Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG3Y89)

Drug Name
Trabectedin Drug Info
Synonyms Ecteinascidin; Ecteinascidin-743; Et-743; Yondelis (TN)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [1] , [2]
Ovarian cancer 2C73 Phase 3 [3]
Cross-matching ID
PubChem CID
108150
ChEBI ID
CHEBI:84050
CAS Number
CAS 114899-77-3
TTD Drug ID
DMG3Y89
INTEDE Drug ID
DR1625
ACDINA Drug ID
D01496

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [6]
Progesterone DMUY35B Premature labour JB00 Approved [7]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [9]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [11]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [12]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [7]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [14]
Progesterone DMUY35B Premature labour JB00 Approved [15]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [17]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [18]
Dopamine DMPGUCF Parkinson disease 8A00.0 Approved [19]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [20]
Propranolol DM79NTF Migraine 8A80 Approved [21]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [22]
Progesterone DMUY35B Premature labour JB00 Approved [23]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [24]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [25]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [26]
Busulfan DMXYJ9C Myeloproliferative syndrome 2A22 Approved [27]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [28]
Ethacrynic acid DM60QMR High blood pressure BA00 Approved [29]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [30]
Melphalan DMOLNHF Multiple myeloma 2A83 Approved [31]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [32]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [35]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [36]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [37]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [38]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [44]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [46]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [47]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [50]
Progesterone DMUY35B Premature labour JB00 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [51]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [53]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [55]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Diazepam DM08E9O Epilepsy 8A60-8A68 Approved [5]
Dapsone DM4LT8A Pneumocystis pneumonia CA40.20 Approved [5]
Ifosfamide DMCT3I8 Solid tumour/cancer 2A00-2F9Z Approved [5]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [5]
Thalidomide DM70BU5 Multiple myeloma 2A83 Approved [5]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [5]
Irbesartan DMTP1DC Hypertension BA00-BA04 Approved [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [4]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [4]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [5]

References

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