Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYKZ6U)

Drug Name
NMS-873 Drug Info
Synonyms NMS 873; NM S873; EX-A353; NMS873
Indication
Disease Entry ICD 11 Status REF
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
71521142
TTD Drug ID
DMYKZ6U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [9]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Fructose DM43AN2 Vomiting MD90 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [6]
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Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [17]
Leflunomide DMR8ONJ Arthritis FA20 Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
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Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [27]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [24]
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Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [34]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [35]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [36]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [18]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [42]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [43]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Paclitaxel DMLB81S Breast carcinoma Approved [48]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [62]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Etretinate DM2CZFA Keratosis ED56 Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [74]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [78]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [80]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
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Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [91]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
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Drug(s) Affected By Calnexin (CANX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [100]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [108]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [66]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [116]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [118]
Gefitinib DM15F0X Colon adenocarcinoma Approved [119]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Etretinate DM2CZFA Keratosis ED56 Approved [121]
Prednisone DM2HG4X Acute asthma CA23 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [123]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [126]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [127]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [129]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [130]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [132]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Gefitinib DM15F0X Colon adenocarcinoma Approved [134]
Prednisone DM2HG4X Acute asthma CA23 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Fluoxetine DM3PD2C Bipolar depression Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [141]
Selenium DM25CGV N. A. N. A. Approved [142]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [143]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [147]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [148]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [151]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [152]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [153]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [156]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [157]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [158]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [160]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Meloxicam DM2AR7L Arthritis FA20 Approved [161]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [163]
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Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [167]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [62]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [132]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [159]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Meloxicam DM2AR7L Arthritis FA20 Approved [168]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [169]
Methotrexate DM2TEOL Anterior urethra cancer Approved [170]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [171]
Quercetin DM3NC4M Obesity 5B81 Approved [172]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [174]
Ethacrynic acid DM60QMR Edema MG29 Approved [175]
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Drug(s) Affected By ERO1-like protein alpha (ERO1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [17]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [176]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [177]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [178]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [176]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [179]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [180]
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Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [182]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [24]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [27]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN valosin-containing protein p97 (VCP) TTYWTI0 TERA_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [3]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Gene/Protein Processing [3]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]

References

1 Proteomics of SARS-CoV-2-infected Host Cells Reveals Therapy Targets. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7.
2 A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.
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