Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCK5DG)

Drug Name
BADGE Drug Info
Synonyms SCHEMBL7915436; GTPL2708; 2,2-Bis[4-(oxiranyloxy)phenyl]propane
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2286
ChEBI ID
CHEBI:34578
CAS Number
CAS 1675-54-3
TTD Drug ID
DMCK5DG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting PPAR-gamma messenger RNA (PPARG mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [7]
AD-5075 DM1SLJ9 Type-2 diabetes 5A11 Terminated [8]
2-chloro-5-nitro-N-phenylbenzamide DMUGQIV Discovery agent N.A. Investigative [9]
L-783483 DM6OTGE Discovery agent N.A. Investigative [10]
LG100754 DMEK4FY Discovery agent N.A. Investigative [11]
L-796449 DMWTGQM Discovery agent N.A. Investigative [12]
L-165461 DMKBSGN Discovery agent N.A. Investigative [12]
AD-5061 DM5WV13 Discovery agent N.A. Investigative [13]
TZD18 DMVCHOX Discovery agent N.A. Investigative [14]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid DM2REIN Discovery agent N.A. Investigative [15]
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Drug(s) Affected By Netrin-1 (NTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [17]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [21]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [22]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [23]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [24]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [25]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [34]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [33]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [35]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [38]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [43]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [41]
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Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [47]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [49]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [50]
Capsaicin DMGMF6V Back pain ME84.Z Approved [51]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [61]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [66]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [61]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [5]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [72]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [73]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [72]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [74]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [75]
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Drug(s) Affected By Insulin-like 3 (INSL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [78]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [80]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [23]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
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Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [84]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [72]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [83]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [72]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [83]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [86]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [83]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [93]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
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Drug(s) Affected By Protein delta homolog 1 (DLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [3]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [78]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Indomethacin DMSC4A7 Bursitis Approved [101]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [102]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Verapamil DMA7PEW Angina pectoris BA40 Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [107]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Meloxicam DM2AR7L Arthritis FA20 Approved [110]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [111]
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Drug(s) Affected By Metal regulatory transcription factor 1 (MTF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [112]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [113]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [114]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [115]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Urethane DM7NSI0 N. A. N. A. Phase 4 [117]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [118]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [119]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [119]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [120]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [121]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [119]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [119]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [124]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [128]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [72]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [17]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [129]
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Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [136]
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Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Selenium DM25CGV N. A. N. A. Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [138]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [139]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [5]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [141]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [52]
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Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [142]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Haloperidol DM96SE0 Delirium Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [136]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PPAR-gamma messenger RNA (PPARG mRNA) TTT2SVW PPARG_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [3]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Protein Interaction/Cellular Processes [4]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Protein Interaction/Cellular Processes [4]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Gene/Protein Processing [5]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Protein Interaction/Cellular Processes [4]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Gene/Protein Processing [5]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Gene/Protein Processing [3]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [5]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]

References

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