Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0E9BR)

• Drug Name: Staurosporine Drug Info
• Synonyms: staurosporine; Staurosporin; (+)-Staurosporine; Antibiotic 230; 62996-74-1; Antibiotic AM 2282; CCRIS 3272; AM-2282; UNII-H88EPA0A3N; Alkaloid AM-2282 from Streptomyces; H88EPA0A3N; CHEMBL388978; CHEBI:15738; CGP 39360; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44259
  ChEBI ID: CHEBI:15738
  CAS Number: CAS 62996-74-1
  TTD Drug ID: DM0E9BR
  VARIDT Drug ID: DR00790

Molecule-Related Drug Atlas

Drug(s) Targeting Inhibitor of nuclear factor kappa-B kinase beta (IKKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[15]
SAR-113945	DMMCA9V	Osteoarthritis	FA00-FA05	Phase 2	[16]
IMD-1041	DMU1MR9	Alzheimer disease	8A20	Phase 2	[17]
IMD-0354	DMOFSLE	Acne vulgaris	ED80	Phase 1	[18]
MLN0415	DMG72VK	Arthritis	FA20	Discontinued in Phase 1	[19]
PF-228	DM32FKD	Discovery agent	N.A.	Investigative	[20]
5-Bromo-6-methoxy-9H-beta-carboline	DM157OQ	Discovery agent	N.A.	Investigative	[21]
5-amino-2-phenyl-oxazole-4-carboxylic acid amide	DMX37ZC	Discovery agent	N.A.	Investigative	[22]
5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide	DM4SWJ7	Discovery agent	N.A.	Investigative	[22]

Drug(s) Targeting Protein kinase C (PRKC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Synthetic hypericin	DMXU4ON	Virus infection	1A24-1D9Z	Phase 3	[23]
APH-0812	DM756GE	Human immunodeficiency virus-1 infection	1C62	Phase 2	[24]
CYCLOPLATAM	DMXR8WN	Solid tumour/cancer	2A00-2F9Z	Phase 2	[25]
AEB07	DMJVN89	Transplant rejection	NE84	Phase 2	[26]
HO/03/03	DMA6HQJ	Diabetic foot ulcer	BD54	Phase 2	[27]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[28]
LXS196	DM65MEL	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[29]
SAFINGOL	DMBGUDR	Psoriasis vulgaris	EA90	Phase 1	[30]
GCC-1290K	DMJ7WRI	Parkinson disease	8A00.0	Phase 1	[31]
AEB701	DM8I4G0	Melanoma	2C30	Phase 1	[32]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[35]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]

Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[39]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[42]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[43]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[44]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[45]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[46]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[42]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[47]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[57]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[61]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[70]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[73]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[74]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[12]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[77]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[77]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[78]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[12]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[77]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[79]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[12]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[80]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[12]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[95]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]

Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[104]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]

Drug(s) Affected By Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[113]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[115]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[117]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[126]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[127]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[134]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[138]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[139]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[138]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]

Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[149]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[150]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[145]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[160]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[161]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[162]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[170]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[171]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[172]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[176]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[177]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[184]

Drug(s) Affected By Large proline-rich protein BAG6 (BAG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[188]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[192]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[195]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[184]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[178]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[199]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[200]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[201]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[119]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[215]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[216]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[219]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[220]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[221]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[101]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[228]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[229]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[233]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[238]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]

Drug(s) Affected By Prostaglandin E synthase 3 (PTGES3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[246]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[149]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[149]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[248]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[253]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]

Drug(s) Affected By Solute carrier family 12 member 5 (SLC12A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[259]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[262]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[263]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[269]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[270]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[273]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[274]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[245]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[277]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[278]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[281]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[282]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[291]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[293]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[101]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[294]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[294]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[104]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[295]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)	TTJ3E9X	IKKB_HUMAN	Inhibitor	[2]
Protein kinase C (PRKC)	TTYVX59	NOUNIPROTAC	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Drug Response	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[7]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Drug Response	[8]
BAG family molecular chaperone regulator 4 (BAG4)	OTUPX3M2	BAG4_HUMAN	Gene/Protein Processing	[8]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Drug Response	[9]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Drug Response	[10]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[11]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[12]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Gene/Protein Processing	[13]

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