Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDBWHY)

• Drug Name: Heroin diacetylmorphine Drug Info
• Synonyms: Diamorphine (TN)

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Approved	[1]

• Cross-matching ID:
  PubChem CID: 5462328
  ChEBI ID: CHEBI:27808
  CAS Number: CAS 561-27-3
  TTD Drug ID: DMDBWHY
  INTEDE Drug ID: DR0807

Molecule-Related Drug Atlas

Drug(s) Metabolized By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[5]

Drug(s) Affected By Integrin beta-1-binding protein 1 (ITGB1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[9]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[12]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[13]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[13]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[14]

Drug(s) Affected By Septin-4 (SEPTIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[24]

Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]

Drug(s) Affected By Synaptogyrin-3 (SYNGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Deformed epidermal autoregulatory factor 1 homolog (DEAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[48]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[63]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[71]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[72]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[72]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[72]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[73]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[74]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[75]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[76]
Methamphetamine	DMPM4SK	Anxiety		Approved	[77]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[78]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[79]

Drug(s) Affected By Synaptotagmin-1 (SYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[98]

Drug(s) Affected By Alpha-actinin-2 (ACTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Amphiphysin (AMPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]

Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]

Drug(s) Affected By Syntaxin-binding protein 1 (STXBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[24]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Bortezomib	DMNO38U	Leukemia		Approved	[39]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[119]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]

Drug(s) Affected By Prolyl endopeptidase-like (PREPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[81]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[126]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[127]

Drug(s) Affected By Myomegalin (PDE4DIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[130]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[127]

Drug(s) Affected By Adropin (ENHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
ORG2058	DMH1M6N	Discovery agent	N.A.	Investigative	[134]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[135]

Drug(s) Affected By Synaptic vesicle glycoprotein 2A (SV2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[137]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[138]

Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[103]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[142]

Drug(s) Affected By Protein Churchill (CHURC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[151]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[126]
Bortezomib	DMNO38U	Leukemia		Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[127]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Mitoferrin-1 (SLC25A37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[50]

Drug(s) Affected By Protein FAM153A (FAM153A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[52]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[3]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[12]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[158]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[37]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[163]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[164]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[166]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[167]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[169]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[170]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[171]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[172]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[173]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[72]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[174]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[171]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[175]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[176]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[175]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Acetylcholinesterase (ACHE) Main DME	DEQ2BAJ	ACES_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Gene/Protein Processing	[3]
Adropin (ENHO)	OT91QASK	ENHO_HUMAN	Gene/Protein Processing	[3]
Alpha-actinin-2 (ACTN2)	OT9FOLD7	ACTN2_HUMAN	Gene/Protein Processing	[3]
Amphiphysin (AMPH)	OTWPGWZX	AMPH_HUMAN	Gene/Protein Processing	[3]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[3]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Gene/Protein Processing	[3]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Gene/Protein Processing	[4]
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6)	OT96NE03	BL1S6_HUMAN	Gene/Protein Processing	[3]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Gene/Protein Processing	[4]
Ceramide glucosyltransferase	OTRT5P5I	CEGT_HUMAN	Gene/Protein Processing	[3]

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