Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3CBD)

• Drug Name: geraniol Drug Info
• Synonyms: GERANIOL; 106-24-1; Lemonol; Geranyl alcohol; trans-Geraniol; (E)-Geraniol; (2E)-3,7-dimethylocta-2,6-dien-1-ol; (E)-Nerol; trans-3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethylocta-2,6-dien-1-ol; Geraniol Extra; Geraniol alcohol; 3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethyl-2,6-octadien-1-ol; beta-Geraniol; 3,7-Dimethyl-trans-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-; Guaniol; t-geraniol; 2E-geraniol; Geraniol (natural); 2-trans-3,7-Dimethyl-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-; CHEBI:17447

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 637566
  ChEBI ID: CHEBI:17447
  CAS Number: CAS 106-24-1
  TTD Drug ID: DMS3CBD

Molecule-Related Drug Atlas

Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[8]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[10]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[11]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[12]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[13]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[14]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[13]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[12]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[15]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[16]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[22]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[59]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[62]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[69]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[62]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[75]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[73]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[85]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[88]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[90]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Menin (MEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Transcription elongation factor SPT5 (SUPT5H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[114]

Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 1 (BMAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[119]

Drug(s) Affected By Citron Rho-interacting kinase (CIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[127]

Drug(s) Affected By Interferon regulatory factor 6 (IRF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]

Drug(s) Affected By Krueppel-like factor 11 (KLF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[135]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Mothers against decapentaplegic homolog 7 (SMAD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By Fanconi anemia group G protein (FANCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By High mobility group protein B3 (HMGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[142]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[146]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[149]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]

Drug(s) Affected By DNA-directed RNA polymerase I subunit RPA34 (POLR1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By PHD finger protein 1 (PHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Bortezomib	DMNO38U	Leukemia		Approved	[118]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[160]

Drug(s) Affected By AP-5 complex subunit zeta-1 (AP5Z1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[163]

Drug(s) Affected By Protein CBFA2T2 (CBFA2T2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[160]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By Mothers against decapentaplegic homolog 6 (SMAD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[172]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3 (CREB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Geminin (GMNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[188]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[189]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[192]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[196]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By Actin-like protein 6A (ACTL6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[201]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[201]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[210]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[214]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[215]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[221]
Fructose	DM43AN2	Vomiting	MD90	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[157]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Homeobox protein Hox-C6 (HOXC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[241]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[247]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[250]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[249]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[256]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Protein C-ets-2 (ETS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[258]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[259]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[262]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Zinc finger protein 40 (HIVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[265]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[266]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[267]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[277]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[284]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[285]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[289]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[292]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]

Drug(s) Affected By Transcription factor BTF3 (BTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[295]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[176]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[298]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[299]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[300]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Homeobox protein Hox-A5 (HOXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[73]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[73]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[73]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[303]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]

Drug(s) Affected By Nuclear autoantigen Sp-100 (SP100)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Thymidylate kinase (DTYMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[114]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[295]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[310]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[157]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[157]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[319]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[321]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]

Drug(s) Affected By ETS-related transcription factor Elf-1 (ELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By General transcription factor IIH subunit 1 (GTF2H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[326]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[328]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[329]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[330]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[331]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[332]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[334]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[339]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[340]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[343]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[345]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[349]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[280]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Bortezomib	DMNO38U	Leukemia		Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[352]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[277]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[352]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[358]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[363]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[365]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]

Drug(s) Affected By DNA-binding protein RFX5 (RFX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]

Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[371]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[157]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]

Drug(s) Affected By ETS translocation variant 1 (ETV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[372]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[373]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[374]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[374]

Drug(s) Affected By Kinetochore-associated protein 1 (KNTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[334]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By Probable global transcription activator SNF2L2 (SMARCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[377]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]

Drug(s) Affected By Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]

Drug(s) Affected By Homeobox protein GBX-2 (GBX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[378]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[326]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[379]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]

Drug(s) Affected By Calcipressin-1 (RCAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[85]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[382]

Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[384]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]

Drug(s) Affected By Telomeric repeat-binding factor 1 (TERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[387]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[388]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[389]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[392]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Krueppel-like factor 3 (KLF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]

Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[394]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[310]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[399]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[400]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[402]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]

Drug(s) Affected By Transcription initiation factor IIB (GTF2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[403]

Drug(s) Affected By Norrin (NDP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[404]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[405]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[407]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[408]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[409]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[410]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Haloperidol	DM96SE0	Delirium		Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[327]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]

Drug(s) Affected By DNA-binding protein SATB1 (SATB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[414]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[414]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[327]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[415]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[416]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[277]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[418]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[419]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[420]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[352]

Drug(s) Affected By Transducin-like enhancer protein 1 (TLE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Activin receptor type-1 (ACVR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[172]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[310]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[422]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[424]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[425]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[327]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[327]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]

Drug(s) Affected By DNA polymerase epsilon catalytic subunit A (POLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[329]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[426]

Drug(s) Affected By HMG domain-containing protein 3 (HMGXB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[427]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[428]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By General transcription factor 3C polypeptide 1 (GTF3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[429]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[430]

Drug(s) Affected By Alpha-globin transcription factor CP2 (TFCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[431]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[160]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]

Drug(s) Affected By Interleukin enhancer-binding factor 2 (ILF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[434]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[433]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By ELAV-like protein 2 (ELAVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[326]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[437]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[438]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[440]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[443]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[315]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[445]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[446]

Drug(s) Affected By Periodic tryptophan protein 1 homolog (PWP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Tripartite motif-containing protein 29 (TRIM29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[447]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[448]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[449]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By Single-minded homolog 2 (SIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[326]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[450]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[309]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]

Drug(s) Affected By Max dimerization protein 4 (MXD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[433]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Kinesin-like protein KIF22 (KIF22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Bortezomib	DMNO38U	Leukemia		Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[453]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[427]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[178]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[300]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Haloperidol	DM96SE0	Delirium		Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Transcription elongation factor A protein-like 1 (TCEAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Bortezomib	DMNO38U	Leukemia		Approved	[454]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[455]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[456]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[133]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[461]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[462]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[63]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[463]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[464]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[466]

Drug(s) Affected By Hepatic leukemia factor (HLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By KRAB domain-containing protein 4 (KRBOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By Homeobox-containing protein 1 (HMBOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[427]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[467]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By ELKS/Rab6-interacting/CAST family member 1 (ERC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]

Drug(s) Affected By Leucine-zipper-like transcriptional regulator 1 (LZTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By GATA zinc finger domain-containing protein 1 (GATAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[176]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[468]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By HMG box transcription factor BBX (BBX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[133]

Drug(s) Affected By Protein ELYS (AHCTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By Transcription factor IIIA (GTF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[133]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[403]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By DNA repair and recombination protein RAD54-like (RAD54L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[471]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[472]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]

Drug(s) Affected By Homeobox protein Hox-B13 (HOXB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[473]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[473]

Drug(s) Affected By Protein Jumonji (JARID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[250]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Amyloid beta precursor protein binding family B member 2 (APBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[474]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[446]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[135]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[352]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[477]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[327]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[474]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By PHD finger protein 21A (PHF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[478]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[479]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[480]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[481]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[485]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[486]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[487]

Drug(s) Affected By DnaJ homolog subfamily C member 1 (DNAJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]

Drug(s) Affected By Transcription factor 12 (TCF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[489]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]

Drug(s) Affected By Max-binding protein MNT (MNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[490]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[491]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[492]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[494]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[495]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]

Drug(s) Affected By Ribosome quality control complex subunit TCF25 (TCF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[433]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[496]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[433]

Drug(s) Affected By E3 ubiquitin-protein ligase TRAIP (TRAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[258]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[449]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[497]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]

Drug(s) Affected By B-cell lymphoma/leukemia 11A (BCL11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[498]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Nuclear body protein SP140-like protein (SP140L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By Leucine zipper transcription factor-like protein 1 (LZTFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[499]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[500]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[401]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Bortezomib	DMNO38U	Leukemia		Approved	[454]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By SLC2A4 regulator (SLC2A4RG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[501]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19A (RNF19A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[388]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[502]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[503]

Drug(s) Affected By ETS homologous factor (EHF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[259]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[427]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[505]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[407]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[506]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[133]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[133]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[133]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By REST corepressor 3 (RCOR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[175]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[479]

Drug(s) Affected By HMG domain-containing protein 4 (HMGXB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[388]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By AF4/FMR2 family member 4 (AFF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[507]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Zinc finger transcription factor Trps1 (TRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[57]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[474]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[508]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]

Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Tyrosine-protein kinase BAZ1B (BAZ1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By DCC-interacting protein 13-alpha (APPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[103]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[510]

Drug(s) Affected By PR domain zinc finger protein 4 (PRDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[511]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[156]

Drug(s) Affected By Unconventional myosin-VI (MYO6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[512]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]

Drug(s) Affected By Zinc finger protein PLAGL1 (PLAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[513]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[514]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]

Drug(s) Affected By Protein PHTF1 (PHTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[401]
Bortezomib	DMNO38U	Leukemia		Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[515]

Drug(s) Affected By Protein timeless homolog (TIMELESS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Trafficking kinesin-binding protein 1 (TRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[516]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Forkhead box protein J3 (FOXJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[102]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[517]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[411]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[494]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]

Drug(s) Affected By RuvB-like 2 (RUVBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[327]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[519]

Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[401]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[360]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[520]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[520]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]

Drug(s) Affected By RuvB-like 1 (RUVBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[477]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[318]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[413]

Drug(s) Affected By Krueppel-like factor 13 (KLF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By FACT complex subunit SPT16 (SUPT16H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[142]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[521]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[94]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[103]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[18]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[18]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[524]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[525]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[526]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[528]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[422]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[210]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[529]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[530]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[531]

Drug(s) Affected By Interleukin-1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[456]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[7]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[456]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[7]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[532]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[533]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[534]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[535]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[534]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[534]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[537]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[538]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[537]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[537]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[540]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[539]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[537]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[541]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[542]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[449]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[7]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[479]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[543]

Drug(s) Affected By Pro-glucagon (GCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[545]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[546]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[547]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[548]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[73]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[550]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[526]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[551]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[552]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[553]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[554]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[555]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[553]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[558]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[559]
Haloperidol	DM96SE0	Delirium		Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Selenium	DM25CGV	N. A.	N. A.	Approved	[561]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[562]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[563]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[564]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[345]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[565]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[566]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[567]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[568]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[569]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[570]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[571]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[572]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[573]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[575]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[575]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[576]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[577]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[147]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[578]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[533]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[581]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[582]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[584]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[585]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[587]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[588]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[589]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[590]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[591]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[571]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[592]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[593]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[594]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[595]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[596]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[481]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[590]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[598]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[599]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[600]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[589]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[571]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[592]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[601]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[443]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[602]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[603]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[50]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[604]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[605]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[607]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[608]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[214]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[609]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[611]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[612]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[613]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[614]

Drug(s) Affected By 5-hydroxytryptamine receptor 3A (HTR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[615]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[616]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[4]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[617]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[615]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[618]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[619]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[570]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[620]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[621]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[146]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[622]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[623]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[624]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[565]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[614]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[569]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[625]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[620]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[626]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[627]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[629]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[630]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[631]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[178]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[632]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[157]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[634]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[635]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[636]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[637]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[638]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[623]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[639]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[640]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[641]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[642]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[643]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[644]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[645]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[646]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[647]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[648]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[649]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[650]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[651]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[652]
Mestranol	DMG3F94	Contraception	QA21	Approved	[653]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[654]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[655]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[656]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[657]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[449]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[658]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[659]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[660]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[661]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[662]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[663]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[664]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[526]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[539]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[657]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[665]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[666]

Drug(s) Affected By Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[667]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[668]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[668]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[427]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-15 (GNA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[668]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]
Caprylic acid	DMLGS82	Discovery agent	N.A.	Investigative	[668]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[669]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[670]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[671]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[672]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[673]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[674]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[675]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[676]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[677]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[678]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[679]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[680]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[681]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[682]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[683]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[684]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[685]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[686]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[687]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[144]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[147]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[670]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[688]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[689]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[690]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[690]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[691]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[692]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[693]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[694]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[3]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Gene/Protein Processing	[4]
Actin-like protein 6A (ACTL6A)	OT0EC5BQ	ACL6A_HUMAN	Gene/Protein Processing	[5]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Gene/Protein Processing	[5]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Gene/Protein Processing	[5]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Gene/Protein Processing	[6]
AF4/FMR2 family member 4 (AFF4)	OTTL5Y8R	AFF4_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Alpha-globin transcription factor CP2 (TFCP2)	OTA246TE	TFCP2_HUMAN	Gene/Protein Processing	[5]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Gene/Protein Processing	[5]

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