Details of the Drug Combination

General Information of Drug Combination (ID: DC2LRUE)

Drug Combination Name
Prednisolone Losartan
Indication
Disease Entry Status REF
COVID-19 Associated Cardiac Involvement Phase 3 [1]
Component Drugs Prednisolone   DMQ8FR2 Losartan   DM72JXH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Prednisolone
Disease Entry ICD 11 Status REF
Acute adrenal insufficiency N.A. Approved [2]
Acute asthma CA23 Approved [2]
Addison disease 5A74.0 Approved [2]
Allergic rhinitis CA08.0 Approved [2]
Angioedema 4A00.15 Approved [2]
Aspiration pneumonitis N.A. Approved [2]
Autoimmune haemolytic anaemia 3A20 Approved [2]
Blepharoconjunctivitis N.A. Approved [2]
Bursitis N.A. Approved [2]
Cerebral edema 8D60.1 Approved [2]
Chronic graft versus host disease N.A. Approved [2]
Congenital adrenal hyperplasia 5A71.01 Approved [2]
Corneal abrasion NA06.4 Approved [2]
Corneal ulcer 9A76 Approved [2]
Crohn disease DD70 Approved [2]
Dacryocystitis N.A. Approved [2]
Demodex blepharitis 1G07 Approved [2]
Dermatitis herpetiformis EB44 Approved [2]
Diamond-Blackfan anemia N.A. Approved [2]
Disorder of orbital region N.A. Approved [2]
Epicondylitis N.A. Approved [2]
Erythema multiforme N.A. Approved [2]
Exanthem N.A. Approved [2]
Fever MG26 Approved [2]
Granuloma annulare N.A. Approved [2]
Hypersensitivity pneumonitis N.A. Approved [2]
Inflammatory bowel disease DD72 Approved [2]
Ischemia-reperfusion injury DB98.B Approved [2]
Keratitis N.A. Approved [2]
Leukemia N.A. Approved [2]
Lupus nephritis 4A40.0Y Approved [2]
Microscopic polyangiitis N.A. Approved [2]
Miliary tuberculosis N.A. Approved [2]
Mycosis fungoides 2B01 Approved [2]
Myeloproliferative neoplasm 2A20 Approved [2]
Pneumocystis pneumonia CA40.20 Approved [2]
Polymyalgia rheumatica N.A. Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Psoriasis EA90 Approved [2]
Psoriatic arthritis FA21 Approved [2]
Rheumatic heart disease N.A. Approved [2]
Rosacea ED90.0 Approved [2]
Sarcoidosis 4B20.5 Approved [2]
Serum sickness N.A. Approved [2]
Severe asthma CA23 Approved [2]
Skin disease EA00-EM0Z Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Sympathetic ophthalmia N.A. Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [2]
Ulcerative colitis DD71 Approved [2]
Multiple sclerosis 8A40 Phase 3 [4]
Acquired thrombocytopenia N.A. Investigative [2]
Asthma CA23 Investigative [2]
Beta-thalassemia major N.A. Investigative [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Iridocyclitis N.A. Investigative [2]
Sjogren syndrome 4A43.20 Investigative [2]
Synovitis N.A. Investigative [2]
Uveitis 9A96.Z Investigative [2]
Prednisolone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [11]
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Prednisolone Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
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Prednisolone Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [13]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [14]
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Prednisolone Interacts with 121 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [15]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [8]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Decreases Expression [8]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [8]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [8]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [8]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Decreases Expression [8]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Decreases Expression [8]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Decreases Expression [8]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [8]
Antiviral innate immune response receptor RIG-I (RIGI) OTFIIC43 RIGI_HUMAN Decreases Expression [8]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [8]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [8]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [8]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [8]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [8]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [8]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Expression [8]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [8]
Neuromedin-B (NMB) OT4NLN6H NMB_HUMAN Decreases Expression [8]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [8]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [8]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [8]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [8]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Expression [8]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Decreases Expression [8]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Decreases Expression [8]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [8]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [8]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [8]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Decreases Expression [8]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Decreases Expression [8]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [8]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [8]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [8]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [8]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Decreases Expression [8]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Decreases Expression [8]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [8]
Prolargin (PRELP) OT9EEBUJ PRELP_HUMAN Increases Expression [8]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Decreases Expression [8]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [8]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Decreases Expression [8]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [8]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Decreases Expression [8]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Increases Expression [8]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [8]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [8]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Increases Expression [8]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [8]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Expression [8]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Decreases Expression [8]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Decreases Expression [8]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Decreases Expression [8]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [8]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [8]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Decreases Expression [8]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Decreases Expression [8]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) OT7G9PQE HERC6_HUMAN Decreases Expression [8]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [8]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [8]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) OTCA9WCM RSAD2_HUMAN Decreases Expression [8]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Decreases Expression [8]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Increases Expression [8]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Decreases Expression [8]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [8]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [8]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [8]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [8]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Decreases Expression [8]
Large neutral amino acids transporter small subunit 2 (SLC7A8) OT8XXVO8 LAT2_HUMAN Increases Expression [8]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Decreases Expression [8]
Paired immunoglobulin-like type 2 receptor alpha (PILRA) OTBE0PLF PILRA_HUMAN Decreases Expression [8]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [8]
Cytochrome P450 2S1 (CYP2S1) OTKHX4RF CP2S1_HUMAN Decreases Expression [16]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [9]
Inactive phospholipase C-like protein 1 (PLCL1) OTJL2C79 PLCL1_HUMAN Increases Expression [9]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [9]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Increases Expression [9]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [9]
Protein FAM200C (FAM200C) OTZOXUEK F200C_HUMAN Increases Expression [9]
Arrestin domain-containing protein 3 (ARRDC3) OTAKW7R9 ARRD3_HUMAN Increases Expression [9]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [9]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Increases Expression [9]
SLAM family member 5 (CD84) OTAY5B0F SLAF5_HUMAN Increases Expression [9]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [17]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) OTMI12L2 BMAL1_HUMAN Increases Expression [18]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Decreases Expression [18]
Period circadian protein homolog 1 (PER1) OTVQF3WX PER1_HUMAN Increases Expression [18]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [19]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [20]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [17]
Albumin (ALB) OTVMM513 ALBU_HUMAN Increases Expression [21]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Increases Expression [21]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Activity [22]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Response To Substance [23]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [24]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [24]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Increases Activity [22]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [17]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [10]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Increases Expression [10]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [10]
Ganglioside GM2 activator (GM2A) OTIRWZC0 SAP3_HUMAN Increases Expression [17]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Decreases Expression [18]
C-X-C chemokine receptor type 2 (CXCR2) OTISGW7L CXCR2_HUMAN Decreases Expression [25]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [17]
Growth/differentiation factor 5 (GDF5) OTOV8S81 GDF5_HUMAN Decreases Expression [26]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Decreases Expression [17]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Decreases Expression [17]
D site-binding protein (DBP) OTE0W7LN DBP_HUMAN Decreases Expression [18]
Cryptochrome-1 (CRY1) OTTGAJT0 CRY1_HUMAN Decreases Expression [18]
Mucin-16 (MUC16) OTHPPE67 MUC16_HUMAN Decreases Expression [27]
Lymphocyte antigen 96 (LY96) OTN4HXA2 LY96_HUMAN Decreases Expression [17]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Increases ADR [28]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Decreases Response To Substance [29]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Increases Metabolism [30]
Mothers against decapentaplegic homolog 1 (SMAD1) OTQSHR25 SMAD1_HUMAN Increases ADR [28]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases ADR [28]
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⏷ Show the Full List of 121 DOT(s)
Indication(s) of Losartan
Disease Entry ICD 11 Status REF
Diabetic kidney disease GB61.Z Approved [5]
Hypertension BA00-BA04 Approved [6]
Prediabetes syndrome N.A. Approved [5]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [7]
Losartan Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Angiotensin II receptor type-1 (AGTR1) TT8DBY3 AGTR1_HUMAN Antagonist [31]
HUMAN type-1 angiotensin II receptor (AGTR1) TTPKMXQ AGTR1_HUMAN Blocker [32]
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Losartan Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [33]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [34]
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Losartan Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [35]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [36]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [35]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [37]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [38]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [38]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [38]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DEL5N6Y UD110_HUMAN Metabolism [38]
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⏷ Show the Full List of 8 DME(s)
Losartan Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases ADR [28]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases ADR [28]
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References

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2 Prednisolone FDA Label
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32 Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol. 2020 Apr 3.
33 Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43.
34 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
35 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
36 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
37 Drug-drug interaction between losartan and paclitaxel in human liver microsomes with different CYP2C8 genotypes. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):493-8.
38 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.