General Information of Drug (ID: DMHG57U)

Drug Name
OPC-34712 Drug Info
Synonyms Brexpiprazole
Indication
Disease Entry ICD 11 Status REF
Major depressive disorder 6A70.3 Approved [1]
Cross-matching ID
PubChem CID
11978813
ChEBI ID
CHEBI:134716
CAS Number
CAS 913611-97-9
TTD Drug ID
DMHG57U
VARIDT Drug ID
DR01335
INTEDE Drug ID
DR0227
ACDINA Drug ID
D00076

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [6]
Haloperidol DM96SE0 Delirium Approved [7]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [8]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [9]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [10]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [11]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [12]
Pimozide DMW83TP Schizophrenia 6A20 Approved [13]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [14]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [15]
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Drug(s) Targeting 5-HT 1A receptor (HTR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [16]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [17]
Vilazodone DM4LECQ Major depressive disorder 6A70.3 Approved [18]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [19]
Gepirone DMGX5Q0 Major depressive disorder 6A70.3 Approved [20]
TERTATOLOL DM2L3D5 Hypertension BA00-BA04 Approved [21]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [22]
Treximet DMU54QB Migraine 8A80 Approved [23]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [24]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [25]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [26]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [27]
Bretylium DM1FX74 Long QT syndrome BC65.0 Approved [28]
Benztropine DMGZOVN Parkinson disease 8A00.0 Approved [29]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [42]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [43]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [44]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [45]
Propranolol DM79NTF Angina pectoris BA40 Approved [46]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [47]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [48]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [48]
Fructose DM43AN2 Vomiting MD90 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [48]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [58]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [59]
Meloxicam DM2AR7L Arthritis FA20 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Epinephrine DM3KJBC Acute asthma CA23 Approved [63]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [71]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [72]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [75]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [47]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [86]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [91]
Selenium DM25CGV N. A. N. A. Approved [71]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [97]
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Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [103]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [104]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [105]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [92]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [97]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [108]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [109]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Modulator [2]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium-dependent dopamine transporter (SLC6A3) DT3BA8L SC6A3_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [5]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Gene/Protein Processing [5]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [5]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Gene/Protein Processing [5]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Gene/Protein Processing [5]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Gene/Protein Processing [5]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Gene/Protein Processing [5]

References

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79 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
80 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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