Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9BI7M)

Drug Name
Duloxetine Drug Info
Synonyms
Yentreve; LY 248686; Cymbalta (TN); Duloxetine (INN); Duloxetine [INN:BAN]; Yentreve (TN); Duloxetine, (+)-isomer; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; (S)-Duloxetine; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Major depressive disorder 6A70.3 Approved [2]
Stress urinary incontinence MF50.20 Approved [2]
Traumatic brain injury NA07.Z Approved [2]
Therapeutic Class
Antidepressants
Cross-matching ID
PubChem CID
60835
ChEBI ID
CHEBI:36795
CAS Number
CAS 116539-59-4
TTD Drug ID
DM9BI7M
VARIDT Drug ID
DR01001
INTEDE Drug ID
DR0554
ACDINA Drug ID
D00220

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Norepinephrine transporter (NET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [10]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [11]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [12]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [10]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [13]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [14]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [15]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [14]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [16]
Levomilnacipran DMV26S8 Fibromyalgia MG30.01 Approved [17]
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Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [10]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [11]
Fluoxetine DM3PD2C Bipolar depression Approved [18]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [19]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [13]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [14]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [18]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [18]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [18]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [30]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [36]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [37]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [38]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [39]
Propranolol DM79NTF Angina pectoris BA40 Approved [40]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
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Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [50]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [54]
Testosterone DM7HUNW Hot flushes GA30 Approved [54]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [55]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [56]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [56]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [57]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [63]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [64]
Aripiprazole DM3NUMH Bipolar I disorder Approved [65]
Fluoxetine DM3PD2C Bipolar depression Approved [66]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [67]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [68]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [5]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [69]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
Ethacrynic acid DM60QMR Edema MG29 Approved [73]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [74]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [75]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [76]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [79]
Verapamil DMA7PEW Angina pectoris BA40 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [83]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [87]
Quinidine DMLPICK N. A. N. A. Approved [88]
Verapamil DMA7PEW Angina pectoris BA40 Approved [89]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [90]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [90]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [91]
Propranolol DM79NTF Angina pectoris BA40 Approved [92]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [93]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [94]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [90]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Verapamil DMA7PEW Angina pectoris BA40 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [98]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [103]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [105]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [106]
Estrone DM5T6US Acne vulgaris ED80 Approved [107]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [108]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [109]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [110]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [111]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [79]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [3]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [5]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [6]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Protein Interaction/Cellular Processes [6]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [7]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [8]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Gene/Protein Processing [9]

References

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2 Duloxetine FDA Label
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