Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVRIC2)

Drug Name
Zileuton Drug Info
Synonyms
Leutrol; Zileutonum; Ziluton; Zyflo; Abbott brand of zileuton; Zyflo CR; Zyflo Filmtab; A 64077; Abbot 64077; Abbott 64077; A-64077; ABBOTT-64077; ABT-077; CTI-02; ZYFLO (TN); ZYFLO, Zileuton; Zileutonum [INN-Latin]; Zyflo (TN); Zileuton (USP/INN); Zileuton [USAN:INN:BAN]; N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea; N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea; (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea; (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Indication
Disease Entry ICD 11 Status REF
Allergic asthma CA23.0 Approved [1]
Asthma CA23 Approved [2]
Intrinsic asthma Approved [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
60490
ChEBI ID
CHEBI:10112
CAS Number
CAS 111406-87-2
TTD Drug ID
DMVRIC2
INTEDE Drug ID
DR1730
ACDINA Drug ID
D00740

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [13]
Silymarin DMXBYQR N. A. N. A. Phase 4 [14]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [15]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [16]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [17]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [18]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [19]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [20]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [21]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [57]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [58]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [10]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [60]
Capsaicin DMGMF6V Back pain ME84.Z Approved [61]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [62]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [39]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [63]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [63]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [63]
Capsaicin DMGMF6V Back pain ME84.Z Approved [64]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [65]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [66]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [67]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [68]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [69]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [70]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [41]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [46]
Estrone DM5T6US Acne vulgaris ED80 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [4]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [52]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [4]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [4]
Haloperidol DM96SE0 Delirium Approved [4]
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Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [4]
Diazepam DM08E9O Alcohol withdrawal Approved [4]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [4]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [4]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [4]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [4]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [4]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [4]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [73]
Fructose DM43AN2 Vomiting MD90 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [10]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [79]
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Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [87]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [88]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [92]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [93]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [96]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [100]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [101]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [102]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [107]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [111]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [113]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [115]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Folic Acid DMEMBJC Colorectal carcinoma Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [120]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [121]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [122]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [123]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [124]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [124]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [6]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [8]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [9]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [10]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Protein Interaction/Cellular Processes [11]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Drug Response [12]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [7]

References

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