Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHWE7P)

Drug Name
Ampicillin Drug Info
Synonyms
ABPC; Acillin; Adobacillin; Alpen; Amblosin; Amcill; Amfipen; Aminobenzylpenicillin; Ampen; Ampichel; Ampicil; Ampicilina; Ampicillanyl; Ampicillina; Ampicilline; Ampicillinum; Ampicin; Ampifarm; Ampikel; Ampimed; Ampipenin; Ampiscel; Ampisyn; Ampivax; Ampivet; Amplacilina; Amplin; Amplipenyl; Amplisom; Amplital; Austrapen; Binotal; Bonapicillin; Britacil; Campicillin; Cimex; Copharcilin; Delcillin; Deripen; Divercillin; Doktacillin; Duphacillin; Grampenil; Guicitrina; Guicitrine; Lifeampil; Morepen; Norobrittin; Nuvapen; Omnipen; Orbicilina; Penbristol; Penbritin; Penbrock; Penicline; Penimic; Pensyn; Pentrex; Pentrexl; Pentrexyl; Polycillin; Ponecil; Princillin; Principen; QIDamp; Racenacillin; Rosampline;Roscillin; Semicillin; Servicillin; Sumipanto; Supen; Synpenin; Texcillin; Tokiocillin; Tolomol; Totacillin; Totalciclina; Totapen; Trifacilina; Ukapen; Ultrabion; Ultrabron; Vampen; Viccillin; Wypicil; Amfipen V; Amipenix S; Ampicillin A; Ampicillin Anhydrous; Ampicillin Base; Ampicillin acid; Ampicillin anhydrate; Ampicillina [DCIT]; Anhydrous ampicillin; Olin Kid; Pen A; Pen A Oral; Pen Ampil;Penbritin paediatric; Penbritin syrup; Pfizerpen A; Semicillin R; Viccillin S; AY 6108; BA 7305; BRL 1341; Bayer 5427; HI 63; P 50; Principen 125; Principen 250; Principen 500; SQ 17382; AB-PC; AB-PCSol; AY-6108; Ambidrin (TN); Ampi-Co; Ampi-Tab; Ampi-bol; Ampicilina [INN-Spanish]; Ampicilline [INN-French]; Ampicillinum [INN-Latin]; Ampipenin, nt3; Ampy-Penyl; Anhydrous ampicillin (JP15); BRL-1341; D-Ampicillin; D-Cillin; KS-R1; Novo-ampicillin; OMNIPEN (AMPICILLIN); Omnipen (TN); Omnipen-N; P-50; Penbritin-S; Penicillin, Aminobenzyl; Pfizerpen-A; Polycillin-N; Polyflex (Veterinary); Ro-Ampen; SK-Ampicillin; Totacillin (sodium); Totacillin-N; WY-5103; Ampicillin (USP/INN); AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2); Ampicillin [USAN:BAN:INN:JAN]; Ampicillin [USAN:INN:BAN:JAN];D-(-)-Ampicillin; D-(-)-alpha-Aminobenzylpenicillin; D-(-)-alpha-Aminopenicillin; D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid; 6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Acute epiglottitis Approved [1]
Acute gonococcal cervicitis Approved [1]
Acute otitis media AB00 Approved [1]
Bacillary dysentery 1A02 Approved [1]
Bacteremia 1A73 Approved [1]
Bacterial endocarditis Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Cholangitis Approved [1]
Chorioamnionitis Approved [1]
Dysentery Approved [1]
Escherichia coli meningitis Approved [1]
Meningococcal meningitis Approved [1]
Peritonitis Approved [1]
Pneumococcal meningitis Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Streptococcal pneumonia Approved [1]
Urinary tract infection GC08 Approved [1]
Paratyphoid fever Investigative [1]
Pelvic inflammatory disease GA05 Investigative [1]
Sinusitis CA0A.Z Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
6249
ChEBI ID
CHEBI:28971
CAS Number
CAS 69-53-4
TTD Drug ID
DMHWE7P
VARIDT Drug ID
DR00712
INTEDE Drug ID
DR2177
ACDINA Drug ID
D00037

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cefazolin DMPDYFR Bacteremia 1A73 Approved [14]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [15]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [16]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [17]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [15]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [18]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [19]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [20]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [21]
Piperacillin DMTBKF3 Acute gonococcal cervicitis Approved [22]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Folic Acid DMEMBJC Colorectal carcinoma Approved [25]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [26]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [32]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [33]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [34]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [35]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [36]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [37]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [38]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [34]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [35]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [35]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [35]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [33]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [39]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [40]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [41]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [4]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [42]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [33]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [43]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [44]
Cefixime DMY60I8 Acute gonococcal cervicitis Approved [4]
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Drug(s) Metabolized By N-acylhomoserine lactone acylase (lacA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [7]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [7]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [7]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [7]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [7]
Drug(s) Metabolized By Beta-lactamase (blaB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [45]
Piperacillin DMTBKF3 Acute gonococcal cervicitis Approved [8]
Cefalotin DMVYSLE Bacteremia 1A73 Approved [8]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [8]
Cephaloridine DM4Y95F Gram-positive bacterial infection 1B74-1G40 Withdrawn from market [8]
Ceftiofur DMR2SOZ Bacterial infection 1A00-1C4Z Approved [46]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [47]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [48]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [47]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [12]
Imipenem DMI9FBP Bacteremia 1A73 Approved [49]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [10]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [49]
Carbapenem DMXZU73 N. A. N. A. Phase 4 [50]
Ceftazidine DMPZTRC N. A. N. A. Phase 4 [10]
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Drug(s) Metabolized By AmpC beta-lactamase (ampC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imipenem DMI9FBP Bacteremia 1A73 Approved [11]
Cefalotin DMVYSLE Bacteremia 1A73 Approved [11]
Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [53]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [58]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [59]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [51]
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Drug(s) Affected By Phospholemman (FXYD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [62]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [66]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
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Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [71]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
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Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
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Drug(s) Affected By Calmegin (CLGN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [77]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [84]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [87]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Prednisone DM2HG4X Acute asthma CA23 Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [101]
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Drug(s) Affected By Dickkopf-related protein 1 (DKK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
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Drug(s) Affected By Chloride intracellular channel protein 3 (CLIC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [110]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [66]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [111]
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Drug(s) Affected By Ceruloplasmin (CP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Verapamil DMA7PEW Angina pectoris BA40 Approved [119]
Selenium DM25CGV N. A. N. A. Approved [120]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [124]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [125]
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Drug(s) Affected By Cystatin-A (CSTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [130]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [131]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [132]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Ethacrynic acid DM60QMR Edema MG29 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [137]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [138]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [139]
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Drug(s) Affected By Arginase-1 (ARG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [143]
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Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [146]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [149]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [150]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [151]
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Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [153]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [155]
Fluoxetine DM3PD2C Bipolar depression Approved [153]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [156]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [157]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Fluoxetine DM3PD2C Bipolar depression Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [158]
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Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [160]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Selenium DM25CGV N. A. N. A. Approved [126]
Epinephrine DM3KJBC Acute asthma CA23 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [166]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [169]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [173]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [177]
Selenium DM25CGV N. A. N. A. Approved [178]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [179]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [180]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gastricsin (PGC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [183]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parathymosin (PTMS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Selenium DM25CGV N. A. N. A. Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [187]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calreticulin (CALR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [126]
Etretinate DM2CZFA Keratosis ED56 Approved [189]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [192]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [193]
Clozapine DMFC71L Schizophrenia 6A20 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-lysine 6-oxidase (LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [195]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [196]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ethanol DMDRQZU Chronic pain MG30 Approved [197]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [199]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [204]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [205]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium- and chloride-dependent creatine transporter 1 (SLC6A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [206]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [207]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [209]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [210]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [212]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [173]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [214]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Selenium DM25CGV N. A. N. A. Approved [126]
Etretinate DM2CZFA Keratosis ED56 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Estrone DM5T6US Acne vulgaris ED80 Approved [216]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [217]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [219]
Diazepam DM08E9O Alcohol withdrawal Approved [220]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [221]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [219]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [223]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc-associated zinc finger protein (MAZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Bortezomib DMNO38U Leukemia Approved [226]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [227]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [187]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [228]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [195]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [157]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Fluoxetine DM3PD2C Bipolar depression Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Calcidiol DMN4CV5 Hypophosphatemia Approved [234]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [236]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [238]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [239]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [240]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 1 (ANKRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ethanol DMDRQZU Chronic pain MG30 Approved [241]
Folic Acid DMEMBJC Colorectal carcinoma Approved [242]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [244]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [245]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbonic anhydrase 9 (CA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [196]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Bortezomib DMNO38U Leukemia Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 7 (DUSP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Folic Acid DMEMBJC Colorectal carcinoma Approved [251]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [252]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [253]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [173]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [154]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filamin A-interacting protein 1-like (FILIP1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [255]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [257]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiomotin (AMOT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Testosterone enanthate DMB6871 N. A. N. A. Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [260]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Arsenic DMTL2Y1 N. A. N. A. Approved [261]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [253]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [114]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [114]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [262]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [263]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
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Drug(s) Affected By Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [264]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Arsenic DMTL2Y1 N. A. N. A. Approved [261]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [265]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterile alpha motif domain-containing protein 1 (SAMD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [264]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [267]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [225]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Lipocalin-15 (LCN15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [66]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [268]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [269]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [270]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein MTSS 2 (MTSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [271]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [267]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbohydrate sulfotransferase 15 (CHST15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [240]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 15 (SLC22A15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [274]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BPI fold-containing family B member 2 (BPIFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [269]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [270]
OXYQUINOLINE DMZVS9Y Discovery agent N.A. Investigative [13]
Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ethanol DMDRQZU Chronic pain MG30 Approved [241]
Capsaicin DMGMF6V Back pain ME84.Z Approved [275]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid phosphatase-related protein type 1 (PLPPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [60]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [264]
OXYQUINOLINE DMZVS9Y Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Jun dimerization protein 2 (JDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [260]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [252]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aquaporin-3 (AQP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arrestin domain-containing protein 3 (ARRDC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [199]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small integral membrane protein 14 (SMIM14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [281]
Testosterone DM7HUNW Hot flushes GA30 Approved [142]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [281]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [281]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [260]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [98]
Ethacrynic acid DM60QMR Edema MG29 Approved [282]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [114]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [114]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-D1 (HOXD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [265]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [274]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [283]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [284]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [285]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk2 (SGK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelial cell-specific molecule 1 (ESM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [287]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [289]
Arsenic DMTL2Y1 N. A. N. A. Approved [290]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [291]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [292]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ]-phosphatase 2, mitochondrial (PDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [252]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [60]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell cycle progression protein 1 (CCPG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [294]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Bortezomib DMNO38U Leukemia Approved [294]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Indomethacin DMSC4A7 Bursitis Approved [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [274]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [296]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [186]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [296]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [297]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [297]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Fluoxetine DM3PD2C Bipolar depression Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [299]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Folic Acid DMEMBJC Colorectal carcinoma Approved [251]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [300]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [243]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pirin (PIR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [114]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Testosterone enanthate DMB6871 N. A. N. A. Approved [259]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
Penicillin V DMKVOYF Acute otitis media AB00 Approved [301]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [302]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [303]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [304]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [305]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [307]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [308]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [309]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [311]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [313]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [315]
Selenium DM25CGV N. A. N. A. Approved [126]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [316]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [317]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [318]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [319]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [320]
Verapamil DMA7PEW Angina pectoris BA40 Approved [321]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [322]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [323]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [324]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [326]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [327]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [328]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [320]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [169]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [322]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [297]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [329]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [330]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [162]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [332]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [331]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [264]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Excitatory amino acid transporter 2 (SLC1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [334]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [335]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Thiamphenicol DMDRKH2 Bacterial infection 1A00-1C4Z Approved [336]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [337]
Quercetin DM3NC4M Obesity 5B81 Approved [338]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [339]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [340]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [342]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [5]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
N-acylhomoserine lactone acylase (lacA) DEIU0XN A0A0A1VBK6_9BURK Substrate [7]
Beta-lactamase (blaB) DET9I1W BLAC_BACUN Substrate [8]
Beta-lactamase (blaB) DETDS7E A0A2S0LB67_9FLAO Substrate [9]
Beta-lactamase (blaB) DEC7JEF A0A1S1G219_9NEIS Substrate [9]
Beta-lactamase (blaB) DEBKS91 A0A1B1FBM9_ACIBA Substrate [10]
AmpC beta-lactamase (ampC) DERI7LO A0A0H3KQ39_BURM1 Substrate [11]
Beta-lactamase (blaB) DEWYT5M D4HFC4_CUTAS Substrate [9]
Beta-lactamase (blaB) DE3FVRW BLA2_BAC17 Substrate [9]
Beta-lactamase (blaB) DEG5Y4W A0A344X3A2_STASP Substrate [9]
Beta-lactamase (blaB) DEQX0DG Q8RIK5_FUSNN Substrate [9]
Beta-lactamase (blaB) DEXB2A9 A0A379CPC3_PLESH Substrate [12]
Beta-lactamase (blaB) DEWMGC3 A0A2U9SV73_9BURK Substrate [9]
Beta-lactamase (blaB) DE52KD0 Q6EZ46_RALPI Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [13]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Gene/Protein Processing [13]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [13]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [13]
Angiomotin (AMOT) OTWHDG9B AMOT_HUMAN Gene/Protein Processing [13]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Gene/Protein Processing [13]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Gene/Protein Processing [13]
Arginase-1 (ARG1) OTHZITAM ARGI1_HUMAN Gene/Protein Processing [13]
Arrestin domain-containing protein 3 (ARRDC3) OTAKW7R9 ARRD3_HUMAN Gene/Protein Processing [13]
Arrestin domain-containing protein 4 (ARRDC4) OTINJ0FX ARRD4_HUMAN Gene/Protein Processing [13]

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107 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
108 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
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126 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
127 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
128 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
129 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
130 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
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