Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY38SB)

• Drug Name: CATECHIN Drug Info
• Synonyms: Cianidanol; (+)-catechin; 154-23-4; Catechuic acid; Cyanidanol; Catechinic acid; D-Catechin; Catergen; Cianidol; (+)-Cyanidanol; (+)-Cyanidan-3-ol; Biocatechin; (+)-Catechin Hydrate; D-(+)-Catechin; Dexcyanidanol; Catechin (flavan); Catechol (flavan); D-Catechol; (2R,3S)-Catechin; (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; Gambier; 3-Cyanidanol, (+)-; Cianidanolum; Catechu; Transepar; Katha; (2R,3S)-(+)-Catechin; Cutch (dye); (+)-Cianidanol; 3,3',4',5,7-Flavanpentol; KB-53; (+)-Cyanidanol-3; CCRIS 6855

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9064
  ChEBI ID: CHEBI:15600
  CAS Number: CAS 7295-85-4
  TTD Drug ID: DMY38SB

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[8]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[12]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[14]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[14]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[15]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[14]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[16]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[17]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[17]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[18]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[19]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[20]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[20]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[21]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[22]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[23]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[24]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[12]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[12]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[25]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[8]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[26]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[27]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[28]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[29]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[14]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[30]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[27]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[31]
Naproxen	DMZ5RGV	Bursitis		Approved	[32]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[33]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[34]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[35]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[14]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[36]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[14]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[37]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[38]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[39]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[40]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[41]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[43]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[9]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[48]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[60]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[63]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[73]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[82]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[82]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[85]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[88]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[89]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[90]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[105]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]

Drug(s) Affected By Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[137]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[140]

Drug(s) Affected By B-lymphocyte antigen CD19 (CD19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[142]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[102]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[145]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[150]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[151]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[152]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[156]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[156]
Bortezomib	DMNO38U	Leukemia		Approved	[159]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[159]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[164]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[171]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[172]

Drug(s) Affected By Interleukin-32 (IL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[174]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[120]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[181]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[102]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[183]

Drug(s) Affected By Homeobox protein Hox-D3 (HOXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[184]
Indomethacin	DMSC4A7	Bursitis		Approved	[185]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[187]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[188]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[137]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[193]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Bortezomib	DMNO38U	Leukemia		Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[140]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[207]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[211]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[213]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Bortezomib	DMNO38U	Leukemia		Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[140]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[142]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[217]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[218]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[142]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[219]

Drug(s) Affected By Fms-related tyrosine kinase 3 ligand (FLT3LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[223]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Host cell factor 1 (HCFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[227]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[229]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[231]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[232]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[233]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[177]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[238]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[239]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[227]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[123]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[249]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[138]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[250]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[177]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[255]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[181]

Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[258]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[259]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Bortezomib	DMNO38U	Leukemia		Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[264]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[265]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]

Drug(s) Affected By Splicing factor 1 (SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[138]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[267]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[268]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[273]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[274]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[275]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[276]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[277]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[278]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]
Haloperidol	DM96SE0	Delirium		Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Selenium	DM25CGV	N. A.	N. A.	Approved	[282]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[283]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Selenium	DM25CGV	N. A.	N. A.	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[288]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[291]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[293]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[293]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[296]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[293]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[293]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[297]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[298]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[302]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[304]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[305]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[309]
Fructose	DM43AN2	Vomiting	MD90	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[312]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[313]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[313]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[321]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[322]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[323]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[325]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[334]
Fructose	DM43AN2	Vomiting	MD90	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[336]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[345]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[346]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[347]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[349]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[350]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Selenium	DM25CGV	N. A.	N. A.	Approved	[352]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[354]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[355]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[357]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[359]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[360]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[365]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[235]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[367]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[368]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[363]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[371]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[372]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[334]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[374]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[375]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[377]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[378]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[379]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[381]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[382]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[384]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[386]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[387]
Fructose	DM43AN2	Vomiting	MD90	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[388]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[386]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[392]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[393]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[397]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[398]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[399]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[400]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[403]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[405]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[406]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[398]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[407]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[408]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[409]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[397]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[400]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[410]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[411]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[412]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[413]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[414]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[381]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[417]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[418]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[321]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[419]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[420]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[422]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[424]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[425]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[427]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[428]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[122]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[430]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[431]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[360]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[383]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[434]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[435]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[436]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[437]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[441]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[442]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[445]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[450]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[451]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[454]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[456]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[457]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[458]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[354]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[424]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[359]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[363]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[432]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[379]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[459]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[460]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[461]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[462]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[463]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[383]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[466]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[350]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[467]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[468]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[469]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[470]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[470]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[471]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[83]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[472]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[473]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[474]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[272]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[475]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[476]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[477]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[478]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[479]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[478]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[1]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
B-lymphocyte antigen CD19 (CD19)	OTCPF9NF	CD19_HUMAN	Gene/Protein Processing	[3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Gene/Protein Processing	[4]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[4]

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