Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML6O4N)

Drug Name
Dimethylformamide Drug Info
Synonyms
N,N-DIMETHYLFORMAMIDE; Dimethylformamide; 68-12-2; N,N-Dimethylmethanamide; Dimethyl formamide; N-Formyldimethylamine; Formamide, N,N-dimethyl-; DMF; Dimethylformamid; Dimetilformamide; Dwumetyloformamid; DMFA; Formyldimethylamine; N,N-Dimethyl formamide; Dimethylforamide; Dimetylformamidu; DMF (amide); NCI-C60913; N,N-Dimethylformamid; n,n,dimethylformamide; Dimethylamid kyseliny mravenci; Caswell No. 366A; Dimetylformamidu [Czech]; Dimethylformamid [German]; Dimetilformamide [Italian]; Dwumetyloformamid [Polish]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6228
ChEBI ID
CHEBI:17741
CAS Number
CAS 68-12-2
TTD Drug ID
DML6O4N
INTEDE Drug ID
DR1120

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Pancreatic elastase 1 (CELA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alpha 1-PI DMXC1K9 Alpha-1 antitrypsin deficiency 5C5A Approved [6]
Erdosteine DM6QFSV Bronchitis CA20 Approved [7]
Sivelestat DM6BZCV Crohn disease DD70 Phase 3 [8]
Mdl 101,146 DMRSOBG Inflammation 1A00-CA43.1 Terminated [9]
WIN-63759 DMRV48P Emphysema CA21 Terminated [10]
SSR-69071 DMWL4MI Chronic obstructive pulmonary disease CA22 Terminated [11]
SYN-1134 DMG2SQM Cystic fibrosis CA25 Terminated [12]
PBI-1101 DMWD1RC Inflammation 1A00-CA43.1 Terminated [13]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [9]
Grassystatin a DM1PWX2 Discovery agent N.A. Investigative [14]
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Drug(s) Targeting Angiotensinogenase renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aliskiren DM1BV7W Hypertension BA00-BA04 Approved [15]
Remikiren DMNAKLY Hypertension BA00-BA04 Approved [16]
SPP-600 DMOVQP8 Hypertension BA00-BA04 Phase 2 [17]
TAK-272 DM81UAZ Type-2 diabetes 5A11 Phase 2 [18]
SR-43845 DMTOCIV Glaucoma/ocular hypertension 9C61 Phase 2 [19]
CP-80794 DMT3ORQ Hypertension BA00-BA04 Phase 2 [20]
SPH3127 DMYL6RA Ulcerative colitis DD71 Phase 2 [21]
VTP-27999 DMQEOD6 Hypertension BA00-BA04 Phase 1 [22]
ACT-178882 DMOZ3AT Cardiovascular disease BA00-BE2Z Phase 1 [23]
CARD-024 DM4SNK8 Cardiovascular disease BA00-BE2Z Phase 1 [24]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Estrone DM5T6US Acne vulgaris ED80 Approved [32]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [33]
Ethanol DMDRQZU Chronic pain MG30 Approved [34]
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [35]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [36]
Theophylline DMRJFN9 Bronchitis CA20 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Ethanol DMDRQZU Chronic pain MG30 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [37]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [43]
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Drug(s) Affected By Lactotransferrin (LTF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Capsaicin DMGMF6V Back pain ME84.Z Approved [46]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [47]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [48]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [51]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [52]
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Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [37]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [59]
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Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ethanol DMDRQZU Chronic pain MG30 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Arsenic DMTL2Y1 N. A. N. A. Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [68]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [70]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [71]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [77]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [82]
Paclitaxel DMLB81S Breast carcinoma Approved [83]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [90]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [82]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [91]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [97]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [100]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [103]
Meloxicam DM2AR7L Arthritis FA20 Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [105]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [106]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [107]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Verapamil DMA7PEW Angina pectoris BA40 Approved [108]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [101]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Meloxicam DM2AR7L Arthritis FA20 Approved [111]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [112]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [119]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [121]
Verapamil DMA7PEW Angina pectoris BA40 Approved [122]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [124]
Selenium DM25CGV N. A. N. A. Approved [125]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [126]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [133]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [137]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [138]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [139]
Selenium DM25CGV N. A. N. A. Approved [70]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [140]
Etretinate DM2CZFA Keratosis ED56 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [144]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
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Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [147]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Selenium DM25CGV N. A. N. A. Approved [149]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [154]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [155]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [156]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [158]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [159]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [160]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [161]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [162]
Gefitinib DM15F0X Colon adenocarcinoma Approved [163]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [166]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [157]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [167]
Paclitaxel DMLB81S Breast carcinoma Approved [168]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [169]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [156]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [170]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [159]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [160]
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Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [172]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [173]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [175]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [176]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [177]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [178]
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Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [171]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [181]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [182]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Testosterone DM7HUNW Hot flushes GA30 Approved [184]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [185]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [184]
Leflunomide DMR8ONJ Arthritis FA20 Approved [186]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [187]
Verapamil DMA7PEW Angina pectoris BA40 Approved [122]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [188]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Selenium DM25CGV N. A. N. A. Approved [70]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [189]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [190]
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Drug(s) Affected By DNA repair protein RAD50 (RAD50)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [191]
Quercetin DM3NC4M Obesity 5B81 Approved [192]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [172]
Testosterone enanthate DMB6871 N. A. N. A. Approved [194]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [173]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensinogenase renin (REN) TTB2MXP RENI_HUMAN Inhibitor [1]
Pancreatic elastase 1 (CELA1) TT3NKIB CELA1_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) Main DME DEVDYN7 CP2E1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Regulation of Drug Effects [4]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Gene/Protein Processing [5]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Gene/Protein Processing [5]
DNA repair protein XRCC2 OTJB2PV4 XRCC2_HUMAN Gene/Protein Processing [5]
DNA repair protein XRCC3 OTK717YY XRCC3_HUMAN Gene/Protein Processing [5]

References

1 Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6.
2 Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury. Int Arch Occup Environ Health. 2019 Oct;92(7):967-975.
3 Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide. J Biochem Mol Toxicol. 2018 Sep;32(9):e22190.
4 The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study. Arch Toxicol. 2019 Nov;93(11):3169-3181. doi: 10.1007/s00204-019-02567-7. Epub 2019 Sep 9.
5 Oxidative stress-related DNA damage and homologous recombination repairing induced by N,N-dimethylformamide. J Appl Toxicol. 2016 Jul;36(7):936-45. doi: 10.1002/jat.3226. Epub 2015 Sep 21.
6 Elastase inhibitors. J Soc Biol. 2001;195(2):143-50.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8 Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995.
11 Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901.
12 EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans.
13 CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage.
14 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
15 Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patie... J Renin Angiotensin Aldosterone Syst. 2009 Sep;10(3):157-67.
16 Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol. 2006 Mar;290(3):F710-9.
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