Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRTSGP)

Drug Name

Amiloride Drug Info

Synonyms

Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)

Indication

Disease Entry	ICD 11	Status	REF
Congestive heart failure	BD10	Approved	[1]
Edema	MG29	Approved	[2]

Therapeutic Class

Diuretics

Cross-matching ID

PubChem CID: 16231
ChEBI ID: CHEBI:2639
CAS Number: CAS 2609-46-3
TTD Drug ID: DMRTSGP
VARIDT Drug ID: DR00207
ACDINA Drug ID: D00029

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Acid-sensing ion channel 1 (ASIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PPC-5650	DM2D7Z0	Pain	MG30-MG3Z	Phase 1	[14]
PcTx1	DMZVJYL	Pain	MG30-MG3Z	Investigative	[15]
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Drug(s) Transported By Organic cation transporter 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[18]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[19]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[20]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[21]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[22]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[23]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[21]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[24]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[30]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[31]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[32]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[21]
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Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[39]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[40]
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Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[45]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[48]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[48]
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Drug(s) Affected By Dysferlin (DYSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[55]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[57]
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Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[66]
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Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[70]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[74]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[75]
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Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[93]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[8]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[98]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[99]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[100]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[101]
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Drug(s) Affected By Myogenic factor 5 (MYF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[105]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[110]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
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Drug(s) Affected By Pancreas/duodenum homeobox protein 1 (PDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[118]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[119]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[120]
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Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[123]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[55]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[125]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[37]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[128]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[129]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[130]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[131]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[132]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[133]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[134]
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Drug(s) Affected By Multidrug and toxin extrusion protein 1 (SLC47A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[135]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[13]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[136]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[13]
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Drug(s) Affected By Glutamate receptor-interacting protein 1 (GRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[143]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[144]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[145]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acid-sensing ion channel 1 (ASIC1)	TTRJYB6	ASIC1_HUMAN	Modulator	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[4]
Organic cation transporter 2 (SLC22A2)	DT9IDPW	S22A2_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Post-Translational Modifications	[6]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Gene/Protein Processing	[7]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[8]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[8]
Diamine oxidase (AOC1)	OTRC220K	AOC1_HUMAN	Gene/Protein Processing	[9]
Dysferlin (DYSF)	OTNSKJU0	DYSF_HUMAN	Gene/Protein Processing	[10]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Gene/Protein Processing	[11]
Glutamate receptor-interacting protein 1 (GRIP1)	OT958HK1	GRIP1_HUMAN	Drug Response	[12]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Gene/Protein Processing	[13]
Myogenic factor 5 (MYF5)	OTTVO2S5	MYF5_HUMAN	Gene/Protein Processing	[10]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2421).
2	Amiloride FDA Label
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42.
5	Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1521-31.
6	Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride. J Cell Biochem. 2005 Oct 1;96(2):376-89. doi: 10.1002/jcb.20512.
7	Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533-43. doi: 10.1038/clpt.1980.75.
8	Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
9	Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. J Biol Chem. 1994 Apr 1;269(13):9921-5.
10	In vivo and in vitro dysferlin expression in human muscle satellite cells. J Neuropathol Exp Neurol. 2004 Oct;63(10):1104-13. doi: 10.1093/jnen/63.10.1104.
11	Reduction in the radiation-induced late S phase and G2 blocks in HL-60 cell populations by amiloride, an efficient inhibitor of the Na+/H+ transporter. Cancer Res. 1998 Feb 1;58(3):413-20.
12	Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.
13	Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Drug Metab Dispos. 2006 Nov;34(11):1868-74. doi: 10.1124/dmd.106.010876. Epub 2006 Aug 23.
14	ClinicalTrials.gov (NCT01449487) Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid. U.S. National Institutes of Health.
15	Challenges in analgesic drug development. Clin Pharmacol Ther. 2009 Oct;86(4):447-50.
16	Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
17	Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84.
18	Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells. Metallomics. 2018 Mar 1;10(3):414-425.
19	Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81.
20	Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52.
21	Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
22	The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. Mol Reprod Dev. 2007 Oct;74(10):1303-11.
23	Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86.
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