Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAMCSR)

• Drug Name: acrolein Drug Info
• Synonyms: ACROLEIN; Acrylaldehyde; 2-Propenal; Propenal; 107-02-8; Acrylic aldehyde; Allyl aldehyde; prop-2-enal; Ethylene aldehyde; Acraldehyde; Aqualin; Magnacide H; 2-Propen-1-one; Aqualine; Slimicide; Crolean; Acquinite; Magnacide; Prop-2-en-1-al; Acrylaldehyd; Akroleina; Akrolein; Acroleine; Acroleina; Papite; Biocide; Aldeide acrilica; Aldehyde acrylique; Acraldehydeacroleina; polyacrolein; Propenaldehyde; trans-Acrolein; NSC 8819; Akrolein [Czech]; Propenal [Czech]; Rcra waste number P003; Magnacide H and B; Akroleina [Polish]; Acroleina [Italian]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 7847
  ChEBI ID: CHEBI:15368
  CAS Number: CAS 107-02-8
  TTD Drug ID: DMAMCSR

Molecule-Related Drug Atlas

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[11]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[12]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[13]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[14]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[15]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[16]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[17]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[18]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[19]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[20]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[30]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[32]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Drug(s) Affected By Prostacyclin synthase (PTGIS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[45]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
NAFAZATROM	DM31CV2	N. A.	N. A.	Terminated	[49]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[51]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[52]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[68]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[77]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[112]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[113]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[119]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[120]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[133]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[142]

Drug(s) Affected By AMP deaminase 3 (AMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]

Drug(s) Affected By Nesprin-2 (SYNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[58]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[168]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[169]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[170]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[175]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[170]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[182]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[188]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[189]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[193]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[198]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[201]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[207]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[213]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[216]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[217]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[221]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[223]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[226]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[151]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[228]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[229]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[230]
Fructose	DM43AN2	Vomiting	MD90	Approved	[49]
Ketoprofen	DMRKXPT	Bursitis		Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[238]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[239]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[244]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[245]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[248]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[58]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[250]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[251]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[252]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[255]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[256]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[257]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[260]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[261]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[217]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[267]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[271]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[273]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[282]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[284]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[285]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[286]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[28]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[30]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[295]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[296]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[298]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[301]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[304]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[305]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[306]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[309]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[312]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[313]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[314]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[315]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[316]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[317]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[318]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[319]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[249]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[325]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[326]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[327]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[328]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[329]
Fructose	DM43AN2	Vomiting	MD90	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[331]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[334]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[340]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[346]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[347]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[350]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[351]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[352]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[160]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Haloperidol	DM96SE0	Delirium		Approved	[354]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[357]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[358]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[318]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[361]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[362]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[366]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[367]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[366]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[371]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[372]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[318]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[331]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[374]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[58]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[375]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[377]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[378]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[379]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[380]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[382]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[384]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[151]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[382]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[386]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[388]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[389]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[390]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[179]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[394]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[395]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[396]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[329]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[397]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[398]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[367]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[400]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[403]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[405]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[410]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[411]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[414]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[416]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[418]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[418]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[419]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[420]

Drug(s) Affected By Atrial natriuretic peptide receptor 3 (NPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[422]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[423]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[424]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[425]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[308]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[427]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[428]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[429]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[430]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[432]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[434]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[436]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[437]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[238]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[440]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[444]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[445]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 5 (KCNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[448]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[449]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[450]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[448]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[451]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[451]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[451]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[452]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[49]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[459]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[460]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[462]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[463]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[464]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[465]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[466]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[467]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[470]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[463]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[471]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[472]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[473]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[462]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[464]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[474]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[249]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[479]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[480]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[482]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[484]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[485]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[486]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[424]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[488]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[489]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[386]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[388]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[491]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[492]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[494]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[495]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[496]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[497]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Bortezomib	DMNO38U	Leukemia		Approved	[498]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[499]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[449]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[500]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[501]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[502]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[503]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[367]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[504]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[505]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[507]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[508]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[509]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[510]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[512]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[513]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[514]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[515]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[516]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[514]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[517]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[427]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[518]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[315]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[519]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[333]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[520]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[521]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[522]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[524]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Fructose	DM43AN2	Vomiting	MD90	Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[526]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[527]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[528]

Drug(s) Affected By Ubiquitin-conjugating enzyme E2 R1 (CDC34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Bortezomib	DMNO38U	Leukemia		Approved	[529]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[531]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[531]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[532]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[533]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[534]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[535]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[536]

Drug(s) Affected By Emerin (EMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[537]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[538]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[540]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[541]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[541]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[437]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[542]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[412]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[543]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[544]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[380]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[547]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[548]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[549]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[550]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[461]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[49]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[553]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[439]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[554]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[555]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[558]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[559]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[560]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[561]
Selenium	DM25CGV	N. A.	N. A.	Approved	[562]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[563]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[564]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[85]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[565]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[85]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[566]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[567]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[568]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[569]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[568]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[571]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[448]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[572]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[573]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[574]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[576]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[576]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[577]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[578]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[576]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[576]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[579]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[438]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[580]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[581]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[375]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[379]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[85]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[545]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[502]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[582]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[367]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[585]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[586]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[588]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[591]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[592]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[591]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[594]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[595]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[596]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[597]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[592]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[598]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[599]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[600]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[601]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[602]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[603]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[604]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[479]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[605]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[227]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[358]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[227]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[607]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[448]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[608]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[609]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[610]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[611]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[612]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[613]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[614]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[615]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[521]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[548]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[198]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[617]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[618]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[620]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[606]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[520]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[622]

Drug(s) Affected By Autophagy-related protein 16-1 (ATG16L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[623]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[624]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[625]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[626]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[627]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[628]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[534]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[629]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[630]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[458]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[631]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[632]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[633]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Selenium	DM25CGV	N. A.	N. A.	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[604]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[479]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[635]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[636]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[139]

Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[638]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[422]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[640]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[198]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[641]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[193]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[640]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[642]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[643]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[357]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]

Drug(s) Affected By Anaphase-promoting complex subunit 2 (ANAPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[644]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[645]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[479]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[395]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[607]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[360]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[646]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[647]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[648]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[649]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[650]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[651]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[652]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[653]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[654]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[656]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[657]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[658]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[659]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[660]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[661]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[662]

Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[663]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[665]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[666]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[668]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[669]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[670]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[671]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[671]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[672]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[70]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[673]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[432]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[674]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[445]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[675]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[676]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[677]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[678]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[357]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[124]

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[679]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[680]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[681]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[448]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[530]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[448]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[681]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Protein Interaction/Cellular Processes	[3]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Biotransformations	[4]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Biotransformations	[4]
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Biotransformations	[5]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Biotransformations	[5]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Drug Response	[6]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Biochemical Pathways	[7]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Gene/Protein Processing	[8]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[9]
Anaphase-promoting complex subunit 2 (ANAPC2)	OTAGLIAO	ANC2_HUMAN	Gene/Protein Processing	[10]

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