Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGEMB7)

Drug Name
Hydrocortisone Drug Info
Synonyms
Acticort; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anucort; Aquacort; Cetacort; Chronocort; Cleiton; Cobadex; Colocort; Corhydron; Cortanal; Cortef; Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisolonum; Cortisporin; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cutisol; Delacort; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Drotic; DuoCort; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Evacort; Ficortril; Fiocortril; Flexicort; Genacort; Glycort; Hidalone; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydrocortal; Hydrocorticosterone; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Idrocortisone; Kyypakkaus; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Nutracort; Optef; Otocort; Penecort; Permicort; Prepcort; Proctocort; Protocort; Rectoid; Sanatison; Schericur; Sigmacort; Signef; Stiefcorcil; Synacort; Tarcortin; Texacort; Timocort; Traumaide; Uniderm; Vytone; Zenoxone; ACETASOL HC; Aeroseb HC; AnusolHC; Aquanil HC; Barseb HC; CaldeCORT Spray; Clear aid; Component of Lubricort; Component of Otalgine; Cortisol alcohol; Cortisporin Otico; Ef corlin; Epiderm H; Esiderm H; Foille Insetti; HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hytone lotion; Idrocortisone [DCIT]; Komed HC; Lacticare HC; Nogenic HC; ORLEX HC; Pediotic Suspension; Polcort H; Preparation H Hydrocortisone Cream; Prevex HC; Proctozone HC; Remederm HC; Scalpicin Capilar; Scheroson F; Systral Hydrocort; Transderma H; VoSol HC; H 4001; Texacort lotion 25; [3H]cortisol; ACETIC ACID W/ HYDROCORTISONE; Acticort (TN); Aeroseb-HC; Ala-Cort; Ala-Scalp; Anti-inflammatory hormone; Anucort-HC; Anusol HC (TN); Balneol-hc; Basan-Corti; Beta-hc; COR-OTICIN; Colocort (TN); Cort-Dome; Cortef (TN); Cortisol, Hydrocortisone; Cremicort-H; Cyclodextrin-encapsulated hydrocortisone; Derm-Aid; Dome-cort; Domolene-HC; Genacort (lotion); Gyno-Cortisone; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); Heb-Cort; Hi-cor; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hytone (TN); Incortin-H; Incortin-hydrogen; Kendall's compound F; Lacticare-HC; Neo-Cortef; Neosporin-H Ear; Nystaform-HC; Otosone-F; Rectasol-HC; Reichstein's substance M; Scalp-Cort; Stie-cort; Component of Neo-Cort-Dome; Hydrocortisone [INN:BAN:JAN]; Hydrocortisone (JP15/USP/INN); 11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Acute adrenal insufficiency Approved [1]
Addison disease 5A74.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Angioedema 4A00.15 Approved [1]
Aspiration pneumonitis Approved [1]
Autoimmune haemolytic anaemia 3A20 Approved [1]
Blepharoconjunctivitis Approved [1]
Bursitis Approved [1]
Cerebral edema 8D60.1 Approved [1]
Corneal abrasion NA06.4 Approved [1]
Corneal ulcer 9A76 Approved [1]
Crohn disease DD70 Approved [1]
Dermatitis herpetiformis EB44 Approved [1]
Diamond-Blackfan anemia Approved [1]
Disorder of orbital region Approved [1]
Erythema multiforme Approved [1]
Exanthem Approved [1]
Gingival disorder Approved [1]
Granuloma annulare Approved [1]
Inflammation 1A00-CA43.1 Approved [2]
Inflammatory bowel disease DD72 Approved [1]
Keratitis Approved [1]
Malignant otitis externa caused by Pseudomonas aeruginosa Approved [1]
Multiple sclerosis 8A40 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Primary cutaneous T-cell lymphoma Approved [1]
Proctitis DB33.Z Approved [1]
Psoriasis EA90 Approved [1]
Psoriatic arthritis FA21 Approved [1]
Rheumatic heart disease Approved [1]
Rosacea ED90.0 Approved [1]
Sarcoidosis 4B20.5 Approved [1]
Serum sickness Approved [1]
Severe asthma CA23 Approved [1]
Systemic lupus erythematosus 4A40.0 Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Ulcerative colitis DD71 Approved [1]
Viral pneumonia Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Congenital adrenal hyperplasia 5A71.01 Phase 2 [4]
Acquired thrombocytopenia Investigative [1]
Asthma CA23 Investigative [1]
Beta-thalassemia major Investigative [1]
Classic Hodgkin lymphoma Investigative [1]
Iridocyclitis Investigative [1]
Phobic disorder Investigative [1]
Rheumatoid arthritis FA20 Investigative [1]
Synovitis Investigative [1]
Tinea pedis 1F28.2 Investigative [1]
Trichinellosis Investigative [1]
Uveitis 9A96.Z Investigative [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
5754
ChEBI ID
CHEBI:17650
CAS Number
CAS 50-23-7
TTD Drug ID
DMGEMB7
VARIDT Drug ID
DR00230
INTEDE Drug ID
DR0819
ACDINA Drug ID
D00314

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [19]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [20]
Fluticasone DMGCSVF Allergic rhinitis CA08.0 Approved [21]
Betamethasone Valerate DMMIAXO Dermatological disease DA24.Y Approved [5]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [5]
Deflazacort DMV0RNS Duchenne dystrophy 8C70 Approved [5]
Prednisone DM2HG4X Acute asthma CA23 Approved [22]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [23]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [24]
Fluocinolone Acetonide DMG2KI4 Choroiditis Approved [5]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Selenium DM25CGV N. A. N. A. Approved [117]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [118]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [68]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [69]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [70]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [71]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [72]
Capsaicin DMGMF6V Back pain ME84.Z Approved [73]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [74]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [47]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [44]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [72]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [72]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [75]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [76]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [79]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [51]
Verapamil DMA7PEW Angina pectoris BA40 Approved [52]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [44]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [44]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [44]
Metronidazole DMTIVEN Abscess Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Steroid 11-beta-hydroxylase (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [54]
deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [51]
Drug(s) Metabolized By Aldosterone synthase (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [55]
deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [56]
Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ethanol DMDRQZU Chronic pain MG30 Approved [60]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [61]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [64]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [64]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [82]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [83]
Cepharanthine DM9Y5JB N. A. N. A. Approved [84]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [85]
Clozapine DMFC71L Schizophrenia 6A20 Approved [86]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [87]
Trifluoperazine DMKBYWI Anxiety Approved [88]
Olanzapine DMPFN6Y Bipolar depression Approved [86]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [91]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [96]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [94]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [97]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [98]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [99]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [100]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [101]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [102]
Ethacrynic acid DM60QMR Edema MG29 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [109]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [113]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [115]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [116]
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Drug(s) Affected By GDH/6PGL endoplasmic bifunctional protein (H6PD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [117]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Testosterone DM7HUNW Hot flushes GA30 Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [122]
Bortezomib DMNO38U Leukemia Approved [123]
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Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [124]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [118]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [11]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [125]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Folic Acid DMEMBJC Colorectal carcinoma Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [134]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [135]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [140]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [140]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [141]
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Drug(s) Affected By Integrin alpha-10 (ITGA10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [144]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [145]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [134]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [146]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [146]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [146]
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Drug(s) Affected By Integrin alpha-5 (ITGA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Ethanol DMDRQZU Chronic pain MG30 Approved [158]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [161]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
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Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [166]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ethanol DMDRQZU Chronic pain MG30 Approved [170]
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Drug(s) Affected By Adhesion G protein-coupled receptor E5 (ADGRE5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [172]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [174]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1X (MT1X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [178]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [153]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [178]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [182]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O1 (FOXO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [184]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [185]
Quercetin DM3NC4M Obesity 5B81 Approved [186]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [188]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [190]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [191]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [192]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Testosterone enanthate DMB6871 N. A. N. A. Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 6 group A member 1 (NR6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [197]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [140]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [198]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [140]
Urethane DM7NSI0 N. A. N. A. Phase 4 [200]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein prune homolog 2 (PRUNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Testosterone enanthate DMB6871 N. A. N. A. Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [201]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [182]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [203]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2S1 (CYP2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [208]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [210]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [212]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [213]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [214]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [215]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [216]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [220]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [222]
Testosterone DM7HUNW Hot flushes GA30 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [224]
Gefitinib DM15F0X Colon adenocarcinoma Approved [225]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [227]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [138]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [234]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [235]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [220]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [237]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [238]
Ethanol DMDRQZU Chronic pain MG30 Approved [170]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [204]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [242]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [243]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [244]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [222]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [244]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [246]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [247]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [236]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [248]
Ethanol DMDRQZU Chronic pain MG30 Approved [249]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Desogestrel DM27U4Y Contraception QA21 Approved [251]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [252]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [253]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [255]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [253]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [256]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Fluoxetine DM3PD2C Bipolar depression Approved [257]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein B-100 (APOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [259]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [260]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [261]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [259]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [262]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [263]
Testosterone DM7HUNW Hot flushes GA30 Approved [264]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Menthol DMG2KW7 Back pain ME84.Z Approved [265]
Paclitaxel DMLB81S Breast carcinoma Approved [266]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [268]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [269]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [270]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [271]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [272]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [273]
Quercetin DM3NC4M Obesity 5B81 Approved [274]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [222]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [276]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [273]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 1 (BMAL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [279]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydroxyacetone phosphate acyltransferase (GNPAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [106]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [280]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [186]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [283]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [284]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [285]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [286]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Prednisone DM2HG4X Acute asthma CA23 Approved [287]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [288]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Period circadian protein homolog 1 (PER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [277]
Haloperidol DM96SE0 Delirium Approved [290]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [246]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [291]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [280]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [293]
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Drug(s) Affected By Trehalase (TREH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [294]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [295]
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [273]
Quercetin DM3NC4M Obesity 5B81 Approved [274]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [192]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rap guanine nucleotide exchange factor 3 (RAPGEF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [297]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [298]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [134]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [299]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [300]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [301]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [302]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [303]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [304]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [305]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [306]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [307]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [308]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [309]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [310]
Epinephrine DM3KJBC Acute asthma CA23 Approved [311]
Chlorthalidone DM4DMBT Edema MG29 Approved [312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Antithrombin-III (SERPINC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Prednisone DM2HG4X Acute asthma CA23 Approved [314]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Testosterone enanthate DMB6871 N. A. N. A. Approved [315]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [314]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [316]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [318]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [319]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [320]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [321]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [322]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [323]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [324]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [325]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [327]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [328]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [329]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [330]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [331]
Ethanol DMDRQZU Chronic pain MG30 Approved [327]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [332]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [333]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-neuropeptide Y (NPY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mifepristone DMGZQEF Cushing disease 5A70 Approved [63]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Guanethidine DM9NSWT Moderate and severe hypertension BA00.Z Approved [336]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Orlistat DMRJSP8 Obesity 5B81 Approved [337]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [338]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Epinephrine DM3KJBC Acute asthma CA23 Approved [340]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [341]
Fructose DM43AN2 Vomiting MD90 Approved [342]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [343]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [344]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [345]
Propranolol DM79NTF Angina pectoris BA40 Approved [346]
Testosterone DM7HUNW Hot flushes GA30 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [348]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [349]
Fructose DM43AN2 Vomiting MD90 Approved [63]
Ketoprofen DMRKXPT Bursitis Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [350]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [351]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [352]
Gefitinib DM15F0X Colon adenocarcinoma Approved [353]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [354]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [94]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [355]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [356]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Gefitinib DM15F0X Colon adenocarcinoma Approved [358]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [94]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [359]
Selenium DM25CGV N. A. N. A. Approved [360]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [361]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [363]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [364]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [365]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Fenoterol DMIP3ZV Asthma CA23 Approved [366]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [367]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [368]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [369]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [370]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [371]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [372]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [178]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [374]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [375]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [371]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [376]
Testosterone DM7HUNW Hot flushes GA30 Approved [264]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [237]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [238]
Ethanol DMDRQZU Chronic pain MG30 Approved [60]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [377]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [215]
Arsenic DMTL2Y1 N. A. N. A. Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [124]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [379]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [91]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [380]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [359]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [381]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kallikrein-1 (KLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [382]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [384]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [382]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [385]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [386]
Selenium DM25CGV N. A. N. A. Approved [387]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [389]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [390]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [391]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [392]
Testosterone DM7HUNW Hot flushes GA30 Approved [393]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [394]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [395]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [396]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [397]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [394]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [398]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [395]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [399]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Terbutaline DMD4381 Asthma CA23 Approved [400]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [401]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [402]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [401]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [401]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [403]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [403]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mineralocorticoid receptor (NR3C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [404]
Testosterone DM7HUNW Hot flushes GA30 Approved [405]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [406]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [407]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [406]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [406]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [197]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [408]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [409]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [178]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [410]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [411]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [412]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [380]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [356]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [413]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [414]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [415]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [416]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [416]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [417]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [417]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [417]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [418]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [419]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [420]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [421]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [422]
Selenium DM25CGV N. A. N. A. Approved [387]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pulmonary surfactant-associated protein C (SFTPC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [400]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [400]
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [286]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [424]
Selenium DM25CGV N. A. N. A. Approved [425]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [426]
Meloxicam DM2AR7L Arthritis FA20 Approved [427]
Methotrexate DM2TEOL Anterior urethra cancer Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Epinephrine DM3KJBC Acute asthma CA23 Approved [428]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [356]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [413]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [415]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [374]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [416]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [416]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [380]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Gefitinib DM15F0X Colon adenocarcinoma Approved [429]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [97]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [130]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [430]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [431]
Quercetin DM3NC4M Obesity 5B81 Approved [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [433]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [371]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [434]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [434]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [244]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [435]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [436]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [437]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filaggrin (FLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [394]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [397]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [394]
Folic Acid DMEMBJC Colorectal carcinoma Approved [131]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [397]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Loricrin (LORICRIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [439]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [397]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [397]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [134]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
SB 203580 DMAET6F N. A. N. A. Terminated [440]
PD98059 DMZC90M Cardiac arrest MC82 Investigative [440]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [63]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [441]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [442]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [443]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [444]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [289]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [445]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [408]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [442]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [446]
Methotrexate DM2TEOL Anterior urethra cancer Approved [447]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [448]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [449]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [450]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-5 (CDH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [451]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [372]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [452]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [453]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Ethanol DMDRQZU Chronic pain MG30 Approved [454]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [455]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [134]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [457]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [458]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [459]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [460]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [461]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [460]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [462]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [463]
Arsenic DMTL2Y1 N. A. N. A. Approved [464]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [465]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [466]
Quercetin DM3NC4M Obesity 5B81 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [467]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [468]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [469]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [470]
Testosterone DM7HUNW Hot flushes GA30 Approved [471]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [472]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor ROR-alpha (RORA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [210]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [473]
Testosterone enanthate DMB6871 N. A. N. A. Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [474]
Ethanol DMDRQZU Chronic pain MG30 Approved [170]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [395]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [475]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [476]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [477]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [479]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [453]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [480]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [481]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [482]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [483]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [484]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [484]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [484]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [485]
Selenium DM25CGV N. A. N. A. Approved [117]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [486]
Quercetin DM3NC4M Obesity 5B81 Approved [487]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [488]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [489]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [178]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [490]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [491]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amiloride-sensitive sodium channel subunit beta (SCNN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [481]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [492]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [493]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
Milchsaure DM462BT Pruritus EC90 Investigative [494]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Amiloride-sensitive sodium channel subunit gamma (SCNN1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [372]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [481]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [201]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [492]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Arsenic DMTL2Y1 N. A. N. A. Approved [378]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Quercetin DM3NC4M Obesity 5B81 Approved [227]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [496]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [204]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [497]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [498]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [499]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [500]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [190]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [501]
Risedronate DM5FLTY Bone Paget disease Approved [502]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [503]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Pamidronate DMB4AVP Bone Paget disease Approved [502]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tight junction protein ZO-1 (TJP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [222]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [505]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Ethanol DMDRQZU Chronic pain MG30 Approved [506]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [507]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [424]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Quercetin DM3NC4M Obesity 5B81 Approved [227]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [488]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [118]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [167]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [508]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone deacetylase 1 (HDAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [510]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [511]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [245]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Splicing factor 1 (SF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Selenium DM25CGV N. A. N. A. Approved [117]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [512]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Benzatropine DMF7EXL Parkinsonian disorder Approved [513]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [377]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [514]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cryptochrome-1 (CRY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [515]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Haloperidol DM96SE0 Delirium Approved [290]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [292]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [516]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [517]
Urethane DM7NSI0 N. A. N. A. Phase 4 [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atypical chemokine receptor 1 (ACKR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [220]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Folic Acid DMEMBJC Colorectal carcinoma Approved [131]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [518]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [139]
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Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [519]
Methotrexate DM2TEOL Anterior urethra cancer Approved [520]
Quercetin DM3NC4M Obesity 5B81 Approved [521]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [522]
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [523]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Ethanol DMDRQZU Chronic pain MG30 Approved [506]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Patatin-like phospholipase domain-containing protein 2 (PNPLA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [182]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [524]
Urethane DM7NSI0 N. A. N. A. Phase 4 [200]
Beta-caryophyllene DM7583A Pain MG30-MG3Z Phase 2 [525]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [526]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [527]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [528]
D-glucose DMMG2TO Discovery agent N.A. Investigative [529]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [530]
Selenium DM25CGV N. A. N. A. Approved [117]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [531]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [532]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [533]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [534]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [535]
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [536]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [537]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [515]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [538]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [175]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [505]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Corticoliberin (CRH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [539]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [539]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [539]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Haloperidol DM96SE0 Delirium Approved [539]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Terbutaline DMD4381 Asthma CA23 Approved [540]
Clozapine DMFC71L Schizophrenia 6A20 Approved [539]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxytocin-neurophysin 1 (OXT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [542]
Clozapine DMFC71L Schizophrenia 6A20 Approved [543]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
Drug(s) Affected By Aldo-keto reductase family 1 member D1 (AKR1D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [209]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [198]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [544]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [545]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [306]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [546]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [547]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [309]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [323]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor II (IGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [216]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [549]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [550]
Testosterone DM7HUNW Hot flushes GA30 Approved [551]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Folic Acid DMEMBJC Colorectal carcinoma Approved [553]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [554]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-binding protein RBBP7 (RBBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [555]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [556]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [280]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [499]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycodelin (PAEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [179]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [209]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [183]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [557]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [558]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-opiomelanocortin (POMC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [559]
Prednisone DM2HG4X Acute asthma CA23 Approved [560]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [561]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [562]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [563]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [330]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [564]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [565]
Ethanol DMDRQZU Chronic pain MG30 Approved [566]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [567]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-box transcription factor TBX19 (TBX19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [196]
Ethanol DMDRQZU Chronic pain MG30 Approved [568]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [569]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [570]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
Drug(s) Affected By Interferon beta (IFNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [571]
Aripiprazole DM3NUMH Bipolar I disorder Approved [572]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [121]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [573]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [574]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [575]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [576]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [577]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [578]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [8]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [9]
Steroid 11-beta-hydroxylase (CYP11B1) DEPE0RD C11B1_HUMAN Substrate [10]
Aldosterone synthase (CYP11B2) DE6TYUK C11B2_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [11]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [12]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Protein Interaction/Cellular Processes [13]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [14]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [15]
Adhesion G protein-coupled receptor E5 (ADGRE5) OTTSB84Q AGRE5_HUMAN Gene/Protein Processing [16]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Gene/Protein Processing [16]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Biotransformations [17]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Gene/Protein Processing [18]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Gene/Protein Processing [18]

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