Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA86FL)

Drug Name
Avastin+/-Tarceva Drug Info
Synonyms
Juglone; juglone; 481-39-0; 5-Hydroxy-1,4-naphthoquinone; 5-Hydroxy-1,4-naphthalenedione; Regianin; Juglon; Nucin; 5-Hydroxynaphthalene-1,4-dione; Walnut extract; 5-Hydroxynaphthoquinone; Akhnot; Yuglon; 8-Hydroxy-1,4-naphthoquinone; CI Natural Brown 7; 1,4-NAPHTHALENEDIONE, 5-HYDROXY-; 5-Hydroxy-p-naphthoquinone; 1,4-Naphthoquinone, 5-hydroxy-; CI 75500; Juglane; Jugnlon; Iuglon; Caswell No 515AA; 1,4-Naphthoquinone, 8-hydroxy-; 5-Hydroxy-1,4-naphthosemiquinone; 5-Hydroxy-1,4-naftochinon; UNII-W6Q80SK9L6; NSC 622948; NSC 153189; CCRIS; JUGLONE
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Phase 3 [1]
Nasopharyngeal carcinoma 2B6B Investigative [2]
Cross-matching ID
PubChem CID
3806
ChEBI ID
CHEBI:15794
CAS Number
CAS 481-39-0
TTD Drug ID
DMA86FL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [11]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [12]
Silymarin DMXBYQR N. A. N. A. Phase 4 [13]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [14]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [15]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [16]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [17]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [18]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [19]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [20]
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Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [21]
Leflunomide DMR8ONJ Arthritis FA20 Approved [22]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [23]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [24]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [25]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [25]
Orotate DMMB29S Discovery agent N.A. Investigative [26]
Lauryl Dimethylamine-N-Oxide DM3W2OE Discovery agent N.A. Investigative [25]
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [6]
Dihydroorotate DM76BGZ Discovery agent N.A. Investigative [27]
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Drug(s) Targeting Rotamase Pin1 (PIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-(2-Naphthyl)-Alanine DMP21ZO Discovery agent N.A. Investigative [28]
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid DMCW5A9 Discovery agent N.A. Investigative [29]
(R)-2-(2-naphthamido)-3-p-tolylpropanoic acid DMXGCYZ Discovery agent N.A. Investigative [29]
3,6,9,12,15,18-HEXAOXAICOSANE DMY26JI Discovery agent N.A. Investigative [28]
(R)-3-(2-naphthamido)-4-m-tolylbutanoic acid DM5TH2W Discovery agent N.A. Investigative [29]
(R)-2-(2-naphthamido)-3-m-tolylpropanoic acid DMVEMNA Discovery agent N.A. Investigative [29]
(R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid DM9WL6O Discovery agent N.A. Investigative [29]
Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2 DM6ONY7 Discovery agent N.A. Investigative [30]
Ac-Phe-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSWTPX Discovery agent N.A. Investigative [30]
Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSE29N Discovery agent N.A. Investigative [30]
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Drug(s) Targeting Vascular endothelial growth factor A (VEGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aflibercept DMT3D5I Central retinal vein occlusion with macular edema Approved [31]
Brolucizumab DMW8QNG Wet age-related macular degeneration 9B78.3Z Approved [32]
Faricimab DM83SEB Diabetic macular edema 9B71.02 Approved [33]
Ranibizumab DMSYPNW Central retinal vein occlusion with macular edema Approved [34]
Bevacizumab DMSD1UN Adenocarcinoma 2D40 Approved [35]
PTC299 DMP9TKE Rheumatoid arthritis FA20 Phase 2 [36]
RG7221 DM8J9DC Colorectal cancer 2B91.Z Phase 2 [37]
RO5520985 DMD3WNP Colorectal cancer 2B91.Z Phase 2 [38]
Abicipar pegol DM59OJ2 Diabetic macular edema 9B71.02 Phase 2 [39]
MP0250 DMR3VCY Non-small-cell lung cancer 2C25.Y Phase 1/2 [40]
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Drug(s) Targeting Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [41]
ADOCIAQUINONE B DMPOU86 Discovery agent N.A. Investigative [4]
4-ethoxynaphthalene-1,2-dione DMUN7KC Discovery agent N.A. Investigative [4]
Drug(s) Targeting M-phase inducer phosphatase 2 (MPIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [42]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [25]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [25]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [25]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [43]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [44]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ Discovery agent N.A. Investigative [44]
ADOCIAQUINONE B DMPOU86 Discovery agent N.A. Investigative [45]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [44]
4-ethoxynaphthalene-1,2-dione DMUN7KC Discovery agent N.A. Investigative [4]
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Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [46]
BMS-986205 DM3MAYQ Melanoma 2C30 Phase 3 [40]
INCB24360 DMIJGT9 Urothelial carcinoma 2C92.0 Phase 3 [47]
NLG8189 DM0798Z Melanoma 2C30 Phase 2/3 [40]
DN1406131 DMQFX8R Solid tumour/cancer 2A00-2F9Z Phase 1 [48]
HTI-1090 DMI4TEC Solid tumour/cancer 2A00-2F9Z Phase 1 [49]
KHK2455 DMLSUQ8 Solid tumour/cancer 2A00-2F9Z Phase 1 [40]
LY3381916 DMONZ1L Solid tumour/cancer 2A00-2F9Z Phase 1 [40]
PF-06840003 DMOX6EJ Glioma 2A00.0 Phase 1 [50]
NLG802 DMP9J5V Solid tumour/cancer 2A00-2F9Z Phase 1 [40]
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Drug(s) Affected By Dihydroorotate dehydrogenase (DHODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [6]
Urethane DM7NSI0 N. A. N. A. Phase 4 [58]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [59]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [8]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [60]
Fructose DM43AN2 Vomiting MD90 Approved [61]
Ketoprofen DMRKXPT Bursitis Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [68]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [71]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Verapamil DMA7PEW Angina pectoris BA40 Approved [73]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [74]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [78]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [79]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [80]
Meloxicam DM2AR7L Arthritis FA20 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Epinephrine DM3KJBC Acute asthma CA23 Approved [84]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [92]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [95]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [98]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [110]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [119]
Testosterone DM7HUNW Hot flushes GA30 Approved [120]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [121]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [122]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [123]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [124]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [126]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [127]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [128]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [136]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [139]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [140]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [143]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [144]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [145]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [147]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [148]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [150]
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Drug(s) Affected By Disabled homolog 2 (DAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Ethanol DMDRQZU Chronic pain MG30 Approved [157]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [68]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Verapamil DMA7PEW Angina pectoris BA40 Approved [73]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [158]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [159]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Meloxicam DM2AR7L Arthritis FA20 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [160]
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Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [163]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [164]
Leflunomide DMR8ONJ Arthritis FA20 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [166]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [167]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [168]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Gefitinib DM15F0X Colon adenocarcinoma Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [59]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [173]
Methotrexate DM2TEOL Anterior urethra cancer Approved [174]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [175]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [178]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [182]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [185]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [186]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [188]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [189]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [3]
Dual specificity protein phosphatase 1 (DUSP1) TTG8HIM DUS1_HUMAN Inhibitor [4]
Indoleamine 2,3-dioxygenase 1 (IDO1) TTZJYKH I23O1_HUMAN Inhibitor [5]
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [4]
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) TT3PQ2Y PYRD_PLAF7 Inhibitor [6]
Rotamase Pin1 (PIN1) TTJNTSI PIN1_HUMAN Inhibitor [2]
Vascular endothelial growth factor A (VEGFA) TTOHSBA VEGFA_HUMAN Inhibitor [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [8]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [8]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [9]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [8]
Dihydroorotate dehydrogenase (DHODH) OTAKFN78 PYRD_HUMAN Gene/Protein Processing [6]
Disabled homolog 2 (DAB2) OTRMQTMZ DAB2_HUMAN Post-Translational Modifications [10]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [8]

References

1 Clinical pipeline report, company report or official report of Roche.
2 Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.PLoS One. 2016 Jun 3;11(6):e0156833.
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54 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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62 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
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66 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
67 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
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72 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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76 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
77 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
78 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
79 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
80 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
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82 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
83 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
84 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
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86 Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
87 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
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91 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
92 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
93 Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
94 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
95 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
96 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
97 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
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99 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
100 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
101 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
102 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
103 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
104 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
105 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
106 Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
107 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
108 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
109 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
110 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
111 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
112 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
113 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
114 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
115 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
116 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
117 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
118 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
119 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
120 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
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122 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
123 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
124 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
125 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
126 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
127 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
128 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
129 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
130 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
131 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
132 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
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135 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
136 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
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145 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
146 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
147 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
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