General Information of Drug Combination (ID: DCEEIW2)

Drug Combination Name
Dexamethasone Methotrexate
Indication
Disease Entry Status REF
Leukemia Phase 3 [1]
Component Drugs Dexamethasone   DMMWZET Methotrexate   DM2TEOL
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Dexamethasone
Disease Entry ICD 11 Status REF
Acute adrenal insufficiency N.A. Approved [2]
Acute asthma CA23 Approved [2]
Addison disease 5A74.0 Approved [2]
Allergic otitis media N.A. Approved [2]
Allergic rhinitis CA08.0 Approved [2]
Angioedema 4A00.15 Approved [2]
Articular cartilage disorder FA34.Y Approved [2]
Autoimmune haemolytic anaemia 3A20 Approved [2]
Blepharoconjunctivitis N.A. Approved [2]
Burkitt lymphoma N.A. Approved [2]
Bursitis N.A. Approved [2]
Central retinal vein occlusion with macular edema N.A. Approved [2]
Cerebral edema 8D60.1 Approved [2]
Congenital adrenal hyperplasia 5A71.01 Approved [2]
Corneal abrasion NA06.4 Approved [2]
Corneal ulcer 9A76 Approved [2]
Crohn disease DD70 Approved [2]
Dermatitis herpetiformis EB44 Approved [2]
Diamond-Blackfan anemia N.A. Approved [2]
Disorder of orbital region N.A. Approved [2]
Epicondylitis N.A. Approved [2]
Erythema multiforme N.A. Approved [2]
Exanthem N.A. Approved [2]
Granuloma annulare N.A. Approved [2]
Inflammatory bowel disease DD72 Approved [2]
Keratitis N.A. Approved [2]
Liver cirrhosis DB93.1 Approved [2]
Lung cancer 2C25.0 Approved [2]
Malignant otitis externa caused by Pseudomonas aeruginosa N.A. Approved [2]
Miliary tuberculosis N.A. Approved [2]
Multiple sclerosis 8A40 Approved [2]
Mycosis fungoides 2B01 Approved [2]
Nausea MD90 Approved [2]
Plasma cell myeloma 2A83.1 Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Psoriasis EA90 Approved [2]
Psoriatic arthritis FA21 Approved [2]
Rheumatic heart disease N.A. Approved [2]
Rheumatoid arthritis FA20 Approved [3]
Rosacea ED90.0 Approved [2]
Sarcoidosis 4B20.5 Approved [2]
Serum sickness N.A. Approved [2]
Skin disease EA00-EM0Z Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [2]
Vomiting MD90 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [4]
Acquired thrombocytopenia N.A. Investigative [2]
Asthma CA23 Investigative [2]
B-cell neoplasm N.A. Investigative [2]
Beta-thalassemia major N.A. Investigative [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Iridocyclitis N.A. Investigative [2]
Keloid EE60 Investigative [2]
Trichinellosis N.A. Investigative [2]
Uveitis 9A96.Z Investigative [2]
Dexamethasone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Agonist [21]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [22]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [23]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [24]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [25]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [26]
Carboxylesterase 2 (CES2) DETHCPD EST2_HUMAN Metabolism [27]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DEDH7FP DHI2_HUMAN Metabolism [28]
------------------------------------------------------------------------------------
Dexamethasone Interacts with 729 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [29]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [30]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [14]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Affects Expression [31]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [32]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) OTDAWAUZ JIP1_HUMAN Increases ADR [33]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [12]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Increases Expression [12]
GRB2-related adapter protein 2 (GRAP2) OTS5NIZ3 GRAP2_HUMAN Increases Expression [12]
AP-1 complex subunit gamma-like 2 (AP1G2) OTTJ7NXL AP1G2_HUMAN Increases Expression [12]
Cell cycle checkpoint protein RAD17 (RAD17) OT1I93DT RAD17_HUMAN Decreases Expression [12]
Endonuclease domain-containing 1 protein (ENDOD1) OTME0ZW5 ENDD1_HUMAN Decreases Expression [12]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Increases Expression [12]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [12]
V(D)J recombination-activating protein 1 (RAG1) OTV131E4 RAG1_HUMAN Decreases Expression [12]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) OTEGNEHW PP2BB_HUMAN Decreases Expression [12]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [12]
Leukocyte surface antigen CD53 (CD53) OT9U5OXJ CD53_HUMAN Increases Expression [12]
Receptor-type tyrosine-protein phosphatase mu (PTPRM) OTCEL6PN PTPRM_HUMAN Increases Expression [12]
Calcipressin-1 (RCAN1) OT1MVXC7 RCAN1_HUMAN Increases Expression [12]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [12]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [12]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [12]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Decreases Expression [12]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [12]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [12]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [12]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Expression [12]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Decreases Expression [12]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [12]
Pre-rRNA-processing protein TSR1 homolog (TSR1) OTCVZFL9 TSR1_HUMAN Decreases Expression [12]
Neurobeachin-like protein 2 (NBEAL2) OTMCAXWR NBEL2_HUMAN Increases Expression [12]
Protein FAM216A (FAM216A) OTL6I6AI F216A_HUMAN Decreases Expression [12]
Junctional adhesion molecule C (JAM3) OTX0F9QL JAM3_HUMAN Increases Expression [12]
Coiled-coil domain-containing protein 86 (CCDC86) OT5YQ0R0 CCD86_HUMAN Decreases Expression [12]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Increases Expression [12]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) OT8P6QNJ CELR3_HUMAN Decreases Expression [12]
PALM2-AKAP2 fusion protein (PALM2AKAP2) OTI618VF PLAK2_HUMAN Increases Expression [12]
Nucleolar protein 16 (NOP16) OT2829ZC NOP16_HUMAN Decreases Expression [12]
Nucleolar complex protein 2 homolog (NOC2L) OTNT7R33 NOC2L_HUMAN Decreases Expression [12]
Plexin-D1 (PLXND1) OTNK9ALK PLXD1_HUMAN Increases Expression [12]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Increases Expression [12]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Increases Expression [12]
Period circadian protein homolog 1 (PER1) OTVQF3WX PER1_HUMAN Increases Expression [34]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [35]
Pulmonary surfactant-associated protein B (SFTPB) OTOHS07E PSPB_HUMAN Increases Expression [36]
Pulmonary surfactant-associated protein A1 (SFTPA1) OT87XL1U SFTA1_HUMAN Decreases Expression [36]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [37]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [38]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Increases Expression [38]
Tyrosine aminotransferase (TAT) OT2CJ91O ATTY_HUMAN Increases Expression [38]
Nuclear receptor subfamily 2 group C member 2 (NR2C2) OTDZWVOJ NR2C2_HUMAN Increases Expression [38]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Increases Expression [38]
Nuclear receptor subfamily 6 group A member 1 (NR6A1) OTFZOOQ9 NR6A1_HUMAN Increases Expression [38]
Nuclear receptor coactivator 2 (NCOA2) OTMQFPBB NCOA2_HUMAN Increases Expression [38]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [38]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Increases Expression [38]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Affects Expression [39]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [39]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Increases Expression [14]
Renin receptor (ATP6AP2) OT0IABVV RENR_HUMAN Decreases Expression [14]
Retinol-binding protein 4 (RBP4) OTL9RBH5 RET4_HUMAN Increases Expression [14]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [14]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [14]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Increases Expression [14]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [14]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [14]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [14]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Expression [14]
Lipid transferase CIDEC (CIDEC) OTMDZ56K CIDEC_HUMAN Increases Expression [14]
Histone-lysine N-methyltransferase PRDM16 (PRDM16) OT0BGA27 PRD16_HUMAN Decreases Expression [14]
Apelin (APLN) OTSWJD7B APEL_HUMAN Decreases Expression [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Increases Expression [40]
Glucoside xylosyltransferase 2 (GXYLT2) OTMLQQKP GXLT2_HUMAN Decreases Expression [15]
Tetraspanin-11 (TSPAN11) OT3GJF1N TSN11_HUMAN Decreases Expression [15]
Glutamate-rich protein 2 (ERICH2) OT0QA5Z1 ERIC2_HUMAN Decreases Expression [15]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3) OTF6I8RV PKHG3_HUMAN Increases Expression [15]
Coiled-coil domain-containing protein 69 (CCDC69) OT43MI0R CCD69_HUMAN Increases Expression [15]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Increases Expression [15]
Isthmin-1 (ISM1) OTZTK2TV ISM1_HUMAN Increases Expression [15]
Transmembrane protein 233 (TMEM233) OT9J7BRF TM233_HUMAN Decreases Expression [15]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [15]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [15]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Decreases Expression [15]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) OTY2PROB P3C2B_HUMAN Increases Expression [15]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Decreases Expression [15]
Cdc42 effector protein 2 (CDC42EP2) OTX3YDPN BORG1_HUMAN Increases Expression [15]
Glutathione S-transferase 3, mitochondrial (MGST3) OTYK80JA MGST3_HUMAN Increases Expression [15]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [15]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Expression [15]
Synaptojanin-2 (SYNJ2) OTLRHXP1 SYNJ2_HUMAN Decreases Expression [15]
Serine/threonine-protein kinase DCLK1 (DCLK1) OTVSPS98 DCLK1_HUMAN Increases Expression [15]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Increases Expression [15]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4) OTQUX50Z LRAD4_HUMAN Decreases Expression [15]
Membrane-associated progesterone receptor component 2 (PGRMC2) OTH6G1CV PGRC2_HUMAN Increases Expression [15]
Protein SLC31A2 (SLC31A2) OTQC136Q COPT2_HUMAN Decreases Expression [15]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Decreases Expression [15]
Glycogenin-2 (GYG2) OTAJ7YEW GLYG2_HUMAN Increases Expression [15]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [15]
Rho GTPase-activating protein 6 (ARHGAP6) OTNVXXFX RHG06_HUMAN Increases Expression [15]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Increases Expression [15]
Perilipin-1 (PLIN1) OT3OAAZ4 PLIN1_HUMAN Increases Expression [15]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Increases Expression [15]
Protein-tyrosine sulfotransferase 1 (TPST1) OTDPQKEA TPST1_HUMAN Decreases Expression [15]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Increases Expression [15]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [15]
Thiamine transporter 1 (SLC19A2) OTH5SB0M S19A2_HUMAN Increases Expression [15]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Increases Expression [15]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Decreases Expression [15]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Decreases Expression [15]
Cartilage intermediate layer protein 1 (CILP) OTKEY2NJ CILP1_HUMAN Increases Expression [15]
Citrate synthase, mitochondrial (CS) OTYLYXMO CISY_HUMAN Increases Expression [15]
Sperm-associated antigen 7 (SPAG7) OTSDFA2D SPAG7_HUMAN Decreases Expression [15]
Claudin-11 (CLDN11) OTNN6UTL CLD11_HUMAN Increases Expression [15]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) OTHODA1F MYCB2_HUMAN Increases Expression [15]
Protein phosphatase 1B (PPM1B) OTZMH6V3 PPM1B_HUMAN Increases Expression [15]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) OT15HOJX AL1L1_HUMAN Increases Expression [15]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Increases Expression [15]
Indolethylamine N-methyltransferase (INMT) OT5NWOZH INMT_HUMAN Increases Expression [15]
Neurexophilin-4 (NXPH4) OTV057AG NXPH4_HUMAN Decreases Expression [15]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B) OT4217NK PDE8B_HUMAN Increases Expression [15]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Expression [15]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Increases Expression [15]
Angiopoietin-related protein 1 (ANGPTL1) OTXIN6V5 ANGL1_HUMAN Increases Expression [15]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Decreases Expression [15]
Cholesterol 25-hydroxylase (CH25H) OT9S2BSW CH25H_HUMAN Decreases Expression [15]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Increases Expression [15]
All-trans-retinol dehydrogenase ADH1B (ADH1B) OTV3TB81 ADH1B_HUMAN Increases Expression [15]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Increases Expression [15]
Haptoglobin-related protein (HPR) OTXSC9UB HPTR_HUMAN Increases Expression [15]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Increases Expression [15]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [15]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [15]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [15]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [15]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [15]
Fatty acid-binding protein, heart (FABP3) OT562DA1 FABPH_HUMAN Increases Expression [15]
Tetranectin (CLEC3B) OTFD29NF TETN_HUMAN Increases Expression [15]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [15]
Glycogen phosphorylase, liver form (PYGL) OTS1YFGR PYGL_HUMAN Increases Expression [15]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Decreases Expression [15]
Acyl-CoA-binding protein (DBI) OT884QY9 ACBP_HUMAN Increases Expression [15]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Increases Expression [15]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [15]
Metallothionein-1B (MT1B) OTUA4FFH MT1B_HUMAN Increases Expression [15]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Decreases Expression [15]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Increases Expression [15]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Decreases Expression [15]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [15]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) OTGEU8IK ODPA_HUMAN Increases Expression [15]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [15]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Decreases Expression [15]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [15]
Inhibin beta B chain (INHBB) OT2QLD11 INHBB_HUMAN Increases Expression [15]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [15]
Protein ELFN1 (ELFN1) OTM7M52U ELFN1_HUMAN Decreases Expression [15]
Zinc finger protein GLI2 (GLI2) OTIRV97L GLI2_HUMAN Decreases Expression [15]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Decreases Expression [15]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) OT9LBJVN ODP2_HUMAN Increases Expression [15]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Decreases Expression [15]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Decreases Expression [15]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [15]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [15]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [15]
Myosin light chain 6B (MYL6B) OTWTRGT7 MYL6B_HUMAN Decreases Expression [15]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Decreases Expression [15]
Rho-related GTP-binding protein RhoQ (RHOQ) OTUBTU57 RHOQ_HUMAN Increases Expression [15]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Decreases Expression [15]
Alpha-2C adrenergic receptor (ADRA2C) OT5B9RKP ADA2C_HUMAN Increases Expression [15]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [15]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Decreases Expression [15]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Increases Expression [15]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [15]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Decreases Expression [15]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Increases Expression [15]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1) OTQW7TMB GPDA_HUMAN Increases Expression [15]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [15]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Decreases Expression [15]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Increases Expression [15]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [15]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1) OTHV25GG CX7A1_HUMAN Increases Expression [15]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [15]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [15]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Increases Expression [15]
Metallothionein-3 (MT3) OTVCZ7HI MT3_HUMAN Increases Expression [15]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [15]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [15]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [15]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Increases Expression [15]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [15]
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1) OT25Z6XH AL4A1_HUMAN Increases Expression [15]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Increases Expression [15]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases Expression [15]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Decreases Expression [15]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) OTQHB52T P5CR1_HUMAN Decreases Expression [15]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [15]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Decreases Expression [15]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [15]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Decreases Expression [15]
Fibrillin-2 (FBN2) OT3KYJQL FBN2_HUMAN Increases Expression [15]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [15]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [15]
Serine/threonine-protein kinase receptor R3 (ACVRL1) OT1HQR88 ACVL1_HUMAN Increases Expression [15]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) OTIOLNHE LICH_HUMAN Increases Expression [15]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Decreases Expression [15]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Increases Expression [15]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [15]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [15]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [15]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Increases Expression [15]
Large proline-rich protein BAG6 (BAG6) OT4Z0S2U BAG6_HUMAN Decreases Expression [15]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [15]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [15]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Decreases Expression [15]
Amphiphysin (AMPH) OTWPGWZX AMPH_HUMAN Increases Expression [15]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Decreases Expression [15]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Decreases Expression [15]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [15]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Decreases Expression [15]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [15]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Increases Expression [15]
Lumican (LUM) OTSRC874 LUM_HUMAN Decreases Expression [15]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Increases Expression [15]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [15]
Sodium/myo-inositol cotransporter (SLC5A3) OT6FY2KA SC5A3_HUMAN Decreases Expression [15]
Phospholipase A and acyltransferase 3 (PLAAT3) OTVXXJ5K PLAT3_HUMAN Increases Expression [15]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [15]
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) OTOFL24U AT1B3_HUMAN Increases Expression [15]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [15]
Microfibrillar-associated protein 2 (MFAP2) OTMHVBTV MFAP2_HUMAN Decreases Expression [15]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Decreases Expression [15]
Growth/differentiation factor 10 (GDF10) OTEVXGJ7 GDF10_HUMAN Decreases Expression [15]
Laminin subunit beta-2 (LAMB2) OT71OI2Y LAMB2_HUMAN Decreases Expression [15]
GDNF family receptor alpha-1 (GFRA1) OT3WBVYB GFRA1_HUMAN Increases Expression [15]
Homeobox protein DLX-5 (DLX5) OTEEFBEU DLX5_HUMAN Decreases Expression [15]
Junctional adhesion molecule B (JAM2) OTHVJJRJ JAM2_HUMAN Decreases Expression [15]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Decreases Expression [15]
Protein eva-1 homolog C (EVA1C) OT18YR25 EVA1C_HUMAN Increases Expression [15]
Reactive oxygen species modulator 1 (ROMO1) OTIEYVBW ROMO1_HUMAN Increases Expression [15]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [15]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [15]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [15]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) OTSSOMUP RPAB5_HUMAN Increases Expression [15]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE) OTXF5ICU GBRE_HUMAN Decreases Expression [15]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Increases Expression [15]
C-X-C motif chemokine 6 (CXCL6) OTFTCQ4O CXCL6_HUMAN Decreases Expression [15]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Increases Expression [15]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [15]
Nucleobindin-2 (NUCB2) OTHO6JWN NUCB2_HUMAN Decreases Expression [15]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Increases Expression [15]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [15]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [15]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Increases Expression [15]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [15]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [15]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Increases Expression [15]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [15]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [15]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) OTF6OC66 GCNT1_HUMAN Increases Expression [15]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Increases Expression [15]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [15]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [15]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Decreases Expression [15]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Decreases Expression [15]
Nexilin (NEXN) OTKB0B0H NEXN_HUMAN Increases Expression [15]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Decreases Expression [15]
Trophinin (TRO) OTRZQMU8 TROP_HUMAN Decreases Expression [15]
Epidermal growth factor receptor kinase substrate 8 (EPS8) OTZ6ES6V EPS8_HUMAN Increases Expression [15]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [15]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [15]
Methanethiol oxidase (SELENBP1) OT3NZNTR SBP1_HUMAN Increases Expression [15]
Beta-2-syntrophin (SNTB2) OTIVMQ2S SNTB2_HUMAN Increases Expression [15]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) OTGTAGCV PPR1A_HUMAN Increases Expression [15]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [15]
Integrin alpha-7 (ITGA7) OTTBTAYW ITA7_HUMAN Increases Expression [15]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [15]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [15]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Decreases Expression [15]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Decreases Expression [15]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [15]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1) OT2E7A6W KANK1_HUMAN Increases Expression [15]
Potassium voltage-gated channel subfamily B member 1 (KCNB1) OTLCU4FR KCNB1_HUMAN Increases Expression [15]
Delta(14)-sterol reductase LBR (LBR) OT1HG3HG LBR_HUMAN Increases Expression [15]
Latent-transforming growth factor beta-binding protein 2 (LTBP2) OTS88GSD LTBP2_HUMAN Decreases Expression [15]
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) OT6A9JT8 PA1B3_HUMAN Decreases Expression [15]
Inorganic pyrophosphatase (PPA1) OTHZK1QB IPYR_HUMAN Increases Expression [15]
Platelet-derived growth factor receptor-like protein (PDGFRL) OTJPRECT PGFRL_HUMAN Decreases Expression [15]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [15]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Increases Expression [15]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Increases Expression [15]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [15]
Ovarian cancer G-protein coupled receptor 1 (GPR68) OT1NXSMN OGR1_HUMAN Decreases Expression [15]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [15]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Increases Expression [15]
Neuronatin (NNAT) OTNRLO7G NNAT_HUMAN Increases Expression [15]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Decreases Expression [15]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [15]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Increases Expression [15]
NADP-dependent malic enzyme, mitochondrial (ME3) OT3XMLYG MAON_HUMAN Increases Expression [15]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Increases Expression [15]
Amine oxidase 3 (AOC3) OT30YKV0 AOC3_HUMAN Increases Expression [15]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Decreases Expression [15]
Cysteine dioxygenase type 1 (CDO1) OTLG1P77 CDO1_HUMAN Increases Expression [15]
Transmembrane protein 132A (TMEM132A) OTNUI7O1 T132A_HUMAN Decreases Expression [15]
Transmembrane protein 44 (TMEM44) OTRUF467 TMM44_HUMAN Decreases Expression [15]
PWWP domain-containing DNA repair factor 3A (PWWP3A) OTXQVL4U PWP3A_HUMAN Decreases Expression [15]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [15]
Fibronectin type III domain-containing protein 1 (FNDC1) OTU2BA12 FNDC1_HUMAN Decreases Expression [15]
BolA-like protein 3 (BOLA3) OTDEDY0S BOLA3_HUMAN Increases Expression [15]
Cordon-bleu protein-like 1 (COBLL1) OTQFN1TC COBL1_HUMAN Increases Expression [15]
Mesoderm-specific transcript homolog protein (MEST) OT8Q4U8Y MEST_HUMAN Increases Expression [15]
Proline-rich transmembrane protein 3 (PRRT3) OT231D18 PRRT3_HUMAN Increases Expression [15]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Expression [15]
Dedicator of cytokinesis protein 11 (DOCK11) OTFSTN6A DOC11_HUMAN Increases Expression [15]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Increases Expression [15]
Transcription factor HIVEP3 (HIVEP3) OTM3QT3L ZEP3_HUMAN Increases Expression [15]
Transmembrane protein 170B (TMEM170B) OT4AS8RJ T170B_HUMAN Increases Expression [15]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Decreases Expression [15]
E3 ubiquitin-protein ligase RNF187 (RNF187) OTXTN1HP RN187_HUMAN Decreases Expression [15]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Expression [15]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Increases Expression [15]
Synaptophysin-like protein 2 (SYPL2) OT6CV0CA SYPL2_HUMAN Increases Expression [15]
Phospholipid phosphatase 4 (PLPP4) OTH5EXZC PLPP4_HUMAN Decreases Expression [15]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases Expression [15]
Tensin-2 (TNS2) OTP72P0F TENS2_HUMAN Increases Expression [15]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Decreases Expression [15]
La-related protein 1B (LARP1B) OT9JZ7K5 LAR1B_HUMAN Increases Expression [15]
Protein sel-1 homolog 3 (SEL1L3) OT10N6Z2 SE1L3_HUMAN Decreases Expression [15]
Scavenger receptor class A member 3 (SCARA3) OT46I38Y SCAR3_HUMAN Decreases Expression [15]
Dermokine (DMKN) OTRIGZMK DMKN_HUMAN Increases Expression [15]
Protein Jade-1 (JADE1) OTBPJIRI JADE1_HUMAN Increases Expression [15]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [15]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Increases Expression [15]
Lysophospholipid acyltransferase 5 (LPCAT3) OTWI96P4 MBOA5_HUMAN Increases Expression [15]
F-box only protein 42 (FBXO42) OTHPN53C FBX42_HUMAN Decreases Expression [15]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) OTXP4QH8 CNKR3_HUMAN Increases Expression [15]
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2) OTKH0NVX DR4L2_HUMAN Increases Expression [15]
Ras-like protein family member 11A (RASL11A) OTDO6CMY RSLBA_HUMAN Increases Expression [15]
Kelch-like protein 17 (KLHL17) OTUWIJIQ KLH17_HUMAN Decreases Expression [15]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [15]
Sushi domain-containing protein 1 (SUSD1) OTR3UGLY SUSD1_HUMAN Increases Expression [15]
Suprabasin (SBSN) OT89RKJH SBSN_HUMAN Increases Expression [15]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Decreases Expression [15]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Decreases Expression [15]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Decreases Expression [15]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Increases Expression [15]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Increases Expression [15]
Scavenger receptor class A member 5 (SCARA5) OTOVA96E SCAR5_HUMAN Increases Expression [15]
SPOC domain-containing protein 1 (SPOCD1) OTF4K46N SPOC1_HUMAN Increases Expression [15]
Nesprin-3 (SYNE3) OTEOJBYB SYNE3_HUMAN Increases Expression [15]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Decreases Expression [15]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [15]
TOM1-like protein 2 (TOM1L2) OTUXXUH8 TM1L2_HUMAN Increases Expression [15]
Protein phosphatase Slingshot homolog 2 (SSH2) OT8NCK82 SSH2_HUMAN Increases Expression [15]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1) OTTOGO05 EEPD1_HUMAN Increases Expression [15]
Peroxiredoxin-like 2C (PRXL2C) OTI8ZAK8 PXL2C_HUMAN Increases Expression [15]
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) OTZ7IIPM LIMS2_HUMAN Increases Expression [15]
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Increases Expression [15]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [15]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Decreases Expression [15]
Acyl-coenzyme A thioesterase 1 (ACOT1) OTXFL7WM ACOT1_HUMAN Increases Expression [15]
Regulating synaptic membrane exocytosis protein 1 (RIMS1) OT10T7CK RIMS1_HUMAN Increases Expression [15]
Metalloprotease TIKI1 (TRABD2A) OTVMA26J TIKI1_HUMAN Increases Expression [15]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Decreases Expression [15]
Chondroitin sulfate synthase 1 (CHSY1) OTB1XSSF CHSS1_HUMAN Decreases Expression [15]
Extracellular matrix organizing protein FRAS1 (FRAS1) OTLPESF3 FRAS1_HUMAN Increases Expression [15]
Protein O-mannosyl-transferase TMTC1 (TMTC1) OTZ7NW96 TMTC1_HUMAN Increases Expression [15]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Decreases Expression [15]
Sodium/hydrogen exchanger 9 (SLC9A9) OT00PCW3 SL9A9_HUMAN Increases Expression [15]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Increases Expression [15]
DCN1-like protein 3 (DCUN1D3) OTG20VWE DCNL3_HUMAN Increases Expression [15]
Cullin-9 (CUL9) OTPUCLZT CUL9_HUMAN Decreases Expression [15]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Decreases Expression [15]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [15]
Trafficking regulator of GLUT4 1 (TRARG1) OTQ1R3JD TARG1_HUMAN Increases Expression [15]
Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12) OTVIBUST GLT12_HUMAN Decreases Expression [15]
Solute carrier family 22 member 15 (SLC22A15) OT60WAAI S22AF_HUMAN Decreases Expression [15]
Protein APCDD1 (APCDD1) OTV9AD0L APCD1_HUMAN Increases Expression [15]
Cell cycle exit and neuronal differentiation protein 1 (CEND1) OTPHOC22 CEND_HUMAN Increases Expression [15]
Glypican-2 (GPC2) OT3WSQE1 GPC2_HUMAN Decreases Expression [15]
Protein odd-skipped-related 2 (OSR2) OTYG371T OSR2_HUMAN Increases Expression [15]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [15]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) OTVLWW9T GPD1L_HUMAN Increases Expression [15]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [15]
Maturin (MTURN) OTEBJNVG MTURN_HUMAN Increases Expression [15]
GTP-binding protein 8 (GTPBP8) OTI8X03A GTPB8_HUMAN Increases Expression [15]
Tetratricopeptide repeat protein 39C (TTC39C) OTKKI81C TT39C_HUMAN Increases Expression [15]
Refilin-B (RFLNB) OTI7ZM75 RFLB_HUMAN Decreases Expression [15]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) OT2SH7HJ CGAT2_HUMAN Decreases Expression [15]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Increases Expression [15]
Interleukin-17 receptor C (IL17RC) OTEFOBSS I17RC_HUMAN Increases Expression [15]
Protein APCDD1-like (APCDD1L) OTP7CAV5 APCDL_HUMAN Decreases Expression [15]
LRRN4 C-terminal-like protein (LRRN4CL) OTJFDTVR LRN4L_HUMAN Increases Expression [15]
Phospholipid phosphatase 5 (PLPP5) OTHT51D6 PLPP5_HUMAN Decreases Expression [15]
Activin receptor type-1C (ACVR1C) OTOTYERF ACV1C_HUMAN Increases Expression [15]
Neuron navigator 1 (NAV1) OT667KTL NAV1_HUMAN Decreases Expression [15]
Nesprin-1 (SYNE1) OTSBSLUH SYNE1_HUMAN Decreases Expression [15]
Interleukin-17 receptor E (IL17RE) OTMFTNLS I17RE_HUMAN Increases Expression [15]
Neuroligin-2 (NLGN2) OTHDYL3H NLGN2_HUMAN Decreases Expression [15]
Tetraspanin-14 (TSPAN14) OT29167O TSN14_HUMAN Increases Expression [15]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Increases Expression [15]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [15]
Protein cornichon homolog 3 (CNIH3) OTNLZ2QS CNIH3_HUMAN Decreases Expression [15]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) OT4WOLA8 ENOX1_HUMAN Decreases Expression [15]
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) OTN3D4ZM PHOP2_HUMAN Increases Expression [15]
Melanocortin-2 receptor accessory protein (MRAP) OTLBWM7X MRAP_HUMAN Increases Expression [15]
Pleckstrin homology domain-containing family O member 2 (PLEKHO2) OT2FTK68 PKHO2_HUMAN Increases Expression [15]
Actin filament-associated protein 1-like 1 (AFAP1L1) OTWNTNDB AF1L1_HUMAN Increases Expression [15]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) OTY829Z3 ABHD5_HUMAN Increases Expression [15]
Cell migration-inducing and hyaluronan-binding protein (CEMIP) OTK80FYN CEMIP_HUMAN Decreases Expression [15]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Increases Expression [15]
Coiled-coil domain-containing protein 107 (CCDC107) OTF1H2TM CC107_HUMAN Increases Expression [15]
RING finger protein 141 (RNF141) OT07ANSG RN141_HUMAN Increases Expression [15]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [15]
Gem-associated protein 6 (GEMIN6) OTE262KF GEMI6_HUMAN Increases Expression [15]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Increases Expression [15]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10) OTCDHAM6 CHC10_HUMAN Increases Expression [15]
SHC-transforming protein 3 (SHC3) OT305NPA SHC3_HUMAN Increases Expression [15]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [15]
Receptor-type tyrosine-protein phosphatase U (PTPRU) OTHDO0QG PTPRU_HUMAN Decreases Expression [15]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Increases Expression [15]
NEDD4-binding protein 2-like 2 (N4BP2L2) OTV2F04G N42L2_HUMAN Decreases Expression [15]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Increases Expression [15]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Decreases Expression [15]
Ribonuclease P/MRP protein subunit POP5 (POP5) OTCZTDJC POP5_HUMAN Increases Expression [15]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Decreases Expression [15]
Protein lifeguard 3 (TMBIM1) OTE47B57 LFG3_HUMAN Increases Expression [15]
Antizyme inhibitor 2 (AZIN2) OT8OB7CG AZIN2_HUMAN Decreases Expression [15]
Fermitin family homolog 2 (FERMT2) OTZNPWWX FERM2_HUMAN Increases Expression [15]
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) OTR3ERMR PLPL2_HUMAN Increases Expression [15]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [15]
Mas-related G-protein coupled receptor member F (MRGPRF) OT74OZ2Z MRGRF_HUMAN Increases Expression [15]
Dapper homolog 3 (DACT3) OTSNQ55G DACT3_HUMAN Decreases Expression [15]
Inactive rhomboid protein 1 (RHBDF1) OTCQ7UDS RHDF1_HUMAN Decreases Expression [15]
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) OTBB799S ACSF2_HUMAN Increases Expression [15]
Isochorismatase domain-containing protein 1 (ISOC1) OTAO7Z87 ISOC1_HUMAN Increases Expression [15]
Galectin-12 (LGALS12) OTNTQULB LEG12_HUMAN Increases Expression [15]
Transcription elongation factor A protein-like 4 (TCEAL4) OTX24CQI TCAL4_HUMAN Increases Expression [15]
C1GALT1-specific chaperone 1 (C1GALT1C1) OTRTZUF5 C1GLC_HUMAN Increases Expression [15]
Small integral membrane protein 12 (SMIM12) OTMOQSL4 SIM12_HUMAN Increases Expression [15]
Intraflagellar transport protein 43 homolog (IFT43) OTKWYQ5C IFT43_HUMAN Decreases Expression [15]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Decreases Expression [15]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [15]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [15]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2) OT0KHLY2 SUCB2_HUMAN Increases Expression [15]
Calmin (CLMN) OT7U5J3T CLMN_HUMAN Increases Expression [15]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Decreases Expression [15]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) OTYXJQCW FGD4_HUMAN Increases Expression [15]
RIPOR family member 3 (RIPOR3) OTHZ4RKK RIPR3_HUMAN Increases Expression [15]
Pseudokinase FAM20A (FAM20A) OT5Z5IW8 FA20A_HUMAN Decreases Expression [15]
Prickle-like protein 1 (PRICKLE1) OT9HHEM9 PRIC1_HUMAN Decreases Expression [15]
Sterile alpha motif domain-containing protein 11 (SAMD11) OT6WRQOX SAM11_HUMAN Decreases Expression [15]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Decreases Expression [15]
Coiled-coil domain-containing protein 85A (CCDC85A) OT2GLF5Z CC85A_HUMAN Increases Expression [15]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [15]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Decreases Expression [15]
Ethanolamine-phosphate cytidylyltransferase (PCYT2) OTT8TAEA PCY2_HUMAN Increases Expression [15]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [15]
Collagen alpha-1(XII) chain (COL12A1) OTHLTV53 COCA1_HUMAN Decreases Expression [15]
Metalloproteinase inhibitor 4 (TIMP4) OT8A68SW TIMP4_HUMAN Increases Expression [15]
MyoD family inhibitor (MDFI) OTIA6YUG MDFI_HUMAN Decreases Expression [15]
Paired mesoderm homeobox protein 2 (PRRX2) OT8UR4AU PRRX2_HUMAN Decreases Expression [15]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [15]
Histone H2A type 1-J (H2AC14) OT5Y4MMC H2A1J_HUMAN Increases Expression [15]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [15]
FYVE and coiled-coil domain-containing protein 1 (FYCO1) OTKZHTZ5 FYCO1_HUMAN Increases Expression [15]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Decreases Expression [15]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [15]
La-related protein 6 (LARP6) OTUQ9QS9 LARP6_HUMAN Decreases Expression [15]
Peroxiredoxin-like 2A (PRXL2A) OTR4X7UH PXL2A_HUMAN Increases Expression [15]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Decreases Expression [15]
Transmembrane protein 204 (TMEM204) OT7X11D9 TM204_HUMAN Decreases Expression [15]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Increases Expression [15]
Chordin-like protein 1 (CHRDL1) OTGMWVVA CRDL1_HUMAN Increases Expression [15]
Protein ABHD14A (ABHD14A) OT94GKE1 ABHEA_HUMAN Increases Expression [15]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (CHCHD7) OTHHROAQ CHCH7_HUMAN Increases Expression [15]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Decreases Expression [15]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Increases Expression [15]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Increases Expression [15]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Decreases Expression [15]
EMILIN-2 (EMILIN2) OTOYK5A8 EMIL2_HUMAN Increases Expression [15]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) OTOOXC7B HOIL1_HUMAN Decreases Expression [15]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Decreases Expression [15]
Carbohydrate sulfotransferase 6 (CHST6) OTXD2IWK CHST6_HUMAN Decreases Expression [15]
N-alpha-acetyltransferase 50 (NAA50) OTFJ8S47 NAA50_HUMAN Increases Expression [15]
Serine/threonine-protein kinase SIK2 (SIK2) OTODY7XG SIK2_HUMAN Increases Expression [15]
Uncharacterized protein C1orf21 (C1ORF21) OTMD7O88 CA021_HUMAN Increases Expression [15]
Solute carrier family 25 member 32 (SLC25A32) OTPP3NWG S2532_HUMAN Increases Expression [15]
Ras association domain-containing protein 4 (RASSF4) OT7YLOFH RASF4_HUMAN Increases Expression [15]
SPARC-related modular calcium-binding protein 2 (SMOC2) OTK1EQ49 SMOC2_HUMAN Increases Expression [15]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Decreases Expression [15]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Increases Expression [15]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Increases Expression [15]
IGF-like family receptor 1 (IGFLR1) OTPUCWQR IGFR1_HUMAN Increases Expression [15]
Reticulophagy regulator 1 (RETREG1) OTYOSLZX RETR1_HUMAN Increases Expression [15]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Decreases Expression [15]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Decreases Expression [15]
Protein eva-1 homolog A (EVA1A) OTCY3Q2M EVA1A_HUMAN Decreases Expression [15]
RING finger protein 122 (RNF122) OT8RE3IM RN122_HUMAN Decreases Expression [15]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) OTNA9G8V MKNK2_HUMAN Increases Expression [15]
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) OT157TY3 TPC_HUMAN Increases Expression [15]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Increases Expression [15]
Plexin-A4 (PLXNA4) OT5XKB3Q PLXA4_HUMAN Increases Expression [15]
Carbohydrate-responsive element-binding protein (MLXIPL) OTR9MLLW MLXPL_HUMAN Increases Expression [15]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Decreases Expression [15]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Decreases Expression [15]
Omega-amidase NIT2 (NIT2) OTC1RAH3 NIT2_HUMAN Increases Expression [15]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [15]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Increases Expression [15]
Teashirt homolog 2 (TSHZ2) OTZWBXXY TSH2_HUMAN Decreases Expression [15]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [15]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) OT5CTQKO PLCD_HUMAN Decreases Expression [15]
Semaphorin-3G (SEMA3G) OTBLVF8V SEM3G_HUMAN Increases Expression [15]
Protein C19orf12 (C19ORF12) OTVSJ1AR CS012_HUMAN Increases Expression [15]
Teneurin-2 (TENM2) OTPLUYEF TEN2_HUMAN Decreases Expression [15]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [15]
Copper homeostasis protein cutC homolog (CUTC) OTOVHLU9 CUTC_HUMAN Increases Expression [15]
PI-PLC X domain-containing protein 1 (PLCXD1) OTU7KCQL PLCX1_HUMAN Increases Expression [15]
Fas apoptotic inhibitory molecule 1 (FAIM) OTR67PGU FAIM1_HUMAN Increases Expression [15]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Decreases Expression [15]
Myotubularin-related protein 10 (MTMR10) OTF6DB4O MTMRA_HUMAN Increases Expression [15]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Decreases Expression [15]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Increases Expression [15]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Decreases Expression [15]
Potassium voltage-gated channel subfamily D member 2 (KCND2) OTIFUVV7 KCND2_HUMAN Decreases Expression [15]
Ankycorbin (RAI14) OT6USGBK RAI14_HUMAN Decreases Expression [15]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Expression [15]
Rho GTPase-activating protein 20 (ARHGAP20) OTG1STV8 RHG20_HUMAN Increases Expression [15]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Decreases Expression [15]
]-phosphatase 2, mitochondrial (PDP2) OTADNMGK PDP2_HUMAN Increases Expression [15]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Increases Expression [15]
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) OTSB4XO0 DPM3_HUMAN Increases Expression [15]
SUMO-activating enzyme subunit 1 (SAE1) OT18HFX5 SAE1_HUMAN Decreases Expression [15]
C-type mannose receptor 2 (MRC2) OTLWQAX1 MRC2_HUMAN Decreases Expression [15]
ATP-binding cassette sub-family D member 2 (ABCD2) OT8RGNH8 ABCD2_HUMAN Increases Expression [15]
Copine-7 (CPNE7) OTR0FJ8A CPNE7_HUMAN Increases Expression [15]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Decreases Expression [15]
Heat shock protein beta-7 (HSPB7) OTLATAOV HSPB7_HUMAN Increases Expression [15]
Tight junction protein ZO-2 (TJP2) OTQUY6BV ZO2_HUMAN Increases Expression [15]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Increases Expression [15]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) OTHTAM54 AAKG2_HUMAN Increases Expression [15]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Increases Expression [15]
Sushi domain-containing protein 2 (SUSD2) OTSJTAZP SUSD2_HUMAN Increases Expression [15]
Zinc finger transcription factor Trps1 (TRPS1) OT7XPPEL TRPS1_HUMAN Decreases Expression [15]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Increases Expression [15]
Potassium voltage-gated channel subfamily G member 1 (KCNG1) OTZ9ZRG8 KCNG1_HUMAN Decreases Expression [15]
ERBB receptor feedback inhibitor 1 (ERRFI1) OT7VZ2IZ ERRFI_HUMAN Increases Expression [15]
A-kinase anchor protein 11 (AKAP11) OT7E2FVD AKA11_HUMAN Decreases Expression [15]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) OTSZE6L4 ATS6_HUMAN Decreases Expression [15]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Increases Expression [15]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Increases Expression [15]
RING finger protein 112 (RNF112) OT0Q9OUQ RN112_HUMAN Decreases Expression [15]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [15]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Increases Expression [15]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [15]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [15]
HIG1 domain family member 1A, mitochondrial (HIGD1A) OTS351DV HIG1A_HUMAN Increases Expression [15]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [15]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Decreases Expression [15]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [15]
Calcium-regulated heat-stable protein 1 (CARHSP1) OTAUG6Y9 CHSP1_HUMAN Decreases Expression [15]
Deoxyribose-phosphate aldolase (DERA) OT8SMO3N DEOC_HUMAN Increases Expression [15]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Increases Expression [15]
C2 domain-containing protein 2 (C2CD2) OTL1K0OB C2CD2_HUMAN Increases Expression [15]
ADP-ribose glycohydrolase OARD1 (OARD1) OTNNWATS OARD1_HUMAN Decreases Expression [15]
Ankyrin repeat and SOCS box protein 1 (ASB1) OT0NZGEI ASB1_HUMAN Decreases Expression [15]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) OTGZO1MT TIM8B_HUMAN Increases Expression [15]
Retinoic acid-induced protein 2 (RAI2) OTR8LX4J RAI2_HUMAN Increases Expression [15]
Mitochondrial pyruvate carrier 1 (MPC1) OT6DYFUO MPC1_HUMAN Increases Expression [15]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Decreases Expression [15]
Cysteine sulfinic acid decarboxylase (CSAD) OT3I2G0A CSAD_HUMAN Increases Expression [15]
Glypican-6 (GPC6) OTNJBESF GPC6_HUMAN Decreases Expression [15]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [15]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) OTTLD0KB SQOR_HUMAN Increases Expression [15]
SET-binding protein (SETBP1) OTKGCOSR SETBP_HUMAN Decreases Expression [15]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [41]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Decreases Expression [41]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Decreases Expression [41]
Collagen alpha-1(X) chain (COL10A1) OTC4G2YC COAA1_HUMAN Increases Expression [41]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Increases Expression [41]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [42]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) OTMI12L2 BMAL1_HUMAN Affects Expression [43]
Syntenin-1 (SDCBP) OTS3NCC5 SDCB1_HUMAN Increases Expression [19]
Transcription factor SOX-1 (SOX1) OTVI1RAR SOX1_HUMAN Increases Expression [44]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [45]
Calsequestrin-2 (CASQ2) OT09MNQ8 CASQ2_HUMAN Affects Expression [44]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Affects Expression [43]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Increases Expression [46]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Affects Expression [47]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [48]
Circadian locomoter output cycles protein kaput (CLOCK) OTNEOJY7 CLOCK_HUMAN Affects Expression [43]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3) OT9ZS72C SRGP3_HUMAN Increases Expression [49]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Increases Expression [20]
Neuronal migration protein doublecortin (DCX) OTISR7K3 DCX_HUMAN Increases Expression [44]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) OTLCYA32 G6PT1_HUMAN Increases Expression [50]
Left-right determination factor 1 (LEFTY1) OT51HVC4 LFTY1_HUMAN Increases Expression [20]
Sciellin (SCEL) OT46SDNQ SCEL_HUMAN Increases Expression [19]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Increases Expression [44]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Increases Expression [51]
Eyes absent homolog 4 (EYA4) OTINGR3Z EYA4_HUMAN Affects Expression [44]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [16]
Eomesodermin homolog (EOMES) OTB9VQFA EOMES_HUMAN Increases Expression [44]
T-box transcription factor TBX6 (TBX6) OTW1Q8RM TBX6_HUMAN Affects Expression [44]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Expression [44]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [52]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [53]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [54]
Pro-opiomelanocortin (POMC) OTV41F7T COLI_HUMAN Decreases Expression [52]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [55]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Increases Expression [56]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases Expression [56]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [56]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [57]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [58]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [59]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases Expression [56]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [19]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [60]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [61]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [62]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [60]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [63]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [57]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Affects Expression [56]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Affects Expression [44]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [64]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [65]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [66]
Transmembrane protein 191B (TMEM191B) OTDKHB0K T191B_HUMAN Decreases Expression [20]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [67]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Expression [19]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Increases Expression [19]
Pulmonary surfactant-associated protein C (SFTPC) OTIZJD09 PSPC_HUMAN Increases Expression [68]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [69]
Myosin-6 (MYH6) OT3YNCH1 MYH6_HUMAN Affects Expression [44]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [19]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Increases Expression [70]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Decreases Expression [55]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Expression [71]
Transcobalamin-2 (TCN2) OT41D0L3 TCO2_HUMAN Decreases Expression [56]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Decreases Expression [72]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Increases Expression [73]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Affects Expression [44]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Increases Expression [74]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [75]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [44]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [76]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Decreases Expression [53]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [77]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [76]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [78]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Increases Expression [79]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Increases Expression [74]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [80]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Decreases Expression [81]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Affects Expression [44]
GMP reductase 1 (GMPR) OTERWHYM GMPR1_HUMAN Increases Expression [20]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [82]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Affects Expression [31]
Interleukin-12 receptor subunit beta-1 (IL12RB1) OTM1IJO2 I12R1_HUMAN Decreases Expression [83]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Increases Expression [44]
Transcription factor GATA-4 (GATA4) OTQHWAZG GATA4_HUMAN Increases Expression [44]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Affects Expression [31]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Decreases Activity [84]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [85]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Expression [86]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Expression [87]
G protein-activated inward rectifier potassium channel 4 (KCNJ5) OTA2MBIE KCNJ5_HUMAN Affects Expression [44]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [88]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [89]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [82]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Increases Expression [90]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G) OTSJYQVQ SCNNG_HUMAN Increases Expression [90]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Increases Activity [91]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX) OTDAC6Z0 PRKX_HUMAN Increases Expression [19]
Transcription factor SOX-10 (SOX10) OTF25ULQ SOX10_HUMAN Increases Expression [44]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Decreases Expression [85]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [54]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [49]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [92]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Affects Localization [93]
Elongation factor 1-alpha 2 (EEF1A2) OT9Z23K5 EF1A2_HUMAN Increases Expression [19]
Homeobox protein engrailed-1 (EN1) OT2DKIDK HME1_HUMAN Increases Expression [44]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [94]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Decreases Expression [88]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Increases Expression [56]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Cleavage [95]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Increases Expression [19]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Activity [96]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [78]
Protein Largen (PRR16) OTG4TEGR LARGN_HUMAN Increases Expression [20]
Zinc finger protein PLAG1 (PLAG1) OTT9AJQY PLAG1_HUMAN Increases Expression [19]
Beclin 1-associated autophagy-related key regulator (ATG14) OTPZDKI0 BAKOR_HUMAN Increases Expression [97]
Histone H3.2 (H3C13) OT97FS6C H32_HUMAN Increases Expression [49]
Cytochrome P450 4Z1 (CYP4Z1) OTKRGJBG CP4Z1_HUMAN Increases Expression [98]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [19]
ATP-dependent RNA helicase TDRD9 (TDRD9) OTS4UBI8 TDRD9_HUMAN Increases Expression [20]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Increases Expression [99]
Ras-responsive element-binding protein 1 (RREB1) OT62460U RREB1_HUMAN Increases Expression [19]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [100]
Neurogenin-1 (NEUROG1) OTMJZP9G NGN1_HUMAN Decreases Expression [20]
Paired mesoderm homeobox protein 2B (PHOX2B) OT3SFR2O PHX2B_HUMAN Affects Expression [44]
Interleukin-12 receptor subunit beta-2 (IL12RB2) OTDLV8H8 I12R2_HUMAN Decreases Expression [83]
Cbp/p300-interacting transactivator 1 (CITED1) OTUJQ3VL CITE1_HUMAN Decreases Expression [44]
Myocilin (MYOC) OT6DAHNF MYOC_HUMAN Increases Expression [57]
Mesoderm posterior protein 1 (MESP1) OTY5QDBN MESP1_HUMAN Decreases Expression [44]
Chitinase domain-containing protein 1 (CHID1) OT4DIUKC CHID1_HUMAN Increases Expression [81]
Negative elongation factor A (NELFA) OT7O6E84 NELFA_HUMAN Increases Expression [19]
Rho-related GTP-binding protein RhoJ (RHOJ) OTWI65OA RHOJ_HUMAN Increases Expression [49]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [101]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Increases Expression [49]
FERM domain-containing protein 4A (FRMD4A) OTJDTIK2 FRM4A_HUMAN Decreases Expression [20]
Vesicular glutamate transporter 2 (SLC17A6) OTP1MJGP VGLU2_HUMAN Increases Expression [44]
ETS-related transcription factor Elf-5 (ELF5) OTLRU8YF ELF5_HUMAN Decreases Expression [20]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Increases Expression [99]
Hepatocyte nuclear factor 3-beta (FOXA2) OTJOCVOY FOXA2_HUMAN Decreases Expression [44]
Potassium voltage-gated channel subfamily E member 2 (KCNE2) OTUO214Y KCNE2_HUMAN Affects Expression [44]
Mitogen-activated protein kinase 11 (MAPK11) OT0AS010 MK11_HUMAN Increases ADR [33]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Increases Response To Substance [102]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Increases ADR [33]
Cadherin-12 (CDH12) OTF2HCGA CAD12_HUMAN Increases ADR [33]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [101]
Poly polymerase 1 (PARP1) OTIESHK4 PARP1_ARATH Increases ADR [33]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Increases ADR [33]
Histidine decarboxylase (hdc) OTM3771T DCHS_RAOOR Increases ADR [33]
Interferon alpha-7 (IFNA7) OTSQ6R46 IFNA7_HUMAN Increases ADR [33]
Polymerase delta-interacting protein 3 (POLDIP3) OTTB5SV7 PDIP3_HUMAN Increases Response To Substance [103]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Decreases Response To Substance [104]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Increases ADR [33]
------------------------------------------------------------------------------------
⏷ Show the Full List of 729 DOT(s)
Indication(s) of Methotrexate
Disease Entry ICD 11 Status REF
Anterior urethra cancer N.A. Approved [5]
Burkitt lymphoma N.A. Approved [5]
Childhood acute lymphoblastic leukemia N.A. Approved [5]
Choriocarcinoma 2C75.0 Approved [6]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [5]
Head and neck cancer 2D42 Approved [5]
Inflammation 1A00-CA43.1 Approved [5]
leukaemia 2A60-2B33 Approved [7]
Leukemia N.A. Approved [5]
Lung cancer 2C25.0 Approved [5]
Mycosis fungoides 2B01 Approved [5]
Posterior urethra cancer N.A. Approved [5]
Psoriasis EA90 Approved [5]
Sensorineural hearing loss disorder N.A. Approved [5]
Urticaria EB00-EB05 Approved [5]
Proliferative vitreoretinopathy 9B78.2 Phase 3 [8]
Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1/2 [9]
Rheumatoid arthritis FA20 Phase 1 [10]
Prostate cancer 2C82.0 Investigative [11]
Methotrexate Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proton-coupled folate transporter (SLC46A1) TTY8Z2E PCFT_HUMAN Modulator [122]
Solute carrier family 19 member 1 (SLC19A1) TT09I7D S19A1_HUMAN Modulator [123]
------------------------------------------------------------------------------------
Methotrexate Interacts with 17 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [124]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [125]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [126]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [127]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [128]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [129]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [130]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [131]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [132]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [133]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [134]
Organic anion transporter 4 (SLC22A11) DT06JWZ S22AB_HUMAN Substrate [135]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [136]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [137]
Multidrug resistance-associated protein 8 (ABCC11) DTWN7FC ABCCB_HUMAN Substrate [138]
Folate transporter 1 (SLC19A1) DTOSN46 S19A1_HUMAN Substrate [139]
Proton-coupled folate transporter (SLC46A1) DTDJEMI PCFT_HUMAN Substrate [140]
------------------------------------------------------------------------------------
⏷ Show the Full List of 17 DTP(s)
Methotrexate Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Metabolism [141]
Methylenetetrahydrofolate reductase (MTHFR) DEOXTPZ MTHR_HUMAN Metabolism [142]
Thymidylate synthase (TYMS) DEASG0Q TYSY_HUMAN Metabolism [142]
Dihydrofolate reductase (DHFR) DE4EGMZ DYR_HUMAN Metabolism [142]
Gamma-Glu-X carboxypeptidase (GGH) DEU7MWJ GGH_HUMAN Metabolism [142]
Folylpolyglutamate synthase (FPGS) DECWT2V FOLC_HUMAN Metabolism [142]
Glutamate carboxypeptidase II (FOLH1) DEN8V7Z FOLH1_HUMAN Metabolism [143]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 DME(s)
Methotrexate Interacts with 1290 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Expression [110]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Decreases Expression [144]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [112]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [145]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [144]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Response To Substance [146]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Response To Substance [147]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Increases Response To Substance [148]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Affects Response To Substance [149]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Response To Substance [148]
TANK-binding kinase 1-binding protein 1 (TBKBP1) OTXTU37H TBKB1_HUMAN Decreases Expression [106]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Expression [106]
AH receptor-interacting protein (AIP) OTDJ3OSV AIP_HUMAN Increases Expression [106]
C-C motif chemokine 21 (CCL21) OT7DOXEM CCL21_HUMAN Decreases Expression [106]
Peroxisomal targeting signal 2 receptor (PEX7) OTM7VBRC PEX7_HUMAN Increases Expression [106]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [106]
AP-3 complex subunit delta-1 (AP3D1) OTJLI0IM AP3D1_HUMAN Decreases Expression [106]
Syntaxin-16 (STX16) OTM7TAOE STX16_HUMAN Increases Expression [106]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Increases Expression [106]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [106]
Synaptojanin-2 (SYNJ2) OTLRHXP1 SYNJ2_HUMAN Increases Expression [106]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Decreases Expression [106]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Decreases Expression [106]
C-C motif chemokine 25 (CCL25) OTLWJ8CJ CCL25_HUMAN Decreases Expression [106]
DNA-directed RNA polymerase I subunit RPA34 (POLR1G) OTEGR9C2 RPA34_HUMAN Decreases Expression [106]
Plexin-B1 (PLXNB1) OTCA7JIT PLXB1_HUMAN Increases Expression [106]
Hypocretin neuropeptide precursor (HCRT) OTQ4FGI9 OREX_HUMAN Decreases Expression [106]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [106]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Increases Expression [106]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) OTI71MUJ ACSL4_HUMAN Increases Expression [106]
Target of Myb1 membrane trafficking protein (TOM1) OT30QA56 TOM1_HUMAN Decreases Expression [106]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [106]
Receptor activity-modifying protein 2 (RAMP2) OTGQXLH5 RAMP2_HUMAN Decreases Expression [106]
Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) OTSLSPZG FCG3B_HUMAN Decreases Expression [106]
ICOS ligand (ICOSLG) OTAD976B ICOSL_HUMAN Decreases Expression [106]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) OTMVHF9E LGR5_HUMAN Decreases Expression [106]
Protein XRP2 (RP2) OTK050I3 XRP2_HUMAN Increases Expression [106]
DnaJ homolog subfamily B member 5 (DNAJB5) OT7WDJ5C DNJB5_HUMAN Decreases Expression [106]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [106]
SUN domain-containing protein 1 (SUN1) OTIU8V4U SUN1_HUMAN Increases Expression [106]
Nuclear factor of activated T-cells 5 (NFAT5) OTKIE59S NFAT5_HUMAN Increases Expression [106]
Interleukin-18 receptor accessory protein (IL18RAP) OTCUB1EV I18RA_HUMAN Decreases Expression [106]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [106]
Putative lipid scramblase CLPTM1 (CLPTM1) OT14QP7N CLPT1_HUMAN Decreases Expression [106]
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) OTZDQ29F TOM40_HUMAN Increases Expression [106]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [106]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [106]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [106]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [106]
Complement C1q subcomponent subunit B (C1QB) OT2G1IOX C1QB_HUMAN Decreases Expression [106]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [106]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Decreases Expression [106]
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) OTREV92I CEAM5_HUMAN Increases Expression [106]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Increases Expression [106]
Complement component C8 alpha chain (C8A) OTIJ65J4 CO8A_HUMAN Increases Expression [106]
Pulmonary surfactant-associated protein B (SFTPB) OTOHS07E PSPB_HUMAN Decreases Expression [106]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Decreases Expression [106]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [106]
CD48 antigen (CD48) OT83ZNPP CD48_HUMAN Decreases Expression [106]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [106]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) OT9LBJVN ODP2_HUMAN Increases Expression [106]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [106]
Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) OT77MV8G CX6A1_HUMAN Decreases Expression [106]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [106]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Expression [106]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [106]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [106]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [106]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Decreases Expression [106]
Cytochrome c oxidase subunit 6B1 (COX6B1) OTNKXYQI CX6B1_HUMAN Decreases Expression [106]
B-lymphocyte antigen CD19 (CD19) OTCPF9NF CD19_HUMAN Decreases Expression [106]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [106]
Antigen-presenting glycoprotein CD1d (CD1D) OT3ROU4J CD1D_HUMAN Increases Expression [106]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Decreases Expression [106]
C-C motif chemokine 3-like 1 (CCL3L1) OTQXCYB1 CL3L1_HUMAN Decreases Expression [106]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Decreases Expression [106]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Decreases Expression [106]
Lymphocyte function-associated antigen 3 (CD58) OTIUGMGS LFA3_HUMAN Increases Expression [106]
Spermidine synthase (SRM) OT4N5MDP SPEE_HUMAN Decreases Expression [106]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases Expression [106]
Mimecan (OGN) OTKP5S4L MIME_HUMAN Decreases Expression [106]
T-cell surface glycoprotein CD3 zeta chain (CD247) OT45FGUX CD3Z_HUMAN Decreases Expression [106]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [106]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Decreases Expression [106]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Increases Expression [106]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Increases Expression [106]
Myeloblastin (PRTN3) OT72MHP7 PRTN3_HUMAN Decreases Expression [106]
N-formyl peptide receptor 2 (FPR2) OTEZ2THZ FPR2_HUMAN Decreases Expression [106]
T-cell surface glycoprotein CD1b (CD1B) OT4D5EG7 CD1B_HUMAN Decreases Expression [106]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Increases Expression [106]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Decreases Expression [106]
Coronin-1A (CORO1A) OTVAZOHC COR1A_HUMAN Decreases Expression [106]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Decreases Expression [106]
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) OTCJD51H FCG2B_HUMAN Decreases Expression [106]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Decreases Expression [106]
ETS-related transcription factor Elf-1 (ELF1) OTV5LKIA ELF1_HUMAN Decreases Expression [106]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Increases Expression [106]
ATP-binding cassette sub-family D member 1 (ABCD1) OT3FL9W0 ABCD1_HUMAN Decreases Expression [106]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [106]
Gap junction alpha-4 protein (GJA4) OTUPCT1V CXA4_HUMAN Decreases Expression [106]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [106]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [106]
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) OTZG1W8W CEAM3_HUMAN Decreases Expression [106]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) OTQOUHVK CEAM6_HUMAN Increases Expression [106]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [106]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Increases Expression [106]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Decreases Expression [106]
Patatin-like phospholipase domain-containing protein 4 (PNPLA4) OT5CVDJM PLPL4_HUMAN Decreases Expression [106]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Decreases Expression [106]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Decreases Expression [106]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Increases Expression [106]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) OT50L4XB ACADV_HUMAN Increases Expression [106]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [106]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [106]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [106]
Serpin H1 (SERPINH1) OTKGI7BS SERPH_HUMAN Decreases Expression [106]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Decreases Expression [106]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Decreases Expression [106]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Decreases Expression [106]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Decreases Expression [106]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Decreases Expression [106]
Trifunctional enzyme subunit beta, mitochondrial (HADHB) OT4Y1I62 ECHB_HUMAN Increases Expression [106]
ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) OT7B6C6M ATP68_HUMAN Decreases Expression [106]
SCAN domain-containing protein 1 (SCAND1) OTRG0AGH SCND1_HUMAN Decreases Expression [106]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Increases Expression [106]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [106]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Decreases Expression [106]
Fibroblast growth factor 12 (FGF12) OTBM9QIO FGF12_HUMAN Decreases Expression [106]
Proline-rich protein 3 (PRR3) OTCWSM5T PRR3_HUMAN Decreases Expression [106]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Decreases Expression [106]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Decreases Expression [106]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [106]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Decreases Expression [106]
Inositol polyphosphate 5-phosphatase OCRL (OCRL) OTQ3L42N OCRL_HUMAN Increases Expression [106]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [106]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) OTF6OC66 GCNT1_HUMAN Increases Expression [106]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Expression [106]
Acetylcholine receptor subunit epsilon (CHRNE) OTGGXGGB ACHE_HUMAN Decreases Expression [106]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Decreases Expression [106]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) OTNOM26L TNR9_HUMAN Decreases Expression [106]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Decreases Expression [106]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Increases Expression [106]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Increases Expression [106]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) OTYOORME NFAC3_HUMAN Increases Expression [106]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Increases Expression [106]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [106]
Natural killer cells antigen CD94 (KLRD1) OTMYLOV4 KLRD1_HUMAN Decreases Expression [106]
Interleukin-15 receptor subunit alpha (IL15RA) OTXP1QC5 I15RA_HUMAN Decreases Expression [106]
Methylglutaconyl-CoA hydratase, mitochondrial (AUH) OT8VKBXX AUHM_HUMAN Increases Expression [106]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Decreases Expression [106]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Increases Expression [106]
EKC/KEOPS complex subunit LAGE3 (LAGE3) OTKBQHZI LAGE3_HUMAN Decreases Expression [106]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Increases Expression [106]
Neutrophil cytosol factor 4 (NCF4) OTX007YL NCF4_HUMAN Decreases Expression [106]
Splicing factor 3B subunit 3 (SF3B3) OTAC9LZT SF3B3_HUMAN Decreases Expression [106]
Protein transport protein Sec23B (SEC23B) OT2NFSIQ SC23B_HUMAN Decreases Expression [106]
Probable E3 ubiquitin-protein ligase HERC1 (HERC1) OT73FVYZ HERC1_HUMAN Increases Expression [106]
Keratin, type II cytoskeletal 71 (KRT71) OTI91X9Z K2C71_HUMAN Decreases Expression [106]
Pyrroline-5-carboxylate reductase 3 (PYCR3) OT3SHY2S P5CR3_HUMAN Decreases Expression [106]
Torsin-2A (TOR2A) OT1EGCDU TOR2A_HUMAN Decreases Expression [106]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Decreases Expression [106]
ER membrane protein complex subunit 10 (EMC10) OTQ6S50X EMC10_HUMAN Decreases Expression [106]
Protein angel homolog 2 (ANGEL2) OT2Q1KU5 ANGE2_HUMAN Increases Expression [106]
Nucleoredoxin (NXN) OT35N40G NXN_HUMAN Decreases Expression [106]
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) OTU2VHWR HIBCH_HUMAN Increases Expression [106]
Nucleolus and neural progenitor protein (NEPRO) OTE5H49L NEPRO_HUMAN Increases Expression [106]
Long-chain fatty acid transport protein 1 (SLC27A1) OTK03OZN S27A1_HUMAN Decreases Expression [106]
Kelch domain-containing protein 10 (KLHDC10) OTLDF1OX KLD10_HUMAN Increases Expression [106]
Mucin-6 (MUC6) OTPVL723 MUC6_HUMAN Decreases Expression [106]
Cytochrome P450 4V2 (CYP4V2) OTQKNK0D CP4V2_HUMAN Increases Expression [106]
Fatty acid 2-hydroxylase (FA2H) OT8HA13U FA2H_HUMAN Decreases Expression [106]
Phospholipid phosphatase-related protein type 4 (PLPPR4) OTBOWTC5 PLPR4_HUMAN Decreases Expression [106]
Adiponectin receptor protein 2 (ADIPOR2) OT2HDTL8 PAQR2_HUMAN Increases Expression [106]
Ras-specific guanine nucleotide-releasing factor RalGPS2 (RALGPS2) OTOYS0SD RGPS2_HUMAN Increases Expression [106]
SURP and G-patch domain-containing protein 2 (SUGP2) OTPUUJYX SUGP2_HUMAN Increases Expression [106]
Spindle and kinetochore-associated protein 3 (SKA3) OTLHEVJD SKA3_HUMAN Decreases Expression [106]
Threonine synthase-like 1 (THNSL1) OTQNFH3E THNS1_HUMAN Decreases Expression [106]
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) OT0HFPCD LIRB2_HUMAN Decreases Expression [106]
Coiled-coil domain-containing protein 82 (CCDC82) OT16EAZ7 CCD82_HUMAN Increases Expression [106]
Leucine repeat adapter protein 25 (FAM89B) OT11J9HL LRA25_HUMAN Decreases Expression [106]
Ubiquitin carboxyl-terminal hydrolase MINDY-1 (MINDY1) OTVLF4G5 MINY1_HUMAN Increases Expression [106]
Programmed cell death protein 7 (PDCD7) OTK5YO7J PDCD7_HUMAN Increases Expression [106]
Trinucleotide repeat-containing gene 6A protein (TNRC6A) OT493IOM TNR6A_HUMAN Increases Expression [106]
N-lysine methyltransferase SETD6 (SETD6) OTH5APN1 SETD6_HUMAN Increases Expression [106]
DmX-like protein 2 (DMXL2) OTB4JWN3 DMXL2_HUMAN Increases Expression [106]
DIS3-like exonuclease 1 (DIS3L) OTYWZ4EM DI3L1_HUMAN Increases Expression [106]
Peptidyl-prolyl cis-trans isomerase-like 4 (PPIL4) OTFTLFJS PPIL4_HUMAN Increases Expression [106]
Spindle and kinetochore-associated protein 2 (SKA2) OTVYF4XT SKA2_HUMAN Decreases Expression [106]
Fatty acyl-CoA reductase 1 (FAR1) OTLHTYIE FACR1_HUMAN Decreases Expression [106]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Decreases Expression [106]
Glycine N-acyltransferase-like protein 1 (GLYATL1) OTS8JSRY GLYL1_HUMAN Increases Expression [106]
Adiponectin receptor protein 1 (ADIPOR1) OT65ZFZN PAQR1_HUMAN Increases Expression [106]
Probable inactive tRNA-specific adenosine deaminase-like protein 3 (ADAT3) OTMEU45R ADAT3_HUMAN Decreases Expression [106]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Increases Expression [106]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Decreases Expression [106]
RUS family member 1 (RUSF1) OTRIIY6J RUSF1_HUMAN Decreases Expression [106]
Hematopoietic SH2 domain-containing protein (HSH2D) OTOGB2BR HSH2D_HUMAN Increases Expression [106]
Mas-related G-protein coupled receptor member X2 (MRGPRX2) OT2XA799 MRGX2_HUMAN Decreases Expression [106]
Cilia- and flagella-associated protein 44 (CFAP44) OT1273MD CFA44_HUMAN Increases Expression [106]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Increases Expression [106]
C-C motif chemokine 13 (CCL13) OTNX0JD0 CCL13_HUMAN Decreases Expression [106]
Zinc finger protein Gfi-1 (GFI1) OT9HB9H8 GFI1_HUMAN Decreases Expression [106]
C-C motif chemokine 19 (CCL19) OTQ2UJMH CCL19_HUMAN Decreases Expression [106]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [106]
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) OTDV54V6 ANKMT_HUMAN Decreases Expression [106]
Protein FAM167B (FAM167B) OT45SD3K F167B_HUMAN Decreases Expression [106]
Enoyl- reductase, mitochondrial (MECR) OTJQ5XKQ MECR_HUMAN Increases Expression [106]
Peroxisomal trans-2-enoyl-CoA reductase (PECR) OT5MS8EM PECR_HUMAN Increases Expression [106]
Ras-related protein Rab-6C (RAB6C) OTA66R5E RAB6C_HUMAN Decreases Expression [106]
Semaphorin-4A (SEMA4A) OT8901H3 SEM4A_HUMAN Decreases Expression [106]
UPF0488 protein C8orf33 (C8ORF33) OTFCF3V5 CH033_HUMAN Decreases Expression [106]
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1) OTHNSDGW RSAD1_HUMAN Increases Expression [106]
MLX-interacting protein (MLXIP) OT30UNI7 MLXIP_HUMAN Increases Expression [106]
Solute carrier family 38 member 10 (SLC38A10) OTXPUL6S S38AA_HUMAN Decreases Expression [106]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) OTPGYWKC NOD2_HUMAN Decreases Expression [106]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [106]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Increases Expression [106]
Complement component C1q receptor (CD93) OT6HZT6H C1QR1_HUMAN Decreases Expression [106]
Achaete-scute homolog 3 (ASCL3) OT1Y3M4K ASCL3_HUMAN Decreases Expression [106]
Protein transport protein Sec31B (SEC31B) OTHV632I SC31B_HUMAN Increases Expression [106]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Increases Expression [106]
Interleukin-17 receptor B (IL17RB) OT0KDNSF I17RB_HUMAN Increases Expression [106]
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) OTAUR5TG PLCC_HUMAN Increases Expression [106]
Keratin, type II cuticular Hb2 (KRT82) OT8Y9T1U KRT82_HUMAN Decreases Expression [106]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Increases Expression [106]
PI-PLC X domain-containing protein 1 (PLCXD1) OTU7KCQL PLCX1_HUMAN Increases Expression [106]
Interleukin-1 receptor-associated kinase 4 (IRAK4) OT9JTJWC IRAK4_HUMAN Increases Expression [106]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [106]
Protein CLN8 (CLN8) OT0D4CB5 CLN8_HUMAN Increases Expression [106]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) OTM3H5OA MALT1_HUMAN Increases Expression [106]
Prenylcysteine oxidase 1 (PCYOX1) OT8FBKY0 PCYOX_HUMAN Increases Expression [106]
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) OTVKZ1DV ATS7_HUMAN Decreases Expression [106]
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) OT0TT8P8 ACSL6_HUMAN Increases Expression [106]
Teneurin-1 (TENM1) OTSKSU4V TEN1_HUMAN Decreases Expression [106]
Serine/threonine-protein kinase TAO2 (TAOK2) OTNUMOZ1 TAOK2_HUMAN Decreases Expression [106]
Two pore channel protein 1 (TPCN1) OTT4C4DI TPC1_HUMAN Increases Expression [106]
Apelin (APLN) OTSWJD7B APEL_HUMAN Decreases Expression [106]
Myotubularin-related protein 7 (MTMR7) OT47NVYM MTMR7_HUMAN Decreases Expression [106]
Ninein-like protein (NINL) OTWIK6HT NINL_HUMAN Increases Expression [106]
Potassium channel subfamily K member 7 (KCNK7) OTFJOWT4 KCNK7_HUMAN Decreases Expression [106]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Decreases Expression [106]
Neuroplastin (NPTN) OTAQKSAU NPTN_HUMAN Decreases Expression [106]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Decreases Expression [106]
Mitochondrial inner membrane protease ATP23 homolog (ATP23) OT303R2T ATP23_HUMAN Increases Expression [106]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [150]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [150]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [107]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Decreases Expression [107]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [107]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [107]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Decreases Expression [107]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Decreases Expression [107]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [107]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [107]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [107]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [107]
Fibroblast growth factor 1 (FGF1) OT8I64X8 FGF1_HUMAN Increases Expression [107]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [107]
Neuromedin-B (NMB) OT4NLN6H NMB_HUMAN Decreases Expression [107]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [107]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [107]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [107]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Increases Expression [107]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [107]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [107]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [107]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Decreases Expression [107]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [107]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Increases Expression [107]
Prolargin (PRELP) OT9EEBUJ PRELP_HUMAN Increases Expression [107]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Decreases Expression [107]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Decreases Expression [107]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Decreases Expression [107]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Decreases Expression [107]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [107]
Probable ATP-dependent RNA helicase DDX10 (DDX10) OTH48438 DDX10_HUMAN Increases Expression [107]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Increases Expression [107]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [107]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Increases Expression [107]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Expression [107]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [107]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [107]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [107]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Decreases Expression [107]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) OT7G9PQE HERC6_HUMAN Decreases Expression [107]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [107]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [107]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Decreases Expression [107]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [107]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [107]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [107]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [107]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Increases Expression [107]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [107]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Increases Expression [107]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [107]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) OT7FCZRM PP4R2_HUMAN Increases Expression [107]
Large neutral amino acids transporter small subunit 2 (SLC7A8) OT8XXVO8 LAT2_HUMAN Increases Expression [107]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [107]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [109]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [109]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [109]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [109]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [109]
Semaphorin-7A (SEMA7A) OT0ZJK64 SEM7A_HUMAN Increases Expression [109]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Increases Expression [109]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Increases Expression [109]
Tight junction protein ZO-3 (TJP3) OTC1K8HC ZO3_HUMAN Increases Expression [109]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Increases Expression [109]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [109]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Increases Expression [109]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Increases Expression [109]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [109]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Expression [109]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [109]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases Expression [109]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [109]
Extracellular superoxide dismutase (SOD3) OTIOZQAB SODE_HUMAN Increases Expression [109]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [109]
Clathrin light chain B (CLTB) OTPW9VRE CLCB_HUMAN Increases Expression [109]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [109]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [109]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Increases Expression [109]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Increases Expression [109]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [109]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Increases Expression [109]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Increases Expression [109]
Proteasome subunit beta type-8 (PSMB8) OTW5XGMF PSB8_HUMAN Increases Expression [109]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Expression [109]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Increases Expression [109]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [109]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Increases Expression [109]
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) OT777OHS KAP1_HUMAN Increases Expression [109]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [109]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Increases Expression [109]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [109]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Increases Expression [109]
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) OTV232Y7 GPDM_HUMAN Increases Expression [109]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Increases Expression [109]
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) OT0AQD93 PP2BC_HUMAN Increases Expression [109]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Increases Expression [109]
Interleukin-13 receptor subunit alpha-1 (IL13RA1) OT59OYXP I13R1_HUMAN Increases Expression [109]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Increases Expression [109]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Increases Expression [109]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [109]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [109]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Increases Expression [109]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [109]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [109]
Peptidyl-prolyl cis-trans isomerase D (PPID) OT2CDF7W PPID_HUMAN Increases Expression [109]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Increases Expression [109]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Increases Expression [109]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Expression [109]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [109]
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) OTHD9KJG KCC2G_HUMAN Increases Expression [109]
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) OTJ5XLVU KCC2D_HUMAN Increases Expression [109]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Expression [109]
Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) OTGQ2AOJ ITPR3_HUMAN Increases Expression [109]
Mitogen-activated protein kinase 11 (MAPK11) OT0AS010 MK11_HUMAN Increases Expression [109]
Cystatin-M (CST6) OTZVHJTF CYTM_HUMAN Increases Expression [109]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [109]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Increases Expression [109]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [109]
Autophagy-related protein 16-1 (ATG16L1) OTEOYC5D A16L1_HUMAN Increases Expression [109]
Cytochrome c oxidase subunit 6B2 (COX6B2) OT5KU3VV CX6B2_HUMAN Increases Expression [109]
Rho-related GTP-binding protein RhoU (RHOU) OTERIAD4 RHOU_HUMAN Increases Expression [109]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [109]
Cysteine protease ATG4D (ATG4D) OTSWUO4R ATG4D_HUMAN Increases Expression [109]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [109]
Interleukin-22 receptor subunit alpha-1 (IL22RA1) OTGVKLBR I22R1_HUMAN Increases Expression [109]
Protein Atg16l2 (ATG16L2) OTJYU0W8 A16L2_HUMAN Increases Expression [109]
Cysteine protease ATG4A (ATG4A) OTDHXAPG ATG4A_HUMAN Increases Expression [109]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [109]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [109]
Claudin-23 (CLDN23) OTN5RV40 CLD23_HUMAN Increases Expression [109]
p53 apoptosis effector related to PMP-22 (PERP) OTP0YL53 PERP_HUMAN Increases Expression [109]
Rho-related GTP-binding protein RhoV (RHOV) OTW4N3QN RHOV_HUMAN Increases Expression [109]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Increases Expression [109]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [109]
Transient receptor potential cation channel subfamily V member 6 (TRPV6) OTZ0LGNO TRPV6_HUMAN Increases Expression [109]
p53-induced death domain-containing protein 1 (PIDD1) OTWFM930 PIDD1_HUMAN Increases Expression [109]
Rho-related GTP-binding protein RhoF (RHOF) OTPA3F8Q RHOF_HUMAN Increases Expression [109]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [109]
Fructose-2,6-bisphosphatase TIGAR (TIGAR) OTR7NMRJ TIGAR_HUMAN Increases Expression [109]
Serine/threonine-protein kinase PAK 6 (PAK6) OTAHPZTT PAK6_HUMAN Increases Expression [109]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) OTPZK76F TAB2_HUMAN Increases Expression [109]
Cingulin (CGN) OTBCQ8AQ CING_HUMAN Increases Expression [109]
Zinc finger protein PLAGL1 (PLAGL1) OTZAO900 PLAL1_HUMAN Increases Expression [109]
Cytosolic phospholipase A2 gamma (PLA2G4C) OTIK5GT5 PA24C_HUMAN Increases Expression [109]
Cofilin-2 (CFL2) OTE2W0DH COF2_HUMAN Increases Expression [109]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) OTYK9JU6 CIA30_HUMAN Increases Expression [109]
Talin-2 (TLN2) OT10QQBC TLN2_HUMAN Increases Expression [109]
Cysteine protease ATG4B (ATG4B) OTQ4RNRM ATG4B_HUMAN Increases Expression [109]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Increases Expression [109]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Expression [151]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [151]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Increases Degradation [151]
Bifunctional purine biosynthesis protein ATIC (ATIC) OT8XE052 PUR9_HUMAN Decreases Expression [144]
Uncharacterized protein C20orf204 (C20ORF204) OT0GVQPP CT204_HUMAN Decreases Expression [110]
Uncharacterized protein CXorf51A (CXORF51A) OTDN5YLP CX05A_HUMAN Increases Expression [110]
Transmembrane protein 120B (TMEM120B) OTA5XMI9 T120B_HUMAN Decreases Expression [110]
Probable ATP-dependent DNA helicase HFM1 (HFM1) OTHV3EFE HFM1_HUMAN Decreases Expression [110]
Homeobox protein HMX2 (HMX2) OTBRXY6D HMX2_HUMAN Increases Expression [110]
Protein FAM181B (FAM181B) OTGZHJ7K F181B_HUMAN Decreases Expression [110]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Decreases Expression [110]
Protein ANKUB1 (ANKUB1) OT8QXDL8 ANKUB_HUMAN Increases Expression [110]
Olfactory receptor 5H1 (OR5H1) OT9YQR5A OR5H1_HUMAN Increases Expression [110]
Uncharacterized protein C15orf62, mitochondrial (C15ORF62) OT2VU9TN CO062_HUMAN Increases Expression [110]
Espin (ESPN) OT7Z6LX2 ESPN_HUMAN Increases Expression [110]
Sperm axonemal maintenance protein CFAP97D1 (CFAP97D1) OTCPE947 CF97D_HUMAN Increases Expression [110]
Putative adrenomedullin-5-like protein (ADM5) OTFOA92Z ADM5_HUMAN Decreases Expression [110]
Fibronectin type III domain-containing protein 10 (FNDC10) OT06NW7W FND10_HUMAN Decreases Expression [110]
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) OT6Y5CC3 PSMD9_HUMAN Decreases Expression [110]
Signal-regulatory protein beta-1 (SIRPB1) OTGHALWJ SIRB1_HUMAN Increases Expression [110]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) OTMI12L2 BMAL1_HUMAN Decreases Expression [110]
C-C chemokine receptor-like 2 (CCRL2) OT5PX0RX CCRL2_HUMAN Decreases Expression [110]
Synaptotagmin-5 (SYT5) OT718PRY SYT5_HUMAN Decreases Expression [110]
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) OTY08SIX CAC1A_HUMAN Increases Expression [110]
Transcription factor SOX-1 (SOX1) OTVI1RAR SOX1_HUMAN Decreases Expression [110]
Ribonuclease T2 (RNASET2) OTWY64L7 RNT2_HUMAN Decreases Expression [110]
Ficolin-1 (FCN1) OTK6ZHXH FCN1_HUMAN Decreases Expression [110]
Transcription factor E2F3 (E2F3) OT5VQMWY E2F3_HUMAN Decreases Expression [110]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Decreases Expression [110]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [110]
Gamma-aminobutyric acid receptor subunit delta (GABRD) OTO38I2R GBRD_HUMAN Decreases Expression [110]
Protein lin-7 homolog A (LIN7A) OTFL3PUX LIN7A_HUMAN Decreases Expression [110]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Increases Expression [110]
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) OT7DVQB0 RPAC1_HUMAN Decreases Expression [110]
Nephrocystin-1 (NPHP1) OTZHCFFQ NPHP1_HUMAN Increases Expression [110]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) OTR7WJES DC1L2_HUMAN Increases Expression [110]
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) OTUA4OLZ PRPF3_HUMAN Decreases Expression [110]
Peptidyl-prolyl cis-trans isomerase H (PPIH) OTB3HCLB PPIH_HUMAN Decreases Expression [110]
Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) OT3CXQJT KCNQ2_HUMAN Decreases Expression [110]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Decreases Expression [110]
Neuronal migration protein doublecortin (DCX) OTISR7K3 DCX_HUMAN Increases Expression [110]
A-kinase anchor protein 7 isoforms alpha and beta (AKAP7) OT0L3PZ6 AKA7A_HUMAN Increases Expression [110]
Peptidase inhibitor 15 (PI15) OTPJL6ML PI15_HUMAN Increases Expression [110]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Increases Expression [110]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Increases Expression [110]
Kalirin (KALRN) OT8WRCBH KALRN_HUMAN Increases Expression [110]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Increases Expression [110]
Adenylate cyclase type 3 (ADCY3) OTGOQM6B ADCY3_HUMAN Decreases Expression [110]
Katanin-interacting protein (KATNIP) OTLLA1BX KATIP_HUMAN Decreases Expression [110]
Centrosomal protein of 104 kDa (CEP104) OTOLRJLH CE104_HUMAN Increases Expression [110]
Germinal-center associated nuclear protein (MCM3AP) OT895FEC GANP_HUMAN Increases Expression [110]
Phospholipid-transporting ATPase IK (ATP8B3) OTZOGEJO AT8B3_HUMAN Decreases Expression [110]
Ecotropic viral integration site 5 protein homolog (EVI5) OTOPAP55 EVI5_HUMAN Increases Expression [110]
Beta-1,4-galactosyltransferase 3 (B4GALT3) OTHX77K8 B4GT3_HUMAN Decreases Expression [110]
Catenin delta-1 (CTNND1) OTUMPSHR CTND1_HUMAN Decreases Expression [110]
Dual specificity protein phosphatase CDC14B (CDC14B) OTAESVOZ CC14B_HUMAN Increases Expression [110]
PRAME family member 11 (PRAMEF11) OT15BWSL PRA11_HUMAN Increases Expression [110]
E3 ubiquitin-protein ligase TRIM13 (TRIM13) OTQIUACB TRI13_HUMAN Increases Expression [110]
Short stature homeobox protein 2 (SHOX2) OTLCZZJW SHOX2_HUMAN Increases Expression [110]
mRNA-capping enzyme (RNGTT) OT59E0KX MCE1_HUMAN Increases Expression [110]
Calcium-transporting ATPase type 2C member 2 (ATP2C2) OTGIHTYQ AT2C2_HUMAN Decreases Expression [110]
Transcription initiation protein SPT3 homolog (SUPT3H) OT7B6FRO SUPT3_HUMAN Decreases Expression [110]
DNA-directed RNA polymerase III subunit RPC9 (CRCP) OT4K9BT7 RPC9_HUMAN Decreases Expression [110]
Decapping and exoribonuclease protein (DXO) OTFDTNW4 DXO_HUMAN Decreases Expression [110]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Increases Expression [110]
Protein furry homolog-like (FRYL) OTBN3XHN FRYL_HUMAN Increases Expression [110]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Decreases Expression [110]
Lysine-specific demethylase 4B (KDM4B) OT5P1UPY KDM4B_HUMAN Increases Expression [110]
Olfactory receptor 2F2 (OR2F2) OTPYQL7R OR2F2_HUMAN Increases Expression [110]
Olfactory receptor 2A4 (OR2A4) OT70V8VC OR2A4_HUMAN Increases Expression [110]
Olfactory receptor 6A2 (OR6A2) OTWKCMOD OR6A2_HUMAN Increases Expression [110]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Increases Expression [110]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Increases Expression [110]
Mitogen-activated protein kinase kinase kinase 6 (MAP3K6) OTOE0Z1R M3K6_HUMAN Decreases Expression [110]
Claudin-9 (CLDN9) OTCKI2IZ CLD9_HUMAN Decreases Expression [110]
Neuronal pentraxin receptor (NPTXR) OTQJEOIH NPTXR_HUMAN Increases Expression [110]
Haptoglobin-related protein (HPR) OTXSC9UB HPTR_HUMAN Decreases Expression [110]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [110]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [110]
Prothymosin alpha (PTMA) OT2W4T1M PTMA_HUMAN Decreases Expression [110]
Asialoglycoprotein receptor 2 (ASGR2) OTFSGOVY ASGR2_HUMAN Decreases Expression [110]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [110]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Decreases Expression [110]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Decreases Expression [110]
Signal recognition particle receptor subunit alpha (SRPRA) OT5NMYTY SRPRA_HUMAN Decreases Expression [110]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Decreases Expression [110]
Fibrocystin (PKHD1) OTAH8SMF PKHD1_HUMAN Decreases Expression [110]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [110]
Protein ELFN1 (ELFN1) OTM7M52U ELFN1_HUMAN Decreases Expression [110]
Myocardial zonula adherens protein (MYZAP) OTAZCNBT MYZAP_HUMAN Decreases Expression [110]
A-kinase anchor protein inhibitor 1 (AKAIN1) OTXO2ZVV AKAI1_HUMAN Increases Expression [110]
Paraneoplastic antigen-like protein 6A (PNMA6A) OTW96SNS PNM6A_HUMAN Increases Expression [110]
Endothelin-converting enzyme 2 (ECE2) OTZLNQVL ECE2_HUMAN Increases Expression [110]
Ras-related protein Rap-2a (RAP2A) OT0JB5S4 RAP2A_HUMAN Increases Expression [110]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Expression [110]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [110]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [110]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Increases Expression [110]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [110]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Increases Expression [110]
Protein L-Myc (MYCL) OT1MFQ5U MYCL_HUMAN Decreases Expression [110]
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Decreases Expression [110]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [110]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4) OTNXIHQU DRB4_HUMAN Decreases Expression [110]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Increases Expression [110]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [110]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Increases Expression [110]
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) OT3UJ4ZU RSMB_HUMAN Decreases Expression [110]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Expression [110]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Increases Expression [110]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [110]
Homeobox protein Hox-B8 (HOXB8) OTKHOD17 HXB8_HUMAN Decreases Expression [110]
Homeobox protein Hox-B9 (HOXB9) OTMVHQOU HXB9_HUMAN Increases Expression [110]
Large ribosomal subunit protein eL33 (RPL35A) OTDDJUWF RL35A_HUMAN Increases Expression [110]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [110]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Decreases Expression [110]
Tryptase beta-2 (TPSB2) OTN769MT TRYB2_HUMAN Increases Expression [110]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Decreases Expression [110]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [110]
Serine/threonine-protein kinase MAK (MAK) OTEU2G41 MAK_HUMAN Decreases Expression [110]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Increases Expression [110]
Synaptotagmin-1 (SYT1) OTVTPOI6 SYT1_HUMAN Increases Expression [110]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Decreases Expression [110]
Tenascin-X (TNXB) OTVBWAV5 TENX_HUMAN Increases Expression [110]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Decreases Expression [110]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Increases Expression [110]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [110]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Decreases Expression [110]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Decreases Expression [110]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Increases Expression [110]
Lens fiber major intrinsic protein (MIP) OTEBLU3E MIP_HUMAN Increases Expression [110]
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) OTBIKWQT GBRA5_HUMAN Decreases Expression [110]
Homeobox protein OTX1 (OTX1) OTRGSGH9 OTX1_HUMAN Decreases Expression [110]
G protein-coupled receptor kinase 4 (GRK4) OTUU8V2S GRK4_HUMAN Increases Expression [110]
Catenin alpha-1 (CTNNA1) OTFC725Z CTNA1_HUMAN Decreases Expression [110]
Merlin (NF2) OT6E5ACG MERL_HUMAN Decreases Expression [110]
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Increases Expression [110]
Alpha-adducin (ADD1) OTTF68DC ADDA_HUMAN Increases Expression [110]
RNA-binding protein FUS (FUS) OTPPNGQO FUS_HUMAN Decreases Expression [110]
DNA-binding protein SMUBP-2 (IGHMBP2) OTAZFPF5 SMBP2_HUMAN Decreases Expression [110]
Large ribosomal subunit protein uL3 (RPL3) OTX6VXLB RL3_HUMAN Decreases Expression [110]
Chymotrypsin-like protease CTRL-1 (CTRL) OTB6NA5O CTRL_HUMAN Decreases Expression [110]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [110]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Decreases Expression [110]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Decreases Expression [110]
Neuronal vesicle trafficking-associated protein 1 (NSG1) OTRIMA50 NSG1_HUMAN Increases Expression [110]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Increases Expression [110]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Increases Expression [110]
Ran-specific GTPase-activating protein (RANBP1) OTQE226K RANG_HUMAN Decreases Expression [110]
Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) OTX31RLZ KI2S2_HUMAN Decreases Expression [110]
G-protein coupled receptor 4 (GPR4) OTIBF32I GPR4_HUMAN Decreases Expression [110]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Decreases Expression [110]
Olfactory marker protein (OMP) OT7JH0DY OMP_HUMAN Decreases Expression [110]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Increases Expression [110]
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) OT61GMNV CY561_HUMAN Increases Expression [110]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Decreases Expression [110]
Proteasome subunit beta type-2 (PSMB2) OTX0UG5W PSB2_HUMAN Decreases Expression [110]
Regulator of G-protein signaling 7 (RGS7) OTDQA90X RGS7_HUMAN Increases Expression [110]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Decreases Expression [110]
Arylsulfatase D (ARSD) OTAHW9M8 ARSD_HUMAN Decreases Expression [110]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Expression [110]
RNA polymerase II elongation factor ELL (ELL) OTCBN5LF ELL_HUMAN Decreases Expression [110]
FAD-linked sulfhydryl oxidase ALR (GFER) OTVK43OK ALR_HUMAN Decreases Expression [110]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) OT536PE7 SCOT1_HUMAN Decreases Expression [110]
Period circadian protein homolog 3 (PER3) OTVKYVJA PER3_HUMAN Increases Expression [110]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [110]
Taste receptor type 2 member 50 (TAS2R50) OTPRMVZW T2R50_HUMAN Decreases Expression [110]
FXYD domain-containing ion transport regulator 4 (FXYD4) OT06IH3H FXYD4_HUMAN Increases Expression [110]
Eukaryotic initiation factor 4A-I (EIF4A1) OTMTBX6N IF4A1_HUMAN Decreases Expression [110]
Ras-related protein Rap-2b (RAP2B) OTD2NDQP RAP2B_HUMAN Decreases Expression [110]
LIM domain transcription factor LMO4 (LMO4) OT5NDCT9 LMO4_HUMAN Increases Expression [110]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Decreases Expression [110]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Expression [110]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [110]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Decreases Expression [110]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [110]
Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) OT2CEYTT SHPS1_HUMAN Increases Expression [110]
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) OT24S8YN ADAM8_HUMAN Decreases Expression [110]
UDP-galactose translocator (SLC35A2) OTQOTOWZ S35A2_HUMAN Decreases Expression [110]
mRNA export factor RAE1 (RAE1) OT54OKC3 RAE1L_HUMAN Increases Expression [110]
Enhancer of rudimentary homolog (ERH) OTJDWX99 ERH_HUMAN Decreases Expression [110]
Histone H3.3 (H3-3B) OT9XHQ3C H33_HUMAN Decreases Expression [110]
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) OT6HTSJT PGBM_HUMAN Increases Expression [110]
Low-density lipoprotein receptor-related protein 2 (LRP2) OTZ6W681 LRP2_HUMAN Increases Expression [110]
Phosphatidylinositol transfer protein alpha isoform (PITPNA) OTTWC00K PIPNA_HUMAN Decreases Expression [110]
Forkhead box protein K2 (FOXK2) OTFXDZ3R FOXK2_HUMAN Increases Expression [110]
High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) OTMCAS2D FCERB_HUMAN Increases Expression [110]
Interferon-induced transmembrane protein 3 (IFITM3) OT2QP8D3 IFM3_HUMAN Decreases Expression [110]
Interferon-induced transmembrane protein 2 (IFITM2) OTAT6TI6 IFM2_HUMAN Decreases Expression [110]
POU domain, class 4, transcription factor 1 (POU4F1) OTMHYGWQ PO4F1_HUMAN Decreases Expression [110]
Collagen alpha-3(IV) chain (COL4A3) OT6SB8X5 CO4A3_HUMAN Increases Expression [110]
Amyloid-beta A4 precursor protein-binding family A member 1 (APBA1) OTUH9JPD APBA1_HUMAN Increases Expression [110]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) OTPV1D60 FKBP4_HUMAN Decreases Expression [110]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Decreases Expression [110]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Decreases Expression [110]
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) OT5WA666 PTN12_HUMAN Increases Expression [110]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Decreases Expression [110]
Rho GTPase-activating protein 1 (ARHGAP1) OT0H2ZBZ RHG01_HUMAN Increases Expression [110]
3',5'-cyclic-AMP phosphodiesterase 4C (PDE4C) OTI8VMHZ PDE4C_HUMAN Increases Expression [110]
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5) OTU4DD4G MGT5A_HUMAN Increases Expression [110]
Uncharacterized protein C17orf67 (C17ORF67) OTCL5EE8 CQ067_HUMAN Decreases Expression [110]
Thyrotroph embryonic factor (TEF) OTY3LAD9 TEF_HUMAN Increases Expression [110]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Decreases Expression [110]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1) OTNYXOZO KCMA1_HUMAN Increases Expression [110]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) OT2LP7LJ SNF5_HUMAN Increases Expression [110]
Receptor-type tyrosine-protein phosphatase eta (PTPRJ) OT10OKOF PTPRJ_HUMAN Increases Expression [110]
Rho GTPase-activating protein 5 (ARHGAP5) OTOQELUN RHG05_HUMAN Increases Expression [110]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Decreases Expression [110]
Lymphocyte cytosolic protein 2 (LCP2) OT57KE22 LCP2_HUMAN Decreases Expression [110]
DNA excision repair protein ERCC-8 (ERCC8) OT0T4WKI ERCC8_HUMAN Increases Expression [110]
Signaling lymphocytic activation molecule (SLAMF1) OTBTT3ZQ SLAF1_HUMAN Decreases Expression [110]
Limbic system-associated membrane protein (LSAMP) OTYXVQX2 LSAMP_HUMAN Decreases Expression [110]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Increases Expression [110]
Interferon regulatory factor 5 (IRF5) OT8SIIAP IRF5_HUMAN Increases Expression [110]
Nucleic acid dioxygenase ALKBH1 (ALKBH1) OTADGU5D ALKB1_HUMAN Affects Expression [110]
Sodium/potassium-transporting ATPase subunit alpha-4 (ATP1A4) OT9PLMBH AT1A4_HUMAN Increases Expression [110]
Integrin alpha-9 (ITGA9) OTHN1IKA ITA9_HUMAN Decreases Expression [110]
Plakophilin-1 (PKP1) OT9HSQ8F PKP1_HUMAN Decreases Expression [110]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Decreases Expression [110]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Increases Expression [110]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Increases Expression [110]
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) OT8RPSOC FKBP8_HUMAN Decreases Expression [110]
ATP-dependent RNA helicase DHX8 (DHX8) OT97S0IH DHX8_HUMAN Decreases Expression [110]
Nuclear receptor coactivator 6 (NCOA6) OTOMIGTV NCOA6_HUMAN Decreases Expression [110]
Raftlin (RFTN1) OT8875JE RFTN1_HUMAN Increases Expression [110]
Chromobox protein homolog 2 (CBX2) OTOQ5WS4 CBX2_HUMAN Increases Expression [110]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Increases Expression [110]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Increases Expression [110]
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) OT5K42IK GAPD1_HUMAN Increases Expression [110]
MAD2L1-binding protein (MAD2L1BP) OT2O2IUJ MD2BP_HUMAN Decreases Expression [110]
Rab GTPase-binding effector protein 1 (RABEP1) OTQROTGT RABE1_HUMAN Increases Expression [110]
SH2 domain-containing adapter protein B (SHB) OTF2HSC0 SHB_HUMAN Decreases Expression [110]
Ficolin-2 (FCN2) OTTHJBKZ FCN2_HUMAN Increases Expression [110]
Transcription elongation factor A protein 2 (TCEA2) OT1OS9TY TCEA2_HUMAN Increases Expression [110]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Decreases Expression [110]
Olfactory receptor 1C1 (OR1C1) OT9WTEX5 OR1C1_HUMAN Decreases Expression [110]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [110]
Tryptase alpha/beta-1 (TPSAB1) OTJYI4WV TRYB1_HUMAN Increases Expression [110]
CCAAT/enhancer-binding protein epsilon (CEBPE) OTKZA25M CEBPE_HUMAN Decreases Expression [110]
Ras-related protein Rab-30 (RAB30) OTW49G8B RAB30_HUMAN Increases Expression [110]
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) OTQBZWSE PTN21_HUMAN Increases Expression [110]
Dual oxidase maturation factor 2 (DUOXA2) OT7AZBZJ DOXA2_HUMAN Decreases Expression [110]
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) OTJ6JTGT HNRL2_HUMAN Increases Expression [110]
R-spondin-4 (RSPO4) OTFX5N3G RSPO4_HUMAN Decreases Expression [110]
Neuroblastoma breakpoint family member 1 (NBPF1) OTAZ55UQ NBPF1_HUMAN Increases Expression [110]
TBC1 domain family member 25 (TBC1D25) OT11OABF TBC25_HUMAN Decreases Expression [110]
Transmembrane protein 176B (TMEM176B) OTEGF2BV T176B_HUMAN Decreases Expression [110]
C2 domain-containing protein 3 (C2CD3) OTC52E7V C2CD3_HUMAN Increases Expression [110]
tRNA-queuosine alpha-mannosyltransferase (GTDC1) OT8OBXKK QTMAN_HUMAN Increases Expression [110]
Coiled-coil domain-containing protein 152 (CCDC152) OTJQTQXC CC152_HUMAN Increases Expression [110]
Coiled-coil domain-containing protein 40 (CCDC40) OTFHEUUN CCD40_HUMAN Decreases Expression [110]
Minichromosome maintenance domain-containing protein 2 (MCMDC2) OTTG0EQU MCMD2_HUMAN Decreases Expression [110]
Synaptotagmin-like protein 3 (SYTL3) OT6TPBA9 SYTL3_HUMAN Increases Expression [110]
Protein lin-52 homolog (LIN52) OT14OQ1C LIN52_HUMAN Increases Expression [110]
Seizure protein 6 homolog (SEZ6) OTCD8K5D SEZ6_HUMAN Decreases Expression [110]
Transmembrane 4 L6 family member 20 (TM4SF20) OTNXU9QW T4S20_HUMAN Decreases Expression [110]
HCLS1-binding protein 3 (HS1BP3) OT5NSZJ1 H1BP3_HUMAN Decreases Expression [110]
Germinal center-associated signaling and motility-like protein (GCSAML) OTYWDOA6 GSAML_HUMAN Increases Expression [110]
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) OT3RBLSK SOLH1_HUMAN Decreases Expression [110]
Intracellular hyaluronan-binding protein 4 (HABP4) OTU223PA HABP4_HUMAN Increases Expression [110]
Coiled-coil domain-containing protein 158 (CCDC158) OTT3RXZN CD158_HUMAN Decreases Expression [110]
RNA-binding protein 26 (RBM26) OTG4C53Y RBM26_HUMAN Decreases Expression [110]
Roquin-1 (RC3H1) OTCU6CYA RC3H1_HUMAN Decreases Expression [110]
Radial spoke head protein 4 homolog A (RSPH4A) OTNDPGEE RSH4A_HUMAN Decreases Expression [110]
Four and a half LIM domains protein 5 (FHL5) OT6C00Z1 FHL5_HUMAN Decreases Expression [110]
Protein PRR14L (PRR14L) OT290EDE PR14L_HUMAN Increases Expression [110]
Centrosome-associated protein 350 (CEP350) OT5Q3AEA CE350_HUMAN Increases Expression [110]
Divergent protein kinase domain 1B (DIPK1B) OTSPU5O5 DIK1B_HUMAN Increases Expression [110]
OTU domain-containing protein 1 (OTUD1) OTE6O5XB OTUD1_HUMAN Decreases Expression [110]
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2) OTLEF5TY DC122_HUMAN Increases Expression [110]
Muscular LMNA-interacting protein (MLIP) OTMT7AII MLIP_HUMAN Increases Expression [110]
Ankyrin repeat domain-containing protein 34A (ANKRD34A) OTI00ROL AN34A_HUMAN Decreases Expression [110]
Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) OTFMZ8I2 MCTP2_HUMAN Decreases Expression [110]
General transcription factor II-I repeat domain-containing protein 2B (GTF2IRD2B) OTO0L3A2 GTD2B_HUMAN Increases Expression [110]
Kelch-like protein 10 (KLHL10) OTB41MP9 KLH10_HUMAN Increases Expression [110]
Proline-rich protein 5-like (PRR5L) OTQ1Z0OU PRR5L_HUMAN Decreases Expression [110]
RPA-related protein RADX (RADX) OTKV8BMJ RADX_HUMAN Increases Expression [110]
Glutamate-rich protein 5 (ERICH5) OTQEY1SQ ERIC5_HUMAN Increases Expression [110]
Ankyrin repeat domain-containing protein 16 (ANKRD16) OTZD4JUO ANR16_HUMAN Decreases Expression [110]
MTOR-associated protein MEAK7 (MEAK7) OT9A8JSO MEAK7_HUMAN Decreases Expression [110]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Expression [110]
F-box only protein 38 (FBXO38) OTSZ3768 FBX38_HUMAN Decreases Expression [110]
Consortin (CNST) OTOUCB98 CNST_HUMAN Increases Expression [110]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Increases Expression [110]
Type-1 angiotensin II receptor-associated protein (AGTRAP) OT02N7LD ATRAP_HUMAN Decreases Expression [110]
Coiled-coil domain-containing protein 171 (CCDC171) OT9NL2D9 CC171_HUMAN Increases Expression [110]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) OTV01EFP C1TM_HUMAN Increases Expression [110]
Transmembrane protein 107 (TMEM107) OT9RMLBJ TM107_HUMAN Decreases Expression [110]
C-type lectin domain family 4 member G (CLEC4G) OTUGTR0H CLC4G_HUMAN Decreases Expression [110]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2) OTR3K733 TPTE2_HUMAN Increases Expression [110]
Sulfhydryl oxidase 2 (QSOX2) OTMLKYFP QSOX2_HUMAN Decreases Expression [110]
Patched domain-containing protein 4 (PTCHD4) OTGJ8NRP PTHD4_HUMAN Increases Expression [110]
Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) OT09MHV0 CR3L2_HUMAN Increases Expression [110]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (PREX2) OTYT1J6J PREX2_HUMAN Decreases Expression [110]
Protein FRA10AC1 (FRA10AC1) OT730MMV F10C1_HUMAN Increases Expression [110]
Mediator of RNA polymerase II transcription subunit 13-like (MED13L) OTSP1W0F MD13L_HUMAN Increases Expression [110]
Immunoglobulin-like domain-containing receptor 2 (ILDR2) OTNNK3VC ILDR2_HUMAN Increases Expression [110]
GRB2-associated and regulator of MAPK protein 2 (GAREM2) OTQNQAC7 GARE2_HUMAN Increases Expression [110]
STE20-related kinase adapter protein alpha (STRADA) OTG1Z6TY STRAA_HUMAN Decreases Expression [110]
#NAME? OTD229X7 MICA3_HUMAN Increases Expression [110]
Aprataxin (APTX) OTPAS5G8 APTX_HUMAN Decreases Expression [110]
Endoplasmic reticulum metallopeptidase 1 (ERMP1) OT9CIEO2 ERMP1_HUMAN Decreases Expression [110]
Nucleoporin p54 (NUP54) OTHOIRMG NUP54_HUMAN Decreases Expression [110]
Keratin, type I cytoskeletal 25 (KRT25) OT4JMRN6 K1C25_HUMAN Increases Expression [110]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Decreases Expression [110]
Cytoplasmic polyadenylation element-binding protein 2 (CPEB2) OTKES4YR CPEB2_HUMAN Decreases Expression [110]
FERM domain-containing protein 5 (FRMD5) OTC73XJK FRMD5_HUMAN Increases Expression [110]
Beta-defensin 132 (DEFB132) OT5SRTW1 DB132_HUMAN Increases Expression [110]
Cytokine-dependent hematopoietic cell linker (CLNK) OTOWK51S CLNK_HUMAN Decreases Expression [110]
Protein polybromo-1 (PBRM1) OT39WUR9 PB1_HUMAN Increases Expression [110]
CUB and zona pellucida-like domain-containing protein 1 (CUZD1) OTDQJVZ8 CUZD1_HUMAN Increases Expression [110]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [110]
Zinc finger protein castor homolog 1 (CASZ1) OTWJ2OR8 CASZ1_HUMAN Increases Expression [110]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [110]
Fibrocystin-L (PKHD1L1) OTREFCAA PKHL1_HUMAN Increases Expression [110]
Protein NLRC5 (NLRC5) OTY8X6MC NLRC5_HUMAN Decreases Expression [110]
Vasculin (GPBP1) OTUXR2GD GPBP1_HUMAN Increases Expression [110]
Ral GTPase-activating protein subunit beta (RALGAPB) OTY8CGA3 RLGPB_HUMAN Increases Expression [110]
Diacylglycerol kinase eta (DGKH) OTYNPJ4B DGKH_HUMAN Decreases Expression [110]
Probable guanine nucleotide exchange factor MCF2L2 (MCF2L2) OTOGFMIH MF2L2_HUMAN Decreases Expression [110]
Ras-related protein Rab-43 (RAB43) OTVCSILI RAB43_HUMAN Decreases Expression [110]
NudC domain-containing protein 3 (NUDCD3) OT2WYBNC NUDC3_HUMAN Decreases Expression [110]
Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON) OTBHAW5K SBSPO_HUMAN Increases Expression [110]
Kinase suppressor of Ras 1 (KSR1) OT9GUVLI KSR1_HUMAN Decreases Expression [110]
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 (NKAIN4) OT91HOEP NKAI4_HUMAN Decreases Expression [110]
Sphingosine-1-phosphate transporter SPNS2 (SPNS2) OTPODAPU SPNS2_HUMAN Decreases Expression [110]
FAD-dependent oxidoreductase domain-containing protein 2 (FOXRED2) OTSJOZ3O FXRD2_HUMAN Decreases Expression [110]
PHD finger protein 6 (PHF6) OT8DXI40 PHF6_HUMAN Increases Expression [110]
Calcium homeostasis endoplasmic reticulum protein (CHERP) OTJL4OB3 CHERP_HUMAN Decreases Expression [110]
GTP-binding protein REM 2 (REM2) OT0RTOI8 REM2_HUMAN Decreases Expression [110]
Cilia- and flagella-associated protein 46 (CFAP46) OTRZZHB9 CFA46_HUMAN Increases Expression [110]
Rhotekin-2 (RTKN2) OTV2AXQM RTKN2_HUMAN Increases Expression [110]
Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST3) OTTW9PDL H6ST3_HUMAN Decreases Expression [110]
Leucine-rich repeat LGI family member 3 (LGI3) OT0CZ85H LGI3_HUMAN Increases Expression [110]
Protein SYS1 homolog (SYS1) OTTVS1LN SYS1_HUMAN Increases Expression [110]
E3 ubiquitin-protein ligase pellino homolog 3 (PELI3) OTCBUSKJ PELI3_HUMAN Increases Expression [110]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [110]
Leucine-rich repeat-containing protein 25 (LRRC25) OTCKAZA5 LRC25_HUMAN Decreases Expression [110]
Chemokine-like protein TAFA-2 (TAFA2) OTU6WP6J TAFA2_HUMAN Decreases Expression [110]
Follistatin-related protein 5 (FSTL5) OT18C29S FSTL5_HUMAN Increases Expression [110]
Kinesin-like protein KIF2B (KIF2B) OTLPAX4N KIF2B_HUMAN Increases Expression [110]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [110]
Prolyl 3-hydroxylase OGFOD1 (OGFOD1) OTTUQ5O3 OGFD1_HUMAN Increases Expression [110]
Ceramide synthase 5 (CERS5) OT5A2DNI CERS5_HUMAN Increases Expression [110]
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) OTBNQCOS LIRA3_HUMAN Decreases Expression [110]
IQ domain-containing protein F1 (IQCF1) OTXFEQ37 IQCF1_HUMAN Decreases Expression [110]
Stress-associated endoplasmic reticulum protein 2 (SERP2) OT5GA6JZ SERP2_HUMAN Increases Expression [110]
Leucine-rich repeat-containing protein 17 (LRRC17) OT3NZSX3 LRC17_HUMAN Increases Expression [110]
ER membrane protein complex subunit 1 (EMC1) OTYAH4LX EMC1_HUMAN Decreases Expression [110]
Androglobin (ADGB) OT1TM9DT ADGB_HUMAN Decreases Expression [110]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (ANKRD44) OTUI0WOO ANR44_HUMAN Decreases Expression [110]
Coiled-coil domain-containing protein 71L (CCDC71L) OT7ECVUW CC71L_HUMAN Decreases Expression [110]
Tetratricopeptide repeat protein 29 (TTC29) OT37KCUL TTC29_HUMAN Increases Expression [110]
Fanconi anemia group B protein (FANCB) OTMZTXB5 FANCB_HUMAN Increases Expression [110]
Hemicentin-2 (HMCN2) OTJK9CGG HMCN2_HUMAN Increases Expression [110]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) OTLUM9L7 PK3C3_HUMAN Increases Expression [110]
Microcephalin (MCPH1) OTYT3TT5 MCPH1_HUMAN Increases Expression [110]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Increases Expression [110]
Telomere repeats-binding bouquet formation protein 2 (TERB2) OTUJDOF8 TERB2_HUMAN Increases Expression [110]
Checkpoint protein HUS1B (HUS1B) OT3VFQWS HUS1B_HUMAN Decreases Expression [110]
Stomatin-like protein 3 (STOML3) OTLQGALK STML3_HUMAN Increases Expression [110]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Increases Expression [110]
Ras and Rab interactor 3 (RIN3) OT5Z6F8O RIN3_HUMAN Decreases Expression [110]
Piwi-like protein 2 (PIWIL2) OT1PXQIF PIWL2_HUMAN Decreases Expression [110]
Glutamate receptor ionotropic, NMDA 3A (GRIN3A) OTQS9GYY NMD3A_HUMAN Increases Expression [110]
Mirror-image polydactyly gene 1 protein (MIPOL1) OTLPN3D0 MIPO1_HUMAN Increases Expression [110]
Chromodomain-helicase-DNA-binding protein 6 (CHD6) OTEHW1U2 CHD6_HUMAN Increases Expression [110]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Decreases Expression [110]
GPI ethanolamine phosphate transferase 3 (PIGO) OTGDOBO1 PIGO_HUMAN Decreases Expression [110]
Guanine nucleotide exchange protein SMCR8 (SMCR8) OT52BQH4 SMCR8_HUMAN Decreases Expression [110]
Partitioning defective 3 homolog B (PARD3B) OTGZ43YI PAR3L_HUMAN Increases Expression [110]
SH3 domain and tetratricopeptide repeat-containing protein 2 (SH3TC2) OTJ6XY2A S3TC2_HUMAN Increases Expression [110]
F-box only protein 41 (FBXO41) OT5MC4TZ FBX41_HUMAN Increases Expression [110]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Increases Expression [110]
Protein POF1B (POF1B) OTFWNK8G POF1B_HUMAN Decreases Expression [110]
GTPase IMAP family member 1 (GIMAP1) OT7AJ1TT GIMA1_HUMAN Decreases Expression [110]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [110]
RUN and FYVE domain-containing protein 2 (RUFY2) OTT9C6SM RUFY2_HUMAN Increases Expression [110]
Stonin-2 (STON2) OT01JHHE STON2_HUMAN Increases Expression [110]
Connector enhancer of kinase suppressor of ras 2 (CNKSR2) OTAGERJ2 CNKR2_HUMAN Increases Expression [110]
Voltage-dependent calcium channel gamma-8 subunit (CACNG8) OTP6227G CCG8_HUMAN Increases Expression [110]
Cationic amino acid transporter 3 (SLC7A3) OTKEFAHV CTR3_HUMAN Decreases Expression [110]
Transmembrane O-methyltransferase (LRTOMT) OTMLESUJ TOMT_HUMAN Increases Expression [110]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [110]
Alpha-2,8-sialyltransferase 8B (ST8SIA2) OTRBBBD8 SIA8B_HUMAN Increases Expression [110]
Sorting nexin-19 (SNX19) OTGNS3HG SNX19_HUMAN Increases Expression [110]
Transmembrane protein 131 (TMEM131) OT72FBLT TM131_HUMAN Decreases Expression [110]
Stalled ribosome sensor GCN1 (GCN1) OTBFVD7Z GCN1_HUMAN Decreases Expression [110]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [110]
Phosphatidate cytidylyltransferase 1 (CDS1) OT2F591M CDS1_HUMAN Increases Expression [110]
Endonuclease 8-like 2 (NEIL2) OTV6JEON NEIL2_HUMAN Decreases Expression [110]
Polyamine deacetylase HDAC10 (HDAC10) OTHCKKUQ HDA10_HUMAN Decreases Expression [110]
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) OT351FKB ERGI1_HUMAN Increases Expression [110]
Autophagy-related protein 2 homolog B (ATG2B) OT7FGFJ1 ATG2B_HUMAN Decreases Expression [110]
Pyrroline-5-carboxylate reductase 2 (PYCR2) OTS2HLGD P5CR2_HUMAN Decreases Expression [110]
FAS-associated factor 2 (FAF2) OTE8CE2E FAF2_HUMAN Increases Expression [110]
RalBP1-associated Eps domain-containing protein 1 (REPS1) OTX4ERRK REPS1_HUMAN Increases Expression [110]
U8 snoRNA-decapping enzyme (NUDT16) OTWSL9JQ NUD16_HUMAN Decreases Expression [110]
THAP domain-containing protein 11 (THAP11) OTEMWLZ0 THA11_HUMAN Increases Expression [110]
E3 ubiquitin-protein ligase CHFR (CHFR) OTRAD2TT CHFR_HUMAN Decreases Expression [110]
Small integral membrane protein 12 (SMIM12) OTMOQSL4 SIM12_HUMAN Decreases Expression [110]
UDP-N-acetylglucosamine transferase subunit ALG14 homolog (ALG14) OTBM7K28 ALG14_HUMAN Increases Expression [110]
OTU domain-containing protein 5 (OTUD5) OTMCR6JM OTUD5_HUMAN Decreases Expression [110]
Solute carrier family 25 member 44 (SLC25A44) OTHHPC3C S2544_HUMAN Decreases Expression [110]
Dedicator of cytokinesis protein 6 (DOCK6) OTPNUVLT DOCK6_HUMAN Increases Expression [110]
Kin of IRRE-like protein 1 (KIRREL1) OTOA7ON7 KIRR1_HUMAN Increases Expression [110]
Spatacsin (SPG11) OTZ7LJX4 SPTCS_HUMAN Affects Expression [110]
Protein SPMIP9 (SPMIP9) OT66UEFP SMIP9_HUMAN Decreases Expression [110]
Coiled-coil domain-containing protein 7 (CCDC7) OTNCL9JR CCDC7_HUMAN Increases Expression [110]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) OT5TS6P7 PCMD1_HUMAN Increases Expression [110]
Transmembrane protein 74 (TMEM74) OT3IZBM0 TMM74_HUMAN Increases Expression [110]
N-acetylneuraminate 9-O-acetyltransferase (CASD1) OT1YB54Z CASD1_HUMAN Decreases Expression [110]
AP-1 complex subunit sigma-3 (AP1S3) OTPCMV24 AP1S3_HUMAN Increases Expression [110]
BTB/POZ domain-containing protein 9 (BTBD9) OTWQ6GA3 BTBD9_HUMAN Decreases Expression [110]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Increases Expression [110]
Sorting nexin-18 (SNX18) OT68KT3X SNX18_HUMAN Increases Expression [110]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Decreases Expression [110]
Ras-related protein Rab-40C (RAB40C) OTM2V2R0 RB40C_HUMAN Increases Expression [110]
Protein ABHD1 (ABHD1) OTY56U02 ABHD1_HUMAN Decreases Expression [110]
CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) OTRKEVTY CK5P2_HUMAN Increases Expression [110]
Insulinoma-associated protein 2 (INSM2) OTNMQUZV INSM2_HUMAN Increases Expression [110]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Decreases Expression [110]
M-phase phosphoprotein 6 (MPHOSPH6) OT6E2S48 MPH6_HUMAN Decreases Expression [110]
Max-binding protein MNT (MNT) OTPC4ANL MNT_HUMAN Decreases Expression [110]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) OTVFRL8G TI17A_HUMAN Decreases Expression [110]
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) OTUKPFOK ROAA_HUMAN Decreases Expression [110]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Decreases Expression [110]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Decreases Expression [110]
Spindlin-2A (SPIN2A) OT93VTU4 SPI2A_HUMAN Increases Expression [110]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [110]
Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B) OTT2ZGSR ATF6B_HUMAN Increases Expression [110]
Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) OT0S09B3 PTN18_HUMAN Decreases Expression [110]
F-box-like/WD repeat-containing protein TBL1Y (TBL1Y) OTA0F7TM TBL1Y_HUMAN Decreases Expression [110]
Serine/threonine-protein phosphatase CPPED1 (CPPED1) OT88U8X5 CPPED_HUMAN Decreases Expression [110]
Suppressor of IKBKE 1 (SIKE1) OT5O11J0 SIKE1_HUMAN Increases Expression [110]
Mitochondrial nucleoid-associated protein 1 (MTNAP1) OT8FB2F8 CQ080_HUMAN Increases Expression [110]
Trichoplein keratin filament-binding protein (TCHP) OTVDMHSY TCHP_HUMAN Decreases Expression [110]
Immediate early response gene 2 protein (IER2) OT5OY8BO IER2_HUMAN Decreases Expression [110]
Protein misato homolog 1 (MSTO1) OT37XCNP MSTO1_HUMAN Decreases Expression [110]
PHD finger protein 23 (PHF23) OTVF5VZC PHF23_HUMAN Decreases Expression [110]
Specifically androgen-regulated gene protein (C1ORF116) OTPYEXDM SARG_HUMAN Increases Expression [110]
DET1- and DDB1-associated protein 1 (DDA1) OTAZIAIH DDA1_HUMAN Increases Expression [110]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Increases Expression [110]
Protein LSM14 homolog B (LSM14B) OTW646HP LS14B_HUMAN Increases Expression [110]
Transient receptor potential cation channel subfamily M member 6 (TRPM6) OTW7SPUV TRPM6_HUMAN Decreases Expression [110]
Protein amnionless (AMN) OTS1TJXG AMNLS_HUMAN Decreases Expression [110]
Complement factor H-related protein 5 (CFHR5) OT7BMOYE FHR5_HUMAN Decreases Expression [110]
Testis-expressed protein 12 (TEX12) OTXHQWTA TEX12_HUMAN Decreases Expression [110]
Calcium-binding protein 8 (CALN1) OTN2XE4T CABP8_HUMAN Increases Expression [110]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Increases Expression [110]
Polymerase delta-interacting protein 3 (POLDIP3) OTTB5SV7 PDIP3_HUMAN Increases Expression [110]
Large ribosomal subunit protein uL4m (MRPL4) OT8AE74Y RM04_HUMAN Decreases Expression [110]
FERM domain-containing protein 8 (FRMD8) OTTH5DUJ FRMD8_HUMAN Decreases Expression [110]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Decreases Expression [110]
Group XIIA secretory phospholipase A2 (PLA2G12A) OTHHCQ17 PG12A_HUMAN Increases Expression [110]
Testicular spindle-associated protein SHCBP1L (SHCBP1L) OTYGG089 SHP1L_HUMAN Decreases Expression [110]
GREB1-like protein (GREB1L) OTZTY5KQ GRB1L_HUMAN Increases Expression [110]
E3 ubiquitin-protein ligase makorin-2 (MKRN2) OTDD1V3O MKRN2_HUMAN Increases Expression [110]
Large subunit GTPase 1 homolog (LSG1) OTDAXJ9L LSG1_HUMAN Decreases Expression [110]
Oxysterol-binding protein-related protein 5 (OSBPL5) OTI1UJXT OSBL5_HUMAN Decreases Expression [110]
Nucleoporin-62 C-terminal-like protein (NUP62CL) OTEN1HET N62CL_HUMAN Increases Expression [110]
Oxysterol-binding protein-related protein 2 (OSBPL2) OTCK671N OSBL2_HUMAN Decreases Expression [110]
Ciliary microtubule inner protein 1 (CIMIP1) OTKOYVKF CMIP1_HUMAN Increases Expression [110]
Mediator of RNA polymerase II transcription subunit 28 (MED28) OTEDM1L5 MED28_HUMAN Decreases Expression [110]
EH domain-containing protein 4 (EHD4) OT7G5JTT EHD4_HUMAN Decreases Expression [110]
Translation initiation factor IF-3, mitochondrial (MTIF3) OTPQ7FPQ IF3M_HUMAN Increases Expression [110]
Kallikrein-15 (KLK15) OT7BVG17 KLK15_HUMAN Decreases Expression [110]
Chordin (CHRD) OTNM60Y1 CHRD_HUMAN Decreases Expression [110]
Sorting nexin-25 (SNX25) OT8JY8M1 SNX25_HUMAN Increases Expression [110]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) OT5HFZXU BACD3_HUMAN Decreases Expression [110]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [110]
Cystatin-9-like (CST9L) OT7GBIWW CST9L_HUMAN Increases Expression [110]
Cilia- and flagella-associated protein 68 (CFAP68) OTG4EK2P CFA68_HUMAN Decreases Expression [110]
tRNA (NSUN3) OTLBKU22 NSUN3_HUMAN Decreases Expression [110]
DENN domain-containing protein 2D (DENND2D) OTXEFJWM DEN2D_HUMAN Decreases Expression [110]
HAUS augmin-like complex subunit 4 (HAUS4) OTFIO49N HAUS4_HUMAN Decreases Expression [110]
PDZ domain-containing protein MAGIX (MAGIX) OT8EU651 MAGIX_HUMAN Increases Expression [110]
Tudor domain-containing protein 3 (TDRD3) OTG83E2C TDRD3_HUMAN Increases Expression [110]
Nuclear exosome regulator NRDE2 (NRDE2) OTJ1V33O NRDE2_HUMAN Increases Expression [110]
Proton-activated chloride channel (PACC1) OTKBS8CC PACC1_HUMAN Increases Expression [110]
Jupiter microtubule associated homolog 2 (JPT2) OTJGPA4T JUPI2_HUMAN Increases Expression [110]
Akirin-1 (AKIRIN1) OTINWTT9 AKIR1_HUMAN Decreases Expression [110]
DNA-directed RNA polymerase I subunit RPA2 (POLR1B) OTKREU8M RPA2_HUMAN Decreases Expression [110]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) OT2MNW8T PKHA5_HUMAN Increases Expression [110]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Increases Expression [110]
Dual specificity protein kinase CLK4 (CLK4) OTD38YJI CLK4_HUMAN Increases Expression [110]
Sp110 nuclear body protein (SP110) OTFW6WH7 SP110_HUMAN Decreases Expression [110]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) OT0X9WGR PATZ1_HUMAN Decreases Expression [110]
UPF0606 protein KIAA1549 (KIAA1549) OTA5B18F K1549_HUMAN Increases Expression [110]
CD209 antigen (CD209) OTCAX8NI CD209_HUMAN Decreases Expression [110]
Frizzled-3 (FZD3) OTIWDN78 FZD3_HUMAN Increases Expression [110]
Odorant-binding protein 2b (OBP2B) OTVKMIM4 OBP2B_HUMAN Increases Expression [110]
Proline-rich nuclear receptor coactivator 2 (PNRC2) OTE7W7Y5 PNRC2_HUMAN Increases Expression [110]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (B3GAT2) OTNSM9XP B3GA2_HUMAN Decreases Expression [110]
Anoctamin-2 (ANO2) OT650E98 ANO2_HUMAN Decreases Expression [110]
Mitochondrial dynamics protein MIEF1 (MIEF1) OTFSP3FS MID51_HUMAN Decreases Expression [110]
Scavenger receptor cysteine-rich type 1 protein M160 (CD163L1) OTZHN1XQ C163B_HUMAN Decreases Expression [110]
Matrix metalloproteinase-26 (MMP26) OT9O89KU MMP26_HUMAN Decreases Expression [110]
Teashirt homolog 2 (TSHZ2) OTZWBXXY TSH2_HUMAN Increases Expression [110]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) OTWHOVZS BAZ1A_HUMAN Decreases Expression [110]
CDC42 small effector protein 1 (CDC42SE1) OTV3MRFE C42S1_HUMAN Decreases Expression [110]
Cysteinyl leukotriene receptor 2 (CYSLTR2) OTRNEOZ0 CLTR2_HUMAN Decreases Expression [110]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Decreases Expression [110]
GPI mannosyltransferase 2 (PIGV) OTI6LT46 PIGV_HUMAN Increases Expression [110]
Probable ATP-dependent RNA helicase DDX28 (DDX28) OTIIHNYN DDX28_HUMAN Decreases Expression [110]
SPATS2-like protein (SPATS2L) OTFO07H8 SPS2L_HUMAN Increases Expression [110]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Decreases Expression [110]
Arginine and glutamate-rich protein 1 (ARGLU1) OTRVRZ4Z ARGL1_HUMAN Increases Expression [110]
Protein FAM118A (FAM118A) OT6EM97E F118A_HUMAN Decreases Expression [110]
Ankyrin repeat and SOCS box protein 6 (ASB6) OTFAJPSF ASB6_HUMAN Decreases Expression [110]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Decreases Expression [110]
Pre-mRNA-splicing factor CWC25 homolog (CWC25) OT96LFJH CWC25_HUMAN Decreases Expression [110]
Gamma-2-syntrophin (SNTG2) OTD8HJCD SNTG2_HUMAN Decreases Expression [110]
Placenta-specific gene 8 protein (PLAC8) OT3SYRUJ PLAC8_HUMAN Decreases Expression [110]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [110]
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) OT452ZDC ADA22_HUMAN Increases Expression [110]
SLAIN motif-containing protein 2 (SLAIN2) OTSM5QIO SLAI2_HUMAN Increases Expression [110]
RNA-binding protein 27 (RBM27) OTBVP6VJ RBM27_HUMAN Increases Expression [110]
Arginine-glutamic acid dipeptide repeats protein (RERE) OT3G4GBZ RERE_HUMAN Increases Expression [110]
Cornulin (CRNN) OTAORBR4 CRNN_HUMAN Increases Expression [110]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) OTP9COQT PISD_HUMAN Decreases Expression [110]
ATP-binding cassette sub-family F member 2 (ABCF2) OTXIBZ3N ABCF2_HUMAN Decreases Expression [110]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) OTHTAM54 AAKG2_HUMAN Decreases Expression [110]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Increases Expression [110]
LIM domain-containing protein 1 (LIMD1) OTN1CG6R LIMD1_HUMAN Decreases Expression [110]
Armadillo repeat-containing X-linked protein 3 (ARMCX3) OTMG7RWW ARMX3_HUMAN Increases Expression [110]
Max-like protein X (MLX) OTZ74KFI MLX_HUMAN Decreases Expression [110]
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) OT6GWW1P NPCL1_HUMAN Increases Expression [110]
Adhesion G protein-coupled receptor E2 (ADGRE2) OTUYJVYG AGRE2_HUMAN Decreases Expression [110]
Dimethylglycine dehydrogenase, mitochondrial (DMGDH) OTPJEWQ8 M2GD_HUMAN Increases Expression [110]
Importin-11 (IPO11) OTG19WN0 IPO11_HUMAN Decreases Expression [110]
Methyl-CpG-binding domain protein 1 (MBD1) OTD19VO6 MBD1_HUMAN Increases Expression [110]
Adherens junction-associated protein 1 (AJAP1) OTAAW121 AJAP1_HUMAN Decreases Expression [110]
Nuclear pore complex protein Nup50 (NUP50) OTOZ98K3 NUP50_HUMAN Decreases Expression [110]
Transcription factor-like 5 protein (TCFL5) OTJL4348 TCFL5_HUMAN Decreases Expression [110]
Malignant T-cell-amplified sequence 1 (MCTS1) OT7SAOJP MCTS1_HUMAN Increases Expression [110]
Signal-transducing adaptor protein 1 (STAP1) OTUTZH0W STAP1_HUMAN Increases Expression [110]
Hippocalcin-like protein 4 (HPCAL4) OT793RNP HPCL4_HUMAN Decreases Expression [110]
Ornithine decarboxylase antizyme 3 (OAZ3) OT8Q5PVB OAZ3_HUMAN Increases Expression [110]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Increases Expression [110]
Rab effector Noc2 (RPH3AL) OT9VFJEL RPH3L_HUMAN Increases Expression [110]
Trinucleotide repeat-containing gene 6B protein (TNRC6B) OTGVT0SH TNR6B_HUMAN Increases Expression [110]
Protein Smaug homolog 1 (SAMD4A) OT4MKCC8 SMAG1_HUMAN Increases Expression [110]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [110]
Solute carrier family 22 member 13 (SLC22A13) OTM96T5U S22AD_HUMAN Increases Expression [110]
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) OTUN9GUS NOD1_HUMAN Decreases Expression [110]
Inversin (INVS) OT8KPESR INVS_HUMAN Increases Expression [110]
F-box/WD repeat-containing protein 1A (BTRC) OT2EZDGR FBW1A_HUMAN Increases Expression [110]
Sodium/hydrogen exchanger 8 (SLC9A8) OTR56QTT SL9A8_HUMAN Decreases Expression [110]
Protein strawberry notch homolog 2 (SBNO2) OT1C6J3K SBNO2_HUMAN Decreases Expression [110]
Serine/threonine-protein kinase SIK3 (SIK3) OTH0V1L5 SIK3_HUMAN Decreases Expression [110]
Hypoxia-inducible factor 3-alpha (HIF3A) OTPWAAMC HIF3A_HUMAN Decreases Expression [110]
Long-chain fatty acid transport protein 6 (SLC27A6) OT2AJU6L S27A6_HUMAN Increases Expression [110]
RNA-binding motif protein, X-linked 2 (RBMX2) OTGGU7N1 RBMX2_HUMAN Decreases Expression [110]
Nucleolar complex protein 2 homolog (NOC2L) OTNT7R33 NOC2L_HUMAN Decreases Expression [110]
DDB1- and CUL4-associated factor 1 (DCAF1) OT3ZDVOE DCAF1_HUMAN Decreases Expression [110]
Meiosis regulator and mRNA stability factor 1 (MARF1) OTYRJ4V2 MARF1_HUMAN Increases Expression [110]
Cyanocobalamin reductase / alkylcobalamin dealkylase (MMACHC) OTX0TT3W MMAC_HUMAN Increases Expression [110]
Protocadherin gamma-A9 (PCDHGA9) OTKJE2H2 PCDG9_HUMAN Increases Expression [110]
Protocadherin gamma-A3 (PCDHGA3) OTTOGYJA PCDG3_HUMAN Decreases Expression [110]
Doublesex- and mab-3-related transcription factor 1 (DMRT1) OT5PU9U1 DMRT1_HUMAN Decreases Expression [110]
RNA-binding protein 8A (RBM8A) OT5SR6G0 RBM8A_HUMAN Decreases Expression [110]
Gap junction alpha-3 protein (GJA3) OTXV6ETF CXA3_HUMAN Increases Expression [110]
Peroxisomal membrane protein 4 (PXMP4) OTNDYSHU PXMP4_HUMAN Increases Expression [110]
Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1) OTSPVITK STYL1_HUMAN Decreases Expression [110]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Increases Expression [110]
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) OT4ZSEEE IF2B2_HUMAN Increases Expression [110]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [111]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Increases Expression [111]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [111]
Protein Mis18-beta (OIP5) OTI5C2DE MS18B_HUMAN Decreases Expression [111]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [111]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [111]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [111]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [111]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [111]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [111]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [111]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Decreases Expression [111]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [111]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [111]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [111]
Arylacetamide deacetylase (AADAC) OT8VACT2 AAAD_HUMAN Increases Expression [111]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Decreases Expression [111]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [111]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [111]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [111]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [111]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [111]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [111]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Expression [111]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Decreases Expression [111]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Increases Expression [111]
G-protein-signaling modulator 2 (GPSM2) OT6RPMRM GPSM2_HUMAN Decreases Expression [111]
55 kDa erythrocyte membrane protein (MPP1) OTA2ENZQ EM55_HUMAN Decreases Expression [111]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [111]
Magnesium transporter NIPA4 (NIPAL4) OT43JC9A NIPA4_HUMAN Increases Expression [111]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Increases Expression [111]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [111]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [111]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [111]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [111]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [111]
DNA excision repair protein ERCC-6-like (ERCC6L) OTE9V7D9 ERC6L_HUMAN Decreases Expression [111]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [111]
Fidgetin (FIGN) OTJF6EZR FIGN_HUMAN Decreases Expression [111]
RRP12-like protein (RRP12) OTQQAEH4 RRP12_HUMAN Increases Expression [111]
Alkaline ceramidase 2 (ACER2) OTS3DDE5 ACER2_HUMAN Increases Expression [111]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [111]
Transmembrane protein 71 (TMEM71) OTA7W26O TMM71_HUMAN Decreases Expression [111]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [111]
Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) OTO4UIDB CCBE1_HUMAN Decreases Expression [111]
Alkylglycerol monooxygenase (AGMO) OTGMAHAT ALKMO_HUMAN Decreases Expression [111]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [111]
Kinesin-like protein KIF18B (KIF18B) OTOBUDOE KI18B_HUMAN Decreases Expression [111]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [111]
Kinetochore protein Spc24 (SPC24) OT1HVYV4 SPC24_HUMAN Decreases Expression [111]
Meiosis-specific nuclear structural protein 1 (MNS1) OT67F3JQ MNS1_HUMAN Decreases Expression [111]
Kelch repeat and BTB domain-containing protein 8 (KBTBD8) OTO8X1UF KBTB8_HUMAN Increases Expression [111]
Kinetochore scaffold 1 (KNL1) OT4Q3LHV KNL1_HUMAN Decreases Expression [111]
Endonuclease 8-like 3 (NEIL3) OTBCI2NS NEIL3_HUMAN Decreases Expression [111]
Enkurin (ENKUR) OTXXBBQT ENKUR_HUMAN Increases Expression [111]
Transcription initiation factor TFIID subunit 4B (TAF4B) OTCICY31 TAF4B_HUMAN Increases Expression [111]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [111]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [111]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [111]
Guanine nucleotide exchange factor C9orf72 (C9ORF72) OT0WH38E CI072_HUMAN Increases Expression [111]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Decreases Expression [111]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [111]
Transmembrane protein 106C (TMEM106C) OTDOD9OQ T106C_HUMAN Decreases Expression [111]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [111]
Fanconi anemia group J protein (BRIP1) OT38QBD4 FANCJ_HUMAN Decreases Expression [111]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [111]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [111]
Ankyrin repeat family A protein 2 (ANKRA2) OTLSLV5A ANRA2_HUMAN Increases Expression [111]
Kinetochore protein Spc25 (SPC25) OTCAS0OH SPC25_HUMAN Decreases Expression [111]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [111]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7) OT3QER33 ENTP7_HUMAN Increases Expression [111]
Phospholipid scramblase 4 (PLSCR4) OT2AMYLY PLS4_HUMAN Decreases Expression [111]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Decreases Expression [111]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [111]
GTPase IMAP family member 2 (GIMAP2) OTHH2EFT GIMA2_HUMAN Decreases Expression [111]
Kelch-like protein 21 (KLHL21) OT28Y2LQ KLH21_HUMAN Increases Expression [111]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [111]
E3 ubiquitin-protein ligase RNF114 (RNF114) OTF06FRP RN114_HUMAN Increases Expression [111]
POTE ankyrin domain family member F (POTEF) OTV3WXYE POTEF_HUMAN Decreases Expression [112]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Increases Expression [112]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [112]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [112]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Decreases Expression [112]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [112]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Decreases Expression [112]
Proteasome subunit alpha type-2 (PSMA2) OTJRT2ZL PSA2_HUMAN Decreases Expression [112]
Endoplasmic reticulum resident protein 29 (ERP29) OTNKANMH ERP29_HUMAN Decreases Expression [112]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Decreases Expression [112]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [112]
Lambda-crystallin homolog (CRYL1) OT0SJSJM CRYL1_HUMAN Increases Expression [112]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Decreases Expression [152]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Secretion [153]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Decreases Expression [154]
Tumor necrosis factor ligand superfamily member 11 (TNFSF11) OTJEPKEQ TNF11_HUMAN Decreases Expression [153]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Increases Expression [152]
Protein SLC31A2 (SLC31A2) OTQC136Q COPT2_HUMAN Increases Expression [155]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [152]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [154]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) OT5QRF09 TNF14_HUMAN Increases Expression [156]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [113]
Integral membrane protein 2A (ITM2A) OT590V63 ITM2A_HUMAN Increases Expression [117]
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) OTUG02U7 KHDR3_HUMAN Increases Expression [117]
Dual specificity protein phosphatase 14 (DUSP14) OTGODFCR DUS14_HUMAN Increases Expression [155]
CCN family member 4 (CCN4) OT69BER9 CCN4_HUMAN Decreases Expression [115]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [117]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [157]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Increases Secretion [158]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Decreases Expression [159]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [117]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Secretion [160]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Increases Expression [155]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [161]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [162]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [159]
Dihydropteridine reductase (QDPR) OTSKOIUX DHPR_HUMAN Decreases Activity [163]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [164]
Intestinal-type alkaline phosphatase (ALPI) OTTQ468O PPBI_HUMAN Increases Activity [165]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Increases Expression [166]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [159]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [167]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Decreases Expression [154]
Desmin (DES) OTI09KBW DESM_HUMAN Increases Expression [168]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [169]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [152]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [170]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [171]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Increases Expression [172]
Adenosine receptor A2b (ADORA2B) OTCDYBBP AA2BR_HUMAN Increases Expression [172]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Decreases Expression [173]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [117]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Decreases Expression [174]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [167]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [174]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Expression [175]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [175]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [152]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Increases Expression [117]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [155]
Collagen alpha-4(IV) chain (COL4A4) OT9G0MCT CO4A4_HUMAN Increases Expression [168]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Decreases Expression [117]
Actin-related protein 2 (ACTR2) OT3C8U5T ARP2_HUMAN Decreases Expression [154]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [160]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [117]
Protein S100-A12 (S100A12) OTF9IIXW S10AC_HUMAN Increases Expression [152]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [152]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [170]
RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2) OTL9Y4IO PPIL2_HUMAN Decreases Expression [154]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [167]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [117]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [154]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Decreases Expression [155]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Decreases Expression [169]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (B3GNT9) OTO385AU B3GN9_HUMAN Increases Expression [117]
Jouberin (AHI1) OT8K2YWY AHI1_HUMAN Increases Expression [176]
Retinoic acid-induced protein 3 (GPRC5A) OTPOCWR7 RAI3_HUMAN Increases Expression [117]
Protein Jumonji (JARID2) OT14UM8H JARD2_HUMAN Decreases Expression [119]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [167]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [117]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) OTH91ETM SIA7E_HUMAN Decreases Expression [117]
Protein FAM117A (FAM117A) OT2FBGGV F117A_HUMAN Decreases Expression [119]
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) OTG6F93V PPIP2_HUMAN Increases Expression [117]
Bcl-2-like protein 12 (BCL2L12) OTS6IFZY B2L12_HUMAN Decreases Expression [177]
Mid1-interacting protein 1 (MID1IP1) OTFCORJM M1IP1_HUMAN Increases Expression [117]
AP-5 complex subunit sigma-1 (AP5S1) OTGS53SC AP5S1_HUMAN Increases Expression [119]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [117]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [117]
Forkhead box protein J3 (FOXJ3) OTXAUJ47 FOXJ3_HUMAN Decreases Expression [154]
RWD domain-containing protein 3 (RWDD3) OTE76DY5 RWDD3_HUMAN Increases Expression [119]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Decreases Response To Substance [178]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Affects Response To Substance [120]
Mediator of RNA polymerase II transcription subunit 15 (MED15) OT0D0JVD MED15_HUMAN Affects Response To Substance [120]
Guanine nucleotide-binding protein subunit alpha-11 (GNA11) OT0K99TO GNA11_HUMAN Affects Response To Substance [120]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2) OT0KHLY2 SUCB2_HUMAN Affects Response To Substance [120]
Alpha-centractin (ACTR1A) OT1QAU16 ACTZ_HUMAN Affects Response To Substance [120]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Affects Response To Substance [120]
DNA-directed RNA polymerase I subunit RPA12 (POLR1H) OT30S3SB RPA12_HUMAN Decreases Response To Substance [179]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [120]
Cip1-interacting zinc finger protein (CIZ1) OT3UKHPI CIZ1_HUMAN Affects Response To Substance [120]
Transcobalamin-2 (TCN2) OT41D0L3 TCO2_HUMAN Affects Metabolism [180]
Elafin (PI3) OT47MTC3 ELAF_HUMAN Affects Response To Substance [120]
CCR4-NOT transcription complex subunit 3 (CNOT3) OT4D5Z9L CNOT3_HUMAN Affects Response To Substance [120]
ATP-dependent RNA helicase DHX15 (DHX15) OT4F98TK DHX15_HUMAN Affects Response To Substance [120]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Affects Response To Substance [120]
PRELI domain containing protein 3B (PRELID3B) OT4TRT4K PLD3B_HUMAN Affects Response To Substance [120]
Exocyst complex component 7 (EXOC7) OT4YA137 EXOC7_HUMAN Affects Response To Substance [120]
Large proline-rich protein BAG6 (BAG6) OT4Z0S2U BAG6_HUMAN Affects Response To Substance [120]
Transducin-like enhancer protein 1 (TLE1) OT50MRZ1 TLE1_HUMAN Affects Response To Substance [120]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Affects Response To Substance [120]
Transcription termination factor 2 (TTF2) OT5LJOWM TTF2_HUMAN Affects Response To Substance [120]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Response To Substance [121]
Nuclear pore complex protein Nup88 (NUP88) OT647WOR NUP88_HUMAN Affects Response To Substance [120]
Mitochondrial enolase superfamily member 1 (ENOSF1) OT65D3ZK ENOF1_HUMAN Affects Response To Substance [120]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Response To Substance [181]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [120]
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1) OT6GB3WR PPRC1_HUMAN Affects Response To Substance [120]
Follistatin-related protein 1 (FSTL1) OT6KEZUD FSTL1_HUMAN Affects Response To Substance [120]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Affects Response To Substance [120]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Affects Response To Substance [120]
Semenogelin-1 (SEMG1) OT6Z4BPQ SEMG1_HUMAN Affects Response To Substance [120]
Glutamate receptor ionotropic, NMDA 3B (GRIN3B) OT7T1OJP NMD3B_HUMAN Affects Response To Substance [120]
Interferon-inducible protein AIM2 (AIM2) OT86QUI8 AIM2_HUMAN Affects Response To Substance [120]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Affects Response To Substance [120]
Peroxisomal membrane protein 11A (PEX11A) OT8MJ9CJ PX11A_HUMAN Affects Response To Substance [120]
Mediator of RNA polymerase II transcription subunit 16 (MED16) OT8SCI48 MED16_HUMAN Affects Response To Substance [120]
Annexin A11 (ANXA11) OT8SRY1C ANX11_HUMAN Affects Response To Substance [120]
ER lumen protein-retaining receptor 1 (KDELR1) OT8YBS5G ERD21_HUMAN Affects Response To Substance [120]
Prostate tumor-overexpressed gene 1 protein (PTOV1) OT94WT5X PTOV1_HUMAN Affects Response To Substance [120]
Cyclic AMP-responsive element-binding protein 3 (CREB3) OT9617UO CREB3_HUMAN Affects Response To Substance [120]
Fibromodulin (FMOD) OT9EJ5H8 FMOD_HUMAN Affects Response To Substance [120]
Epsilon-sarcoglycan (SGCE) OT9F17JB SGCE_HUMAN Affects Response To Substance [120]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Affects Response To Substance [120]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Affects Response To Substance [120]
Extended synaptotagmin-1 (ESYT1) OTA8NSJF ESYT1_HUMAN Affects Response To Substance [120]
Cleavage and polyadenylation specificity factor subunit 1 (CPSF1) OTAU1KOM CPSF1_HUMAN Affects Response To Substance [120]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Affects Response To Substance [120]
Protein DGCR6 (DGCR6) OTBOXM33 DGCR6_HUMAN Affects Response To Substance [120]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Affects Response To Substance [120]
Potassium channel subfamily K member 1 (KCNK1) OTBXPTKX KCNK1_HUMAN Affects Response To Substance [120]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Response To Substance [182]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Response To Substance [181]
Creatine kinase U-type, mitochondrial (CKMT1A) OTCINHH5 KCRU_HUMAN Affects Response To Substance [120]
KRR1 small subunit processome component homolog (KRR1) OTCMJ3K3 KRR1_HUMAN Affects Response To Substance [120]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Affects Response To Substance [120]
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) OTCYYCAC HGS_HUMAN Affects Response To Substance [120]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) OTD13PJN RBMS1_HUMAN Affects Response To Substance [120]
Src kinase-associated phosphoprotein 1 (SKAP1) OTD4ZKAL SKAP1_HUMAN Affects Response To Substance [120]
Multiple epidermal growth factor-like domains protein 9 (MEGF9) OTDQWTY4 MEGF9_HUMAN Affects Response To Substance [120]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) OTDS5WAU PIN1_HUMAN Affects Response To Substance [120]
Cytoskeleton-associated protein 4 (CKAP4) OTDUC9ME CKAP4_HUMAN Affects Response To Substance [120]
Cystatin-SN (CST1) OTE4I83Q CYTN_HUMAN Affects Response To Substance [120]
Pseudouridine-5'-phosphatase (PUDP) OTEPEJLX HDHD1_HUMAN Affects Response To Substance [120]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Affects Response To Substance [120]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Affects Response To Substance [120]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Affects Response To Substance [120]
Endophilin-B2 (SH3GLB2) OTF7BB9S SHLB2_HUMAN Affects Response To Substance [120]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) OTF7CGO2 2A5G_HUMAN Affects Response To Substance [120]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) OTFHWIY8 DHRS2_HUMAN Affects Response To Substance [120]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Response To Substance [183]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Increases Response To Substance [121]
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) OTFRWOLM HNRH1_HUMAN Affects Response To Substance [120]
m7GpppN-mRNA hydrolase (DCP2) OTG3VKPS DCP2_HUMAN Affects Response To Substance [120]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Affects Response To Substance [120]
Tomoregulin-1 (TMEFF1) OTH6M3CH TEFF1_HUMAN Affects Response To Substance [120]
Phospholipid-transporting ATPase ABCA3 (ABCA3) OTH6MSKQ ABCA3_HUMAN Decreases Response To Substance [184]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) OTHIXBGW GBG11_HUMAN Affects Response To Substance [120]
Nectin-2 (NECTIN2) OTIE0W6O NECT2_HUMAN Affects Response To Substance [120]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Affects Response To Substance [120]
Serine hydroxymethyltransferase, cytosolic (SHMT1) OTIINA3J GLYC_HUMAN Affects Response To Substance [185]
Spartin (SPART) OTIVOS2I SPART_HUMAN Affects Response To Substance [120]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Affects Response To Substance [120]
Polycomb protein EED (EED) OTJFHCDF EED_HUMAN Affects Response To Substance [120]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Affects Response To Substance [120]
Unconventional myosin-VI (MYO6) OTJQYRC7 MYO6_HUMAN Affects Response To Substance [120]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Affects Response To Substance [120]
Interferon regulatory factor 6 (IRF6) OTKJ44EV IRF6_HUMAN Affects Response To Substance [120]
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) OTKMW34I SH3L3_HUMAN Affects Response To Substance [120]
Ras-related protein Rab-1A (RAB1A) OTKPHRD0 RAB1A_HUMAN Affects Response To Substance [120]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Affects Response To Substance [120]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Response To Substance [186]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Decreases Response To Substance [187]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Increases Response To Substance [121]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Affects Response To Substance [120]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Affects Response To Substance [120]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8) OTMEAWKO NDUS8_HUMAN Affects Response To Substance [120]
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) OTMKHVWC C1TC_HUMAN Affects Response To Substance [188]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Affects Response To Substance [120]
Glycine cleavage system H protein, mitochondrial (GCSH) OTNC1OKA GCSH_HUMAN Affects Response To Substance [120]
Pulmonary surfactant-associated protein D (SFTPD) OTNKPDJC SFTPD_HUMAN Increases ADR [33]
Hepatoma-derived growth factor-related protein 3 (HDGFL3) OTNN7WYH HDGR3_HUMAN Affects Response To Substance [120]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) OTNONPMB GLCNE_HUMAN Affects Response To Substance [120]
Splicing factor 3B subunit 1 (SF3B1) OTNTX2DG SF3B1_HUMAN Affects Response To Substance [120]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Affects Response To Substance [120]
ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4) OTOA8VAL AR6P4_HUMAN Affects Response To Substance [120]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Affects Response To Substance [120]
Solute carrier family 52, riboflavin transporter, member 2 (SLC52A2) OTPC6NXA S52A2_HUMAN Affects Response To Substance [120]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Affects Response To Substance [120]
Centrosomal protein of 57 kDa (CEP57) OTPOHLIX CEP57_HUMAN Affects Response To Substance [120]
CD99 antigen (CD99) OTPUZ5DE CD99_HUMAN Affects Response To Substance [120]
Large ribosomal subunit protein uL23 (RPL23A) OTPYLCCX RL23A_HUMAN Affects Response To Substance [120]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [189]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Affects Response To Substance [190]
45 kDa calcium-binding protein (SDF4) OTQ7WFYW CAB45_HUMAN Affects Response To Substance [120]
Calsyntenin-1 (CLSTN1) OTQN35G2 CSTN1_HUMAN Affects Response To Substance [120]
Double-stranded RNA-specific adenosine deaminase (ADAR) OTQNOHR8 DSRAD_HUMAN Decreases Response To Substance [191]
Keratin, type I cytoskeletal 23 (KRT23) OTQW6UAG K1C23_HUMAN Increases Response To Substance [121]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Response To Substance [121]
Cyclin-dependent kinase 2-associated protein 2 (CDK2AP2) OTR99SJ8 CDKA2_HUMAN Affects Response To Substance [120]
TNFAIP3-interacting protein 1 (TNIP1) OTRAOTEW TNIP1_HUMAN Affects Response To Substance [181]
Methyl-CpG-binding domain protein 3 (MBD3) OTRL76H5 MBD3_HUMAN Affects Response To Substance [120]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Decreases Response To Substance [183]
Dr1-associated corepressor (DRAP1) OTRWLF6D NC2A_HUMAN Affects Response To Substance [120]
Formin-binding protein 1 (FNBP1) OTSJ5KKA FNBP1_HUMAN Affects Response To Substance [120]
Lumican (LUM) OTSRC874 LUM_HUMAN Decreases Response To Substance [121]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Response To Substance [121]
NKG2-C type II integral membrane protein (KLRC2) OTT4N86S NKG2C_HUMAN Affects Response To Substance [120]
Talin-1 (TLN1) OTTD2YXM TLN1_HUMAN Affects Response To Substance [120]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Decreases Response To Substance [121]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Affects Response To Substance [120]
CASP8-associated protein 2 (CASP8AP2) OTTWT68S C8AP2_HUMAN Increases Response To Substance [181]
Rab11 family-interacting protein 2 (RAB11FIP2) OTTX9RWE RFIP2_HUMAN Affects Response To Substance [120]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Affects Response To Substance [120]
AMP deaminase 1 (AMPD1) OTU17BCI AMPD1_HUMAN Affects Response To Substance [190]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Affects Response To Substance [120]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Affects Response To Substance [120]
AT-rich interactive domain-containing protein 5B (ARID5B) OTUQ4CQY ARI5B_HUMAN Affects Abundance [192]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Affects Response To Substance [120]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Decreases Response To Substance [121]
Membralin (TMEM259) OTVH9HD8 MBRL_HUMAN Affects Response To Substance [120]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Decreases Abundance [138]
Ensconsin (MAP7) OTVSSJ33 MAP7_HUMAN Affects Response To Substance [120]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) OTVT1Q25 B3GN3_HUMAN Affects Response To Substance [120]
E3 ubiquitin-protein ligase KCMF1 (KCMF1) OTVTKFAU KCMF1_HUMAN Affects Response To Substance [120]
PHD finger protein 10 (PHF10) OTWDR4EX PHF10_HUMAN Affects Response To Substance [120]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Affects Response To Substance [120]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Affects Response To Substance [120]
Arfaptin-1 (ARFIP1) OTXHWO6M ARFP1_HUMAN Affects Response To Substance [120]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Affects Response To Substance [120]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Affects Response To Substance [120]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Affects Response To Substance [120]
Carbamoyl-phosphate synthase , mitochondrial (CPS1) OTXV8NSR CPSM_HUMAN Affects Response To Substance [120]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) OTY2PROB P3C2B_HUMAN Affects Response To Substance [120]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Increases ADR [33]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Increases Response To Substance [121]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Affects Response To Substance [120]
Ena/VASP-like protein (EVL) OTZ8ZDNY EVL_HUMAN Affects Response To Substance [120]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Affects Response To Substance [181]
Lysine-specific demethylase 6A (KDM6A) OTZM3MJJ KDM6A_HUMAN Affects Response To Substance [120]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Affects Response To Substance [120]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Affects Response To Substance [120]
------------------------------------------------------------------------------------
⏷ Show the Full List of 1290 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Ph+ Acute Lymphoblastic Leukemia DCM6UWN N. A. Phase 4 [193]
Acute Lymphoblastic Leukemia DCIWJEH N. A. Phase 2 [194]
Acute Lymphoblastic Leukemia DCCALVA N. A. Phase 2 [195]
B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 DCW6FDO N. A. Phase 1 [196]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT00707083) Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
2 Dexamethasone FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3447).
4 Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17. doi: 10.1056/NEJMoa2021436.
5 Methotrexate FDA Label
6 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 040632.
7 Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for ... Trials. 2015 Mar 4;16:77.
8 ClinicalTrials.gov (NCT04136366) The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy. U.S. National Institutes of Health.
9 ClinicalTrials.gov (NCT04352465) Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients. U.S. National Institutes of Health.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034238)
11 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
12 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
13 Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol. 2005 Mar;67(3):845-55.
14 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
15 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
16 Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor. Toxicol Appl Pharmacol. 2020 Aug 15;401:115118. doi: 10.1016/j.taap.2020.115118. Epub 2020 Jul 1.
17 Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicol In Vitro. 2010 Apr;24(3):822-9. doi: 10.1016/j.tiv.2009.12.011. Epub 2009 Dec 13.
18 NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells. Biochem Biophys Res Commun. 2001 Dec 14;289(4):851-6. doi: 10.1006/bbrc.2001.6067.
19 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
20 Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
21 Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
22 Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605.
23 Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
24 Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90.
25 Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.
26 Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7.
27 In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84.
28 Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.
29 Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
30 Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91.
31 Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota. Food Chem Toxicol. 2019 Sep;131:110562. doi: 10.1016/j.fct.2019.110562. Epub 2019 Jun 7.
32 Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
33 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
34 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
35 Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39.
36 Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Steroids. 2006 Oct;71(10):895-901.
37 Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):718-23.
38 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
39 Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos. 2009 Jul;30(5):241-58.
40 The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro. 2011 Feb;25(1):80-90.
41 Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
42 Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun. 2002 Mar 1;291(3):680-6. doi: 10.1006/bbrc.2002.6510.
43 Glucocorticoids affect 24 h clock genes expression in human adipose tissue explant cultures. PLoS One. 2012;7(12):e50435. doi: 10.1371/journal.pone.0050435. Epub 2012 Dec 10.
44 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
45 Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res. 2005 Sep 1;11(17):6333-41. doi: 10.1158/1078-0432.CCR-05-0148.
46 Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4 upregulation in primary human hepatocytes. Pharmacol Rep. 2013;65(5):1322-35. doi: 10.1016/s1734-1140(13)71491-9.
47 Dexamethasone affects Fas- and serum deprivation-induced cell death of human osteoblastic cells through survivin regulation. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1153-65. doi: 10.1177/039463201002300419.
48 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
49 Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
50 G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.
51 Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clin Cancer Res. 2005 Sep 1;11(17):6342-51. doi: 10.1158/1078-0432.CCR-05-0596.
52 Male pseudohermaphroditism with hypertension due to a 17alpha-hydroxylation deficiency. Clin Endocrinol (Oxf). 1976 Jan;5(1):53-61.
53 Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells. Curr Med Sci. 2019 Jun;39(3):356-362. doi: 10.1007/s11596-019-2043-1. Epub 2019 Jun 17.
54 Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L249-57. doi: 10.1152/ajplung.00088.2006. Epub 2006 Sep 22.
55 Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells. Immunopharmacology. 1994 Jan-Feb;27(1):43-55. doi: 10.1016/0162-3109(94)90006-x.
56 Glucocorticoid regulation of human eosinophil gene expression. J Steroid Biochem Mol Biol. 2003 Mar;84(4):441-52. doi: 10.1016/s0960-0760(03)00065-7.
57 Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure. Arch Ophthalmol. 2008 Dec;126(12):1700-6. doi: 10.1001/archophthalmol.2008.512.
58 Effects of inhaled beclomethasone compared to systemic dexamethasone on lung inflammation in preterm infants at risk of chronic lung disease. Pediatr Pulmonol. 1999 Jun;27(6):383-7. doi: 10.1002/(sici)1099-0496(199906)27:6<383::aid-ppul4>3.0.co;2-v.
59 Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000 May;130(2):289-98. doi: 10.1038/sj.bjp.0703272.
60 1 alpha,25-(OH)2 vitamin D3 enhances expression of the genes encoding Ca(2+)-binding proteins MRP-8 and MRP-14. Am J Physiol. 1992 Jan;262(1 Pt 1):C235-42. doi: 10.1152/ajpcell.1992.262.1.C235.
61 Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC Musculoskelet Disord. 2011 Apr 27;12(1):82. doi: 10.1186/1471-2474-12-82.
62 Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma. Eur Respir J. 2006 Jun;27(6):1160-7. doi: 10.1183/09031936.06.00078605. Epub 2006 Mar 1.
63 Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med. 1997 Feb;155(2):704-10. doi: 10.1164/ajrccm.155.2.9032216.
64 Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
65 Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
66 Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms. Toxicol Sci. 2015 Feb;143(2):441-53. doi: 10.1093/toxsci/kfu243. Epub 2014 Dec 1.
67 Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. Immunology. 1992 Apr;75(4):674-9.
68 Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung. J Clin Invest. 1989 Apr;83(4):1191-7. doi: 10.1172/JCI114000.
69 Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. Horm Metab Res. 2005 Oct;37(10):593-601. doi: 10.1055/s-2005-870525.
70 Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation. Toxicol Sci. 2012 Feb;125(2):488-95. doi: 10.1093/toxsci/kfr304. Epub 2011 Nov 1.
71 Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
72 Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum. 2006 Nov;54(11):3513-22. doi: 10.1002/art.22170.
73 Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009 Feb;30(2):348-55. doi: 10.1093/carcin/bgn266. Epub 2008 Nov 26.
74 Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes. J Neuroimmunol. 1999 Mar 1;95(1-2):165-73. doi: 10.1016/s0165-5728(99)00011-9.
75 [A study on the heterogeneous apoptosis of lymphocytes, eosinophils, and neutrophils from peripheral blood of asthmatic patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2003 Oct;26(10):610-4.
76 Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. Asian J Androl. 2008 Jul;10(4):635-41. doi: 10.1111/j.1745-7262.2008.00352.x. Epub 2007 Dec 20.
77 Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res. 2005 Sep 1;11(17):6352-8. doi: 10.1158/1078-0432.CCR-04-1931.
78 Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology. 2009 Apr 28;258(2-3):148-56. doi: 10.1016/j.tox.2009.01.016. Epub 2009 Jan 22.
79 Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J Leukoc Biol. 1999 Dec;66(6):909-14. doi: 10.1002/jlb.66.6.909.
80 Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. Food Chem Toxicol. 2023 Sep;179:113949. doi: 10.1016/j.fct.2023.113949. Epub 2023 Jul 17.
81 Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 2006 Apr 15;107(8):3221-8. doi: 10.1182/blood-2005-07-2843. Epub 2005 Dec 15.
82 Cyclic changes in the expression of p57(kip2) in human endometrium and its regulation by steroid hormones in endometrial stromal cells in vitro. Reprod Sci. 2012 Jan;19(1):92-101. doi: 10.1177/1933719111414209. Epub 2011 Nov 7.
83 Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol. 1998 Sep 15;161(6):2723-30.
84 Inhibitory effect of glucocorticoids on human-cloned 5-hydroxytryptamine3A receptor expressed in xenopus oocytes. Anesthesiology. 2004 Sep;101(3):660-5. doi: 10.1097/00000542-200409000-00014.
85 MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2023 Jun;39(3):867-883. doi: 10.1007/s10565-021-09645-6. Epub 2021 Sep 19.
86 p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol. 2005 Jun;19(6):1569-83. doi: 10.1210/me.2004-0528. Epub 2005 Apr 7.
87 Inhibitory effect of glucocorticoid for osteoblast apoptosis induced by activated peripheral blood mononuclear cells. Endocrinology. 1998 Apr;139(4):2032-40. doi: 10.1210/endo.139.4.5932.
88 Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring. Cell Biol Toxicol. 2023 Oct;39(5):2051-2067. doi: 10.1007/s10565-021-09691-0. Epub 2022 Mar 4.
89 Bisphenol A induces differentiation of human preadipocytes in the absence of glucocorticoid and is inhibited by an estrogen-receptor antagonist. Nutr Diabetes. 2014 Jan 13;4(1):e102. doi: 10.1038/nutd.2013.43.
90 Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone. Am J Physiol Cell Physiol. 2000 Sep;279(3):C762-70. doi: 10.1152/ajpcell.2000.279.3.C762.
91 Differential effect of dexamethasone on cell death and STAT5 activation during in vitro eosinopoiesis. Br J Haematol. 2003 Dec;123(5):933-41. doi: 10.1046/j.1365-2141.2003.04700.x.
92 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
93 The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem. 1997 Nov 7;272(45):28471-8. doi: 10.1074/jbc.272.45.28471.
94 Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur J Cancer. 2006 Dec;42(18):3287-93. doi: 10.1016/j.ejca.2006.07.018. Epub 2006 Oct 27.
95 Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology. 2005 Mar;146(3):1391-7. doi: 10.1210/en.2004-1152. Epub 2004 Dec 2.
96 Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Clin Exp Immunol. 2000 Oct;122(1):20-7. doi: 10.1046/j.1365-2249.2000.01344.x.
97 Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation. Toxicology. 2021 Feb 15;449:152664. doi: 10.1016/j.tox.2020.152664. Epub 2021 Jan 5.
98 Conditional regulation of the human CYP4X1 and CYP4Z1 genes. Arch Biochem Biophys. 2005 Apr 15;436(2):377-85. doi: 10.1016/j.abb.2005.02.022.
99 miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats. Toxicol Appl Pharmacol. 2020 May 15;395:114979. doi: 10.1016/j.taap.2020.114979. Epub 2020 Mar 29.
100 Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010 Jan;130(1):141-9. doi: 10.1038/jid.2009.210.
101 Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003 Nov 1;102(9):3379-86. doi: 10.1182/blood-2003-05-1417. Epub 2003 Jul 10.
102 [Effect of human recombinant PDCD5 protein on cell apoptosis of multiple myeloma KM3 cells induced by dexamethasone and its mechanism]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):725-31. doi: 10.3969/j.issn.1672-7347.2010.07.013.
103 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
104 Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer Biol Ther. 2005 Nov;4(11):1226-33. doi: 10.4161/cbt.4.11.2093. Epub 2005 Nov 5.
105 Thymidylate synthase pharmacogenetics. Invest New Drugs. 2005 Dec;23(6):533-7. doi: 10.1007/s10637-005-4021-7.
106 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
107 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
108 UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate. Biochem Pharmacol. 2011 Jan 1;81(1):60-70.
109 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
110 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
111 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
112 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
113 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
114 Effects of methotrexate on vascular endothelial growth factor, angiopoietin 1, and angiopoietin 2 in nasal polyps. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):e129-32. doi: 10.2500/ajra.2011.25.3618.
115 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
116 Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Ann Rheum Dis. 2016 Feb;75(2):439-48. doi: 10.1136/annrheumdis-2014-206305. Epub 2015 Jan 9.
117 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
118 Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. Biomed Res Int. 2014;2014:616025. doi: 10.1155/2014/616025. Epub 2014 May 19.
119 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
120 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
121 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
122 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213).
123 Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. J Biol Chem. 1998 Apr 3;273(14):8106-11.
124 Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
125 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
126 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
127 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
128 Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158.
129 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
130 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
131 Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
132 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
133 Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9.
134 Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74.
135 Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71.
136 Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9.
137 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
138 ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci. 2010 Nov;101(11):2404-10.
139 Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204.
140 Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. J Pharm Pharmacol. 2009 Jul;61(7):911-8.
141 Genetics of rheumatoid arthritis. Mayo Clin Proc. 2006 Jan;81(1):94-101.
142 The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
143 Understanding and managing methotrexate nephrotoxicity. Oncologist. 2006 Jun;11(6):694-703.
144 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
145 Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cell Physiol Biochem. 2007;20(6):967-76.
146 SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients. Toxicol Sci. 2014 Nov;142(1):196-209. doi: 10.1093/toxsci/kfu162. Epub 2014 Aug 14.
147 The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther. 2006 Feb;5(2):438-49. doi: 10.1158/1535-7163.MCT-05-0243.
148 P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
149 Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
150 Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
151 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
152 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
153 Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand. Arthritis Rheum. 2004 Dec;50(12):3831-43. doi: 10.1002/art.20637.
154 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
155 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
156 Peripheral blood expression profiles of bone morphogenetic proteins, tumor necrosis factor-superfamily molecules, and transcription factor Runx2 could be used as markers of the form of arthritis, disease activity, and therapeutic responsiveness. J Rheumatol. 2010 Feb;37(2):246-56. doi: 10.3899/jrheum.090167. Epub 2009 Dec 15.
157 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
158 [Increased secretion of vasopressin and edema formation in high dosage methotrexate therapy]. Z Gesamte Inn Med. 1988 Aug 1;43(15):411-4.
159 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
160 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
161 Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
162 [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
163 [Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency]. Arch Fr Pediatr. 1991 Dec;48(10):719-22.
164 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
165 Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem. 2006 Sep 1;99(1):146-55. doi: 10.1002/jcb.20908.
166 Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. Arthritis Res Ther. 2006;8(6):R169. doi: 10.1186/ar2078.
167 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
168 Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy. J Toxicol Clin Toxicol. 1996;34(3):301-5. doi: 10.3109/15563659609013794.
169 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
170 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
171 Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
172 Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action. Arthritis Res Ther. 2012 Jun 8;14(3):R138. doi: 10.1186/ar3871.
173 The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid arthritis. Clin Exp Rheumatol. 2011 Nov-Dec;29(6):963-9. Epub 2011 Dec 22.
174 Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
175 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
176 [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
177 Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells. Cancer Biol Ther. 2013 Jul;14(7):587-96. doi: 10.4161/cbt.24591. Epub 2013 May 10.
178 Networking of differentially expressed genes in human cancer cells resistant to methotrexate. Genome Med. 2009 Sep 4;1(9):83. doi: 10.1186/gm83.
179 ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2. Biochem Cell Biol. 2006 Apr;84(2):199-206. doi: 10.1139/o05-173.
180 MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. Neurology. 2005 Mar 8;64(5):912-3. doi: 10.1212/01.WNL.0000152840.26156.74.
181 Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy. J Rheumatol. 2012 Aug;39(8):1524-32. doi: 10.3899/jrheum.120092. Epub 2012 Jul 1.
182 Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth. Ann Hematol. 2014 Mar;93(3):485-492. doi: 10.1007/s00277-013-1939-2. Epub 2013 Oct 24.
183 Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics. 2008 Aug 11;1:35. doi: 10.1186/1755-8794-1-35.
184 Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther. 2006 Aug;5(8):1986-94.
185 Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. Am J Hematol. 2011 Jan;86(1):98-101. doi: 10.1002/ajh.21897.
186 Overexpression of S100A4 in human cancer cell lines resistant to methotrexate. BMC Cancer. 2010 Jun 1;10:250. doi: 10.1186/1471-2407-10-250.
187 Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma. J Proteomics. 2013 Oct 8;91:393-404. doi: 10.1016/j.jprot.2013.07.022. Epub 2013 Aug 2.
188 A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum. 2007 Jun;56(6):1765-75. doi: 10.1002/art.22640.
189 [Expression of C1QBP gene and its correlation with drug resistance in human resistance choriocarcinoma cell line]. Zhonghua Fu Chan Ke Za Zhi. 2014 Aug;49(8):616-20.
190 Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2006 Sep;54(9):2830-9. doi: 10.1002/art.22032.
191 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. J Biol Chem. 2017 Mar 24;292(12):4873-4884.
192 Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia. Br J Haematol. 2014 Aug;166(3):410-20.
193 ClinicalTrials.gov (NCT02690922) Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients
194 ClinicalTrials.gov (NCT03117751) Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma
195 ClinicalTrials.gov (NCT04329325) Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
196 ClinicalTrials.gov (NCT01371630) Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia