Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML0GZ2)

• Drug Name: Lead acetate Drug Info
• Synonyms: LEAD ACETATE; Lead diacetate; Lead(II) acetate; Lead(2+) acetate; 301-04-2; Acetic acid, lead salt; Unichem PBA; Lead di(acetate); Normal lead acetate; Dibasic lead acetate; Lead dibasic acetate; Bleiacetat [German]; lead(2+) diacetate; Plumbous acetate; Salt of saturn; Sugar of lead; Caswell No. 523A; Lead acetate (anhydrous); RCRA waste number U144; Acetate de plomb [French]; Lead acetate (Pb(Ac)2); Acetic acid lead(2+) salt; CCRIS 356; Acetic acid, lead(2+) salt; Acetic acid, lead(2 +) salt; UNII-KL498O6790; Acetate de plomb

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9317
  CAS Number: CAS 301-04-2
  TTD Drug ID: DML0GZ2

Molecule-Related Drug Atlas

Drug(s) Targeting Ferrochelatase (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[7]
Methyl aminolevulinate	DMIUX3D	Acne vulgaris	ED80	Approved	[8]
N-Methylmesoporphyrin Containing Copper	DMKZL5H	Discovery agent	N.A.	Investigative	[7]
N-Methylmesoporphyrin	DM4FMZP	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[10]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[23]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[24]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[20]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[25]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[25]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[26]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Fructose	DM43AN2	Vomiting	MD90	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]

Drug(s) Affected By Adenine phosphoribosyltransferase (APRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[42]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]

Drug(s) Affected By Solute carrier family 12 member 8 (SLC12A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[60]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[67]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[82]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[83]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[87]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[80]

Drug(s) Affected By Metallothionein 1H-like protein 1 (MT1HL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[87]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[90]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[91]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[94]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[95]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[99]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[97]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[80]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[109]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[110]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[111]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[115]

Drug(s) Affected By Tryptophan 2,3-dioxygenase (TDO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[87]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[120]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[24]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[121]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[87]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[128]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[83]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[130]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[121]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[133]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Haloperidol	DM96SE0	Delirium		Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[134]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Transmembrane protein 255A (TMEM255A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[24]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[139]

Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[128]

Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[109]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[141]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[97]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[150]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[151]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[152]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[94]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[162]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[165]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[168]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[169]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[180]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[188]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[165]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[169]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[190]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[191]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[194]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[195]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[159]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[199]

Drug(s) Affected By Proteinase-activated receptor 3 (F2RL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[102]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[24]

Drug(s) Affected By Beta-1,3-galactosyltransferase 2 (B3GALT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[204]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[139]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]

Drug(s) Affected By Coagulation factor XIII A chain (F13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[208]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[218]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[224]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[233]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[236]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[147]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[238]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[239]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[240]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[241]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[42]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[243]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[244]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[240]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[245]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[247]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[248]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[249]
Methamphetamine	DMPM4SK	Anxiety		Approved	[250]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Haloperidol	DM96SE0	Delirium		Approved	[11]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[190]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[255]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[260]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[261]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[262]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[263]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[267]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[271]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[273]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[277]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[279]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[280]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[281]

Drug(s) Affected By Gastrin (GAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Terbutaline	DMD4381	Asthma	CA23	Approved	[283]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[282]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[284]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[282]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[285]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[286]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[11]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[287]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[288]
Fructose	DM43AN2	Vomiting	MD90	Approved	[11]
Ketoprofen	DMRKXPT	Bursitis		Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[290]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[291]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[294]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[295]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[300]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[301]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[97]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[304]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[306]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[307]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Haloperidol	DM96SE0	Delirium		Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[309]
Selenium	DM25CGV	N. A.	N. A.	Approved	[310]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[311]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[318]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[320]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[321]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[322]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[183]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[329]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[330]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[331]
Fructose	DM43AN2	Vomiting	MD90	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[95]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[334]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[339]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[342]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[348]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[349]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[354]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[357]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[358]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[361]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[362]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[363]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[273]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[273]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[368]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[369]

Drug(s) Affected By rRNA 2'-O-methyltransferase fibrillarin (FBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[370]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[370]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[371]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[373]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[261]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[374]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[375]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[376]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[377]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[378]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[379]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[380]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[381]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[382]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[383]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[386]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[378]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[387]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[388]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[389]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[377]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[380]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[390]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[391]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[393]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[395]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[396]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[375]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[183]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[11]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[399]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[400]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[402]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[404]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[361]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[406]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[408]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[409]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[410]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[375]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[412]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[413]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[416]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[417]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[418]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[420]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[421]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[422]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[189]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[396]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[424]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[428]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[431]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[433]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[435]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[437]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[438]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[439]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[442]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[73]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[408]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[446]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[447]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Metal regulatory transcription factor 1 (MTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[448]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[449]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[450]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[449]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[451]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[42]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[452]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[454]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[455]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[459]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]

Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[460]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[461]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[462]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[463]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[464]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[465]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[466]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[468]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[469]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ferrochelatase (FECH)	TTQ6VF4	HEMH_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[2]
Adenine phosphoribosyltransferase (APRT)	OT5ZUKVF	APT_HUMAN	Gene/Protein Processing	[3]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[4]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Arrestin domain-containing protein 4 (ARRDC4)	OTINJ0FX	ARRD4_HUMAN	Gene/Protein Processing	[4]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Gene/Protein Processing	[4]

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