Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8E54P)

Drug Name
BUTEIN Drug Info
Synonyms
butein; 487-52-5; 2',3,4,4'-Tetrahydroxychalcone; 3,4,2',4'-Tetrahydroxychalcone; 2',4',3,4-Tetrahydroxychalcone; UNII-4WVS5M0LGF; EINECS 207-659-5; 4WVS5M0LGF; (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; CHEMBL128000; CHEBI:3237; (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; ,3,4-Tetrahydroxychalcone; Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI); Acrylophenone, 2',4'-dihydroxy-3-(3,4-dihy
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281222
ChEBI ID
CHEBI:3237
CAS Number
CAS 487-52-5
TTD Drug ID
DM8E54P

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [9]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [2]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [10]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [10]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [11]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [11]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [11]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [9]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [11]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [12]
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Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [13]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [14]
Captopril DM458UM Chronic heart failure BD1Z Approved [15]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [16]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [17]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [18]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [19]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [20]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [21]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [22]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [23]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [26]
Etidronic acid DM1XHYJ Bone Paget disease Approved [23]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [23]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [28]
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Drug(s) Affected By Securin (PTTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [35]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [41]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [42]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [43]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [52]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [56]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [63]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [73]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [74]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [75]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [76]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [81]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [82]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [83]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [84]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [75]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [97]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [98]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [102]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [103]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [108]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [109]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [107]
Ethacrynic acid DM60QMR Edema MG29 Approved [110]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [111]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [113]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [115]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [41]
Meloxicam DM2AR7L Arthritis FA20 Approved [116]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [117]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [118]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [124]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [125]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [126]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [127]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [130]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Verapamil DMA7PEW Angina pectoris BA40 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [73]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [137]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [141]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [142]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [143]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [84]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Selenium DM25CGV N. A. N. A. Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [147]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [149]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [151]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [152]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [155]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [158]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [1]
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [4]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [5]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Post-Translational Modifications [4]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Gene/Protein Processing [6]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Protein Interaction/Cellular Processes [7]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Protein Interaction/Cellular Processes [5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [8]

References

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2 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
3 The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer. Chem Biol Interact. 2014 Sep 5;220:41-50. doi: 10.1016/j.cbi.2014.06.006. Epub 2014 Jun 12.
4 Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221074346. doi: 10.1177/09603271221074346.
5 Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells. Toxicol In Vitro. 2010 Oct;24(7):1927-34. doi: 10.1016/j.tiv.2010.08.002. Epub 2010 Aug 7.
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7 Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. Toxicol In Vitro. 2013 Mar;27(2):874-81. doi: 10.1016/j.tiv.2013.01.003. Epub 2013 Jan 11.
8 Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicol In Vitro. 2018 Oct;52:222-234.
9 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
10 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
12 Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
13 Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
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15 Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
16 Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
17 Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
18 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
19 Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
20 Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
21 Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
22 Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71.
23 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
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25 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
26 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
27 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
28 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
29 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
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32 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
33 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
34 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
35 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
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