General Information of Drug (ID: DMG3Y89)

Drug Name
Trabectedin Drug Info
Synonyms Ecteinascidin; Ecteinascidin-743; Et-743; Yondelis (TN)
Indication
Disease Entry ICD 11 Status REF
Leiomyosarcoma 2B58 Approved [1]
Liposarcoma 2B59 Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Ovarian cancer 2C73 Phase 3 [3]
Cross-matching ID
PubChem CID
108150
ChEBI ID
CHEBI:84050
CAS Number
CAS 114899-77-3
TTD Drug ID
DMG3Y89
INTEDE Drug ID
DR1625
ACDINA Drug ID
D01496

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [10]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [11]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [12]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [13]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [14]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [16]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [13]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [20]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [21]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [22]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [23]
Propranolol DM79NTF Angina pectoris BA40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [28]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [29]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [30]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [31]
Ethacrynic acid DM60QMR Edema MG29 Approved [32]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [33]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [34]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [39]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [40]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Estrone DM5T6US Acne vulgaris ED80 Approved [42]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [43]
Ethanol DMDRQZU Chronic pain MG30 Approved [44]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
Estrone DM5T6US Acne vulgaris ED80 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [53]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [58]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [5]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [5]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [5]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [5]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [5]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [77]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [82]
Etretinate DM2CZFA Keratosis ED56 Approved [83]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [92]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [98]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [99]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [102]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [99]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Gefitinib DM15F0X Colon adenocarcinoma Approved [110]
Selenium DM25CGV N. A. N. A. Approved [111]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [112]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Selenium DM25CGV N. A. N. A. Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [116]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [117]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Verapamil DMA7PEW Angina pectoris BA40 Approved [121]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [122]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Selenium DM25CGV N. A. N. A. Approved [111]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [124]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [125]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Prednisone DM2HG4X Acute asthma CA23 Approved [130]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [130]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Epinephrine DM3KJBC Acute asthma CA23 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Fluoxetine DM3PD2C Bipolar depression Approved [135]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [137]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [138]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [139]
Gefitinib DM15F0X Colon adenocarcinoma Approved [140]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [142]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [146]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [4]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [4]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [6]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Gene/Protein Processing [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [6]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Gene/Protein Processing [6]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Gene/Protein Processing [7]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Gene/Protein Processing [7]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [7]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) OTRAFFX2 GPX4_HUMAN Gene/Protein Processing [7]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Drug Response [8]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Gene/Protein Processing [6]

References

1 Trabectedin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2774).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
6 Selective effects of the anticancer drug Yondelis (ET-743) on cell-cycle promoters. Mol Pharmacol. 2005 Nov;68(5):1496-503. doi: 10.1124/mol.105.013615. Epub 2005 Jun 16.
7 Trabectedin induces ferroptosis via regulation of HIF-1/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells. Chem Biol Interact. 2023 Jan 5;369:110262. doi: 10.1016/j.cbi.2022.110262. Epub 2022 Nov 14.
8 The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary. Clin Cancer Res. 2011 Jul 1;17(13):4462-73. doi: 10.1158/1078-0432.CCR-10-2987. Epub 2011 May 27.
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11 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
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13 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
14 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
15 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
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19 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
20 Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
21 Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
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23 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
24 Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
25 Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55.
26 Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
27 Retinoid X receptor alpha regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec;68(6):1590-6.
28 Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3.
29 Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos. 1995 Jan;23(1):119-23.
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32 Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7.
33 Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.
34 Metabolism of melphalan by rat liver microsomal glutathione S-transferase. Chem Biol Interact. 2005 Apr 15;152(2-3):101-6.
35 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
36 Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96.
37 Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9.
38 Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55.
39 A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300.
40 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
41 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
42 Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. Drug Metab Dispos. 2000 Feb;28(2):110-2.
43 Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6.
44 CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
45 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
46 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
47 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
48 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
49 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
50 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
51 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
52 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
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