Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBGZI3)

Drug Name
Chlorpromazine Drug Info
Synonyms
Aminasine; Aminazin; Aminazine; Ampliactil; Amplicitil; Amplictil; BC 135; Chlor-PZ; Chlor-Promanyl; Chlordelazine; Chlorderazin; Chloropromazine; Chlorpromados; Chlorpromanyl (discontinued); Chlorpromazin; Chlorpromazine (USP/INN); Chlorpromazine Tannate; Chlorpromazine [USAN:INN:BAN]; Chlorpromazinum; Chlorpromazinum [INN-Latin]; Clorpromazina; Clorpromazina [INN-Spanish]; Clorpromazina [Italian]; Contomin; Cromedazine; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746; JHICC02042; Largactil; Largactil (TN); Largactil Liquid; Largactil Oral Drops; Largactilothiazine; Largactyl; Megaphen; Novo-Chlorpromazine; Novomazina; Phenactyl; Phenathyl; Phenothiazine hydrochloride; Plegomasine; Plegomazin; Prazilpromactil; Proma; Promactil; Promazil; Propaphen; Propaphenin; Prozil; Psychozine; SKF 2601-A; SKF 2601A; SKF-2601; Sanopron; Thorazine; Thorazine (TN); Thorazine Spansule; Thorazine Suppositories; Thorazine hydrochloride; Torazina; Wintermin; Z80
Indication
Disease Entry ICD 11 Status REF
Acute intermittent hepatic porphyria 5C58.11 Approved [1]
Disruptive behavior disorder Approved [1]
Psychotic disorder 6A20-6A25 Approved [1]
Schizophrenia 6A20 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [4]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [4]
Therapeutic Class
Antipsychotic Agents
Cross-matching ID
PubChem CID
2726
ChEBI ID
CHEMBL71
CAS Number
CAS 34468-21-8
TTD Drug ID
DMBGZI3
VARIDT Drug ID
DR00502
INTEDE Drug ID
DR0308
ACDINA Drug ID
D00124

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HUMAN clathrin-mediated endocytosis (RME)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triflupromazine DMKFQJP Nausea MD90 Approved [16]
Thiethylperazine DMU3IET Nausea MD90 Approved [16]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [16]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [17]
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [18]
Haloperidol DM96SE0 Delirium Approved [19]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [20]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [21]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [22]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [23]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [24]
Pimozide DMW83TP Schizophrenia 6A20 Approved [25]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [26]
Risperidone DMN6DXL Bipolar I disorder Approved [27]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [28]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [6]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [6]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [43]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [50]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [55]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
Propranolol DM79NTF Angina pectoris BA40 Approved [59]
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Drug(s) Metabolized By Docosahexaenoic acid omega-hydroxylase (CYP4F11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [10]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [10]
Benzphetamine DMIJATC Obesity 5B81 Approved [10]
Ethylmorphine DM0YROF Discovery agent N.A. Investigative [10]
Drug(s) Affected By D(2) dopamine receptor (DRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Droperidol DM0DXA8 Nausea MD90 Approved [60]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [60]
Zuclopenthixol DMKYD5N Schizophrenia 6A20 Approved [60]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [61]
Sulpiride DMF54ZG Schizophrenia 6A20 Approved [62]
Risperidone DMN6DXL Bipolar I disorder Approved [63]
Olanzapine DMPFN6Y Bipolar depression Approved [64]
Methamphetamine DMPM4SK Anxiety Approved [65]
Bromocriptine DMVE3TK Acromegaly 5A60.0 Approved [66]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [67]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [69]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [70]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [71]
Capsaicin DMGMF6V Back pain ME84.Z Approved [72]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [73]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [74]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [73]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [69]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [60]
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Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [13]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [11]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
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Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [85]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [86]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [87]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [13]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
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Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [11]
Fluoxetine DM3PD2C Bipolar depression Approved [11]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Haloperidol DM96SE0 Delirium Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
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Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
Haloperidol DM96SE0 Delirium Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Clozapine DMFC71L Schizophrenia 6A20 Approved [13]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [13]
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Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [11]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [11]
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Drug(s) Affected By Lathosterol oxidase (SC5D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Fluoxetine DM3PD2C Bipolar depression Approved [101]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [104]
Haloperidol DM96SE0 Delirium Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Clozapine DMFC71L Schizophrenia 6A20 Approved [105]
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Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [109]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Fluoxetine DM3PD2C Bipolar depression Approved [109]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
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Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [81]
Clozapine DMFC71L Schizophrenia 6A20 Approved [11]
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Drug(s) Affected By Acid ceramidase (ASAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [118]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [121]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [13]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [11]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
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Drug(s) Affected By D(1A) dopamine receptor (DRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [60]
Haloperidol DM96SE0 Delirium Approved [123]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [124]
Pergolide mesylate DM5GKOV N. A. N. A. Approved [125]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [126]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [127]
Methamphetamine DMPM4SK Anxiety Approved [128]
Clozapine DMFC71L Schizophrenia 6A20 Approved [129]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [130]
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Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [134]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [136]
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Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [139]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Testosterone DM7HUNW Hot flushes GA30 Approved [104]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Gefitinib DM15F0X Colon adenocarcinoma Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [145]
Etretinate DM2CZFA Keratosis ED56 Approved [146]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [147]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [153]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [154]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [118]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Prednisone DM2HG4X Acute asthma CA23 Approved [156]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [157]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [158]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [159]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [159]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [160]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [161]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [162]
Etidronic acid DM1XHYJ Bone Paget disease Approved [159]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [159]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [163]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Menthol DMG2KW7 Back pain ME84.Z Approved [169]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [171]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [173]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase LATS1 (LATS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [176]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [178]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [172]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [179]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [183]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [184]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Testosterone enanthate DMB6871 N. A. N. A. Approved [185]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [189]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Gefitinib DM15F0X Colon adenocarcinoma Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Selenium DM25CGV N. A. N. A. Approved [191]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [192]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [193]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [196]
Oxprenolol DM51OQW Anxiety Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [198]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [199]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [200]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [196]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [201]
Indomethacin DMSC4A7 Bursitis Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1-acid glycoprotein 1 (ORM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serotransferrin (TF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [206]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [207]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [208]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [210]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [211]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [212]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [213]
Cepharanthine DM9Y5JB N. A. N. A. Approved [214]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [215]
Clozapine DMFC71L Schizophrenia 6A20 Approved [216]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [217]
Trifluoperazine DMKBYWI Anxiety Approved [218]
Olanzapine DMPFN6Y Bipolar depression Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [219]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [220]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [221]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [222]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [224]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [225]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [227]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [228]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [230]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [231]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein B (MYBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [176]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [234]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [237]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [238]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [239]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [240]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [242]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1-acid glycoprotein 2 (ORM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [12]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [245]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [248]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [249]
Epinephrine DM3KJBC Acute asthma CA23 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [251]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [252]
Fructose DM43AN2 Vomiting MD90 Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor-like protein (MST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [255]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [256]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [257]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [205]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [257]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [260]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [261]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [262]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [263]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [264]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [265]
Gefitinib DM15F0X Colon adenocarcinoma Approved [266]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [270]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [271]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [272]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Gefitinib DM15F0X Colon adenocarcinoma Approved [273]
Quercetin DM3NC4M Obesity 5B81 Approved [274]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [275]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [279]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [176]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [281]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Testosterone enanthate DMB6871 N. A. N. A. Approved [282]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [281]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [283]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-F (CCNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [274]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [285]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [286]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [287]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [283]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG2 (BTG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [248]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [288]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [289]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [290]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [286]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [291]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [292]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [293]
Gefitinib DM15F0X Colon adenocarcinoma Approved [294]
Selenium DM25CGV N. A. N. A. Approved [281]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [288]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [295]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [296]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [297]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Testosterone DM7HUNW Hot flushes GA30 Approved [299]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [300]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [301]
Leflunomide DMR8ONJ Arthritis FA20 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
Arsenic DMTL2Y1 N. A. N. A. Approved [303]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [304]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [305]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [306]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [307]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [308]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [219]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [309]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [310]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [311]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [312]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [287]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [315]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [316]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [317]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-1 (TFDP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [245]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Menthol DMG2KW7 Back pain ME84.Z Approved [169]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [319]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [221]
Bortezomib DMNO38U Leukemia Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG3 (BTG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [288]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [288]
Paclitaxel DMLB81S Breast carcinoma Approved [321]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [288]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [322]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [323]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [324]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [326]
Methotrexate DM2TEOL Anterior urethra cancer Approved [327]
Quercetin DM3NC4M Obesity 5B81 Approved [328]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Ethacrynic acid DM60QMR Edema MG29 Approved [329]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [330]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [331]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [332]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromosome transmission fidelity protein 18 homolog (CHTF18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [334]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [235]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Folic Acid DMEMBJC Colorectal carcinoma Approved [335]
Menthol DMG2KW7 Back pain ME84.Z Approved [169]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [336]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 9 (DUSP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [337]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [338]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [255]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [339]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [340]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [297]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Testosterone DM7HUNW Hot flushes GA30 Approved [299]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [341]
Ethanol DMDRQZU Chronic pain MG30 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase delta subunit 4 (POLD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [338]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [319]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [221]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Methotrexate DM2TEOL Anterior urethra cancer Approved [345]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [346]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Menthol DMG2KW7 Back pain ME84.Z Approved [169]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [347]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [347]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D(3) dopamine receptor (DRD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [348]
Clozapine DMFC71L Schizophrenia 6A20 Approved [349]
Risperidone DMN6DXL Bipolar I disorder Approved [350]
Folic Acid DMEMBJC Colorectal carcinoma Approved [351]
Methamphetamine DMPM4SK Anxiety Approved [352]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [353]
Droperidol DM0DXA8 Nausea MD90 Approved [60]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [60]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [60]
Trifluoperazine DMKBYWI Anxiety Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D(4) dopamine receptor (DRD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clozapine DMFC71L Schizophrenia 6A20 Approved [354]
Haloperidol DM96SE0 Delirium Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [338]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [319]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
Methamphetamine DMPM4SK Anxiety Approved [355]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [356]
Droperidol DM0DXA8 Nausea MD90 Approved [60]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 1 (ND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [359]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [360]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [172]
Capsaicin DMGMF6V Back pain ME84.Z Approved [361]
Haloperidol DM96SE0 Delirium Approved [60]
Thiothixene DMDINC4 Schizophrenia 6A20 Approved [60]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [362]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [5]
HUMAN clathrin-mediated endocytosis (RME) TTAIY2U . Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [8]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [9]
Docosahexaenoic acid omega-hydroxylase (CYP4F11) DEIZLTN CP4FB_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Gene/Protein Processing [11]
Alpha-1-acid glycoprotein 1 (ORM1) OTZKSBRE A1AG1_HUMAN Protein Interaction/Cellular Processes [12]
Alpha-1-acid glycoprotein 2 (ORM2) OTRJGZP8 A1AG2_HUMAN Protein Interaction/Cellular Processes [12]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [13]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Gene/Protein Processing [11]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [14]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [14]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [15]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [14]
BAG family molecular chaperone regulator 4 (BAG4) OTUPX3M2 BAG4_HUMAN Gene/Protein Processing [14]

References

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