HUMAN Decreases Expression [152]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [152]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [152]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Decreases Expression [152]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Decreases Expression [152]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Decreases Expression [152]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Decreases Expression [152]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [152]
Centromere protein C (CENPC) OTVJ6VE9 CENPC_HUMAN Increases Expression [152]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [152]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Decreases Expression [152]
CTD small phosphatase-like protein 2 (CTDSPL2) OTPF8W4P CTSL2_HUMAN Decreases Expression [152]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Decreases Expression [152]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [152]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [152]
Rho GTPase-activating protein 1 (ARHGAP1) OT0H2ZBZ RHG01_HUMAN Decreases Expression [152]
FACT complex subunit SSRP1 (SSRP1) OT5TYJK9 SSRP1_HUMAN Decreases Expression [152]
Sodium/bile acid cotransporter 7 (SLC10A7) OTYLAWNV NTCP7_HUMAN Increases Expression [152]
Apolipoprotein B receptor (APOBR) OT9EUZX3 APOBR_HUMAN Decreases Expression [152]
Nuclear factor 1 A-type (NFIA) OTDHQ9CG NFIA_HUMAN Decreases Expression [152]
Interferon-related developmental regulator 2 (IFRD2) OT2URF18 IFRD2_HUMAN Decreases Expression [152]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [152]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Decreases Expression [152]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [152]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Decreases Expression [152]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [152]
Phosducin-like protein (PDCL) OTDNHIXG PHLP_HUMAN Increases Expression [152]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Expression [152]
Protein OS-9 (OS9) OTB5B2TY OS9_HUMAN Increases Expression [152]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [152]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [152]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [152]
Rap guanine nucleotide exchange factor 1 (RAPGEF1) OTZ0TBN1 RPGF1_HUMAN Decreases Expression [152]
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A) OTVDV4IT PDE7A_HUMAN Decreases Expression [152]
Nuclear transcription factor Y subunit gamma (NFYC) OTZVVEV7 NFYC_HUMAN Decreases Expression [152]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [152]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [152]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Decreases Expression [152]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [152]
Neutral alpha-glucosidase AB (GANAB) OTYLXY4M GANAB_HUMAN Decreases Expression [152]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) OT43TTX0 2A5D_HUMAN Decreases Expression [152]
Kinesin-like protein KIF22 (KIF22) OTY6X6BL KIF22_HUMAN Decreases Expression [152]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1) OTJWIO4T KI3S1_HUMAN Decreases Expression [152]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3) OT3PSLDL KI2S3_HUMAN Decreases Expression [152]
DAZ-associated protein 2 (DAZAP2) OTNURO9F DAZP2_HUMAN Decreases Expression [152]
Neutrophil cytosol factor 4 (NCF4) OTX007YL NCF4_HUMAN Decreases Expression [152]
kinase isozyme 2, mitochondrial (PDK2) OTM436F9 PDK2_HUMAN Decreases Expression [152]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [152]
Ras suppressor protein 1 (RSU1) OTO5GHT1 RSU1_HUMAN Increases Expression [152]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Decreases Expression [152]
NF-kappa-B inhibitor beta (NFKBIB) OTY1ZJXH IKBB_HUMAN Increases Expression [152]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [152]
Neuronal pentraxin-1 (NPTX1) OTKVHCV0 NPTX1_HUMAN Decreases Expression [152]
Coiled-coil domain-containing protein 6 (CCDC6) OTXRQDYG CCDC6_HUMAN Decreases Expression [152]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Increases Expression [152]
Solute carrier family 35 member G1 (SLC35G1) OTKZUA8O S35G1_HUMAN Decreases Expression [152]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6) OTWSXW4O PARP6_HUMAN Decreases Expression [152]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [152]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Expression [152]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Increases Expression [152]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Decreases Expression [152]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [152]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Decreases Expression [152]
Vesicle transport protein SFT2C (SFT2D3) OT0IEAAR SFT2C_HUMAN Decreases Expression [152]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [152]
Torsin-1A-interacting protein 1 (TOR1AIP1) OTTG8MAK TOIP1_HUMAN Decreases Expression [152]
Tetratricopeptide repeat protein 39A (TTC39A) OT80PQWX TT39A_HUMAN Increases Expression [152]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Increases Expression [152]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Increases Expression [152]
G-protein coupled receptor 157 (GPR157) OTE7K9D7 GP157_HUMAN Decreases Expression [152]
Obscurin (OBSCN) OTT14OVX OBSCN_HUMAN Decreases Expression [152]
G kinase-anchoring protein 1 (GKAP1) OTHZRJ56 GKAP1_HUMAN Increases Expression [152]
Protein TASOR 2 (TASOR2) OTN4VE8H TASO2_HUMAN Decreases Expression [152]
Sushi domain-containing protein 4 (SUSD4) OTWCJTT3 SUSD4_HUMAN Decreases Expression [152]
Proteasome adapter and scaffold protein ECM29 (ECPAS) OT1C0KOI ECM29_HUMAN Increases Expression [152]
DENN domain-containing protein 4C (DENND4C) OT8SYN47 DEN4C_HUMAN Increases Expression [152]
Pecanex-like protein 4 (PCNX4) OTV474RQ PCX4_HUMAN Increases Expression [152]
Protein SPT2 homolog (SPTY2D1) OT1RY99Z SPT2_HUMAN Increases Expression [152]
CWF19-like protein 1 (CWF19L1) OTAMYTOW C19L1_HUMAN Decreases Expression [152]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Increases Expression [152]
Tyrosine-protein kinase STYK1 (STYK1) OT61CSU7 STYK1_HUMAN Increases Expression [152]
SPRY domain-containing SOCS box protein 3 (SPSB3) OTHGEE2K SPSB3_HUMAN Increases Expression [152]
E3 ubiquitin-protein ligase TRIM65 (TRIM65) OTSQTK3A TRI65_HUMAN Decreases Expression [152]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) OT7RWBKE LRFN4_HUMAN Decreases Expression [152]
Type-1 angiotensin II receptor-associated protein (AGTRAP) OT02N7LD ATRAP_HUMAN Decreases Expression [152]
Transmembrane protein 92 (TMEM92) OTTKJ2C0 TMM92_HUMAN Decreases Expression [152]
MICOS complex subunit MIC27 (APOOL) OTC1WT8O MIC27_HUMAN Increases Expression [152]
DnaJ homolog subfamily C member 14 (DNAJC14) OT7DPIVN DJC14_HUMAN Decreases Expression [152]
TBC1 domain family member 9 (TBC1D9) OTSSCTB5 TBCD9_HUMAN Increases Expression [152]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) OTMQXW7S RAPH1_HUMAN Increases Expression [152]
Serine/threonine-protein kinase MARK2 (MARK2) OTJWGLUZ MARK2_HUMAN Decreases Expression [152]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [152]
Probable C-mannosyltransferase DPY19L4 (DPY19L4) OTQ89TXA D19L4_HUMAN Increases Expression [152]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [152]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Increases Expression [152]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [152]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Increases Expression [152]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) OT991XS0 PP4P1_HUMAN Decreases Expression [152]
Kinectin (KTN1) OTQAV541 KTN1_HUMAN Increases Expression [152]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) OTZQE7PW SMS1_HUMAN Increases Expression [152]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [152]
RNA-binding protein MEX3D (MEX3D) OTAUWRK7 MEX3D_HUMAN Decreases Expression [152]
Dynein axonemal assembly factor 5 (DNAAF5) OTN0CT52 DAAF5_HUMAN Decreases Expression [152]
Syntaxin-12 (STX12) OT5IBQ62 STX12_HUMAN Increases Expression [152]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Increases Expression [152]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Increases Expression [152]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Decreases Expression [152]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) OT4ZYV73 PKHM2_HUMAN Decreases Expression [152]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Decreases Expression [152]
Xaa-Arg dipeptidase (PM20D2) OTD2Y7LU P20D2_HUMAN Increases Expression [152]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [152]
Abl interactor 1 (ABI1) OT5H4M62 ABI1_HUMAN Increases Expression [152]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Increases Expression [152]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Decreases Expression [152]
CAP-Gly domain-containing linker protein 4 (CLIP4) OT75KVQK CLIP4_HUMAN Increases Expression [152]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Decreases Expression [152]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) OT6WKC13 GALT4_HUMAN Increases Expression [152]
Coiled-coil domain-containing protein 82 (CCDC82) OT16EAZ7 CCD82_HUMAN Increases Expression [152]
SH2 domain-containing protein 3C (SH2D3C) OTAGXO0N SH2D3_HUMAN Decreases Expression [152]
Methyltransferase-like protein 27 (METTL27) OTOF0GTU MET27_HUMAN Decreases Expression [152]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Decreases Expression [152]
Protein KRI1 homolog (KRI1) OT1IGOK7 KRI1_HUMAN Increases Expression [152]
ATPase family gene 2 protein homolog A (AFG2A) OTPZKWN7 AFG2A_HUMAN Increases Expression [152]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [152]
Retinol dehydrogenase 13 (RDH13) OT48VJ65 RDH13_HUMAN Increases Expression [152]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [152]
Polyhomeotic-like protein 3 (PHC3) OTTTLIAP PHC3_HUMAN Increases Expression [152]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Decreases Expression [152]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [152]
Tubulin--tyrosine ligase (TTL) OTSS1CK4 TTL_HUMAN Decreases Expression [152]
Protein NEDD1 (NEDD1) OTBD6X77 NEDD1_HUMAN Increases Expression [152]
Protein FAM76A (FAM76A) OT28WHO4 FA76A_HUMAN Increases Expression [152]
Proline-rich protein 7 (PRR7) OT56XAQK PRR7_HUMAN Decreases Expression [152]
Transmembrane protein 254 (TMEM254) OTGDPU8S TM254_HUMAN Decreases Expression [152]
Retinol dehydrogenase 11 (RDH11) OTIND43N RDH11_HUMAN Increases Expression [152]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Increases Expression [152]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [152]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [152]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [152]
Elongator complex protein 5 (ELP5) OTW5R7YD ELP5_HUMAN Decreases Expression [152]
DDB1- and CUL4-associated factor 11 (DCAF11) OTNSGYK1 DCA11_HUMAN Decreases Expression [152]
Arginine/serine-rich protein PNISR (PNISR) OTUM02FW PNISR_HUMAN Increases Expression [152]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Decreases Expression [152]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [152]
Protein THEM6 (THEM6) OT51SVLH THEM6_HUMAN Decreases Expression [152]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [152]
Hexosaminidase D (HEXD) OTTMQKLM HEXD_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase RNF138 (RNF138) OTPU0CO4 RN138_HUMAN Increases Expression [152]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) OTA6Q5E0 HNRLL_HUMAN Increases Expression [152]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [152]
tRNA-splicing endonuclease subunit Sen15 (TSEN15) OT14UW31 SEN15_HUMAN Decreases Expression [152]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [152]
Protein N-lysine methyltransferase METTL21A (METTL21A) OTXJTNXY MT21A_HUMAN Increases Expression [152]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [152]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [152]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [152]
Protein FAM168A (FAM168A) OTDXQCS5 F168A_HUMAN Increases Expression [152]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [152]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [152]
Ras-related protein Rab-8B (RAB8B) OTBPUHV9 RAB8B_HUMAN Decreases Expression [152]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [152]
Phosphorylase b kinase regulatory subunit beta (PHKB) OTKXZZIU KPBB_HUMAN Increases Expression [152]
BLOC-2 complex member HPS3 (HPS3) OTAKROK7 HPS3_HUMAN Decreases Expression [152]
F-box/WD repeat-containing protein 7 (FBXW7) OTJXE4OT FBXW7_HUMAN Decreases Expression [152]
Polyamine deacetylase HDAC10 (HDAC10) OTHCKKUQ HDA10_HUMAN Decreases Expression [152]
NXPE family member 3 (NXPE3) OTLVZ8W2 NXPE3_HUMAN Increases Expression [152]
Transmembrane protein 230 (TMEM230) OTAFALFV TM230_HUMAN Decreases Expression [152]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [152]
Ankyrin repeat domain-containing protein 9 (ANKRD9) OT7VGO6G ANKR9_HUMAN Increases Expression [152]
ADP-ribosylation factor-like protein 8A (ARL8A) OTEYM6FA ARL8A_HUMAN Increases Expression [152]
m7GpppX diphosphatase (DCPS) OT1FZVC9 DCPS_HUMAN Decreases Expression [152]
Protein FAM241B (FAM241B) OTLISLRC F241B_HUMAN Increases Expression [152]
R3H domain-containing protein 4 (R3HDM4) OTE0Q78Q R3HD4_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase CHFR (CHFR) OTRAD2TT CHFR_HUMAN Decreases Expression [152]
ATP-dependent DNA helicase DDX11 (DDX11) OT1WR3MD DDX11_HUMAN Decreases Expression [152]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Increases Expression [152]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Increases Expression [152]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [152]
Uncharacterized protein C9orf85 (C9ORF85) OTJWBPL3 CI085_HUMAN Increases Expression [152]
Pannexin-2 (PANX2) OTAQ2S8R PANX2_HUMAN Increases Expression [152]
Ribosomal protein S6 kinase delta-1 (RPS6KC1) OT2LRTG4 KS6C1_HUMAN Increases Expression [152]
Structural maintenance of chromosomes protein 6 (SMC6) OT3IBHQD SMC6_HUMAN Increases Expression [152]
Protein orai-2 (ORAI2) OTYISRYH ORAI2_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase RING2 (RNF2) OTFPLOIN RING2_HUMAN Increases Expression [152]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [152]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Decreases Expression [152]
Sigma non-opioid intracellular receptor 1 (SIGMAR1) OTDORW5C SGMR1_HUMAN Decreases Expression [152]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [152]
Apolipoprotein L4 (APOL4) OTTOH86V APOL4_HUMAN Decreases Expression [152]
Protein NipSnap homolog 1 (NIPSNAP1) OTKXKUT8 NIPS1_HUMAN Decreases Expression [152]
Protein FAM118B (FAM118B) OTRLY4B0 F118B_HUMAN Increases Expression [152]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Decreases Expression [152]
TM2 domain-containing protein 3 (TM2D3) OT6MS96W TM2D3_HUMAN Increases Expression [152]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [152]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Decreases Expression [152]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [152]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Decreases Expression [152]
Coiled-coil domain-containing protein 32 (CCDC32) OTPPUFIF CCD32_HUMAN Increases Expression [152]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [152]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [152]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [152]
TM2 domain-containing protein 2 (TM2D2) OTB51WEY TM2D2_HUMAN Increases Expression [152]
Sphingosine-1-phosphate phosphatase 1 (SGPP1) OT9X54CQ SGPP1_HUMAN Increases Expression [152]
FSD1-like protein (FSD1L) OTBQ48RF FSD1L_HUMAN Increases Expression [152]
C-type lectin domain family 7 member A (CLEC7A) OTRTBH27 CLC7A_HUMAN Increases Expression [152]
Serrate RNA effector molecule homolog (SRRT) OTMYPSWV SRRT_HUMAN Decreases Expression [152]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) OT07Z2RQ PACN1_HUMAN Increases Expression [152]
Sterile alpha motif domain-containing protein 10 (SAMD10) OTBKWB5C SAM10_HUMAN Decreases Expression [152]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Decreases Expression [152]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [152]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [152]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [152]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [152]
Oxysterol-binding protein-related protein 2 (OSBPL2) OTCK671N OSBL2_HUMAN Increases Expression [152]
Dual specificity protein phosphatase 15 (DUSP15) OTS6PQYL DUS15_HUMAN Decreases Expression [152]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) OT5HFZXU BACD3_HUMAN Increases Expression [152]
UPF0696 protein C11orf68 (C11ORF68) OTOKOGZ6 CK068_HUMAN Decreases Expression [152]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Decreases Expression [152]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Decreases Expression [152]
ESF1 homolog (ESF1) OTHEDM0A ESF1_HUMAN Increases Expression [152]
RNA polymerase II-associated protein 3 (RPAP3) OTCW17LF RPAP3_HUMAN Increases Expression [152]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3) OTZ1AARI SDS3_HUMAN Increases Expression [152]
Caspase activity and apoptosis inhibitor 1 (CAAP1) OTD2DN1Z CAAP1_HUMAN Increases Expression [152]
Kinesin-like protein KIF9 (KIF9) OT7W6VI1 KIF9_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [152]
Transcription factor IIIB 50 kDa subunit (BRF2) OT2C6TH2 BRF2_HUMAN Increases Expression [152]
Retinoid-inducible serine carboxypeptidase (SCPEP1) OT43LYEZ RISC_HUMAN Increases Expression [152]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) OT0X9WGR PATZ1_HUMAN Decreases Expression [152]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [152]
DnaJ homolog subfamily C member 4 (DNAJC4) OT4BUBQU DNJC4_HUMAN Decreases Expression [152]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Decreases Expression [152]
Carbohydrate sulfotransferase 11 (CHST11) OTNJJ5Q1 CHSTB_HUMAN Decreases Expression [152]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Decreases Expression [152]
Putative RNA-binding protein Luc7-like 1 (LUC7L) OT77JDB7 LUC7L_HUMAN Increases Expression [152]
Prefoldin subunit 4 (PFDN4) OT5NRHER PFD4_HUMAN Increases Expression [152]
Solute carrier family 35 member C2 (SLC35C2) OT9H15XZ S35C2_HUMAN Decreases Expression [152]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Decreases Expression [152]
Endophilin-B2 (SH3GLB2) OTF7BB9S SHLB2_HUMAN Decreases Expression [152]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [152]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Decreases Expression [152]
RNA-binding protein PNO1 (PNO1) OT010GIS PNO1_HUMAN Increases Expression [152]
DDB1- and CUL4-associated factor 13 (DCAF13) OTQQ0QXT DCA13_HUMAN Increases Expression [152]
FGFR1 oncogene partner 2 (FGFR1OP2) OTAHO1ZC FGOP2_HUMAN Increases Expression [152]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [152]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Increases Expression [152]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [152]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Increases Expression [152]
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) OT91IAYT CLN6_HUMAN Decreases Expression [152]
AFG2-interacting ribosome maturation factor (AIRIM) OTGG814L AIRIM_HUMAN Increases Expression [152]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) OTE69HV8 B3GN2_HUMAN Decreases Expression [152]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase KCMF1 (KCMF1) OTVTKFAU KCMF1_HUMAN Increases Expression [152]
Stromal interaction molecule 2 (STIM2) OTYNXAW0 STIM2_HUMAN Decreases Expression [152]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Increases Expression [152]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [152]
E3 ubiquitin-protein ligase RNF14 (RNF14) OTWX0D0H RNF14_HUMAN Increases Expression [152]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Decreases Expression [152]
Beta-1,4-galactosyltransferase 6 (B4GALT6) OTBM8F2U B4GT6_HUMAN Increases Expression [152]
LIM domain-containing protein 1 (LIMD1) OTN1CG6R LIMD1_HUMAN Increases Expression [152]
Protein NDRG3 (NDRG3) OTJTJCHD NDRG3_HUMAN Decreases Expression [152]
LIM domain and actin-binding protein 1 (LIMA1) OTONPC9R LIMA1_HUMAN Increases Expression [152]
AF4/FMR2 family member 4 (AFF4) OTTL5Y8R AFF4_HUMAN Increases Expression [152]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [152]
Methyl-CpG-binding domain protein 1 (MBD1) OTD19VO6 MBD1_HUMAN Decreases Expression [152]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [152]
Cell division cycle protein 23 homolog (CDC23) OTC4O83E CDC23_HUMAN Increases Expression [152]
Anaphase-promoting complex subunit 5 (ANAPC5) OTGTJNNR APC5_HUMAN Decreases Expression [152]
Calcipressin-3 (RCAN3) OTTS3CQA RCAN3_HUMAN Decreases Expression [152]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) OT4DLRYY ASAP1_HUMAN Decreases Expression [152]
Tetratricopeptide repeat protein 7A (TTC7A) OTDHLPQM TTC7A_HUMAN Decreases Expression [152]
Nucleosome assembly protein 1-like 2 (NAP1L2) OT8QI4GF NP1L2_HUMAN Increases Expression [152]
Protein PHTF1 (PHTF1) OTYCZ84A PHTF1_HUMAN Increases Expression [152]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) OTNQ351N PSD13_HUMAN Increases Expression [152]
Cytosolic carboxypeptidase 1 (AGTPBP1) OTR92JFR CBPC1_HUMAN Increases Expression [152]
Serine/threonine-protein kinase ICK (CILK1) OTWOYEYP CILK1_HUMAN Increases Expression [152]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [152]
Myotubularin-related protein 6 (MTMR6) OTQPAWI3 MTMR6_HUMAN Increases Expression [152]
Phospholipase A-2-activating protein (PLAA) OTZ7NJGA PLAP_HUMAN Increases Expression [152]
Phenylalanine--tRNA ligase alpha subunit (FARSA) OT3U1P20 SYFA_HUMAN Decreases Expression [152]
Nck-associated protein 1 (NCKAP1) OTEZQXXJ NCKP1_HUMAN Increases Expression [152]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [152]
ARF GTPase-activating protein GIT1 (GIT1) OTHO92S5 GIT1_HUMAN Decreases Expression [152]
RING finger protein 11 (RNF11) OTFBJSKQ RNF11_HUMAN Increases Expression [152]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Decreases Expression [152]
Carbohydrate sulfotransferase 2 (CHST2) OTV11IZF CHST2_HUMAN Decreases Expression [152]
G-protein-signaling modulator 3 (GPSM3) OT2MO458 GPSM3_HUMAN Decreases Expression [152]
U6 snRNA-associated Sm-like protein LSm4 (LSM4) OTLKJB3A LSM4_HUMAN Decreases Expression [152]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H) OT7GM7MX RPC8_HUMAN Decreases Expression [152]
NEDD8 ultimate buster 1 (NUB1) OTWA6RTX NUB1_HUMAN Increases Expression [152]
Selenoprotein K (SELENOK) OTKM7N7P SELK_HUMAN Increases Expression [152]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [152]
Numb-like protein (NUMBL) OTWMTMMH NUMBL_HUMAN Increases Expression [152]
ATPase MORC2 (MORC2) OT52A8BJ MORC2_HUMAN Increases Expression [152]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [166]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Expression [166]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [166]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [166]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Expression [166]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [166]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [166]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [167]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Decreases Expression [168]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Increases Stability [169]
Myc box-dependent-interacting protein 1 (BIN1) OTK8O0X8 BIN1_HUMAN Increases Expression [157]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [170]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [155]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Expression [155]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [157]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [171]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Decreases Degradation [172]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [157]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [157]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [173]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Activity [174]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [175]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [155]
DENN domain-containing protein 4B (DENND4B) OTFEO8KG DEN4B_HUMAN Increases Expression [176]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [176]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [176]
Natural cytotoxicity triggering receptor 1 (NCR1) OT6MZKQY NCTR1_HUMAN Decreases Expression [177]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [171]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [176]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [173]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [178]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Response To Substance [179]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [180]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [181]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [182]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [183]
Galectin-2 (LGALS2) OTY08TMQ LEG2_HUMAN Decreases Expression [157]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [184]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [185]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [155]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [155]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Activity [153]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [155]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Localization [174]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [155]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [167]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [176]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [176]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [186]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [167]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [176]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [187]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Decreases Expression [183]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [188]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [155]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Increases Expression [167]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [187]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [157]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [167]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [155]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [100]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [189]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Expression [167]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Expression [167]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Phosphorylation [190]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [155]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [176]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [191]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [155]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [155]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [171]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [176]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [192]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Affects Expression [168]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [153]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [155]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [176]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [167]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [155]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [167]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [181]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Increases Expression [165]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [181]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Decreases Expression [157]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Decreases Expression [155]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Increases Expression [165]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Activity [181]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [157]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [193]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Decreases Expression [157]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [155]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Degradation [194]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [157]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [167]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [195]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [171]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [176]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [184]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [176]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [196]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [196]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [197]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [153]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [198]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Activity [184]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Decreases Expression [183]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [199]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Increases Expression [157]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [195]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Decreases Expression [155]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [157]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [200]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Increases Cleavage [186]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [155]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [171]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [157]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12) OTGR132Z NAL12_HUMAN Increases Expression [155]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Decreases Expression [201]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Affects Expression [168]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [173]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Expression [167]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [192]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Cleavage [202]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Expression [157]
Heat shock factor protein 2 (HSF2) OTXNJIJ9 HSF2_HUMAN Increases Expression [203]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [195]
Fragile X messenger ribonucleoprotein 1 (FMR1) OTWEV0T5 FMR1_HUMAN Decreases Expression [157]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [204]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [174]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Cleavage [186]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [180]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Affects Expression [192]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [157]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [205]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Cleavage [202]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Activity [174]
Interleukin-18 receptor 1 (IL18R1) OT83XMPQ IL18R_HUMAN Increases Expression [167]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [206]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [169]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Decreases Expression [155]
Cullin-1 (CUL1) OTXPE1UZ CUL1_HUMAN Increases Expression [167]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [157]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Decreases Expression [192]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [202]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Increases Expression [167]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [191]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [183]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Increases Expression [167]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [207]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [208]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [208]
TIR domain-containing adapter molecule 2 (TICAM2) OTK7GIJ5 TCAM2_HUMAN Increases Expression [155]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [209]
Ectodysplasin-A receptor-associated adapter protein (EDARADD) OT0G52MC EDAD_HUMAN Increases Expression [167]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [157]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [171]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [192]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [155]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [210]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Decreases Expression [157]
MOB kinase activator 3A (MOB3A) OTILIOXF MOB3A_HUMAN Decreases Expression [157]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Expression [211]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Decreases Expression [157]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [212]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [165]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [167]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [155]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [176]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [213]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Decreases Phosphorylation [214]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [157]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [167]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Increases Expression [167]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [192]
Sphingosine kinase 1 (SPHK1) OTWYPBVD SPHK1_HUMAN Decreases Expression [215]
Anaphase-promoting complex subunit 11 (ANAPC11) OTK2SJXR APC11_HUMAN Decreases Expression [157]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [176]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Decreases Expression [157]
Adenine DNA glycosylase (MUTYH) OTXTKI7Q MUTYH_HUMAN Decreases Expression [157]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [155]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Expression [167]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [157]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Increases Expression [171]
Rho-related BTB domain-containing protein 2 (RHOBTB2) OT2DATFX RHBT2_HUMAN Increases Response To Substance [216]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Response To Substance [217]
Palmitoyl thioesterase CPT1C (CPT1C) OT8F1MBF CPT1C_HUMAN Increases Response To Substance [216]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Affects Response To Substance [218]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Response To Substance [219]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Increases Response To Substance [220]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Response To Substance [216]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Response To Substance [216]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Increases Response To Substance [216]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Response To Substance [216]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [221]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Response To Substance [216]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Response To Substance [216]
Unconventional myosin-Va (MYO5A) OTMWLP3E MYO5A_HUMAN Increases Response To Substance [216]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Response To Substance [222]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Response To Substance [223]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Increases Response To Substance [216]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Increases Response To Substance [224]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Increases Response To Substance [223]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Response To Substance [216]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Response To Substance [216]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Response To Substance [184]
------------------------------------------------------------------------------------
⏷ Show the Full List of 686 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Multiple Myeloma DC4DYZA N. A. Phase 3 [225]
Multiple Myeloma DC8SOTE N. A. Phase 3 [226]
Multiple Myeloma DCPG97F N. A. Phase 3 [227]
Multiple Myeloma DC51QO5 N. A. Phase 2 [228]
Relapsed or Refractory Multiple Myeloma DCP0GBM N. A. Phase 2 [229]
Multiple Myeloma DCUKT0G N. A. Phase 2 [230]
Lymphoma DC1P7A2 N. A. Phase 2 [231]
Multiple Myeloma DC2UGER N. A. Phase 2 [232]
Multiple Myeloma DC1SGGR N. A. Phase 1 [233]
Multiple Myeloma DC6B7B1 N. A. Phase 1 [234]
Refractory Multiple Myeloma DCQ1M1S N. A. Phase 1 [235]
Multiple Myeloma DCVMOZF N. A. Phase 1 [236]
Breast carcinoma DC0GJLH KPL1 Investigative [237]
Adenocarcinoma DCSECRO CAOV3 Investigative [238]
------------------------------------------------------------------------------------
⏷ Show the Full List of 14 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00335348) Bortezomib and Dexamethasone as Treatment and Maintenance for Multiple Myeloma Relapse
2 Dexamethasone FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3447).
4 Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17. doi: 10.1056/NEJMoa2021436.
5 Bortezomib FDA Label
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
8 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
9 Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol. 2005 Mar;67(3):845-55.
10 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
11 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
12 Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor. Toxicol Appl Pharmacol. 2020 Aug 15;401:115118. doi: 10.1016/j.taap.2020.115118. Epub 2020 Jul 1.
13 Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicol In Vitro. 2010 Apr;24(3):822-9. doi: 10.1016/j.tiv.2009.12.011. Epub 2009 Dec 13.
14 NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells. Biochem Biophys Res Commun. 2001 Dec 14;289(4):851-6. doi: 10.1006/bbrc.2001.6067.
15 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
16 Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
17 Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
18 Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605.
19 Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
20 Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90.
21 Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.
22 Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7.
23 In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84.
24 Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.
25 A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica. 1999 Mar;29(3):269-79.
26 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
27 Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol. 2000 Mar;22(3):360-6.
28 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
29 Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
30 Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91.
31 Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
32 Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota. Food Chem Toxicol. 2019 Sep;131:110562. doi: 10.1016/j.fct.2019.110562. Epub 2019 Jun 7.
33 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
34 Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
35 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
36 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
37 Effects of nitroglycerin and dexamethasone on nitric oxide and endothelin derived from alveolar macrophages in patients with mild and middle asthma. Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):363-6.
38 Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
39 Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. Drug Metab Dispos. 2005 Jul;33(7):1004-16.
40 Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep;68(3):747-57.
41 Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39.
42 The modulation of aromatase and estrogen receptor alpha in cultured human dermal papilla cells by dexamethasone: a novel mechanism for selective action of estrogen via estrogen receptor beta? J Invest Dermatol. 2006 Sep;126(9):2010-8.
43 Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Steroids. 2006 Oct;71(10):895-901.
44 An evidence for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor in HepG2 cells. Physiol Res. 2008;57(3):427-35.
45 Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60.
46 Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):718-23.
47 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
48 Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos. 2009 Jul;30(5):241-58.
49 Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism. Toxicology. 2010 Nov 9;277(1-3):11-9.
50 The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro. 2011 Feb;25(1):80-90.
51 CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
52 Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
53 Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS One. 2012;7(1):e30443.
54 The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):90-9.
55 Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48.
56 Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):348-54.
57 Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
58 Dexamethasone induces human glutathione S transferase alpha 1 (hGSTA1) expression through the activation of glucocorticoid receptor (hGR). Toxicology. 2017 Jun 15;385:59-66.
59 Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun. 2002 Mar 1;291(3):680-6. doi: 10.1006/bbrc.2002.6510.
60 Glucocorticoids affect 24 h clock genes expression in human adipose tissue explant cultures. PLoS One. 2012;7(12):e50435. doi: 10.1371/journal.pone.0050435. Epub 2012 Dec 10.
61 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
62 Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res. 2005 Sep 1;11(17):6333-41. doi: 10.1158/1078-0432.CCR-05-0148.
63 Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4 upregulation in primary human hepatocytes. Pharmacol Rep. 2013;65(5):1322-35. doi: 10.1016/s1734-1140(13)71491-9.
64 Dexamethasone affects Fas- and serum deprivation-induced cell death of human osteoblastic cells through survivin regulation. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1153-65. doi: 10.1177/039463201002300419.
65 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
66 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
67 Glucocorticoid regulation of human eosinophil gene expression. J Steroid Biochem Mol Biol. 2003 Mar;84(4):441-52. doi: 10.1016/s0960-0760(03)00065-7.
68 Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
69 G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.
70 Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation. Toxicol Sci. 2012 Feb;125(2):488-95. doi: 10.1093/toxsci/kfr304. Epub 2011 Nov 1.
71 Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clin Cancer Res. 2005 Sep 1;11(17):6342-51. doi: 10.1158/1078-0432.CCR-05-0596.
72 The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue. Toxicology. 2020 Dec 1;445:152600. doi: 10.1016/j.tox.2020.152600. Epub 2020 Sep 22.
73 Male pseudohermaphroditism with hypertension due to a 17alpha-hydroxylation deficiency. Clin Endocrinol (Oxf). 1976 Jan;5(1):53-61.
74 Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells. Curr Med Sci. 2019 Jun;39(3):356-362. doi: 10.1007/s11596-019-2043-1. Epub 2019 Jun 17.
75 Effects of inhaled beclomethasone compared to systemic dexamethasone on lung inflammation in preterm infants at risk of chronic lung disease. Pediatr Pulmonol. 1999 Jun;27(6):383-7. doi: 10.1002/(sici)1099-0496(199906)27:6<383::aid-ppul4>3.0.co;2-v.
76 miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats. Toxicol Appl Pharmacol. 2020 May 15;395:114979. doi: 10.1016/j.taap.2020.114979. Epub 2020 Mar 29.
77 Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L249-57. doi: 10.1152/ajplung.00088.2006. Epub 2006 Sep 22.
78 Cyclic changes in the expression of p57(kip2) in human endometrium and its regulation by steroid hormones in endometrial stromal cells in vitro. Reprod Sci. 2012 Jan;19(1):92-101. doi: 10.1177/1933719111414209. Epub 2011 Nov 7.
79 Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans. Diabetologia. 1993 Jan;36(1):84-7. doi: 10.1007/BF00399099.
80 Differential effect of thalidomide and dexamethasone on the transcription factor NF-kappa B. Int Immunopharmacol. 2001 Jan;1(1):49-61. doi: 10.1016/s0162-3109(00)00265-4.
81 Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells. Immunopharmacology. 1994 Jan-Feb;27(1):43-55. doi: 10.1016/0162-3109(94)90006-x.
82 Chemotaxis of human CD4+ eosinophils. Int Arch Allergy Immunol. 2001;125 Suppl 1:19-21. doi: 10.1159/000053847.
83 Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12.
84 Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure. Arch Ophthalmol. 2008 Dec;126(12):1700-6. doi: 10.1001/archophthalmol.2008.512.
85 Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000 May;130(2):289-98. doi: 10.1038/sj.bjp.0703272.
86 Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009 Feb;30(2):348-55. doi: 10.1093/carcin/bgn266. Epub 2008 Nov 26.
87 Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1--implications for steroid-induced myopathy. Clin Endocrinol (Oxf). 2010 Jul;73(1):126-32. doi: 10.1111/j.1365-2265.2009.03683.x. Epub 2009 Aug 4.
88 1 alpha,25-(OH)2 vitamin D3 enhances expression of the genes encoding Ca(2+)-binding proteins MRP-8 and MRP-14. Am J Physiol. 1992 Jan;262(1 Pt 1):C235-42. doi: 10.1152/ajpcell.1992.262.1.C235.
89 Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC Musculoskelet Disord. 2011 Apr 27;12(1):82. doi: 10.1186/1471-2474-12-82.
90 Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma. Eur Respir J. 2006 Jun;27(6):1160-7. doi: 10.1183/09031936.06.00078605. Epub 2006 Mar 1.
91 Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med. 1997 Feb;155(2):704-10. doi: 10.1164/ajrccm.155.2.9032216.
92 Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. Food Chem Toxicol. 2023 Sep;179:113949. doi: 10.1016/j.fct.2023.113949. Epub 2023 Jul 17.
93 Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J Leukoc Biol. 1999 Dec;66(6):909-14. doi: 10.1002/jlb.66.6.909.
94 Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
95 Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms. Toxicol Sci. 2015 Feb;143(2):441-53. doi: 10.1093/toxsci/kfu243. Epub 2014 Dec 1.
96 Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. Immunology. 1992 Apr;75(4):674-9.
97 Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung. J Clin Invest. 1989 Apr;83(4):1191-7. doi: 10.1172/JCI114000.
98 Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation. Toxicology. 2021 Feb 15;449:152664. doi: 10.1016/j.tox.2020.152664. Epub 2021 Jan 5.
99 Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. Horm Metab Res. 2005 Oct;37(10):593-601. doi: 10.1055/s-2005-870525.
100 Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma. PLoS One. 2013 May 16;8(5):e64369. doi: 10.1371/journal.pone.0064369. Print 2013.
101 Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids. J Biol Chem. 1992 Dec 15;267(35):24917-20.
102 Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood. 1999 Feb 15;93(4):1287-98.
103 PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. Eur J Cancer. 2005 Nov;41(17):2745-53. doi: 10.1016/j.ejca.2005.09.001. Epub 2005 Oct 18.
104 Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
105 The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
106 Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum. 2006 Nov;54(11):3513-22. doi: 10.1002/art.22170.
107 CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61. doi: 10.1078/0171-9335-00298.
108 Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes. J Neuroimmunol. 1999 Mar 1;95(1-2):165-73. doi: 10.1016/s0165-5728(99)00011-9.
109 Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor. Circulation. 2001 Dec 4;104(23):2826-31. doi: 10.1161/hc4801.099737.
110 [A study on the heterogeneous apoptosis of lymphocytes, eosinophils, and neutrophils from peripheral blood of asthmatic patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2003 Oct;26(10):610-4.
111 Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. Asian J Androl. 2008 Jul;10(4):635-41. doi: 10.1111/j.1745-7262.2008.00352.x. Epub 2007 Dec 20.
112 Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res. 2005 Sep 1;11(17):6352-8. doi: 10.1158/1078-0432.CCR-04-1931.
113 Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology. 2009 Apr 28;258(2-3):148-56. doi: 10.1016/j.tox.2009.01.016. Epub 2009 Jan 22.
114 Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology. 2005 Mar;146(3):1391-7. doi: 10.1210/en.2004-1152. Epub 2004 Dec 2.
115 Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 2006 Apr 15;107(8):3221-8. doi: 10.1182/blood-2005-07-2843. Epub 2005 Dec 15.
116 Theophylline and dexamethasone induce peroxisome proliferator-activated receptor-gamma expression in human eosinophils. Pharmacology. 2006;77(1):33-7. doi: 10.1159/000092376. Epub 2006 Mar 29.
117 Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab. 2000 Aug;85(8):2678-84. doi: 10.1210/jcem.85.8.6733.
118 Differential effect of dexamethasone on cell death and STAT5 activation during in vitro eosinopoiesis. Br J Haematol. 2003 Dec;123(5):933-41. doi: 10.1046/j.1365-2141.2003.04700.x.
119 Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death Differ. 2001 Mar;8(3):279-88. doi: 10.1038/sj.cdd.4400815.
120 Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol. 1998 Sep 15;161(6):2723-30.
121 Inhibitory effect of glucocorticoids on human-cloned 5-hydroxytryptamine3A receptor expressed in xenopus oocytes. Anesthesiology. 2004 Sep;101(3):660-5. doi: 10.1097/00000542-200409000-00014.
122 MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2023 Jun;39(3):867-883. doi: 10.1007/s10565-021-09645-6. Epub 2021 Sep 19.
123 p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol. 2005 Jun;19(6):1569-83. doi: 10.1210/me.2004-0528. Epub 2005 Apr 7.
124 Inhibitory effect of glucocorticoid for osteoblast apoptosis induced by activated peripheral blood mononuclear cells. Endocrinology. 1998 Apr;139(4):2032-40. doi: 10.1210/endo.139.4.5932.
125 Dexamethasone increases fluid absorption via Na+/H+ exchanger (NHE) 3 activation in normal human middle ear epithelial cells. Eur J Pharmacol. 2006 Apr 24;536(1-2):12-8. doi: 10.1016/j.ejphar.2006.02.031. Epub 2006 Feb 28.
126 Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring. Cell Biol Toxicol. 2023 Oct;39(5):2051-2067. doi: 10.1007/s10565-021-09691-0. Epub 2022 Mar 4.
127 Bisphenol A induces differentiation of human preadipocytes in the absence of glucocorticoid and is inhibited by an estrogen-receptor antagonist. Nutr Diabetes. 2014 Jan 13;4(1):e102. doi: 10.1038/nutd.2013.43.
128 Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone. Am J Physiol Cell Physiol. 2000 Sep;279(3):C762-70. doi: 10.1152/ajpcell.2000.279.3.C762.
129 [Inhibitory effects of Galectin-3 on the inflammatory cytokines and chemokines in guinea pig asthma models]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):355-8.
130 Regulation of type III iodothyronine deiodinase expression in human cell lines. Endocrinology. 2006 Dec;147(12):5845-54. doi: 10.1210/en.2006-0590. Epub 2006 Aug 24.
131 Apoptosis of airway epithelial cells induced by corticosteroids. Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1939-47. doi: 10.1164/ajrccm.164.10.2103013.
132 IL-10 synergizes with dexamethasone in inhibiting human T cell proliferation. J Pharmacol Exp Ther. 1998 May;285(2):915-9.
133 CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells. Immunology. 2002 Feb;105(2):155-62. doi: 10.1046/j.0019-2805.2001.01359.x.
134 Subacute myelopathy: an unusual paraneoplastic complication of Hodgkin's disease. Med Pediatr Oncol. 1988;16(4):284-6. doi: 10.1002/mpo.2950160413.
135 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
136 The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem. 1997 Nov 7;272(45):28471-8. doi: 10.1074/jbc.272.45.28471.
137 Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur J Cancer. 2006 Dec;42(18):3287-93. doi: 10.1016/j.ejca.2006.07.018. Epub 2006 Oct 27.
138 Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Clin Exp Immunol. 2000 Oct;122(1):20-7. doi: 10.1046/j.1365-2249.2000.01344.x.
139 Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene. Eur J Hum Genet. 2003 Aug;11(8):619-22. doi: 10.1038/sj.ejhg.5201015.
140 Conditional regulation of the human CYP4X1 and CYP4Z1 genes. Arch Biochem Biophys. 2005 Apr 15;436(2):377-85. doi: 10.1016/j.abb.2005.02.022.
141 Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. Am J Physiol. 1997 Nov;273(5):L1090-5. doi: 10.1152/ajplung.1997.273.5.L1090.
142 Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010 Jan;130(1):141-9. doi: 10.1038/jid.2009.210.
143 Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003 Nov 1;102(9):3379-86. doi: 10.1182/blood-2003-05-1417. Epub 2003 Jul 10.
144 Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction. Toxicology. 2017 Mar 1;378:95-106. doi: 10.1016/j.tox.2017.01.009. Epub 2017 Jan 11.
145 [Effect of human recombinant PDCD5 protein on cell apoptosis of multiple myeloma KM3 cells induced by dexamethasone and its mechanism]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):725-31. doi: 10.3969/j.issn.1672-7347.2010.07.013.
146 IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells. Mol Cancer Ther. 2006 Feb;5(2):457-66. doi: 10.1158/1535-7163.MCT-05-0340.
147 Important role of caspase-8 for chemosensitivity of ALL cells. Clin Cancer Res. 2011 Dec 15;17(24):7605-13. doi: 10.1158/1078-0432.CCR-11-0513. Epub 2011 Oct 18.
148 Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest. 1991 Feb;87(2):680-6. doi: 10.1172/JCI115046.
149 Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line. Cancer Sci. 2010 Mar;101(3):767-73. doi: 10.1111/j.1349-7006.2009.01432.x. Epub 2010 Jan 7.
150 PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Clin Cancer Res. 2006 Jan 1;12(1):49-56. doi: 10.1158/1078-0432.CCR-05-0929.
151 Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer Biol Ther. 2005 Nov;4(11):1226-33. doi: 10.4161/cbt.4.11.2093. Epub 2005 Nov 5.
152 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
153 The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol Cancer Ther. 2004 Jan;3(1):59-70.
154 Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells. Mol Cancer Ther. 2008 Aug;7(8):2298-307. doi: 10.1158/1535-7163.MCT-08-0186.
155 Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
156 Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition. Cancer Sci. 2010 Jun;101(6):1403-8. doi: 10.1111/j.1349-7006.2010.01544.x. Epub 2010 Mar 15.
157 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
158 Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22.
159 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
160 CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. Neurobiol Dis. 2016 Apr;88:118-24.
161 Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos. 2005 Nov;33(11):1723-8.
162 Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. Drug Metab Dispos. 2005 Jun;33(6):771-7.
163 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
164 Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes. Drug Metab Dispos. 2006 Apr;34(4):702-8.
165 Increasing intratumor C/EBP- LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. J Exp Clin Cancer Res. 2018 Nov 27;37(1):286. doi: 10.1186/s13046-018-0967-0.
166 Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. Chem Biol Interact. 2011 May 30;191(1-3):239-49.
167 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
168 Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma. Eur J Haematol. 2010 Mar;84(3):212-22. doi: 10.1111/j.1600-0609.2009.01381.x. Epub 2009 Nov 17.
169 Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Oncogene. 2005 Jan 13;24(3):419-30. doi: 10.1038/sj.onc.1208212.
170 The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. Oncogene. 2003 Aug 7;22(32):4953-63. doi: 10.1038/sj.onc.1206656.
171 The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4706-19. doi: 10.1167/iovs.06-1147.
172 Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models. J Ovarian Res. 2013 Nov 9;6(1):78. doi: 10.1186/1757-2215-6-78.
173 Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res. 2005 Jul 15;65(14):6294-304. doi: 10.1158/0008-5472.CAN-05-0686.
174 PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. J Biol Chem. 2006 Apr 28;281(17):11923-32. doi: 10.1074/jbc.M508533200. Epub 2006 Jan 30.
175 Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells. J Biol Chem. 2010 Feb 26;285(9):6091-100. doi: 10.1074/jbc.M109.014092. Epub 2009 Dec 18.
176 Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol. 2004 Nov;24(22):9695-704. doi: 10.1128/MCB.24.22.9695-9704.2004.
177 Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Haematologica. 2009 Apr;94(4):470-8. doi: 10.3324/haematol.13783. Epub 2009 Feb 19.
178 PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5.
179 Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II. Toxicol Lett. 2013 Nov 25;223(2):109-15. doi: 10.1016/j.toxlet.2013.09.006. Epub 2013 Sep 18.
180 Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 2010 Jan;6(1):19-35. doi: 10.4161/auto.6.1.10323.
181 Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol. 2008 Jun;10(3):309-19. doi: 10.1215/15228517-2007-063. Epub 2008 Apr 29.
182 Combined effects of lapatinib and bortezomib in human epidermal receptor 2 (HER2)-overexpressing breast cancer cells and activity of bortezomib against lapatinib-resistant breast cancer cells. Cancer Sci. 2010 Oct;101(10):2220-6. doi: 10.1111/j.1349-7006.2010.01662.x. Epub 2010 Aug 5.
183 Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays. Molecules. 2019 Feb 27;24(5):841. doi: 10.3390/molecules24050841.
184 Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res. 2005 Dec 15;65(24):11658-66. doi: 10.1158/0008-5472.CAN-05-2370.
185 Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-B activity. Exp Hematol. 2013 Feb;41(2):209-18. doi: 10.1016/j.exphem.2012.10.002. Epub 2012 Oct 11.
186 Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. Leukemia. 2006 Jun;20(6):1017-27. doi: 10.1038/sj.leu.2404200.
187 A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma. Cancer Res. 2007 Dec 15;67(24):11859-66. doi: 10.1158/0008-5472.CAN-07-1701.
188 Reduction in BCL-2 levels by 26S proteasome inhibition with bortezomib is associated with induction of apoptosis in small cell lung cancer. Lung Cancer. 2005 Aug;49(2):163-70. doi: 10.1016/j.lungcan.2005.01.006.
189 Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells. Mol Cancer Ther. 2008 Dec;7(12):3807-15. doi: 10.1158/1535-7163.MCT-08-0641.
190 Distinct Orchestration and Dynamic Processes on -H2AX and p-H3 for Two Major Types of Genotoxic Chemicals Revealed by Mass Spectrometry Analysis. Chem Res Toxicol. 2020 Aug 17;33(8):2108-2119. doi: 10.1021/acs.chemrestox.0c00104. Epub 2020 Jun 17.
191 The selective activator protein-1 inhibitor T-5224 regulates the IRF4/MYC axis and exerts cooperative antimyeloma activity with bortezomib. Chem Biol Interact. 2023 Oct 1;384:110687. doi: 10.1016/j.cbi.2023.110687. Epub 2023 Aug 31.
192 Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study. Turk J Haematol. 2015 Sep;32(3):206-12. doi: 10.4274/tjh.2014.0058.
193 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
194 Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol Cancer Ther. 2005 Oct;4(10):1533-40. doi: 10.1158/1535-7163.MCT-05-0068.
195 Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors. Blood. 2011 Dec 8;118(24):6368-79. doi: 10.1182/blood-2011-06-363911. Epub 2011 Sep 13.
196 The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res. 2008 Jun 15;68(12):4783-90. doi: 10.1158/0008-5472.CAN-07-6483.
197 Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther. 2009 Apr;8(4):959-70. doi: 10.1158/1535-7163.MCT-08-0905.
198 SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib. Apoptosis. 2007 Jul;12(7):1327-38. doi: 10.1007/s10495-007-0063-y.
199 Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells. Mol Cancer Ther. 2006 Dec;5(12):3032-41. doi: 10.1158/1535-7163.MCT-05-0474.
200 Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma. Eur J Cancer. 2008 Apr;44(6):876-84. doi: 10.1016/j.ejca.2008.02.022. Epub 2008 Mar 14.
201 [Salvage therapy with proteasome inhibitor bortezomib for relapsed and refractory multiple myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec;14(6):1146-50.
202 Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003 Feb 15;101(4):1530-4. doi: 10.1182/blood-2002-08-2543. Epub 2002 Sep 26.
203 The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. J Biol Chem. 2014 May 2;289(18):12705-15. doi: 10.1074/jbc.M113.513242. Epub 2014 Mar 11.
204 Bortezomib induces apoptosis in human neuroblastoma CHP126 cells. Pharmazie. 2010 Mar;65(3):213-8.
205 S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma. J Pathol. 2008 Dec;216(4):483-94. doi: 10.1002/path.2433.
206 Long-term incubation with proteasome inhibitors (PIs) induces IB degradation via the lysosomal pathway in an IB kinase (IKK)-dependent and IKK-independent manner. J Biol Chem. 2013 Nov 8;288(45):32777-32786. doi: 10.1074/jbc.M113.480921. Epub 2013 Oct 1.
207 TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology. 2007 Mar;45(3):649-58. doi: 10.1002/hep.21555.
208 A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res. 2005 Aug 1;11(15):5526-33. doi: 10.1158/1078-0432.CCR-05-0081.
209 Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis. Mol Cell Biochem. 2011 Nov;357(1-2):83-94. doi: 10.1007/s11010-011-0878-2. Epub 2011 May 19.
210 [Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1016-20.
211 [Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):898-901.
212 The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. J Biol Chem. 2010 Mar 5;285(10):6904-12. doi: 10.1074/jbc.M109.038331. Epub 2010 Jan 5.
213 Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 2009 Dec 15;69(24):9367-75. doi: 10.1158/0008-5472.CAN-09-2616.
214 Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. 2008 Oct 1;112(7):2917-26. doi: 10.1182/blood-2007-12-130823. Epub 2008 Jul 18.
215 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochem Biophys Res Commun. 2011 Feb 4;405(1):31-6. doi: 10.1016/j.bbrc.2010.12.111. Epub 2010 Dec 30.
216 Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
217 Tumor cells can evade dependence on autophagy through adaptation. Biochem Biophys Res Commun. 2012 Aug 31;425(3):684-8. doi: 10.1016/j.bbrc.2012.07.090. Epub 2012 Jul 25.
218 Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function. Toxicol Appl Pharmacol. 2015 Feb 15;283(1):1-8. doi: 10.1016/j.taap.2014.12.015. Epub 2015 Jan 6.
219 Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res. 2006 Apr 1;66(7):3773-81. doi: 10.1158/0008-5472.CAN-05-2961.
220 Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res. 2006 Jun 15;66(12):6072-9. doi: 10.1158/0008-5472.CAN-06-0125.
221 Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res. 2003 Oct 1;63(19):6174-7.
222 Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS One. 2011;6(12):e27996. doi: 10.1371/journal.pone.0027996. Epub 2011 Dec 22.
223 Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014 Dec 18;5(12):e1580. doi: 10.1038/cddis.2014.537.
224 Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia. 2013 Oct;27(10):1970-80. doi: 10.1038/leu.2013.222. Epub 2013 Jul 23.
225 ClinicalTrials.gov (NCT01470131) A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma
226 ClinicalTrials.gov (NCT01002248) Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients
227 ClinicalTrials.gov (NCT01734928) Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
228 ClinicalTrials.gov (NCT02902965) Study of Ibrutinib in Combination With Bortezomib and Dexamethasone in Subjects With Relapsed/Relapsed and Refractory Multiple Myeloma
229 ClinicalTrials.gov (NCT00773838) Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)
230 ClinicalTrials.gov (NCT05432414) PVd Versus Vd in NDMM Patients With RI
231 ClinicalTrials.gov (NCT00740415) Rituximab, Bortezomib,Bendamustine , Dexamethasone, Patients With Mantle Cell Lymphoma
232 ClinicalTrials.gov (NCT01056276) Study to Evaluate the Combination of Bendamustine, Bortezomib and Dexamethasone (BBD) in the First-Line Treatment of Patients With Multiple Myeloma Who Are Not Candidates for High Dose Chemotherapy
233 ClinicalTrials.gov (NCT00401011) Safety & Efficacy Study of Perifosine + Bortezomib +/- Dexamethasone for Multiple Myeloma Patients
234 ClinicalTrials.gov (NCT01497093) Study to Determine the Maximum Tolerated Dose for the Combination of Pomalidomide, Bortezomib and Low-Dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
235 ClinicalTrials.gov (NCT01212952) Pomalidomide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
236 ClinicalTrials.gov (NCT00560352) Safety Study of Dasatinib With Bortezomib (Velcade) and Dexamethasone for Multiple Myeloma
237 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
238 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.