Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXBYQR)

Drug Name
Silymarin Drug Info
Synonyms
Milk thistle extract; Sabal serrulata extract; 84604-20-6; AN-35849; FT-0656490; A835184; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one
Cross-matching ID
PubChem CID
5213
ChEBI ID
CHEBI:125451
CAS Number
CAS 65666-07-1
TTD Drug ID
DMXBYQR
VARIDT Drug ID
DR01185
INTEDE Drug ID
DR1913

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [7]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [8]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [9]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [10]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [11]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [12]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [13]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [14]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [15]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [16]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [20]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [23]
Metronidazole DMTIVEN Abscess Approved [24]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [25]
Ethanol DMDRQZU Chronic pain MG30 Approved [26]
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Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [28]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [31]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [32]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [34]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [35]
Topotecan DMP6G8T Central nervous system neoplasm Approved [36]
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Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Ketoprofen DMRKXPT Bursitis Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Haloperidol DM96SE0 Delirium Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [49]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [50]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [55]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [3]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [3]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [56]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [55]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [3]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [58]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [55]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [62]
Etidronic acid DM1XHYJ Bone Paget disease Approved [59]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [59]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [64]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Capsaicin DMGMF6V Back pain ME84.Z Approved [73]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Etretinate DM2CZFA Keratosis ED56 Approved [78]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [86]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [87]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [88]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [87]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [92]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Selenium DM25CGV N. A. N. A. Approved [77]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [95]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Etretinate DM2CZFA Keratosis ED56 Approved [78]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [88]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [110]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [112]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [113]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [114]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Fluoxetine DM3PD2C Bipolar depression Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [123]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [126]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [127]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [128]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [129]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [96]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [133]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [134]
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Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Ethanol DMDRQZU Chronic pain MG30 Approved [138]
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Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [139]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [140]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Prednisone DM2HG4X Acute asthma CA23 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Fluoxetine DM3PD2C Bipolar depression Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [147]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [150]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Folic Acid DMEMBJC Colorectal carcinoma Approved [153]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [154]
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Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Verapamil DMA7PEW Angina pectoris BA40 Approved [160]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [110]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [162]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [163]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [165]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [166]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [166]
Gefitinib DM15F0X Colon adenocarcinoma Approved [167]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [38]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [168]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [169]
Methotrexate DM2TEOL Anterior urethra cancer Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [172]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [173]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) Main DME DEYGVN4 UD11_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [4]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [5]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [6]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Gene/Protein Processing [6]

References

1 Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4.
2 Role of UDP-glucuronosyltransferase 1A1 in the metabolism and pharmacokinetics of silymarin flavonolignans in patients with HCV and NAFLD. Molecules. 2017 Jan 15;22(1). pii: E142.
3 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
4 Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007 Apr;96(2):227-36. doi: 10.1093/toxsci/kfl147. Epub 2006 Oct 31.
5 Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study. Toxicol Appl Pharmacol. 2010 Sep 1;247(2):116-28.
6 Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int J Cancer. 2008 Jul 1;123(1):41-50. doi: 10.1002/ijc.23485.
7 5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9. Neurol Res. 2009 Oct;31(8):848-52.
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