Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3CBD)

• Drug Name: geraniol Drug Info
• Synonyms: GERANIOL; 106-24-1; Lemonol; Geranyl alcohol; trans-Geraniol; (E)-Geraniol; (2E)-3,7-dimethylocta-2,6-dien-1-ol; (E)-Nerol; trans-3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethylocta-2,6-dien-1-ol; Geraniol Extra; Geraniol alcohol; 3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethyl-2,6-octadien-1-ol; beta-Geraniol; 3,7-Dimethyl-trans-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-; Guaniol; t-geraniol; 2E-geraniol; Geraniol (natural); 2-trans-3,7-Dimethyl-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-; CHEBI:17447

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 637566
  ChEBI ID: CHEMBL25719
  CAS Number: CAS 106-24-1
  TTD Drug ID: DMS3CBD

Molecule-Related Drug Atlas

Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[7]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[9]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[10]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[11]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[12]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[13]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[12]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[11]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[12]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[14]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[31]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[35]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[40]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[38]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[49]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[50]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[57]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Menin (MEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[72]

Drug(s) Affected By Transcription elongation factor SPT5 (SUPT5H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[83]

Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 1 (BMAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[87]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[96]

Drug(s) Affected By Interferon regulatory factor 6 (IRF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By Krueppel-like factor 11 (KLF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]

Drug(s) Affected By Fanconi anemia group G protein (FANCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By High mobility group protein B3 (HMGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[109]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]

Drug(s) Affected By DNA-directed RNA polymerase I subunit RPA34 (POLR1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[121]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By PHD finger protein 1 (PHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[127]

Drug(s) Affected By AP-5 complex subunit zeta-1 (AP5Z1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Protein CBFA2T2 (CBFA2T2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[127]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Mothers against decapentaplegic homolog 6 (SMAD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[136]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3 (CREB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]

Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[152]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[153]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[156]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]

Drug(s) Affected By Actin-like protein 6A (ACTL6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[172]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[173]
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[124]

Drug(s) Affected By Homeobox protein Hox-C6 (HOXC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[185]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[190]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[180]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[193]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[196]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[195]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[192]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]

Drug(s) Affected By Zinc finger protein 40 (HIVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[204]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[205]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[214]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[215]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[123]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[217]

Drug(s) Affected By Transcription factor BTF3 (BTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[218]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[221]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[222]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[223]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Nuclear autoantigen Sp-100 (SP100)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[225]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[218]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[226]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[124]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[124]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[233]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[238]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]

Drug(s) Affected By ETS-related transcription factor Elf-1 (ELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By General transcription factor IIH subunit 1 (GTF2H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[243]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[245]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[246]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[255]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[221]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[264]

Drug(s) Affected By DNA-binding protein RFX5 (RFX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]

Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[124]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[196]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[221]

Drug(s) Affected By ETS translocation variant 1 (ETV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[271]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]

Drug(s) Affected By Kinetochore-associated protein 1 (KNTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[250]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]

Drug(s) Affected By Probable global transcription activator SNF2L2 (SMARCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Homeobox protein GBX-2 (GBX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[274]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[243]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]

Drug(s) Affected By Calcipressin-1 (RCAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[278]

Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[281]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[282]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Krueppel-like factor 3 (KLF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]

Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[288]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[226]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[221]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[289]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[290]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Transcription initiation factor IIB (GTF2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[291]

Drug(s) Affected By Norrin (NDP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[292]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[294]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[97]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[295]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[298]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[234]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[300]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Haloperidol	DM96SE0	Delirium		Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[301]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[303]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[301]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[304]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[305]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[306]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[307]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[309]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[310]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[312]

Drug(s) Affected By Transducin-like enhancer protein 1 (TLE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Activin receptor type-1 (ACVR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[83]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[136]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[226]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[314]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[238]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[301]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[301]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[147]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]

Drug(s) Affected By DNA polymerase epsilon catalytic subunit A (POLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By HMG domain-containing protein 3 (HMGXB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[316]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[317]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By General transcription factor 3C polypeptide 1 (GTF3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[121]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[318]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Alpha-globin transcription factor CP2 (TFCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[320]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[127]

Drug(s) Affected By Interleukin enhancer-binding factor 2 (ILF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[321]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[322]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[321]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[161]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[323]

Drug(s) Affected By ELAV-like protein 2 (ELAVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[243]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Periodic tryptophan protein 1 homolog (PWP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]

Drug(s) Affected By Tripartite motif-containing protein 29 (TRIM29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[326]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[327]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]

Drug(s) Affected By Single-minded homolog 2 (SIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[243]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[328]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[225]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[329]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[330]

Drug(s) Affected By Max dimerization protein 4 (MXD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[321]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[321]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]

Drug(s) Affected By Kinesin-like protein KIF22 (KIF22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[331]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[316]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Haloperidol	DM96SE0	Delirium		Approved	[301]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Transcription elongation factor A protein-like 1 (TCEAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[334]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[335]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[102]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]

Drug(s) Affected By Hepatic leukemia factor (HLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By KRAB domain-containing protein 4 (KRBOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By Homeobox-containing protein 1 (HMBOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[316]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By ELKS/Rab6-interacting/CAST family member 1 (ERC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[147]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[109]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[121]

Drug(s) Affected By Leucine-zipper-like transcriptional regulator 1 (LZTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By GATA zinc finger domain-containing protein 1 (GATAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[140]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By HMG box transcription factor BBX (BBX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[102]

Drug(s) Affected By Protein ELYS (AHCTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By Transcription factor IIIA (GTF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[102]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By DNA repair and recombination protein RAD54-like (RAD54L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[343]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[344]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]

Drug(s) Affected By Protein Jumonji (JARID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Amyloid beta precursor protein binding family B member 2 (APBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[312]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[104]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[312]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[301]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[345]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By PHD finger protein 21A (PHF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[350]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[352]

Drug(s) Affected By DnaJ homolog subfamily C member 1 (DNAJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]

Drug(s) Affected By Transcription factor 12 (TCF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[147]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[354]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]

Drug(s) Affected By Max-binding protein MNT (MNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[356]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[360]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Ribosome quality control complex subunit TCF25 (TCF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[321]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[321]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[362]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[321]

Drug(s) Affected By E3 ubiquitin-protein ligase TRAIP (TRAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[363]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[327]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[364]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Nuclear body protein SP140-like protein (SP140L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]

Drug(s) Affected By Leucine zipper transcription factor-like protein 1 (LZTFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[366]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By SLC2A4 regulator (SLC2A4RG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[368]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19A (RNF19A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[370]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]

Drug(s) Affected By ETS homologous factor (EHF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[372]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[316]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[374]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[295]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[375]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[102]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[102]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By REST corepressor 3 (RCOR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[139]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[351]

Drug(s) Affected By HMG domain-containing protein 4 (HMGXB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[369]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By AF4/FMR2 family member 4 (AFF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[376]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Zinc finger transcription factor Trps1 (TRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[29]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[345]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[97]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[377]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]

Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Tyrosine-protein kinase BAZ1B (BAZ1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By DCC-interacting protein 13-alpha (APPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[378]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[71]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[379]

Drug(s) Affected By PR domain zinc finger protein 4 (PRDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[282]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[380]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[123]

Drug(s) Affected By Unconventional myosin-VI (MYO6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Zinc finger protein PLAGL1 (PLAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[384]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]

Drug(s) Affected By Protein PHTF1 (PHTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[289]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[385]

Drug(s) Affected By Protein timeless homolog (TIMELESS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]

Drug(s) Affected By Trafficking kinesin-binding protein 1 (TRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[386]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]

Drug(s) Affected By Forkhead box protein J3 (FOXJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[70]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[86]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]

Drug(s) Affected By RuvB-like 2 (RUVBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]

Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[289]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[261]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[390]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]

Drug(s) Affected By RuvB-like 1 (RUVBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[30]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[391]

Drug(s) Affected By Krueppel-like factor 13 (KLF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By FACT complex subunit SPT16 (SUPT16H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[392]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[61]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[51]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[51]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[393]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[395]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[398]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[399]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[400]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[401]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[403]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[314]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[404]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[405]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[406]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[6]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[6]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[407]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[408]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[409]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[410]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[408]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[408]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[411]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[410]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[408]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[413]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[327]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[6]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[351]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[414]

Drug(s) Affected By Pro-glucagon (GCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[415]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[416]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[417]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[418]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[419]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[420]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[423]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[424]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[425]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[426]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[427]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[428]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[430]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[432]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[433]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[434]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[393]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[424]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[425]

Drug(s) Affected By 5-hydroxytryptamine receptor 3A (HTR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[435]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[436]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[3]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[437]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[104]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[435]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[124]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[441]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[446]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[447]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[327]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[450]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[451]

Drug(s) Affected By Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[129]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[453]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[453]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[316]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-15 (GNA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[453]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]
Caprylic acid	DMLGS82	Discovery agent	N.A.	Investigative	[453]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[454]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[455]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[456]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[457]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[458]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[461]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[464]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[456]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[466]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[234]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Gene/Protein Processing	[3]
Actin-like protein 6A (ACTL6A)	OT0EC5BQ	ACL6A_HUMAN	Gene/Protein Processing	[4]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Gene/Protein Processing	[4]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Gene/Protein Processing	[4]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Gene/Protein Processing	[5]
AF4/FMR2 family member 4 (AFF4)	OTTL5Y8R	AFF4_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[6]
Alpha-globin transcription factor CP2 (TFCP2)	OTA246TE	TFCP2_HUMAN	Gene/Protein Processing	[4]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Gene/Protein Processing	[4]
AP-5 complex subunit zeta-1 (AP5Z1)	OTXIPLFH	AP5Z1_HUMAN	Gene/Protein Processing	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2467).
• [2] Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.
• [3] Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances. Biochem Biophys Res Commun. 2015 Nov 27;467(4):1090-6. doi: 10.1016/j.bbrc.2015.09.074. Epub 2015 Oct 9.
• [4] Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
• [5] Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. Biochem Cell Biol. 2006 Feb;84(1):102-11.
• [6] The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
• [7] TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
• [8] Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.
• [9] Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
• [10] Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).
• [12] 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
• [13] Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.
• [14] AZT-induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation. FEBS Lett. 1996 Nov 4;396(2-3):323-6. doi: 10.1016/0014-5793(96)01124-6.
• [15] Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
• [16] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [17] Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species. Chem Res Toxicol. 2012 Apr 16;25(4):873-83. doi: 10.1021/tx2004882. Epub 2012 Feb 21.
• [18] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [19] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [20] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [21] Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503129. doi: 10.1016/j.mrgentox.2019.503129. Epub 2019 Dec 27.
• [22] E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
• [23] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [24] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [25] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [26] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [27] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [28] Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. Eur J Pharmacol. 2007 Oct 1;571(2-3):97-105.
• [29] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [30] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [31] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [32] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [33] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [34] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [35] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [36] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [37] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [38] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [39] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [40] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [41] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [42] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [43] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [44] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [45] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [46] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [47] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [48] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [49] Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
• [50] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [51] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [52] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [53] Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.
• [54] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [55] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [56] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [57] Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
• [58] Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
• [59] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [60] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [61] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [62] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [63] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [64] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [65] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [66] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [67] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [68] Molecular analysis of MEN1 expression in MCF7, T47D and MDA-MB 468 breast cancer cell lines treated with adriamycin using RT-PCR and immunocytochemistry. Daru. 2010;18(1):17-22.
• [69] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [70] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [71] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [72] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [73] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [74] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [75] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [76] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [77] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [78] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [79] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [80] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [81] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [82] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [83] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [84] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [85] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [86] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [87] Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One. 2011;6(9):e25612. doi: 10.1371/journal.pone.0025612. Epub 2011 Sep 28.
• [88] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [89] Glucocorticoids affect 24 h clock genes expression in human adipose tissue explant cultures. PLoS One. 2012;7(12):e50435. doi: 10.1371/journal.pone.0050435. Epub 2012 Dec 10.
• [90] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [91] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [92] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [93] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [94] Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
• [95] ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
• [96] Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
• [97] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [98] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [99] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [100] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [101] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [102] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [103] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [104] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [105] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [106] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [107] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [108] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [109] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [110] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [111] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [112] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [113] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [114] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [115] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [116] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [117] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [118] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [119] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [120] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [121] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [122] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [123] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [124] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [125] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [126] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [127] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [128] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [129] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [130] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [131] Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
• [132] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [133] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [134] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [135] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [136] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [137] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [138] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [139] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [140] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [141] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [142] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [143] Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):231-8. doi: 10.1016/j.taap.2009.02.003. Epub 2009 Feb 12.
• [144] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [145] N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle. 2007 Feb 15;6(4):467-70. doi: 10.4161/cc.6.4.3856. Epub 2007 Feb 12.
• [146] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [147] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [148] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [149] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [150] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [151] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [152] Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of Krppel-like factor 7 by morphine. Exp Cell Res. 2003 Dec 10;291(2):340-51. doi: 10.1016/s0014-4827(03)00408-7.
• [153] The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide. Clin Cancer Res. 2005 Jun 15;11(12):4610-9.
• [154] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [155] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [156] Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
• [157] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [158] Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. J Mol Endocrinol. 2009 Feb;42(2):87-103. doi: 10.1677/JME-08-0076. Epub 2008 Nov 4.
• [159] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [160] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [161] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [162] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [163] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [164] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [165] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [166] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [167] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [168] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [169] Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
• [170] Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
• [171] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [172] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [173] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [174] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [175] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [176] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [177] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [178] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [179] Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
• [180] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [181] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [182] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [183] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [184] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [185] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [186] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [187] Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res. 2006 Jan;100(1):86-92.
• [188] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [189] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [190] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [191] Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
• [192] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [193] Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
• [194] Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
• [195] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [196] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [197] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [198] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [199] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [200] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [201] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [202] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [203] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [204] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [205] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [206] Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
• [207] Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34. doi: 10.1016/j.bbrc.2004.12.151.
• [208] Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. Exp Biol Med (Maywood). 2013 Aug 1;238(8):932-42. doi: 10.1177/1535370213492689. Epub 2013 Jul 24.
• [209] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [210] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [211] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [212] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [213] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [214] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [215] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [216] Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
• [217] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [218] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [219] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [220] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [221] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [222] Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum. 2006 Nov;54(11):3513-22. doi: 10.1002/art.22170.
• [223] Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues. Mol Endocrinol. 2006 Mar;20(3):573-83. doi: 10.1210/me.2005-0165. Epub 2005 Nov 3.
• [224] System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PLoS One. 2019 Aug 22;14(8):e0220894. doi: 10.1371/journal.pone.0220894. eCollection 2019.
• [225] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [226] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [227] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [228] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [229] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [230] Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
• [231] Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Int J Cancer. 2009 Jul 15;125(2):264-75. doi: 10.1002/ijc.24341.
• [232] Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
• [233] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [234] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [235] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [236] Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
• [237] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [238] Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
• [239] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [240] Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000 Jun 1;60(11):3065-71.
• [241] Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res. 2006 Jul 1;66(13):6615-21. doi: 10.1158/0008-5472.CAN-05-4566.
• [242] XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):155-62. doi: 10.1016/j.taap.2010.12.009. Epub 2010 Dec 28.
• [243] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [244] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [245] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [246] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [247] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [248] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [249] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [250] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [251] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [252] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [253] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [254] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [255] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [256] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [257] Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
• [258] Study of As(2)O(3) regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1932-1937. doi: 10.1080/21691401.2019.1613419.
• [259] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [260] Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
• [261] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [262] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [263] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [264] Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
• [265] The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
• [266] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [267] Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
• [268] High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
• [269] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [270] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [271] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [272] Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells. Cell Biol Toxicol. 2023 Feb;39(1):1-18. doi: 10.1007/s10565-022-09726-0. Epub 2022 May 31.
• [273] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [274] Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
• [275] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [276] PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem. 2019 Nov 22;294(47):17941-17950. doi: 10.1074/jbc.RA119.009881. Epub 2019 Oct 9.
• [277] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [278] Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radic Biol Med. 2003 Sep 1;35(5):528-39. doi: 10.1016/s0891-5849(03)00358-7.
• [279] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [280] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [281] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [282] Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
• [283] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [284] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [285] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [286] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [287] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [288] Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.
• [289] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [290] Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys. 2006 Oct 15;454(2):107-13. doi: 10.1016/j.abb.2006.08.016. Epub 2006 Aug 30.
• [291] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [292] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [293] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [294] The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells. Neurotoxicology. 2009 May;30(3):368-76.
• [295] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [296] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [297] Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
• [298] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [299] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [300] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [301] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [302] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [303] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [304] Antitumor effects of histone deacetylase inhibitor on Ewing's family tumors. Int J Cancer. 2005 Sep 20;116(5):784-92. doi: 10.1002/ijc.21069.
• [305] Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
• [306] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [307] Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
• [308] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [309] Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
• [310] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [311] Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):219-29. doi: 10.1016/j.taap.2005.12.015. Epub 2006 Feb 21.
• [312] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [313] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [314] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [315] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [316] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [317] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [318] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [319] Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
• [320] Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells. J Nutr. 2006 Jan;136(1):75-82.
• [321] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [322] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [323] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [324] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [325] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [326] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [327] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [328] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [329] Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011 Mar 21;24(3):340-9. doi: 10.1021/tx1003112. Epub 2011 Jan 14.
• [330] Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
• [331] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
• [332] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [333] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
• [334] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [335] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [336] Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J. 2011 Sep 1;438(2):349-58. doi: 10.1042/BJ20101653.
• [337] Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol. 2005 Oct;167(4):947-57. doi: 10.1016/S0002-9440(10)61185-6.
• [338] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [339] Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
• [340] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [341] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [342] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [343] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [344] New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. Breast Cancer Res. 2006;8(1):R1. doi: 10.1186/bcr1362. Epub 2005 Dec 9.
• [345] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [346] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [347] Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition. Acta Pharm Sin B. 2020 Jun;10(6):1061-1072. doi: 10.1016/j.apsb.2020.01.016. Epub 2020 Jan 31.
• [348] Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
• [349] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [350] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [351] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [352] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [353] Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
• [354] Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
• [355] Oxidative stress modulates KLF6Full and its splice variants. Alcohol Clin Exp Res. 2012 Nov;36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. Epub 2012 Apr 6.
• [356] Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024. doi: 10.1016/j.bmc.2018.06.027. Epub 2018 Jun 20.
• [357] DNA double-strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H(2)O(2) appear to increase chromatin bridges and resultant cytokinesis failure. Free Radic Biol Med. 2017 Jul;108:129-145. doi: 10.1016/j.freeradbiomed.2017.03.025. Epub 2017 Mar 24.
• [358] Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
• [359] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [360] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [361] Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
• [362] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [363] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [364] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [365] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [366] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [367] Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. doi: 10.4049/jimmunol.1003919. Epub 2011 Jul 18.
• [368] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [369] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [370] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [371] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [372] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [373] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [374] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [375] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [376] Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
• [377] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [378] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [379] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [380] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [381] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [382] An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
• [383] Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J Nutr Biochem. 2006 Apr;17(4):250-6. doi: 10.1016/j.jnutbio.2005.05.004. Epub 2005 Jun 13.
• [384] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [385] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [386] Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model. Arch Toxicol. 2012 Apr;86(4):571-89.
• [387] [Differential proteomic expression in human liver cells stimulated by hydroquinone]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Nov;24(11):658-61.
• [388] Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins. Bioorg Med Chem. 2011 Aug 15;19(16):4710-20. doi: 10.1016/j.bmc.2011.07.005. Epub 2011 Jul 13.
• [389] Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.
• [390] The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013 Jun;20(6):661-9. doi: 10.1177/1933719112462630. Epub 2012 Nov 26.
• [391] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [392] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [393] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [394] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [395] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [396] Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
• [397] Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
• [398] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [399] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [400] Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
• [401] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [402] Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
• [403] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [404] Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. PLoS One. 2013 Dec 3;8(12):e82086. doi: 10.1371/journal.pone.0082086. eCollection 2013.
• [405] Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
• [406] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [407] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [408] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [409] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [410] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [411] Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
• [412] Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther. 2002 Oct;303(1):300-7. doi: 10.1124/jpet.102.036939.
• [413] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [414] Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
• [415] Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
• [416] Effects of metoclopramide on duodenal motility and flow events, glucose absorption, and incretin hormone release in response to intraduodenal glucose infusion. Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1326-33. doi: 10.1152/ajpgi.00476.2009. Epub 2010 Sep 9.
• [417] Glucagon secretion in primary endogenous hypertriglyceridemia before and after clofibrate treatment. Metabolism. 1975 Aug;24(8):901-14. doi: 10.1016/0026-0495(75)90081-5.
• [418] Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2003 Aug;88(8):3829-34. doi: 10.1210/jc.2003-030199.
• [419] Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):375-84. doi: 10.1016/j.taap.2012.11.015. Epub 2012 Nov 28.
• [420] Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
• [421] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [422] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [423] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [424] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [425] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [426] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [427] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [428] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [429] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [430] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [431] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [432] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [433] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [434] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [435] Inhibitory effect of glucocorticoids on human-cloned 5-hydroxytryptamine3A receptor expressed in xenopus oocytes. Anesthesiology. 2004 Sep;101(3):660-5. doi: 10.1097/00000542-200409000-00014.
• [436] Interactions of metoclopramide and ergotamine with human 5-HT(3A) receptors and human 5-HT reuptake carriers. Br J Pharmacol. 2005 Oct;146(4):543-52. doi: 10.1038/sj.bjp.0706351.
• [437] The effects of fentanyl-like opioids and hydromorphone on human 5-HT3A receptors. Anesth Analg. 2008 Jul;107(1):107-12. doi: 10.1213/ane.0b013e31817342c2.
• [438] Impairment of hypoxia-induced HIF-1 signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. doi: 10.1007/s00204-015-1549-y. Epub 2015 Jun 17.
• [439] Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3;24(6):980-91. doi: 10.1038/sj.onc.1208095.
• [440] Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
• [441] Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
• [442] Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
• [443] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [444] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [445] Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
• [446] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [447] Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth. J Cell Biochem. 2005 Nov 1;96(4):760-74. doi: 10.1002/jcb.20474.
• [448] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [449] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [450] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [451] Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
• [452] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [453] Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. J Biol Chem. 2005 Mar 25;280(12):11807-15. doi: 10.1074/jbc.M411508200. Epub 2004 Dec 14.
• [454] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [455] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [456] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [457] Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
• [458] Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
• [459] The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
• [460] Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
• [461] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [462] Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
• [463] Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
• [464] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [465] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [466] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.