Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGIZF5)

Drug Name
Hydroxyflutamide Drug Info
Synonyms
HFT; Hydroxyniphtholide; PC1193; Sch 16423; Hydroxy-flutamide; OH-flutamide; Sch-16423; Alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide; Alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide; 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
91649
CAS Number
CAS 52806-53-8
TTD Drug ID
DMGIZF5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [6]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [7]
Darolutamide DMV7YFT Prostate cancer 2C82.0 Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [9]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [10]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [11]
Fludrocortisone DMUDIR8 Addison disease 5A74.0 Approved [12]
ARN-509 DMT81LZ Acute myeloid leukaemia 2A60 Approved [13]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [14]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [15]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [4]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [4]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [16]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [19]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [29]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [30]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [31]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [33]
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Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [34]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [38]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [39]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [40]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [40]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [41]
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Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [44]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ethanol DMDRQZU Chronic pain MG30 Approved [47]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [48]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [49]
Arsenic DMTL2Y1 N. A. N. A. Approved [50]
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Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [52]
Selenium DM25CGV N. A. N. A. Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [54]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [55]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [44]
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Drug(s) Affected By Beta-microseminoprotein (MSMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Folic Acid DMEMBJC Colorectal carcinoma Approved [60]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [62]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [63]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [61]
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Drug(s) Affected By Prolactin-inducible protein (PIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [66]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [66]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [67]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [68]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [69]
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plastin-2 (LCP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [84]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [86]
Arsenic DMTL2Y1 N. A. N. A. Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Dydrogesterone DMAKIDV Menstrual disorder GA20.3 Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [92]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [93]
Finasteride DMWV3TZ Baldness, male pattern Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Panobinostat DM58WKG Chronic graft versus host disease Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [99]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
Testosterone DM7HUNW Hot flushes GA30 Approved [5]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [101]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [107]
Gefitinib DM15F0X Colon adenocarcinoma Approved [108]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [111]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [102]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [112]
Paclitaxel DMLB81S Breast carcinoma Approved [113]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [101]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [115]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [122]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [5]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [124]
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Drug(s) Affected By Splicing factor 1 (SF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [125]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [127]
Benzatropine DMF7EXL Parkinsonian disorder Approved [128]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [129]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Androgen receptor (AR) TTS64P2 ANDR_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Gene/Protein Processing [3]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Drug Response [4]
Beta-microseminoprotein (MSMB) OTYORAJC MSMB_HUMAN Gene/Protein Processing [3]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Post-Translational Modifications [5]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Post-Translational Modifications [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Post-Translational Modifications [5]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Plastin-2 (LCP1) OTK61F2A PLSL_HUMAN Gene/Protein Processing [3]

References

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2 Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44.
3 Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
4 TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicol Appl Pharmacol. 2016 Sep 15;307:91-101. doi: 10.1016/j.taap.2016.07.018. Epub 2016 Jul 27.
5 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
6 Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004 Apr;3(2):171-87.
7 Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
9 Molecular mechanism of androgen action. Trends Endocrinol Metab. 1998 Oct 1;9(8):317-24.
10 Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
11 Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 2010 May;121(1):1-11.
12 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
13 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
14 CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res. 2008 Mar 15;68(6):1715-22.
15 Expression of androgen receptor on fibroblast and hepatocyte of rats after deep second-degree burn caused by scalding. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):362-4.
16 Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015 Jul 13;43(12):5880-97. doi: 10.1093/nar/gkv262. Epub 2015 Apr 23.
17 Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282.
18 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
19 Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.
20 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
21 Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
22 Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. doi: 10.1016/j.tox.2003.09.012.
23 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
24 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
25 Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
26 Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
27 Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol. 2009 Feb 1;77(3):384-96. doi: 10.1016/j.bcp.2008.10.035. Epub 2008 Nov 6.
28 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
29 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
30 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
31 Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 2003 Sep;15(9):851-9. doi: 10.1016/s0898-6568(03)00036-6.
32 Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
33 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
34 Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Aug;90(8):4858-65. doi: 10.1210/jc.2005-0330. Epub 2005 May 24.
35 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
36 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
37 Use of organ culture to study the human fetal testis development: effect of retinoic acid. J Clin Endocrinol Metab. 2006 Jul;91(7):2696-703.
38 Inhibition of CYP17 expression by adrenal androgens and transforming growth factor beta in adrenocortical cells. Acta Biochim Pol. 2004;51(4):907-17.
39 Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem. 2008 Mar 14;283(11):6925-34. doi: 10.1074/jbc.M708432200. Epub 2008 Jan 9.
40 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
41 A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21. J Enzyme Inhib Med Chem. 2006 Oct;21(5):547-56.
42 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
43 A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
44 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
45 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
46 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
47 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
48 Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposure. Toxicol Lett. 2021 Oct 15;351:78-88. doi: 10.1016/j.toxlet.2021.08.007. Epub 2021 Aug 25.
49 Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
50 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
51 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
52 Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta. 2001 Oct;312(1-2):213-9. doi: 10.1016/s0009-8981(01)00626-x.
53 EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.
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