Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9BI7M)

Drug Name

Duloxetine Drug Info

Synonyms

Yentreve; LY 248686; Cymbalta (TN); Duloxetine (INN); Duloxetine [INN:BAN]; Yentreve (TN); Duloxetine, (+)-isomer; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; (S)-Duloxetine; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[1] , [2]

Therapeutic Class

Antidepressants

Cross-matching ID

PubChem CID: 60835
ChEBI ID: CHEBI:36795
CAS Number: CAS 116539-59-4
TTD Drug ID: DM9BI7M
VARIDT Drug ID: DR01001
INTEDE Drug ID: DR0554
ACDINA Drug ID: D00220

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[9]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[12]
Oxaliplatin	DMQNWRD	Colorectal cancer	2B91.Z	Approved	[13]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[14]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[15]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[16]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[21]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[22]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[23]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[24]
Propranolol	DM79NTF	Migraine	8A80	Approved	[25]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[28]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[29]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[31]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[32]
Estrone	DM5T6US	Menopausal and postmenopausal disorder	GA30	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
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Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[35]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[36]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[37]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[35]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[38]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[39]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[40]
Venlafaxine	DMR6QH0	Depression	6A70-6A7Z	Approved	[39]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[41]
Levomilnacipran	DMV26S8	Fibromyalgia	MG30.01	Approved	[42]
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Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[35]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[36]
Fluoxetine	DM3PD2C	Depression	6A70-6A7Z	Approved	[43]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[44]
Sertraline	DM0FB1J	Depression	6A70-6A7Z	Approved	[45]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[38]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[39]
Citalopram	DM2G9AE	Depression	6A70-6A7Z	Approved	[43]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[43]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[43]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[3] , [4]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[3] , [4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)^{Main DME}	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Cytochrome P450 1A2 (CYP1A2)^{Main DME}	DEJGDUW	CP1A2_HUMAN	Substrate	[5]

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References

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