Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAMCSR)

Drug Name
acrolein Drug Info
Synonyms
ACROLEIN; Acrylaldehyde; 2-Propenal; Propenal; 107-02-8; Acrylic aldehyde; Allyl aldehyde; prop-2-enal; Ethylene aldehyde; Acraldehyde; Aqualin; Magnacide H; 2-Propen-1-one; Aqualine; Slimicide; Crolean; Acquinite; Magnacide; Prop-2-en-1-al; Acrylaldehyd; Akroleina; Akrolein; Acroleine; Acroleina; Papite; Biocide; Aldeide acrilica; Aldehyde acrylique; Acraldehydeacroleina; polyacrolein; Propenaldehyde; trans-Acrolein; NSC 8819; Akrolein [Czech]; Propenal [Czech]; Rcra waste number P003; Magnacide H and B; Akroleina [Polish]; Acroleina [Italian]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7847
ChEBI ID
CHEMBL721
CAS Number
CAS 107-02-8
TTD Drug ID
DMAMCSR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
LY3526318 DMFXNQM Chronic low-back pain MG30 Phase 2 [13]
HX-100 DMFRM15 Diabetic neuropathy 8C0Z Phase 1 [14]
NPPB DMFIWAN Discovery agent N.A. Investigative [15]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [16]
[3H]resolvin D1 DMFT0HU Discovery agent N.A. Investigative [17]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [18]
icilin DMYVOL9 Discovery agent N.A. Investigative [19]
4-oxo-nonenal DMPX1J9 Discovery agent N.A. Investigative [20]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [21]
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Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [31]
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Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Etretinate DM2CZFA Keratosis ED56 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [40]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
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Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
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Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [66]
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Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [72]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [73]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [74]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [78]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [79]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
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Drug(s) Affected By Ferritin light chain (FTL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [51]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Ethanol DMDRQZU Chronic pain MG30 Approved [87]
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Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [92]
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Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Folic Acid DMEMBJC Colorectal carcinoma Approved [95]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [98]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [99]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
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Drug(s) Affected By AMP deaminase 3 (AMPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [102]
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Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Testosterone enanthate DMB6871 N. A. N. A. Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [106]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [107]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [108]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [109]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
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Drug(s) Affected By Nesprin-2 (SYNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [66]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [102]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [113]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [114]
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Drug(s) Affected By Claudin-5 (CLDN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [116]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [117]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [118]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [119]
Urethane DM7NSI0 N. A. N. A. Phase 4 [120]
CS-600G DM1PV4Y N. A. N. A. Phase 3 [121]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [122]
LY294002 DMY1AFS Neuroblastoma 2D11.2 Phase 1 [123]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [118]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [130]
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Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Selenium DM25CGV N. A. N. A. Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [133]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [134]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [135]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [136]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [140]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [142]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [144]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [147]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [149]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [151]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [152]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [154]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Capsaicin DMGMF6V Back pain ME84.Z Approved [155]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Etretinate DM2CZFA Keratosis ED56 Approved [157]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [160]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Selenium DM25CGV N. A. N. A. Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [166]
Epinephrine DM3KJBC Acute asthma CA23 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [169]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [170]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [171]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [173]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [174]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [177]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [179]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [180]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [182]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [183]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [184]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [185]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [186]
Fructose DM43AN2 Vomiting MD90 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [189]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [191]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [192]
Methotrexate DM2TEOL Anterior urethra cancer Approved [193]
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Drug(s) Affected By Matrilysin (MMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [197]
Clozapine DMFC71L Schizophrenia 6A20 Approved [198]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromelysin-2 (MMP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [165]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Haloperidol DM96SE0 Delirium Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [144]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [204]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [205]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [204]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [206]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [207]
Methotrexate DM2TEOL Anterior urethra cancer Approved [208]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [209]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [210]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [211]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [212]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [189]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [215]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [216]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [217]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Selenium DM25CGV N. A. N. A. Approved [51]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [93]
Etretinate DM2CZFA Keratosis ED56 Approved [219]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [221]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [222]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [223]
Quercetin DM3NC4M Obesity 5B81 Approved [224]
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Drug(s) Affected By Atrial natriuretic peptide receptor 3 (NPR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Folic Acid DMEMBJC Colorectal carcinoma Approved [95]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [225]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [226]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [227]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [228]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [229]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [230]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [231]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [233]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [234]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
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Drug(s) Affected By Potassium voltage-gated channel subfamily A member 5 (KCNA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [235]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Pergolide mesylate DM5GKOV N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [238]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [239]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [240]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [240]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [240]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [241]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [242]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [243]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [245]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [246]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [247]
Gefitinib DM15F0X Colon adenocarcinoma Approved [248]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [251]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [242]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [252]
Paclitaxel DMLB81S Breast carcinoma Approved [253]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [254]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [241]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [259]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [260]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [261]
Testosterone DM7HUNW Hot flushes GA30 Approved [262]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [264]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [265]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [147]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [267]
Leflunomide DMR8ONJ Arthritis FA20 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [268]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [269]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [270]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [272]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Methotrexate DM2TEOL Anterior urethra cancer Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [275]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [278]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [279]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [107]
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Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Testosterone enanthate DMB6871 N. A. N. A. Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [280]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [281]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [107]
Bortezomib DMNO38U Leukemia Approved [282]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [283]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [238]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [284]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [190]
Gefitinib DM15F0X Colon adenocarcinoma Approved [285]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [286]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Etretinate DM2CZFA Keratosis ED56 Approved [287]
Prednisone DM2HG4X Acute asthma CA23 Approved [288]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage metalloelastase (MMP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [165]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [290]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [291]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [290]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [200]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [292]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [293]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [291]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [294]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [296]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Gefitinib DM15F0X Colon adenocarcinoma Approved [297]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [183]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [298]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [192]
Ethacrynic acid DM60QMR Edema MG29 Approved [299]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [301]
Epinephrine DM3KJBC Acute asthma CA23 Approved [302]
Quercetin DM3NC4M Obesity 5B81 Approved [303]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Fructose DM43AN2 Vomiting MD90 Approved [304]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [305]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [306]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [307]
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Drug(s) Affected By Ubiquitin-conjugating enzyme E2 R1 (CDC34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Bortezomib DMNO38U Leukemia Approved [308]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [309]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [310]
Urethane DM7NSI0 N. A. N. A. Phase 4 [120]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [311]
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Drug(s) Affected By Emerin (EMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Testosterone enanthate DMB6871 N. A. N. A. Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Ethanol DMDRQZU Chronic pain MG30 Approved [312]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [107]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [313]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [114]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [111]
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Drug(s) Affected By Mucin-5AC (MUC5AC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [314]
Selenium DM25CGV N. A. N. A. Approved [315]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [316]
Capsaicin DMGMF6V Back pain ME84.Z Approved [317]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [49]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [318]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [49]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [320]
Gefitinib DM15F0X Colon adenocarcinoma Approved [202]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [321]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [322]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [323]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [324]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [325]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Testosterone DM7HUNW Hot flushes GA30 Approved [327]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [328]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [329]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [330]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [333]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [333]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [334]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [335]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [333]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [333]
Ethacrynic acid DM60QMR Edema MG29 Approved [333]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [336]
Selenium DM25CGV N. A. N. A. Approved [51]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [337]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [234]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [338]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [339]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [340]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [342]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [343]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Etretinate DM2CZFA Keratosis ED56 Approved [287]
Quercetin DM3NC4M Obesity 5B81 Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [345]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [346]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [347]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [349]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [350]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [144]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [352]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [349]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [350]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [353]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [354]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [355]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [356]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [357]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [352]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [358]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-1 (TFDP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [340]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [360]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Menthol DMG2KW7 Back pain ME84.Z Approved [361]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [107]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [362]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [363]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [364]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [365]
Arsenic DMTL2Y1 N. A. N. A. Approved [366]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [268]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [139]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [368]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [370]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [371]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [373]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [340]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [360]
Ethacrynic acid DM60QMR Edema MG29 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy-related protein 16-1 (ATG16L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [377]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [378]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [379]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [350]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [380]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [381]
Quercetin DM3NC4M Obesity 5B81 Approved [382]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [383]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Selenium DM25CGV N. A. N. A. Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [384]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [385]
Testosterone DM7HUNW Hot flushes GA30 Approved [327]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [386]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [387]
Ethanol DMDRQZU Chronic pain MG30 Approved [388]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [389]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [390]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [391]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [390]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [392]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [226]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [393]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [395]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [139]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [396]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [133]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [395]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [133]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [397]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [141]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [376]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [399]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anaphase-promoting complex subunit 2 (ANAPC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [400]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [111]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [111]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Selenium DM25CGV N. A. N. A. Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [402]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [385]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ethanol DMDRQZU Chronic pain MG30 Approved [403]
Menthol DMG2KW7 Back pain ME84.Z Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [404]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [405]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [406]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [407]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [408]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [409]
Topotecan DMP6G8T Central nervous system neoplasm Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [411]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [405]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [412]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [413]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [414]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [415]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [416]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [417]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [418]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [419]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [420]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [421]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [376]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [225]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [422]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [424]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [225]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [309]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [237]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [424]
Urethane DM7NSI0 N. A. N. A. Phase 4 [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transformation-sensitive protein p120 (TRPA1) TTELV3W TRPA1_HUMAN Activator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Biotransformations [3]
Aldo-keto reductase family 1 member A1 (AKR1A1) OTZT9NOW AK1A1_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Drug Response [5]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Biochemical Pathways [6]
AMP deaminase 3 (AMPD3) OT5SP1KJ AMPD3_HUMAN Gene/Protein Processing [7]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [8]
Anaphase-promoting complex subunit 2 (ANAPC2) OTAGLIAO ANC2_HUMAN Gene/Protein Processing [9]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Gene/Protein Processing [10]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Protein Interaction/Cellular Processes [11]

References

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3 Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts. Chem Res Toxicol. 2012 Mar 19;25(3):722-9.
4 Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):487-504.
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6 In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. J Neural Transm (Vienna). 2007;114(12):1559-67. doi: 10.1007/s00702-007-0789-2. Epub 2007 Aug 10.
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10 Apigenin and apigenin-7, 4'-O-dioctanoate protect against acrolein-aggravated inflammation via inhibiting the activation of NLRP3 inflammasome and HMGB1/MYD88/NF-B signaling pathway in Human umbilical vein endothelial cells (HUVEC). Food Chem Toxicol. 2022 Oct;168:113400. doi: 10.1016/j.fct.2022.113400. Epub 2022 Aug 31.
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22 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
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24 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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34 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
35 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
36 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
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41 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
42 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
43 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
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