Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTMLRN)

Drug Name
MICROCYSTIN-LR Drug Info
Synonyms
Akerstox; Microcystin-a; 5-L-Argininecyanoginosin LA; Toxin I (Microcystis aeruginosa); Cyanoginosin LA, 5-L-arginine-; Toxin T 17 (Microcystis aeruginosa); BRN 4779759; Toxin, blue green alga, Microcystis aeruginosa; AC1O5MXK; DTXSID00424146; 128657-50-1; LS-55782
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
445434
ChEBI ID
CHEBI:6925
CAS Number
CAS 101043-37-2
TTD Drug ID
DMTMLRN
VARIDT Drug ID
DR01417

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serine/threonine PP1-alpha (PPP1CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [2]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [12]
PALASONIN DMDTP1R Discovery agent N.A. Investigative [2]
TAUTOMYCIN DMC92DQ Discovery agent N.A. Investigative [2]
CANTHARIDIC_ACID DME32XU Discovery agent N.A. Investigative [2]
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [15]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Selenium DM25CGV N. A. N. A. Approved [19]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [20]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [32]
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Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [23]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [35]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [44]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Haloperidol DM96SE0 Delirium Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [48]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [49]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [53]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
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Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [65]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [67]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [68]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [65]
Paclitaxel DMLB81S Breast carcinoma Approved [69]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [78]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [79]
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Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Ketoprofen DMRKXPT Bursitis Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
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Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Fructose DM43AN2 Vomiting MD90 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [92]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [94]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [96]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [97]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [101]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [102]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Verapamil DMA7PEW Angina pectoris BA40 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [108]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [111]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [115]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [116]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
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Drug(s) Affected By GTPase NRas (NRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [119]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [120]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [65]
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Drug(s) Affected By Interferon beta (IFNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Aripiprazole DM3NUMH Bipolar I disorder Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [127]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [128]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [128]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [129]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [130]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [131]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [134]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [135]
Selenium DM25CGV N. A. N. A. Approved [136]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [137]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [138]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [142]
Paclitaxel DMLB81S Breast carcinoma Approved [143]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [144]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [146]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
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Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Selenium DM25CGV N. A. N. A. Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [153]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [15]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [135]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [159]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [160]
Fructose DM43AN2 Vomiting MD90 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [162]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
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Drug(s) Affected By Integrin beta-1 (ITGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [169]
Fructose DM43AN2 Vomiting MD90 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [172]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Selenium DM25CGV N. A. N. A. Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [181]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Selenium DM25CGV N. A. N. A. Approved [114]
Etretinate DM2CZFA Keratosis ED56 Approved [184]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [185]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [169]
Quercetin DM3NC4M Obesity 5B81 Approved [186]
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Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Quercetin DM3NC4M Obesity 5B81 Approved [188]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [189]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [190]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [192]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [193]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [194]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [195]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [134]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [134]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [196]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [154]
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Drug(s) Affected By Intestinal-type alkaline phosphatase (ALPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [198]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [198]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [199]
Wortmannin DM8EVK5 Haematological malignancy 2B33.Y Terminated [197]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [200]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [173]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [201]
cycloheximide DMGDA3C Discovery agent N.A. Investigative [202]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [203]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [204]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [205]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [15]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [162]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [206]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [207]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [209]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [210]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Verapamil DMA7PEW Angina pectoris BA40 Approved [211]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [212]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [213]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein tau (MAPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [216]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [217]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Testosterone enanthate DMB6871 N. A. N. A. Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [221]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [222]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [223]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [223]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [224]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Fluoxetine DM3PD2C Bipolar depression Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [227]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [228]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [171]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [231]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [232]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [233]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [234]
Quercetin DM3NC4M Obesity 5B81 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ezrin (EZR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [236]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Selenium DM25CGV N. A. N. A. Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [238]
Haloperidol DM96SE0 Delirium Approved [236]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [239]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [240]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [241]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [242]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [243]
Bortezomib DMNO38U Leukemia Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Selenium DM25CGV N. A. N. A. Approved [35]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [247]
Etretinate DM2CZFA Keratosis ED56 Approved [248]
Methotrexate DM2TEOL Anterior urethra cancer Approved [249]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [250]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [251]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-galactosidase (GLB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [254]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [255]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [258]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [177]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [260]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [261]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [261]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [177]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lutropin-choriogonadotropic hormone receptor (LHCGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [262]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [264]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [265]
Gefitinib DM15F0X Colon adenocarcinoma Approved [266]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [270]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Follicle-stimulating hormone receptor (FSHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [272]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [272]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [272]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [273]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [274]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [201]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [275]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [276]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [214]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [277]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [279]
Selenium DM25CGV N. A. N. A. Approved [35]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [115]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin regulatory light polypeptide 9 (MYL9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [46]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [284]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [285]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [286]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [287]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [288]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [272]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [289]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [290]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [213]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [291]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [292]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [293]
Gefitinib DM15F0X Colon adenocarcinoma Approved [294]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [296]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [297]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [289]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [298]
Paclitaxel DMLB81S Breast carcinoma Approved [299]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [300]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [272]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [213]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [291]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SHC-transforming protein 1 (SHC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [301]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [302]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Bortezomib DMNO38U Leukemia Approved [303]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [304]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [305]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [306]
Arsenic DMTL2Y1 N. A. N. A. Approved [307]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [308]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [35]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [186]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Folic Acid DMEMBJC Colorectal carcinoma Approved [315]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [321]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [322]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [214]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [324]
Selenium DM25CGV N. A. N. A. Approved [35]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [325]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [325]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [82]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [326]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [330]
Paclitaxel DMLB81S Breast carcinoma Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [332]
Quercetin DM3NC4M Obesity 5B81 Approved [333]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [334]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [336]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [337]
Testosterone DM7HUNW Hot flushes GA30 Approved [338]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [339]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [340]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [341]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [342]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [344]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [345]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [346]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin receptor substrate 1 (IRS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [348]
Testosterone DM7HUNW Hot flushes GA30 Approved [349]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [351]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [352]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [353]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [358]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [359]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [360]
Haloperidol DM96SE0 Delirium Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Clozapine DMFC71L Schizophrenia 6A20 Approved [236]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Orlistat DMRJSP8 Obesity 5B81 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [312]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [362]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Etretinate DM2CZFA Keratosis ED56 Approved [184]
Prednisone DM2HG4X Acute asthma CA23 Approved [363]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [364]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS translocation variant 5 (ETV5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [366]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [367]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [368]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [371]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [142]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [372]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [373]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [374]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [375]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [376]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Prednisone DM2HG4X Acute asthma CA23 Approved [363]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [377]
Quercetin DM3NC4M Obesity 5B81 Approved [378]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [379]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [381]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [383]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [384]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [383]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [385]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [386]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [384]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [120]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paxillin (PXN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [389]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [390]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [391]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [392]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [394]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [395]
Methamphetamine DMPM4SK Anxiety Approved [396]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [397]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [395]
Urethane DM7NSI0 N. A. N. A. Phase 4 [398]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [399]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [394]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Gefitinib DM15F0X Colon adenocarcinoma Approved [400]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [401]
Selenium DM25CGV N. A. N. A. Approved [35]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [402]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [378]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [403]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Methotrexate DM2TEOL Anterior urethra cancer Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [405]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [406]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [407]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [408]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [410]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [410]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [411]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [412]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [413]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [414]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [212]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [415]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [416]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [417]
Meloxicam DM2AR7L Arthritis FA20 Approved [418]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [419]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [421]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [422]
Quercetin DM3NC4M Obesity 5B81 Approved [423]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [424]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [425]
Testosterone DM7HUNW Hot flushes GA30 Approved [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [46]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [232]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [427]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [428]
Methotrexate DM2TEOL Anterior urethra cancer Approved [429]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [430]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [431]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [433]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [436]
Quercetin DM3NC4M Obesity 5B81 Approved [437]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [438]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [438]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [121]
Pamidronate DMB4AVP Bone Paget disease Approved [439]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [441]
Methotrexate DM2TEOL Anterior urethra cancer Approved [239]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [442]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [443]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [444]
Testosterone DM7HUNW Hot flushes GA30 Approved [445]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [446]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [321]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [447]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [243]
Bortezomib DMNO38U Leukemia Approved [244]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [65]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [448]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [449]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [241]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [450]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [451]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [452]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [453]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [454]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [207]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [284]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Verapamil DMA7PEW Angina pectoris BA40 Approved [211]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [415]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Meloxicam DM2AR7L Arthritis FA20 Approved [455]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O1 (FOXO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [456]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pappalysin-1 (PAPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [458]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [459]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [460]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [461]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [462]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [463]
Testosterone DM7HUNW Hot flushes GA30 Approved [426]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [464]
Pamidronate DMB4AVP Bone Paget disease Approved [439]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [465]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [466]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [284]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [417]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [467]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [468]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [469]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [470]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [115]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [377]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [471]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [472]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [348]
Testosterone DM7HUNW Hot flushes GA30 Approved [445]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [450]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein transport protein Sec23A (SEC23A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [474]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [475]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [476]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [153]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [199]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [475]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [477]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adipogenesis regulatory factor (ADIRF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [405]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [478]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [479]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [480]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [481]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [482]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [483]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [484]
Prednisone DM2HG4X Acute asthma CA23 Approved [485]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [485]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [486]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [487]
Epinephrine DM3KJBC Acute asthma CA23 Approved [488]
Quercetin DM3NC4M Obesity 5B81 Approved [333]
Fluoxetine DM3PD2C Bipolar depression Approved [489]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin light chain kinase 3 (MYLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [177]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [490]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [173]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [491]
Drug(s) Affected By Immediate early response gene 5-like protein (IER5L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [492]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [493]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [494]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [198]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Jade-1 (JADE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferroxidase HEPHL1 (HEPHL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
Milchsaure DM462BT Pruritus EC90 Investigative [496]
Drug(s) Affected By Chondroitin sulfate proteoglycan 4 (CSPG4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [497]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [498]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [498]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [499]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [500]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NEDD4-binding protein 2 (N4BP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Urethane DM7NSI0 N. A. N. A. Phase 4 [398]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [219]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [309]
Milchsaure DM462BT Pruritus EC90 Investigative [496]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stimulator of interferon genes protein (STING1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [447]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [459]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [490]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [501]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [502]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase SIAH1 (SIAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [503]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [348]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [504]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium leak channel NALCN (NALCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [506]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [153]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [507]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [173]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Nesprin-1 (SYNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CDK5 and ABL1 enzyme substrate 1 (CABLES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [508]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [509]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [498]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arginine/serine-rich protein PNISR (PNISR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [510]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Bortezomib DMNO38U Leukemia Approved [244]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [368]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [511]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Titin (TTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [512]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [490]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [513]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [153]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [514]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 13 (FGF13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [516]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [517]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [518]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [519]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [284]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [520]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [456]
Quercetin DM3NC4M Obesity 5B81 Approved [521]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [522]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [523]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [524]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanylate-binding protein 5 (GBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [459]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Arsenic DMTL2Y1 N. A. N. A. Approved [307]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [525]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [526]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [501]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3C (SEMA3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Quercetin DM3NC4M Obesity 5B81 Approved [527]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [177]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [313]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [528]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FH2 domain-containing protein 1 (FHDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [177]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [481]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [529]
Urethane DM7NSI0 N. A. N. A. Phase 4 [398]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
Milchsaure DM462BT Pruritus EC90 Investigative [496]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 7 (MS4A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [447]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [530]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [531]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [532]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [533]
EUGENOL DM7US1H Discovery agent N.A. Patented [531]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Integrator complex subunit 2 (INTS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [368]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [259]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [529]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [534]
Milchsaure DM462BT Pruritus EC90 Investigative [496]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 180 (CCDC180)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [177]
Urethane DM7NSI0 N. A. N. A. Phase 4 [398]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [514]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [535]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By DNA (DNMT3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [536]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [537]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [538]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [529]
Ethanol DMDRQZU Chronic pain MG30 Approved [539]
Folic Acid DMEMBJC Colorectal carcinoma Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein timeless homolog (TIMELESS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [540]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Arsenic DMTL2Y1 N. A. N. A. Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [153]
Paclitaxel DMLB81S Breast carcinoma Approved [331]
Topotecan DMP6G8T Central nervous system neoplasm Approved [476]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transformation/transcription domain-associated protein (TRRAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Bortezomib DMNO38U Leukemia Approved [244]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [460]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen D1 (MAGED1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [316]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [493]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [317]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA (DNMT3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [541]
Methotrexate DM2TEOL Anterior urethra cancer Approved [239]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [536]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [537]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [538]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [542]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [458]
Ethanol DMDRQZU Chronic pain MG30 Approved [539]
Folic Acid DMEMBJC Colorectal carcinoma Approved [543]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [544]
Sulfinpyrazone DMEV954 Gout FA25 Approved [545]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [546]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [547]
Methotrexate DM2TEOL Anterior urethra cancer Approved [548]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [549]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [550]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [551]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [552]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [553]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [554]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [555]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [556]
Methotrexate DM2TEOL Anterior urethra cancer Approved [557]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [558]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [559]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [559]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [560]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [561]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [562]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [563]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [560]
Trospium chloride DM32XZT Discovery agent N.A. Approved [564]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [550]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [82]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [565]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [550]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immunoglobulin-binding protein 1 (IGBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [368]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [481]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [529]
Urethane DM7NSI0 N. A. N. A. Phase 4 [398]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [567]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [263]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [309]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [173]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine PP1-alpha (PPP1CA) TTFLH0E PP1A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Post-Translational Modifications [3]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Gene/Protein Processing [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [6]
Arginine/serine-rich protein PNISR (PNISR) OTUM02FW PNISR_HUMAN Gene/Protein Processing [7]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [8]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [9]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [5]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Post-Translational Modifications [10]
Beta-galactosidase (GLB1) OTB0TKAG BGAL_HUMAN Gene/Protein Processing [11]

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563 Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
564 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
565 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
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