Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBGZI3)

• Drug Name: Chlorpromazine Drug Info
• Synonyms: Aminasine; Aminazin; Aminazine; Ampliactil; Amplicitil; Amplictil; BC 135; Chlor-PZ; Chlor-Promanyl; Chlordelazine; Chlorderazin; Chloropromazine; Chlorpromados; Chlorpromanyl (discontinued); Chlorpromazin; Chlorpromazine (USP/INN); Chlorpromazine Tannate; Chlorpromazine [USAN:INN:BAN]; Chlorpromazinum; Chlorpromazinum [INN-Latin]; Clorpromazina; Clorpromazina [INN-Spanish]; Clorpromazina [Italian]; Contomin; Cromedazine; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746; JHICC02042; Largactil; Largactil (TN); Largactil Liquid; Largactil Oral Drops; Largactilothiazine; Largactyl; Megaphen; Novo-Chlorpromazine; Novomazina; Phenactyl; Phenathyl; Phenothiazine hydrochloride; Plegomasine; Plegomazin; Prazilpromactil; Proma; Promactil; Promazil; Propaphen; Propaphenin; Prozil; Psychozine; SKF 2601-A; SKF 2601A; SKF-2601; Sanopron; Thorazine; Thorazine (TN); Thorazine Spansule; Thorazine Suppositories; Thorazine hydrochloride; Torazina; Wintermin; Z80

Indication

Disease Entry	ICD 11	Status	REF
Acute intermittent hepatic porphyria	5C58.11	Approved	[1]
Disruptive behavior disorder		Approved	[1]
Psychotic disorder	6A20-6A25	Approved	[1]
Schizophrenia	6A20	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[4]

• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 2726
  ChEBI ID: CHEBI:3647
  CAS Number: CAS 34468-21-8
  TTD Drug ID: DMBGZI3
  VARIDT Drug ID: DR00502
  INTEDE Drug ID: DR0308
  ACDINA Drug ID: D00124

Molecule-Related Drug Atlas

Drug(s) Targeting HUMAN clathrin-mediated endocytosis (RME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triflupromazine	DMKFQJP	Nausea	MD90	Approved	[18]
Thiethylperazine	DMU3IET	Nausea	MD90	Approved	[18]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[18]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[19]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[20]
Haloperidol	DM96SE0	Delirium		Approved	[21]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[22]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[23]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[24]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[25]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[26]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[27]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[28]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[29]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[32]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[43]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[37]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[44]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[89]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[90]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[91]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[92]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[93]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[94]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[95]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[45]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[46]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[49]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[51]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[53]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[527]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[527]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[527]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[528]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[109]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[529]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[530]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[531]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[62]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[55]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[57]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[58]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[59]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[60]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[564]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[565]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[566]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[567]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[568]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[569]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[91]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[570]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[571]

Drug(s) Metabolized By Docosahexaenoic acid omega-hydroxylase (CYP4F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[10]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[10]
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[10]
Ethylmorphine	DM0YROF	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[62]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[62]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[62]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[63]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[64]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[65]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[66]
Methamphetamine	DMPM4SK	Anxiety		Approved	[67]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[68]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[69]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[70]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[72]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[75]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[79]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[80]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[62]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[86]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[96]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[97]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[39]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[102]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[103]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[91]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[106]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[107]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[90]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[91]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[86]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[90]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[108]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[91]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[109]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[91]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[86]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[62]

Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[13]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[118]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[120]

Drug(s) Affected By Serine protease hepsin (HPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[128]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[13]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Haloperidol	DM96SE0	Delirium		Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Haloperidol	DM96SE0	Delirium		Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[15]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[15]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[13]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[13]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[137]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Haloperidol	DM96SE0	Delirium		Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[11]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[145]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[137]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[151]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[151]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[13]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[114]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[13]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[163]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[165]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[168]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[128]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[13]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[62]
Haloperidol	DM96SE0	Delirium		Approved	[172]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[173]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[174]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[176]
Methamphetamine	DMPM4SK	Anxiety		Approved	[177]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[178]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[179]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[185]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Haloperidol	DM96SE0	Delirium		Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Selenium	DM25CGV	N. A.	N. A.	Approved	[189]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[190]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[194]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[201]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[17]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[17]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[17]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[17]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[208]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[210]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[212]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[216]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[217]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[217]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[220]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[217]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[217]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[217]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[222]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]

Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[226]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[231]

Drug(s) Affected By Serine/threonine-protein kinase LATS1 (LATS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[229]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[230]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[242]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[245]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[249]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[250]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[253]
Oxprenolol	DM51OQW	Anxiety		Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[255]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[256]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[257]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[253]
Chlorpropamide	DMPHZQE	Non-insulin dependent diabetes	5A11	Approved	[258]
Indomethacin	DMSC4A7	Bursitis		Approved	[259]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[260]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[262]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[264]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[265]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[266]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[267]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[268]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[269]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[270]
Fructose	DM43AN2	Vomiting	MD90	Approved	[62]
Ketoprofen	DMRKXPT	Bursitis		Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[273]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[274]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[278]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[279]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[281]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[282]

Drug(s) Affected By Alpha-1-acid glycoprotein 1 (ORM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]

Drug(s) Affected By Alpha-fetoprotein (AFP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[283]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[286]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[287]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[291]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[293]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[294]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[295]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[296]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[297]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[298]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[300]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[303]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[304]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[305]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[305]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Haloperidol	DM96SE0	Delirium		Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Terbutaline	DMD4381	Asthma	CA23	Approved	[306]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[305]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[307]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[305]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[308]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[310]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[311]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[312]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[313]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[314]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[315]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[316]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[314]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[318]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[319]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[321]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[322]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Selenium	DM25CGV	N. A.	N. A.	Approved	[324]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[325]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[329]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[330]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[331]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[333]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[334]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[321]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[336]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[337]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[278]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[340]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[342]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[329]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[345]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[346]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[346]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[347]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[350]

Drug(s) Affected By D-amino-acid oxidase (DAO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[352]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[355]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[357]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[360]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[361]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[362]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[363]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[364]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[365]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[367]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]

Drug(s) Affected By Alpha-1-acid glycoprotein 2 (ORM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[369]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[372]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Fructose	DM43AN2	Vomiting	MD90	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[377]

Drug(s) Affected By Hepatocyte growth factor-like protein (MST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[378]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[379]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[290]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[380]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[379]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[381]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[382]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[383]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[386]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[387]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[392]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[400]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[403]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[406]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[407]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[408]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[409]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[410]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[412]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[329]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[330]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[416]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[417]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[321]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[420]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]

Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[424]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[426]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[427]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[428]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[430]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[433]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[434]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[435]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[436]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[437]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[429]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[439]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[443]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[444]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[445]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[446]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[447]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[448]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[449]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[449]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[450]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[451]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[452]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[453]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[449]

Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[455]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[456]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[457]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[458]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[459]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[342]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[461]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[329]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[462]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[463]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[410]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[465]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[466]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[467]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[468]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[330]
Bortezomib	DMNO38U	Leukemia		Approved	[471]

Drug(s) Affected By Protein BTG3 (BTG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[429]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[429]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[472]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[429]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[429]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[473]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[474]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[475]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[476]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[478]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[479]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[480]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[481]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[482]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[483]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[484]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[485]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[486]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[487]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[488]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[321]

Drug(s) Affected By Chromosome transmission fidelity protein 18 homolog (CHTF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[489]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[490]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[491]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[226]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]

Drug(s) Affected By Dual specificity protein phosphatase 9 (DUSP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[492]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[493]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[494]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[458]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[495]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[17]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[17]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[17]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[17]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[17]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[496]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[420]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[497]

Drug(s) Affected By DNA polymerase delta subunit 4 (POLD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[493]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[170]

Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[226]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[501]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[501]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[502]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[503]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[504]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[347]
Methamphetamine	DMPM4SK	Anxiety		Approved	[505]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[506]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[62]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[62]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[62]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[62]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[507]
Haloperidol	DM96SE0	Delirium		Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[493]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[425]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]
Methamphetamine	DMPM4SK	Anxiety		Approved	[508]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[509]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[62]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[62]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 1 (ND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[510]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[512]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[229]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[514]
Haloperidol	DM96SE0	Delirium		Approved	[62]
Thiothixene	DMDINC4	Schizophrenia	6A20	Approved	[62]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[515]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[516]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[517]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[516]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[517]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[518]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[516]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[516]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[516]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[519]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[520]

Drug(s) Affected By S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[521]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[234]
Indomethacin	DMSC4A7	Bursitis		Approved	[522]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[524]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[525]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[521]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[474]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[62]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[532]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[432]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[534]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[535]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[536]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[537]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[538]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[539]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[432]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[540]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[541]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[108]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[542]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[543]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[544]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[545]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[546]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[547]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[548]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[549]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[550]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[93]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[93]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[551]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[552]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[552]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[555]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[557]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[558]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[559]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[560]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[129]

Drug(s) Affected By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[517]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[561]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[562]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[563]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[5]
HUMAN clathrin-mediated endocytosis (RME)	TTAIY2U	.	Inhibitor	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Docosahexaenoic acid omega-hydroxylase (CYP4F11)	DEIZLTN	CP4FB_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[11]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[12]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[13]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Protein Interaction/Cellular Processes	[14]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Protein Interaction/Cellular Processes	[14]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[15]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Gene/Protein Processing	[16]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[16]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[17]
AP-1 complex subunit sigma-1A (AP1S1)	OTQ2H8DN	AP1S1_HUMAN	Gene/Protein Processing	[13]

References

• [1] Chlorpromazine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 83).
• [3] ClinicalTrials.gov (NCT04366739) Repurposing of Chlorpromazine in Covid-19 Treatment. U.S. National Institutes of Health.
• [4] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
• [5] Modulatory role of dopamine D2 receptors and fundamental role of L-type Ca2+ channels in the induction of long-term potentiation in the basolateral... Eur J Pharmacol. 2009 Mar 15;606(1-3):90-3.
• [6] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
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