Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4DG1Y)

Drug Name
naringin Drug Info
Synonyms Naringoside; AC1NR4U8; 4',5,7-Trihydroxyflavanone-7-rutinoside; 4',5,7-Trihydroxyflavanone-7-rhamnoglucoside
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442428
ChEBI ID
CHEBI:28819
CAS Number
CAS 10236-47-2
TTD Drug ID
DM4DG1Y
VARIDT Drug ID
DR00581

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Investigative Drug(s)
Preclinical Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium-independent organic anion transporter (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [9]
Drug(s) Metabolized By Alpha-L-rhamnosidase (lrA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HY-N2258 DML4IAX N. A. N. A. Preclinical [3]
Rutin DMEHRAJ Discovery agent N.A. Investigative [3]
Ginsenoside Re DM46FVD N. A. N. A. Investigative [3]
PNA-l-rhamnopyranoside DMZF7RQ N. A. N. A. Investigative [3]
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [10]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [12]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [13]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [14]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [15]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [16]
Capsaicin DMGMF6V Back pain ME84.Z Approved [17]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [18]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [19]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [20]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [21]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [24]
Ethacrynic acid DM60QMR Edema MG29 Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [27]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [28]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [29]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [29]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [29]
Capsaicin DMGMF6V Back pain ME84.Z Approved [30]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [31]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [32]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [33]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [34]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [35]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [36]
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Drug(s) Affected By Dihydrofolate reductase (DHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [41]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [42]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [43]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [45]
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Drug(s) Affected By GTPase HRas (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [52]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [55]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [61]
Pamidronate DMB4AVP Bone Paget disease Approved [62]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [63]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [75]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [80]
Paclitaxel DMLB81S Breast carcinoma Approved [81]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
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Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [94]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [95]
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Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Panobinostat DM58WKG Chronic graft versus host disease Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [101]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [104]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [106]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [112]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Fluoxetine DM3PD2C Bipolar depression Approved [115]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Epinephrine DM3KJBC Acute asthma CA23 Approved [123]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [124]
Fructose DM43AN2 Vomiting MD90 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [126]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [127]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [130]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [131]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [133]
Gefitinib DM15F0X Colon adenocarcinoma Approved [134]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [137]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [128]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [138]
Paclitaxel DMLB81S Breast carcinoma Approved [139]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [140]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [127]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [130]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [131]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [146]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [147]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [149]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Gefitinib DM15F0X Colon adenocarcinoma Approved [153]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Etretinate DM2CZFA Keratosis ED56 Approved [154]
Prednisone DM2HG4X Acute asthma CA23 Approved [155]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [113]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [156]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [159]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [80]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [160]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [161]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [164]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [165]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [166]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [167]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [168]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [121]
Meloxicam DM2AR7L Arthritis FA20 Approved [171]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [172]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [173]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [174]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Verapamil DMA7PEW Angina pectoris BA40 Approved [175]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [119]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [169]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Meloxicam DM2AR7L Arthritis FA20 Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [113]
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Drug(s) Affected By FAS-associated death domain protein (FADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [177]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [170]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [50]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [180]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [182]
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Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [187]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [188]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium-independent organic anion transporter (SLCO1A2) TTUGD21 SO1A2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alpha-L-rhamnosidase (lrA) Main DME DEBI82Z A0A1V8Q7P3_9BIF Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [4]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [7]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [7]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [8]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4738).
2 Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther. 2007 Apr;81(4):495-502.
3 Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25.
4 Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. Food Chem Toxicol. 2013 Jan;51:97-105. doi: 10.1016/j.fct.2012.07.033. Epub 2012 Jul 27.
5 Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells. J Tissue Eng Regen Med. 2017 Jan;11(1):276-284. doi: 10.1002/term.1911. Epub 2014 Jun 11.
6 Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis. 2008 Sep;29(9):1701-9. doi: 10.1093/carcin/bgn055. Epub 2008 Feb 22.
7 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20;23(12):1921-35.
8 Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. Biopharm Drug Dispos. 2005 Oct;26(7):295-300.
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1219).
10 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
11 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
12 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
13 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
14 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
15 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
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