Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0WX6I)

Drug Name

Primidone Drug Info

Synonyms

Cyral; Desoxyphenobarbital; Desoxyphenobarbitone; Hexadiona; Lepimidin; Lepsiral; Liskantin; Majsolin; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidona; Primidonum; Primoline; Prysoline; Resimatil; Sertan; Apotex Brand of Primidone; Astra Brand of Primidone; AstraZeneca Brand of Primidone; Desitin Brand of Primidone; Draxis Brand of Primidone; Holsten Brand of Primidone; Pms Primidone; Primidon Holsten; Primidone Methanol Solution; Xcel Brand of Primidone; Zeneca Brand of Primidone; P 7295; Roe 101; Apo-Primidone; Hexamidine (the antispasmodic); Hexamidine(the antispasmodic); Liskantin (TN); Medi-Pets; Mylepsinum (TN); Mysoline (TN); Primidona [INN-Spanish]; Primidone (primaclone); Primidonum [INN-Latin]; Prysoline (TN); Pyrimidone Medi-pets; Resimatil (TN); Sanofi-Synthelabo Brand of Primidone; Sertan (TN); Apo-Primidone (TN); Pyrimidone (Medi-pets); Primidone (JP15/USP/INN); Primidone [USAN:INN:BAN:JAN]; 2-Deoxyphenobarbital; 2-Desoxyphenobarbital; 4,4'-(Hexamethylenedioxy)dibenzamidine; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion [German]; 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione; 5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione; 5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine; 5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione; 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6); 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6) [German]; 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione; 5-ethylhe xahydro-4,6-dioxo-5-phenylpyrimidine

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Approved	[1]
Epilepsy with generalized tonic-clonic seizures		Approved	[2]
Focal epilepsy		Approved	[2]

Therapeutic Class

Anticonvulsants

Cross-matching ID

PubChem CID: 4909
ChEBI ID: CHEBI:8412
CAS Number: CAS 125-33-7
TTD Drug ID: DM0WX6I
INTEDE Drug ID: DR1340
ACDINA Drug ID: D00555

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[3]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[11]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[3]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[3]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[12]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[3]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[3]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[13]
Meprobamate	DMHM93Y	Anxiety		Approved	[3]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[14]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[21]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[29]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[30]
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Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[6]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[6]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[6]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[33]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[35]
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Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[37]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[38]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[45]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[46]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[46]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[47]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[45]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[46]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[48]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[45]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[49]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
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Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[7]
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Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[9]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
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Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
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Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Fructose	DM43AN2	Vomiting	MD90	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[73]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[74]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[73]
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Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]
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Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[85]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[86]
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Drug(s) Affected By Glutathione hydrolase 7 (GGT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[6]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[91]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[93]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[94]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Antagonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)^{Main DME}	DE5IED8	CP2C9_HUMAN	Substrate	[4]
Mephenytoin 4-hydroxylase (CYP2C19)^{Main DME}	DEGTFWK	CP2CJ_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Drug Response	[6]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Drug Response	[6]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[7]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[8]
Glutathione hydrolase 7 (GGT7)	OTW4IO3I	GGT7_HUMAN	Drug Response	[6]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Gene/Protein Processing	[7]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Gene/Protein Processing	[7]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Gene/Protein Processing	[9]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Gene/Protein Processing	[9]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Gene/Protein Processing	[10]

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