Details of Disease

Disease Name

Rectal carcinoma

rectal cancer; cancer of rectum; cancer of the rectum; carcinoma of the rectum; carcinoma of rectum; rectum carcinoma; rectal carcinoma

Definition

A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas.

Disease Hierarchy

DISOSUFD: Epithelial neoplasm of rectum

DIS5926S: Rectal cancer

DISH9F1N: Carcinoma

DIS5PYL0: Colorectal carcinoma

DIS8FRR7: Rectal carcinoma

Disease Identifiers

MONDO ID

MONDO_0044937

MESH ID

D012004

UMLS CUI

C0007113

MedGen ID

40100

General Information of Disease (ID: DIS8FRR7)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 59 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACAT1	TTK3C21	Limited	Genetic Variation	[1]
BUB1	TT78309	Limited	Genetic Variation	[2]
CLCA1	TT3AF4R	Limited	Altered Expression	[3]
COASY	TT4YO0Z	Limited	Biomarker	[4]
DHCR24	TTTK0NH	Limited	Biomarker	[5]
DPYD	TTZPS91	Limited	Biomarker	[6]
EIF2AK1	TTRUJBV	Limited	Biomarker	[7]
FGF8	TTIUF3J	Limited	Biomarker	[8]
GGH	TTZJRL0	Limited	Biomarker	[9]
GMNN	TT390KA	Limited	Altered Expression	[10]
HMGCS2	TTS0EZJ	Limited	Altered Expression	[11]
HSD17B2	TT0PT1R	Limited	Altered Expression	[11]
IFNGR2	TT13TL0	Limited	Biomarker	[12]
KIR2DS2	TTV3CFI	Limited	Genetic Variation	[13]
MAGEA3	TTWSKHD	Limited	Biomarker	[14]
PIM3	TTCGOIN	Limited	Biomarker	[15]
PMS1	TTX1ISF	Limited	Biomarker	[16]
RAPGEF3	TTOE7I0	Limited	Biomarker	[17]
REG4	TTVZEHU	Limited	Altered Expression	[18]
RPS6KA1	TTIXKA4	Limited	Genetic Variation	[19]
RPS6KA2	TT0ZW9O	Limited	Genetic Variation	[19]
SCG3	TTY5R9H	Limited	Biomarker	[20]
SERPINB5	TT1KW50	Limited	Biomarker	[21]
STC2	TT4EFTR	Limited	Altered Expression	[22]
TDG	TTEXRQD	Limited	Altered Expression	[23]
TDGF1	TTN7HMG	Limited	Biomarker	[24]
TKT	TT04R7I	Limited	Altered Expression	[25]
TKTL1	TTNQ1J3	Limited	Biomarker	[25]
TYMP	TTO0IB8	Limited	Altered Expression	[26]
UBC	TTBP3XA	Limited	Biomarker	[27]
UMPS	TTAFJUD	Limited	Genetic Variation	[28]
VKORC1	TTEUC8H	Limited	Genetic Variation	[29]
CD274	TT8ZLTI	Disputed	Altered Expression	[30]
ABCC4	TTUEAFL	Strong	Genetic Variation	[31]
AHSG	TTKF4WV	Strong	Biomarker	[32]
ALOX12	TT12ABZ	Strong	Genetic Variation	[33]
ALOX5AP	TTDMBF5	Strong	Genetic Variation	[34]
CA9	TT2LVK8	Strong	Biomarker	[35]
CASP10	TTX5HEK	Strong	Altered Expression	[36]
CCL20	TT2XAZY	Strong	Biomarker	[37]
CDKN1B	TTLGFVW	Strong	Biomarker	[6]
CEACAM3	TTPX7I5	Strong	Biomarker	[38]
EGFR	TTGKNB4	Strong	Altered Expression	[39]
EPHA4	TTG84D3	Strong	Biomarker	[40]
IL23R	TT6H4QR	Strong	Biomarker	[41]
LGR5	TTTSGRH	Strong	Biomarker	[42]
MMP7	TTMTWOS	Strong	Altered Expression	[43]
MSRB1	TT1QUZV	Strong	Biomarker	[44]
NRAS	TTW2R9X	Strong	Genetic Variation	[45]
PDK1	TTCZOF2	Strong	Biomarker	[19]
PTGER2	TT1ZAVI	Strong	Genetic Variation	[33]
QPCT	TTJ7YTV	Strong	Biomarker	[46]
SATB1	TTLFRIC	Strong	Biomarker	[47]
TMBIM6	TT7QSMG	Strong	Altered Expression	[48]
TP53BP1	TTX4UE9	Strong	Altered Expression	[49]
UCHL5	TTSX29Z	Strong	Biomarker	[50]
UGT1A1	TT34ZAF	Strong	Genetic Variation	[51]
TXNRD3	TTDYFVB	Definitive	Genetic Variation	[52]
VDR	TTK59TV	Definitive	Genetic Variation	[53]
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⏷ Show the Full List of 59 DTT(s)

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ASNS	DEXISVQ	Limited	Altered Expression	[54]
SMOX	DEOH5V3	Limited	Altered Expression	[55]
ACSS2	DEE76VW	Strong	Genetic Variation	[56]
------------------------------------------------------------------------------------

This Disease Is Related to 92 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADAM11	OTPTVW5W	Limited	Biomarker	[57]
AKIRIN2	OTQ6WSKW	Limited	Biomarker	[58]
ALDH7A1	OTV57BZD	Limited	Biomarker	[59]
ALDOB	OT7FR69A	Limited	Biomarker	[60]
APBB3	OTNUTR0N	Limited	Biomarker	[61]
ATAD1	OTJ02XFL	Limited	Genetic Variation	[62]
BAGE4	OT2LPTMI	Limited	Biomarker	[63]
BMPR1B	OTGFN0OD	Limited	Genetic Variation	[64]
BPIFB6	OTRZVDSE	Limited	Biomarker	[65]
CCDC88A	OT3SSYYC	Limited	Genetic Variation	[66]
CCRL2	OT5PX0RX	Limited	Biomarker	[7]
CHD4	OTBDEHDP	Limited	Biomarker	[67]
CHI3L1	OT2Z7VJH	Limited	Biomarker	[68]
CLEC4D	OTT7X1UC	Limited	Genetic Variation	[69]
COIL	OTP4I4DL	Limited	Genetic Variation	[70]
CORO7	OTG7MEAJ	Limited	Biomarker	[71]
DNAJC12	OTNU59PT	Limited	Altered Expression	[72]
DYNLL2	OTLIT58K	Limited	Altered Expression	[73]
EMD	OTR8ZANE	Limited	Biomarker	[74]
EXT1	OTRPALJK	Limited	Genetic Variation	[75]
FJX1	OT8SVTSS	Limited	Altered Expression	[76]
GDF10	OTEVXGJ7	Limited	Genetic Variation	[64]
HOMER2	OT4JGKJF	Limited	Altered Expression	[20]
IFNGR1	OTCTQBWW	Limited	Genetic Variation	[12]
IQGAP2	OTX2UA7P	Limited	Altered Expression	[77]
KIR2DS4	OT00N6UJ	Limited	Biomarker	[13]
KIR2DS5	OTXLEN11	Limited	Biomarker	[13]
LARS1	OT4557NF	Limited	Biomarker	[78]
MACC1	OTV3DLX0	Limited	Altered Expression	[79]
MAGED4B	OTO37U7W	Limited	Altered Expression	[76]
MARCHF11	OTODNSYN	Limited	Biomarker	[80]
MUC6	OTPVL723	Limited	Genetic Variation	[81]
MYRF	OTKF6AEB	Limited	Biomarker	[82]
NARS1	OTFS4J1W	Limited	Genetic Variation	[83]
PCK2	OTJ8LX4N	Limited	Biomarker	[84]
PEAK1	OTVVM637	Limited	Altered Expression	[85]
PPP1R16B	OTZJFX5C	Limited	Biomarker	[86]
PRKAG2	OTHTAM54	Limited	Biomarker	[87]
RAB5C	OTQE5QQ2	Limited	Biomarker	[88]
RAD18	OTQ9PLNT	Limited	Biomarker	[89]
RAPH1	OTMQXW7S	Limited	Biomarker	[90]
RBM4	OT5SFQA3	Limited	Altered Expression	[91]
RCC2	OTUJVTLS	Limited	Altered Expression	[92]
RUNDC3A	OTHP1DRS	Limited	Biomarker	[20]
SAGE1	OT4H6FFA	Limited	Biomarker	[93]
SEPTIN9	OT1VMRFQ	Limited	Biomarker	[94]
SIRT7	OT5M4OT4	Limited	Altered Expression	[95]
SPAAR	OTWXG2R8	Limited	Biomarker	[96]
SPNS1	OTSJ3BJ2	Limited	Genetic Variation	[83]
STARD13	OTB4U1HY	Limited	Altered Expression	[73]
TENM4	OT91K3FC	Limited	Genetic Variation	[97]
THSD7A	OT7249HH	Limited	Biomarker	[98]
MAGEB6	OTOTV1FU	Disputed	Biomarker	[99]
ASCL2	OT3D62WB	moderate	Altered Expression	[100]
MCC	OTQVI1EM	moderate	Biomarker	[101]
MUC2	OT3X4QVX	moderate	Biomarker	[102]
ACCS	OTHIHI9D	Strong	Genetic Variation	[56]
AFAP1L1	OTWNTNDB	Strong	Altered Expression	[103]
APC	OTKV0TIK	Strong	Biomarker	[104]
ARID3A	OTZZ4SFP	Strong	Altered Expression	[105]
AZIN2	OT8OB7CG	Strong	Biomarker	[106]
BRMS1	OTV5A6LL	Strong	Altered Expression	[107]
C2orf68	OTNNFK6R	Strong	Altered Expression	[108]
CEACAM7	OTKFDTZY	Strong	Biomarker	[38]
CERS4	OTV5ENAX	Strong	Altered Expression	[109]
CERS5	OT5A2DNI	Strong	Altered Expression	[109]
CHD5	OTS5EVHH	Strong	Posttranslational Modification	[110]
CHPT1	OT4FJ0K3	Strong	Biomarker	[111]
DHDDS	OTVLYBUS	Strong	Biomarker	[111]
EIF1	OTB4GZ0V	Strong	Biomarker	[112]
EIF5	OT79PQUN	Strong	Biomarker	[112]
EIF6	OTEXMUED	Strong	Biomarker	[112]
FH	OTEQWU6Q	Strong	Genetic Variation	[69]
GADL1	OTJM4A0R	Strong	Biomarker	[106]
GPX2	OTXI2NTI	Strong	Genetic Variation	[113]
INTU	OTXB13E6	Strong	Genetic Variation	[114]
KLF5	OT1ABI9N	Strong	Biomarker	[115]
MSH6	OT46FP09	Strong	Biomarker	[116]
PCDHB3	OTEDVXZY	Strong	Posttranslational Modification	[117]
PLA2G15	OT6VJTPA	Strong	Genetic Variation	[56]
PMS2	OTNLWTMI	Strong	Genetic Variation	[118]
PSG2	OT2EIXAI	Strong	Biomarker	[38]
PTPN4	OT6SXU5Y	Strong	Altered Expression	[119]
PTPRF	OTH5KF2D	Strong	Biomarker	[120]
RAB1A	OTKPHRD0	Strong	Genetic Variation	[121]
RAN	OT2TER5M	Strong	Genetic Variation	[122]
SCO2	OTJQQDRS	Strong	Biomarker	[123]
STAT2	OTO9G2RZ	Strong	Biomarker	[124]
TAS2R16	OT67HLNS	Strong	Genetic Variation	[125]
TCN1	OTW6A49Y	Strong	Genetic Variation	[126]
SELENOF	OT2JFB3S	Definitive	Biomarker	[52]
SELENON	OTSGKO5M	Definitive	Genetic Variation	[52]
------------------------------------------------------------------------------------


⏷ Show the Full List of 92 DOT(s)

References

1	Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.J Dig Dis. 2012 Jan;13(1):24-32. doi: 10.1111/j.1751-2980.2011.00551.x.
2	Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.Jpn J Cancer Res. 1999 Aug;90(8):837-40. doi: 10.1111/j.1349-7006.1999.tb00824.x.
3	High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy.Int J Med Sci. 2018 Jul 30;15(11):1171-1178. doi: 10.7150/ijms.26685. eCollection 2018.
4	CoA Synthase (COASY) Mediates Radiation Resistance via PI3K Signaling in Rectal Cancer.Cancer Res. 2020 Jan 15;80(2):334-346. doi: 10.1158/0008-5472.CAN-19-1161. Epub 2019 Nov 8.
5	Value of adding dynamic contrast-enhanced MRI visual assessment to conventional MRI and clinical assessment in the diagnosis of complete tumour response to chemoradiotherapy for rectal cancer.Eur Radiol. 2019 Mar;29(3):1104-1113. doi: 10.1007/s00330-018-5719-1. Epub 2018 Sep 21.
6	Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.Gastroenterol Res Pract. 2017;2017:2808235. doi: 10.1155/2017/2808235. Epub 2017 Feb 23.
7	Analysis of histological therapeutic effect, apoptosis rate and p53 status after combined treatment with radiation, hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers.Br J Cancer. 1998;77(1):159-66. doi: 10.1038/bjc.1998.25.
8	FGF8 induces therapy resistance in neoadjuvantly radiated rectal cancer.J Cancer Res Clin Oncol. 2019 Jan;145(1):77-86. doi: 10.1007/s00432-018-2757-7. Epub 2018 Oct 1.
9	Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer.Cancer Chemother Pharmacol. 2017 Jun;79(6):1077-1085. doi: 10.1007/s00280-017-3295-8. Epub 2017 Apr 17.
10	Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors.J Cell Physiol. 2005 Jan;202(1):215-22. doi: 10.1002/jcp.20120.
11	The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.Tumour Biol. 2015 Sep;36(10):7675-83. doi: 10.1007/s13277-015-3503-2. Epub 2015 May 1.
12	Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.Carcinogenesis. 2011 Nov;32(11):1660-7. doi: 10.1093/carcin/bgr189. Epub 2011 Aug 22.
13	HLA-Cw polypmorphism and killer cell immunoglobulin-like receptor (KIR) gene analysis in Korean colorectal cancer patients.Int J Surg. 2014;12(8):815-20. doi: 10.1016/j.ijsu.2014.06.012. Epub 2014 Jul 4.
14	Hospital volume and outcome in rectal cancer patients; results of a population-based study in the Netherlands.Eur J Surg Oncol. 2019 Apr;45(4):613-619. doi: 10.1016/j.ejso.2018.12.018. Epub 2018 Dec 26.
15	Pim-3 as a potential predictor of chemoradiotherapy resistance in locally advanced rectal cancer patients.Sci Rep. 2017 Nov 22;7(1):16043. doi: 10.1038/s41598-017-16153-3.
16	Associations of Genetic Variations in Mismatch Repair Genes MSH3 and PMS1 with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy.Cancer Res Treat. 2019 Jul;51(3):1198-1206. doi: 10.4143/crt.2018.527. Epub 2018 Dec 26.
17	PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway.Anal Cell Pathol (Amst). 2019 Jan 23;2019:7145198. doi: 10.1155/2019/7145198. eCollection 2019.
18	Overexpression of REG4 confers an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy.J Surg Oncol. 2014 Dec;110(8):1002-10. doi: 10.1002/jso.23764. Epub 2014 Aug 22.
19	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.Mutat Res. 2011 Jan 10;706(1-2):13-20. doi: 10.1016/j.mrfmmm.2010.10.005. Epub 2010 Oct 28.
20	Identification of two novel biomarkers of rectal carcinoma progression and prognosis via co-expression network analysis.Oncotarget. 2017 Jun 27;8(41):69594-69609. doi: 10.18632/oncotarget.18646. eCollection 2017 Sep 19.
21	SERPINB5 Expression: Association with CCRT Response and Prognostic Value in Rectal Cancer.Int J Med Sci. 2018 Feb 12;15(4):376-384. doi: 10.7150/ijms.22823. eCollection 2018.
22	Gene expression analyses identify a relationship between stanniocalcin 2 and the malignant behavior of colorectal cancer.Onco Targets Ther. 2018 Oct 18;11:7155-7168. doi: 10.2147/OTT.S167780. eCollection 2018.
23	Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency.DNA Repair (Amst). 2012 Jul 1;11(7):616-23. doi: 10.1016/j.dnarep.2012.04.004. Epub 2012 May 17.
24	GRP78 Protein Expression as Prognostic Values in Neoadjuvant Chemoradiotherapy and Laparoscopic Surgery for Locally Advanced Rectal Cancer.Cancer Res Treat. 2015 Oct;47(4):804-12. doi: 10.4143/crt.2014.121. Epub 2015 Jan 30.
25	Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy.BMC Cancer. 2011 Aug 19;11:363. doi: 10.1186/1471-2407-11-363.
26	Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer.Anticancer Res. 2016 May;36(5):2433-40.
27	Multiple differential expression networks identify key genes in rectal cancer.Cancer Biomark. 2016;16(3):435-44. doi: 10.3233/CBM-160582.
28	A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.Radiat Oncol. 2017 Mar 27;12(1):62. doi: 10.1186/s13014-017-0800-5.
29	Pharmacogenomics: from bedside to clinical practice.Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R89-93. doi: 10.1093/hmg/ddl087.
30	Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.PLoS One. 2019 Feb 26;14(2):e0212978. doi: 10.1371/journal.pone.0212978. eCollection 2019.
31	Prognostic and Therapeutic Potential Implications of Genetic Variability in Prostaglandin E2 Pathway Genes in Rectal Cancer.Anticancer Res. 2017 Jan;37(1):281-291. doi: 10.21873/anticanres.11319.
32	Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer.Int J Cancer. 2015 Aug 15;137(4):911-20. doi: 10.1002/ijc.29448. Epub 2015 Feb 5.
33	Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.Carcinogenesis. 2014 Sep;35(9):2121-6. doi: 10.1093/carcin/bgu119. Epub 2014 Jun 7.
34	Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.Genes Chromosomes Cancer. 2013 May;52(5):437-49. doi: 10.1002/gcc.22042. Epub 2013 Feb 12.
35	Clinical value of significance of Hypoxia Inducible Factor-1, Glucose Transporter-1 and Carbonic Anhydrase IX in rectal cancer after preoperative chemoradiotherapy.J BUON. 2019 Mar-Apr;24(2):456-463.
36	Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.Oncology. 2008;74(3-4):229-36. doi: 10.1159/000151392. Epub 2008 Aug 21.
37	Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers.Radiother Oncol. 2018 Jun;127(3):392-395. doi: 10.1016/j.radonc.2018.05.004. Epub 2018 May 16.
38	Ultrasound/CT combined with serum CEA/CA19.9 in the diagnosis and prognosis of rectal cancer.J BUON. 2018 May-Jun;23(3):592-597.
39	Higher nuclear EGFR expression is a better predictor of survival in rectal cancer patients following neoadjuvant chemoradiotherapy than cytoplasmic EGFR expression.Oncol Lett. 2019 Feb;17(2):1551-1558. doi: 10.3892/ol.2018.9756. Epub 2018 Nov 26.
40	The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells.J Cell Biochem. 2017 Mar;118(3):442-445. doi: 10.1002/jcb.25738. Epub 2016 Sep 30.
41	The immune microenvironment of the colorectal tumor: Involvement of immunity genes and microRNAs belonging to the TH17 pathway.Biochim Biophys Acta. 2015 Aug;1856(1):28-38. doi: 10.1016/j.bbcan.2015.04.001. Epub 2015 Apr 21.
42	Leucine-rich repeat-containing G protein-coupled receptor 5 and CD133 expression is associated with tumor progression and resistance to preoperative chemoradiotherapy in low rectal cancer.Oncol Lett. 2017 Dec;14(6):7791-7798. doi: 10.3892/ol.2017.7207. Epub 2017 Oct 18.
43	MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer.In Vivo. 2018 Jan-Feb;32(1):133-138. doi: 10.21873/invivo.11215.
44	The influence of the CHIEF pathway on colorectal cancer-specific mortality.PLoS One. 2014 Dec 26;9(12):e116169. doi: 10.1371/journal.pone.0116169. eCollection 2014.
45	Mutational analysis and clinical correlation of metastatic colorectal cancer.Cancer. 2014 May 15;120(10):1482-90. doi: 10.1002/cncr.28599. Epub 2014 Feb 5.
46	Pathogenicity of A600V variant in exon 12 of the MSH2 gene detected in a Japanese kindred with Lynch syndrome.Jpn J Clin Oncol. 2012 Jan;42(1):78-82. doi: 10.1093/jjco/hyr162. Epub 2011 Nov 14.
47	Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer.Cancer Biol Ther. 2015;16(12):1738-45. doi: 10.1080/15384047.2015.1095408.
48	Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.J Pathol. 2006 Feb;208(3):340-9. doi: 10.1002/path.1902.
49	53BP1 expression and immunoscore are associated with the efficacy of neoadjuvant chemoradiotherapy for rectal cancer.Strahlenther Onkol. 2020 May;196(5):465-473. doi: 10.1007/s00066-019-01559-x. Epub 2019 Dec 11.
50	Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.PLoS One. 2018 Feb 23;13(2):e0193125. doi: 10.1371/journal.pone.0193125. eCollection 2018.
51	An expansion study of genotype-driven weekly irinotecan and capecitabine in combination with neoadjuvant radiotherapy for locally advanced rectal cancer with UGT1A1 11 genotype.Therap Adv Gastroenterol. 2019 Jun 6;12:1756284819852293. doi: 10.1177/1756284819852293. eCollection 2019.
52	Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer.PLoS One. 2012;7(5):e37312. doi: 10.1371/journal.pone.0037312. Epub 2012 May 17.
53	Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors.Nutr Cancer. 2010;62(4):436-42. doi: 10.1080/01635580903441204.
54	Deficiency in asparagine synthetase expression in rectal cancers receiving concurrent chemoradiotherapy: negative prognostic impact and therapeutic relevance.Tumour Biol. 2014 Jul;35(7):6823-30. doi: 10.1007/s13277-014-1895-z. Epub 2014 Apr 13.
55	Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.Cancer Chemother Pharmacol. 2008 Aug;62(3):517-27. doi: 10.1007/s00280-007-0633-2. Epub 2007 Nov 7.
56	Trends and outcomes in laparoscopic versus open surgery for rectal cancer from 2005 to 2016 using the ACS-NSQIP database, a retrospective cohort study.Int J Surg. 2019 Mar;63:71-76. doi: 10.1016/j.ijsu.2019.02.006. Epub 2019 Feb 13.
57	Multidisciplinary Conference and Clinical Management of Rectal Cancer.J Am Coll Surg. 2018 May;226(5):874-880. doi: 10.1016/j.jamcollsurg.2018.01.056. Epub 2018 Mar 23.
58	Prognostic value of nuclear FBI-1 in patients with rectal cancer with or without preoperative radiotherapy.Oncol Lett. 2019 Nov;18(5):5301-5309. doi: 10.3892/ol.2019.10890. Epub 2019 Sep 19.
59	Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation After Laparoscopic Nerve-Preserving Radical Proctectomy for Rectal Cancer: A Prospective Controlled Trial.Am J Mens Health. 2017 May;11(3):641-646. doi: 10.1177/1557988316665084. Epub 2016 Aug 24.
60	High Expression of Aldolase B Confers a Poor Prognosis for Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy.J Cancer. 2017 Apr 9;8(7):1197-1204. doi: 10.7150/jca.18197. eCollection 2017.
61	Localization of mesenteric lymph node metastases in relation to the level of arterial ligation in rectal cancer surgery.Eur J Surg Oncol. 2019 Jun;45(6):989-994. doi: 10.1016/j.ejso.2019.01.183. Epub 2019 Feb 5.
62	CYP1A1, cigarette smoking, and colon and rectal cancer.Am J Epidemiol. 2004 Nov 1;160(9):842-52. doi: 10.1093/aje/kwh298.
63	Effect of Akt activation and experimental pharmacological inhibition on responses to neoadjuvant chemoradiotherapy in rectal cancer.Br J Surg. 2018 Jan;105(2):e192-e203. doi: 10.1002/bjs.10695.
64	Genetic variation in bone morphogenetic protein and colon and rectal cancer.Int J Cancer. 2012 Feb 1;130(3):653-64. doi: 10.1002/ijc.26047. Epub 2011 Apr 27.
65	Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature.Epigenomics. 2016 Sep;8(9):1193-207. doi: 10.2217/epi-2016-0044. Epub 2016 Aug 16.
66	Association between operative technique and intrusive thoughts on health-related Quality of Life 3years after APE/ELAPE for rectal cancer: results from a national Swedish cohort with comparison with normative Swedish data.Cancer Med. 2018 Jun;7(6):2727-2735. doi: 10.1002/cam4.1402. Epub 2018 Apr 17.
67	Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent Chemoradiotherapy.Int J Mol Sci. 2019 Aug 21;20(17):4087. doi: 10.3390/ijms20174087.
68	The Assessment of Clinical Usage and Prognostic Value of YKL-40 Serum Levels in Patients With Rectal Cancer Without Distant Metastasis.Technol Cancer Res Treat. 2018 Jan 1;17:1533033818765209. doi: 10.1177/1533033818765209.
69	Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort.Environ Int. 2019 May;126:242-251. doi: 10.1016/j.envint.2019.02.010. Epub 2019 Feb 26.
70	Sphincter-saving proctectomy for rectal cancer with NO COIL transanal tube and without ostoma. Clinical outcomes, cost effectiveness and quality of life in the elderly.Minerva Chir. 2019 Feb;74(1):19-25. doi: 10.23736/S0026-4733.18.07755-6. Epub 2018 Apr 13.
71	Monitoring perioperative serum albumin can identify anastomotic leakage in colorectal cancer patients with curative intent.Asian J Surg. 2018 Jan;41(1):30-38. doi: 10.1016/j.asjsur.2016.07.009. Epub 2016 Jul 19.
72	Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer.Exp Mol Pathol. 2015 Jun;98(3):338-45. doi: 10.1016/j.yexmp.2015.03.029. Epub 2015 Mar 21.
73	Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.Int J Oncol. 2006 Nov;29(5):1127-32.
74	T3 subclassification using the EMD/mesorectum ratio predicts neoadjuvant chemoradiation outcome in T3 rectal cancer patients.Br J Radiol. 2018 Jan;91(1081):20170617. doi: 10.1259/bjr.20170617. Epub 2017 Nov 21.
75	Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers.Surgery. 2002 Jul;132(1):27-33. doi: 10.1067/msy.2002.125357.
76	In vitro evaluation of dual-antigenic PV1 peptide vaccine in head and neck cancer patients.Hum Vaccin Immunother. 2019;15(1):167-178. doi: 10.1080/21645515.2018.1520584. Epub 2018 Oct 12.
77	Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer.Genes Chromosomes Cancer. 2016 Apr;55(4):311-321. doi: 10.1002/gcc.22329.
78	Treatment possibilities for low anterior resection syndrome: a review of the literature.Int J Colorectal Dis. 2018 Mar;33(3):251-260. doi: 10.1007/s00384-017-2954-x. Epub 2018 Jan 8.
79	Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy.Anticancer Res. 2012 Apr;32(4):1527-31.
80	Robot-assisted Versus Laparoscopic Surgery for Rectal Cancer: A Phase II Open Label Prospective Randomized Controlled Trial.Ann Surg. 2018 Feb;267(2):243-251. doi: 10.1097/SLA.0000000000002321.
81	Association of MUC6-minisatellite variants with susceptibility to rectal carcinoma.Mol Biol Rep. 2013 Jan;40(1):303-8. doi: 10.1007/s11033-012-2062-5. Epub 2012 Oct 10.
82	Long-term outcomes of surgery alone versus surgery following preoperative chemoradiotherapy for early T3 rectal cancer: A propensity score analysis.Medicine (Baltimore). 2017 Mar;96(12):e6362. doi: 10.1097/MD.0000000000006362.
83	Metabolic Syndrome, as Defined Based on Parameters Including Visceral Fat Area, Predicts Complications After Surgery for Rectal Cancer.Obes Surg. 2020 Jan;30(1):319-326. doi: 10.1007/s11695-019-04163-1.
84	Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.BMC Cancer. 2014 Mar 6;14:160. doi: 10.1186/1471-2407-14-160.
85	PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d.Cell Death Dis. 2018 Feb 15;9(3):271. doi: 10.1038/s41419-018-0320-8.
86	Affinity proteomics led identification of vimentin as a potential biomarker in colon cancers: insights from serological screening and computational modelling.Mol Biosyst. 2015 Jan;11(1):159-69. doi: 10.1039/c4mb00506f. Epub 2014 Oct 16.
87	Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.Carcinogenesis. 2010 Sep;31(9):1604-11. doi: 10.1093/carcin/bgq142. Epub 2010 Jul 9.
88	Rab5C enhances resistance to ionizing radiation in rectal cancer.J Mol Med (Berl). 2019 Jun;97(6):855-869. doi: 10.1007/s00109-019-01760-6. Epub 2019 Apr 9.
89	RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase-9-caspase-3-dependent apoptotic pathway.Cancer Med. 2019 Jun;8(6):3094-3104. doi: 10.1002/cam4.2203. Epub 2019 Apr 29.
90	Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma.PLoS One. 2016 Apr 5;11(4):e0152940. doi: 10.1371/journal.pone.0152940. eCollection 2016.
91	Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer.Genomics. 2016 Apr;107(4):138-44. doi: 10.1016/j.ygeno.2016.02.003. Epub 2016 Feb 17.
92	Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.Clin Cancer Res. 2015 Aug 15;21(16):3759-70. doi: 10.1158/1078-0432.CCR-14-3294. Epub 2015 Apr 24.
93	A combined strategy of SAGE and quantitative PCR Provides a 13-gene signature that predicts preoperative chemoradiotherapy response and outcome in rectal cancer.Clin Cancer Res. 2011 Jun 15;17(12):4145-54. doi: 10.1158/1078-0432.CCR-10-2257. Epub 2011 Apr 5.
94	Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.Oncotarget. 2016 Sep 20;7(38):62547-62558. doi: 10.18632/oncotarget.11534.
95	Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.Theranostics. 2017 Mar 22;7(5):1346-1359. doi: 10.7150/thno.18804. eCollection 2017.
96	SPAR - a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial.BMC Cancer. 2019 Dec 17;19(1):1229. doi: 10.1186/s12885-019-6405-7.
97	Predictors of readmission and reoperation in patients with colorectal cancer.Support Care Cancer. 2020 May;28(5):2339-2350. doi: 10.1007/s00520-019-05050-2. Epub 2019 Sep 4.
98	Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report.BMC Nephrol. 2019 Feb 6;20(1):43. doi: 10.1186/s12882-019-1236-y.
99	Neoadjuvant (Chemo)radiotherapy With Total Mesorectal Excision Only Is Not Sufficient to Prevent Lateral Local Recurrence in Enlarged Nodes: Results of the Multicenter Lateral Node Study of Patients With Low cT3/4 Rectal Cancer.J Clin Oncol. 2019 Jan 1;37(1):33-43. doi: 10.1200/JCO.18.00032. Epub 2018 Nov 7.
100	Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.Ann Surg Oncol. 2019 May;26(5):1401-1411. doi: 10.1245/s10434-019-07172-7. Epub 2019 Jan 31.
101	Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.J Med Genet. 1994 Apr;31(4):312-6. doi: 10.1136/jmg.31.4.312.
102	Short chain fatty acids and colon cancer.J Nutr. 2002 Dec;132(12):3804S-3808S. doi: 10.1093/jn/132.12.3804S.
103	AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.Cancer Med. 2014 Aug;3(4):759-74. doi: 10.1002/cam4.237. Epub 2014 Apr 10.
104	Comparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles.Mol Cancer. 2018 Dec 21;17(1):177. doi: 10.1186/s12943-018-0923-9.
105	ARID3A Positivity Correlated With Favorable Prognosis in Patients With Residual Rectal Cancer After Neoadjuvant Chemoradiotherapy.Anticancer Res. 2019 Jun;39(6):2845-2853. doi: 10.21873/anticanres.13413.
106	Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?.Eur Radiol. 2018 Jul;28(7):3059-3065. doi: 10.1007/s00330-018-5329-y. Epub 2018 Feb 15.
107	Effect of BRMS1 on tumorigenicity and metastasis of human rectal cancer.Cell Biochem Biophys. 2014 Sep;70(1):505-9. doi: 10.1007/s12013-014-9948-x.
108	Interaction between C2ORF68 and HuR in human colorectal cancer.Oncol Rep. 2019 Mar;41(3):1918-1928. doi: 10.3892/or.2019.6973. Epub 2019 Jan 21.
109	Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.Oncol Rep. 2018 Dec;40(6):3489-3500. doi: 10.3892/or.2018.6712. Epub 2018 Sep 18.
110	Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.J Biol Regul Homeost Agents. 2015 Oct-Dec;29(4):889-93.
111	Operative Mortality Prediction for Primary Rectal Cancer: Age Matters.J Am Coll Surg. 2019 Apr;228(4):627-633. doi: 10.1016/j.jamcollsurg.2018.12.014. Epub 2019 Jan 8.
112	Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6.Oncotarget. 2017 Sep 5;8(60):101224-101243. doi: 10.18632/oncotarget.20642. eCollection 2017 Nov 24.
113	Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer.Genes Chromosomes Cancer. 2012 Jun;51(6):598-605. doi: 10.1002/gcc.21946. Epub 2012 Feb 27.
114	Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.Clin Cancer Res. 2015 Apr 1;21(7):1583-90. doi: 10.1158/1078-0432.CCR-14-0857. Epub 2015 Jan 14.
115	CORRIGENDUM: Correction of 4th author's name: The Krppel-like factor (KLF5) as a predictive biomarker in preoperative chemoradiation therapy for rectal cancer.Ann Surg Treat Res. 2019 Sep;97(3):157. doi: 10.4174/astr.2019.97.3.157. Epub 2019 Aug 29.
116	Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers.Ann Surg Oncol. 2013 Jun;20(6):1829-36. doi: 10.1245/s10434-012-2858-5. Epub 2013 Jan 29.
117	Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers.J Pathol. 2018 Jun;245(2):222-234. doi: 10.1002/path.5073. Epub 2018 Apr 20.
118	A case of early onset rectal cancer of Lynch syndrome with a novel deleterious PMS2 mutation.Jpn J Clin Oncol. 2015 Oct;45(10):987-92. doi: 10.1093/jjco/hyv108. Epub 2015 Aug 1.
119	Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.Cancer Sci. 2019 Jul;110(7):2258-2272. doi: 10.1111/cas.14031. Epub 2019 May 23.
120	Low Ligation of Inferior Mesenteric Artery in Laparoscopic Anterior Resection for Rectal Cancer Reduces Genitourinary Dysfunction: Results From a Randomized Controlled Trial (HIGHLOW Trial).Ann Surg. 2019 Jun;269(6):1018-1024. doi: 10.1097/SLA.0000000000002947.
121	Pathologic Staging Inconsistency Between ypT4N0 (stage II) and ypT1-2N1 (stage III) After Preoperative Chemoradiotherapy and Total Mesorectal Excision in Rectal Cancer: A Multi-Institutional Study.Clin Colorectal Cancer. 2019 Mar;18(1):e130-e139. doi: 10.1016/j.clcc.2018.11.003. Epub 2018 Nov 23.
122	3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.PLoS One. 2015 Jul 6;10(7):e0131125. doi: 10.1371/journal.pone.0131125. eCollection 2015.
123	Pretreatment expression of 13 molecular markers as a predictor of tumor responses after neoadjuvant chemoradiation in rectal cancer.Ann Surg. 2014 Mar;259(3):508-15. doi: 10.1097/SLA.0b013e31829b3916.
124	JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
125	Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.BMC Gastroenterol. 2017 Sep 15;17(1):104. doi: 10.1186/s12876-017-0659-9.
126	Overexpression of Transcobalamin 1 is an Independent Negative Prognosticator in Rectal Cancers Receiving Concurrent Chemoradiotherapy.J Cancer. 2017 May 12;8(8):1330-1337. doi: 10.7150/jca.18274. eCollection 2017.