Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTAJP7)

• Drug Name: Butanoic Acid Drug Info
• Synonyms: butyric acid; butanoic acid; n-Butyric acid; 107-92-6; n-Butanoic acid; propylformic acid; ethylacetic acid; 1-propanecarboxylic acid; Butanic acid; butyrate; 1-Butyric acid; Buttersaeure; butanoate; Kyselina maselna; Butyric acid (natural); Propanecarboxylic acid; Buttersaeure [German]; 1-butanoic acid; FEMA Number 2221; Kyselina maselna [Czech]; FEMA No. 2221; CCRIS 6552; HSDB 940; butoic acid; Ethyacetic Acid; 2-butanoate; NSC 8415; UNII-40UIR9Q29H; UN2820; AI3-15306; EINECS 203-532-3; BRN 0906770; CH3-[CH2]2-COOH; 40UIR9Q29H

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 264
  ChEBI ID: CHEBI:30772
  CAS Number: CAS 107-92-6
  TTD Drug ID: DMTAJP7
  VARIDT Drug ID: DR01475

Molecule-Related Drug Atlas

Drug(s) Targeting Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hexafluronium bromide	DMFY307	Spasm	MB47.3	Approved	[8]
MEPTAZINOL	DMPSB8F	Pain	MG30-MG3Z	Approved	[9]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[10]
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[11]
Plasma derived human butyrylcholinesterase	DMF3IBC	Neurotoxicity	NE61	Phase 1	[12]
Protexia	DME1Y9W	Alzheimer disease	8A20	Phase 1	[13]
JES-9501	DMYR3IE	Alzheimer disease	8A20	Phase 1	[14]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[15]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[15]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[15]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]

Drug(s) Transported By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[26]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[26]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[27]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[28]
Gabapentin enacarbil	DMJY2TM	Postherpetic neuralgia	1E91.5	Phase 2	[3]
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[29]
Hydroxyacetic Acid	DMQFBH6	Discovery agent	N.A.	Investigative	[30]
biotin	DMKMCE1	Discovery agent	N.A.	Investigative	[31]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[32]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[35]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[36]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[48]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[49]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[50]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[51]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Haloperidol	DM96SE0	Delirium		Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[55]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[63]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]

Drug(s) Affected By Porphobilinogen deaminase (HMBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[74]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[78]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[74]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[84]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[96]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[101]

Drug(s) Affected By Eosinophil peroxidase (EPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[105]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[106]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Bone marrow proteoglycan (PRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[112]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[113]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[133]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[134]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[138]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[139]
Fructose	DM43AN2	Vomiting	MD90	Approved	[35]
Ketoprofen	DMRKXPT	Bursitis		Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[143]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[150]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]

Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[152]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[157]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[133]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[179]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[178]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[180]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[181]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[182]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[185]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[190]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[192]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[193]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[192]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[35]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[195]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[196]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[198]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[212]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[213]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[214]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[215]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[219]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[220]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[221]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[222]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[222]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[222]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[223]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[224]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[225]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[226]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[227]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[228]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[35]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[230]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[237]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[237]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[240]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[241]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[242]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[242]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[243]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[244]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[242]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[242]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[242]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[245]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[246]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[248]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[249]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[251]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[252]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[223]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[253]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[254]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[255]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[256]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[257]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[258]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[265]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[266]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[65]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[273]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[274]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[275]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[276]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[277]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[278]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[279]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[280]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[281]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[282]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[283]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[285]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[285]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[286]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[287]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[289]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[290]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[290]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[290]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[291]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[290]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[294]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[295]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[296]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[296]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[294]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[294]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[301]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[302]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[303]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[302]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[308]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[310]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[311]

Drug(s) Affected By Glutathione S-transferase A3 (GSTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[230]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[313]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[314]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Bortezomib	DMNO38U	Leukemia		Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[318]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[264]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[326]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[330]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[331]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[333]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[334]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[339]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[340]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[337]

Drug(s) Affected By Retinal dehydrogenase 2 (ALDH1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[341]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[341]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[341]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[341]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[341]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[342]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[341]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[345]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]

Drug(s) Affected By Complement C3 (C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[347]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[65]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[351]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[352]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[353]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[356]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[357]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[360]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[361]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[362]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[363]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[364]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[365]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[366]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[367]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[368]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[369]

Drug(s) Affected By Hemoglobin subunit zeta (HBZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[373]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[376]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[377]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]

Drug(s) Affected By Glycophorin-A (GYPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[81]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[379]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[380]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[381]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[382]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[35]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[383]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[384]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[385]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[386]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[363]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[387]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[369]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[389]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[366]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[366]

Drug(s) Affected By HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[390]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[391]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[392]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[393]
Bortezomib	DMNO38U	Leukemia		Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[395]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[399]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[400]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[403]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[404]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[405]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[407]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[408]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[410]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[412]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[414]

Drug(s) Affected By Plasma protease C1 inhibitor (SERPING1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[415]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[416]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[419]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Fructose	DM43AN2	Vomiting	MD90	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[421]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[424]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[429]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[430]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[431]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[433]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[178]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[323]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[436]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[437]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[438]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[439]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[440]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[441]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[442]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[443]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[444]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[442]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase C (PTPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[445]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[448]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]

Drug(s) Affected By Complement factor H (CFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[449]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[450]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[319]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[452]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[453]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[456]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[457]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[50]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[457]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[458]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[459]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[460]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[461]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[466]
Fructose	DM43AN2	Vomiting	MD90	Approved	[467]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[445]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[468]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[470]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[471]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[472]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[473]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[421]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[474]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[186]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[475]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[475]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[475]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[476]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[477]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[478]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[479]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[480]
Selenium	DM25CGV	N. A.	N. A.	Approved	[427]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[481]

Drug(s) Affected By Ras-related protein R-Ras (RRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[484]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[485]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[450]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[486]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[240]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[489]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[490]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[491]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[493]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Indomethacin	DMSC4A7	Bursitis		Approved	[495]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]

Drug(s) Affected By High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[496]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[497]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[498]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[499]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Cathepsin E (CTSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[414]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[500]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[503]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[319]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[504]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[505]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[506]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[507]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[508]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[509]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]

Drug(s) Affected By Ras-related protein Rab-3A (RAB3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[512]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[513]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[514]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[515]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[516]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[518]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Bortezomib	DMNO38U	Leukemia		Approved	[121]

Drug(s) Affected By 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[519]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[520]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[484]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[521]
Protoporphyrin IX	DMWYE7A	Discovery agent	N.A.	Investigative	[522]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[524]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Haloperidol	DM96SE0	Delirium		Approved	[527]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[528]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[456]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[529]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[531]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[532]
Fructose	DM43AN2	Vomiting	MD90	Approved	[467]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[533]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[534]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[535]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[536]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[537]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[538]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[539]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[540]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[541]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[542]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[535]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[544]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[545]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[546]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[534]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[537]

Drug(s) Affected By Transketolase (TKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[547]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[548]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[552]

Drug(s) Affected By Coronin-1A (CORO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[553]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[89]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[555]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[556]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[559]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[560]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[198]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[352]

Drug(s) Affected By G-protein coupled receptor 183 (GPR183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[324]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[561]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[519]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[324]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[562]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[563]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[562]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[264]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[562]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[565]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[566]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[567]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]

Drug(s) Affected By 26S proteasome regulatory subunit 7 (PSMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[568]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[569]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[570]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[572]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[573]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[532]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[574]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[575]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[576]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[577]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[579]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[580]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[581]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[352]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[585]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[586]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[587]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[588]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[423]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[589]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[533]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[590]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[198]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[591]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[321]

Drug(s) Affected By Gastrotropin (FABP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[593]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[594]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[595]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[597]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[323]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[598]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[599]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[600]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[520]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[601]

Drug(s) Affected By Amyloid beta precursor like protein 1 (APLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[602]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 4 (PSMD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[603]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[604]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[605]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[603]

Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[606]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[607]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[376]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Actin-related protein 3 (ACTR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[527]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[527]

Drug(s) Affected By Alpha-centractin (ACTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]

Drug(s) Affected By Lysozyme C (LYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[327]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[608]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[609]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[610]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[393]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[611]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[568]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[614]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[615]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[616]

Drug(s) Affected By Hemoglobin subunit gamma-2 (HBG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[617]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[618]
Primaquine	DMWQ16I	Malaria	1F40-1F45	Approved	[618]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[383]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[619]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[620]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[620]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]

Drug(s) Affected By SRSF protein kinase 2 (SRPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[621]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[622]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[623]

Drug(s) Affected By G-protein-signaling modulator 2 (GPSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[624]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[625]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[626]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[404]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[627]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[628]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[629]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[603]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[630]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[621]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[631]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[533]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[563]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[160]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[632]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[62]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[633]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[634]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Bortezomib	DMNO38U	Leukemia		Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[635]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[395]

Drug(s) Affected By Dynamin-1 (DNM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]

Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[527]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[639]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[640]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[642]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[643]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[642]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[502]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[644]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[645]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[646]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[647]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[648]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[50]

Drug(s) Affected By Son of sevenless homolog 2 (SOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[157]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[520]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[649]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[326]

Drug(s) Affected By Serine/arginine-rich splicing factor 4 (SRSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[651]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[605]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[603]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[603]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[652]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[653]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[654]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[655]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[656]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By N-myc-interactor (NMI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[657]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[658]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]

Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[660]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[661]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[662]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[605]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[580]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[663]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[664]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[665]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[666]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[667]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[668]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[669]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[670]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[671]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[527]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[527]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By AT-rich interactive domain-containing protein 5B (ARID5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[673]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Indomethacin	DMSC4A7	Bursitis		Approved	[674]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[675]

Drug(s) Affected By Toll-like receptor 1 (TLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[330]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Sodium channel protein type 9 subunit alpha (SCN9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[676]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[677]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[105]

Drug(s) Affected By Beta-synuclein (SNCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[678]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[679]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[680]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[681]

Drug(s) Affected By Interleukin-20 receptor subunit beta (IL20RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[682]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[624]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Rab11 family-interacting protein 1 (RAB11FIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[603]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]

Drug(s) Affected By Lysophosphatidylcholine acyltransferase 2 (LPCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[326]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[662]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Reticulon-4 receptor-like 2 (RTN4RL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[330]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[500]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[484]

Drug(s) Affected By CD302 antigen (CD302)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[683]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[684]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]

Drug(s) Affected By tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]

Drug(s) Affected By Transmembrane protein 87A (TMEM87A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[324]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]

Drug(s) Affected By Lysophosphatidylcholine acyltransferase 1 (LPCAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[594]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[359]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[623]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[685]

Drug(s) Affected By TBC1 domain family member 16 (TBC1D16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[686]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[324]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[622]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[324]

Drug(s) Affected By Programmed cell death 6-interacting protein (PDCD6IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[687]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[688]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[689]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[623]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[690]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase U (PTPRU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[691]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[692]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[662]

Drug(s) Affected By Histone acetyltransferase KAT5 (KAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[693]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[694]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[695]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[696]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[621]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[694]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[89]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[697]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[577]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[527]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[357]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 3 (MS4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]

Drug(s) Affected By Putative protein-lysine deacylase ABHD14B (ABHD14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]

Drug(s) Affected By SRSF protein kinase 1 (SRPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[642]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[642]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[621]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[698]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[699]

Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[700]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[701]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[655]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[702]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[703]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[704]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[705]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[688]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]

Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[527]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[706]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[649]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[552]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[707]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[708]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[709]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[561]

Drug(s) Affected By C-type lectin domain family 7 member A (CLEC7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[710]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[711]
Bortezomib	DMNO38U	Leukemia		Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[712]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[713]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[714]

Drug(s) Affected By Protein FAM117A (FAM117A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[324]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[581]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[715]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[716]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[717]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[670]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[718]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[719]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[644]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[715]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[720]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[721]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[720]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[722]

Drug(s) Affected By Ethanolamine kinase 2 (ETNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[319]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[319]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[723]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[562]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[724]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[725]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[563]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[726]

Drug(s) Affected By Very long chain fatty acid elongase 2 (ELOVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[682]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[520]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[511]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[484]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[708]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[328]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]

Drug(s) Affected By Tropomodulin-2 (TMOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[324]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[605]
Oxamflatin	DM1TG3C	Solid tumour/cancer	2A00-2F9Z	Terminated	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[727]
Apicidin	DM83WVF	Solid tumour/cancer	2A00-2F9Z	Investigative	[324]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[395]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[605]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[728]

Drug(s) Affected By Endothelial protein C receptor (PROCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[724]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[482]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By RING finger protein 24 (RNF24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[324]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[324]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]

Drug(s) Affected By Protein canopy homolog 2 (CNPY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[568]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[729]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By Toll-like receptor 6 (TLR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[394]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[330]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[500]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[730]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[113]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-5 (ATF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[694]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[731]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[469]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[732]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[484]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[733]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[330]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[734]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[735]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[157]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[610]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Nuclear receptor corepressor 2 (NCOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[484]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[736]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[737]

Drug(s) Affected By Unconventional myosin-XVI (MYO16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[603]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[484]

Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[738]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[739]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[740]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[741]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Monocarboxylate transporter 1 (SLC16A1)	DT342ZG	MOT1_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 4 (PSMD4)	OTH1VZTM	PSMD4_HUMAN	Gene/Protein Processing	[5]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Gene/Protein Processing	[5]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Gene/Protein Processing	[5]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Gene/Protein Processing	[5]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Gene/Protein Processing	[5]
Actin-related protein 3 (ACTR3)	OT05LJSH	ARP3_HUMAN	Gene/Protein Processing	[5]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[6]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[7]
Alpha-centractin (ACTR1A)	OT1QAU16	ACTZ_HUMAN	Gene/Protein Processing	[5]

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