Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB0NVQ)

Drug Name
Steroid derivative 1 Drug Info
Synonyms PMID26882240-Compound-23
Cross-matching ID
PubChem CID
66414
ChEBI ID
CHEBI:28955
CAS Number
CAS 362-07-2
TTD Drug ID
DMB0NVQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Hypoxia-inducible factor 1 (HIF-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26882240-Compound-1 DMPAE8N N. A. N. A. Patented [1]
2,2-dimethylbenzopyran derivative 2 DM9XUYM N. A. N. A. Patented [1]
Oligooxopiperazine derivative 1 DM74T5L N. A. N. A. Patented [1]
2,2-dimethylbenzopyran derivative 3 DMTCPSQ N. A. N. A. Patented [1]
Triptolidenol analog 1 DMZTPUA N. A. N. A. Patented [1]
Aromatic and heteroaryl compound 1 DMXW0PV N. A. N. A. Patented [1]
Steroid derivative 4 DMJPYVS N. A. N. A. Patented [1]
PMID26882240-Compound-32 DMJS4RP N. A. N. A. Patented [1]
Imidazo [1,2-a]pyridine compound 1 DMWABOJ N. A. N. A. Patented [1]
PMID26882240-Compound-7 DMOX8E3 N. A. N. A. Patented [1]
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Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [8]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [9]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [13]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [14]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [15]
Testosterone DM7HUNW Hot flushes GA30 Approved [16]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [17]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [20]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [21]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [27]
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Drug(s) Affected By Pro-epidermal growth factor (EGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [16]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [8]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [9]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Etretinate DM2CZFA Keratosis ED56 Approved [40]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [47]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [48]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [49]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [48]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [53]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [8]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Etretinate DM2CZFA Keratosis ED56 Approved [40]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [49]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [76]
Etretinate DM2CZFA Keratosis ED56 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [86]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [8]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [39]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [8]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [107]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [108]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [109]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [110]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [75]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [114]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [7]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [120]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [122]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [123]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [126]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [127]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [128]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [129]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [131]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [132]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [133]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [134]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Prednisone DM2HG4X Acute asthma CA23 Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [137]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Fluoxetine DM3PD2C Bipolar depression Approved [139]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [144]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [145]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [146]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [147]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [81]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [148]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [149]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [47]
Meloxicam DM2AR7L Arthritis FA20 Approved [152]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [153]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [154]
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Drug(s) Affected By Peroxiredoxin-4 (PRDX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [158]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [161]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [162]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [163]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [164]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [165]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [166]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Gefitinib DM15F0X Colon adenocarcinoma Approved [168]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [75]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [170]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [171]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [133]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [172]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [173]
Quercetin DM3NC4M Obesity 5B81 Approved [174]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [179]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [180]
Minoxidil DMA2Z4F Alopecia ED70 Approved [181]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [182]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [181]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [183]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [185]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [185]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [188]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [189]
Testosterone DM7HUNW Hot flushes GA30 Approved [16]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [190]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [191]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [192]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [193]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [194]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [195]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [196]
Ethacrynic acid DM60QMR Edema MG29 Approved [197]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [198]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [199]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [200]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [203]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [204]
Epinephrine DM3KJBC Acute asthma CA23 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [206]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [207]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [175]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
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Drug(s) Affected By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [209]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [209]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [209]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [210]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [209]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [213]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [214]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hypoxia-inducible factor 1 (HIF-1) TTUX68I NOUNIPROTAC Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Drug Response [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Post-Translational Modifications [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [4]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [4]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [7]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [4]

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104 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
105 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
106 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
107 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
108 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
109 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
110 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
111 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
112 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
113 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
114 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
115 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
116 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
117 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
118 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
119 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
120 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
121 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
122 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
123 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
124 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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