General Information of Drug Therapeutic Target (DTT) (ID: TTMH124)

DTT Name Cytochrome P450 2B6 (CYP2B6)
Synonyms Cytochrome P450 IIB1; CYPIIB6; 1,4-cineole 2-exo-monooxygenase
Gene Name CYP2B6
DTT Type
Literature-reported target
[1]
BioChemical Class
Paired donor oxygen oxidoreductase
UniProt ID
CP2B6_HUMAN
TTD ID
T11793
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.14.13.-
Sequence
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
Function
In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. Cytochromes P450 are a group of heme-thiolate monooxygenases.
KEGG Pathway
Arachidonic acid metabolism (hsa00590 )
Retinol metabolism (hsa00830 )
Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
Drug metabolism - cytochrome P450 (hsa00982 )
Metabolic pathways (hsa01100 )
Chemical carcinogenesis - receptor activation (hsa05207 )
Lipid and atherosclerosis (hsa05417 )
Reactome Pathway
Xenobiotics (R-HSA-211981 )
CYP2E1 reactions (R-HSA-211999 )
Fatty acids (R-HSA-211935 )
BioCyc Pathway
MetaCyc:HS09587-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Cytochrome P450 2B6 (CYP2B6) DME Info
Gene Name CYP2B6
86 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [2]
Artemether DM48QOT Malaria 1F40-1F45 Approved [3]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [4]
Benzphetamine DMIJATC Obesity 5B81 Approved [5]
Brivaracetam DMSEPK8 Complex partial seizure 8A68.0 Approved [6]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [7]
Capsaicin DMGMF6V Back pain ME84.Z Approved [8]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [9]
Cenobamate DM8KLU9 Complex partial seizure 8A68.0 Approved [10]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [11]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [12]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [13]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [14]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [15]
Clotiazepam DM59AZT Anxiety disorder 6B00-6B0Z Approved [16]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [17]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [18]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [19]
Diazepam DM08E9O Alcohol withdrawal Approved [20]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [21]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [22]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [23]
Enasidenib DM8QXOC N. A. N. A. Approved [24]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [25]
Estrone DM5T6US Acne vulgaris ED80 Approved [26]
Fexinidazole DMOYE70 African trypanosomiasis 1F51 Approved [27]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [28]
Fluoxetine DM3PD2C Bipolar depression Approved [29]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [30]
Hydrocodone bitartrate DMIAPBE N. A. N. A. Approved [31]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [32]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [33]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [18]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [34]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [35]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [36]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [37]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [3]
Loperamide DMOJZQ9 Diarrhea ME05.1 Approved [38]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [39]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [40]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [41]
Meperidine DMX4GND Pain MG30-MG3Z Approved [3]
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [11]
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [42]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [43]
Methylphenobarbital DMDSWAG Anxiety Approved [44]
Methyltestosterone DMWLFGO Advanced cancer 2A00-2F9Z Approved [45]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [46]
Mianserin DMVKA4O Depression 6A70-6A7Z Approved [30]
Midazolam DMXOELT Agitation 6A70.3 Approved [47]
MLN9708 DMCMETN Amyloidosis 5D00 Approved [48]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [49]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [50]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [51]
Perhexiline DMINO7Z Angina pectoris BA40 Approved [52]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [53]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [9]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [54]
Prasugrel DM7MT6E Acute coronary syndrome BA41 Approved [55]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [30]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [57]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [23]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [58]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [34]
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [61]
Temazepam DM02A65 Insomnia 7A00-7A0Z Approved [62]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [3]
Testosterone enanthate DMB6871 N. A. N. A. Approved [3]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [3]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [63]
Tramadol DMRQD04 Osteoarthritis FA00-FA05 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [65]
Trofosfamide DMHB2C3 Non-hodgkin lymphoma 2B33.5 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [3]
Velpatasvir DMGF8ZQ N. A. N. A. Approved [67]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Vonoprazan DMO6315 Helicobacter infection DA42-DA63 Approved [68]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [69]
Voxelotor DMCS6M5 Sickle-cell disorder 3A51 Approved [70]
ZOTEPINE DMF3VXA Anxiety disorder 6B00-6B0Z Approved [71]
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⏷ Show the Full List of 86 Approved Drug(s)
6 Clinical Trial Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clomethiazole DMSPN58 Stroke 8B20 Phase 3 [34]
Esketamine DMVU687 Depression 6A70-6A7Z Phase 3 [36]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [72]
Dexloxiglumide DM52HUD Pancreatic malfunction DC30-DC3Z Phase 2 [73]
R-roscovitine DMSH108 Non-small-cell lung cancer 2C25.Y Phase 2 [74]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [75]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)
3 Discontinued Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Seratrodast DMPNTDL Allergic asthma CA23.0 Discontinued in Phase 3 [11]
FCP-3P1 DMTQLIJ Arteriosclerosis BD40 Discontinued in Phase 2 [76]
Banoxantrone DMK5I07 Acute lymphoblastic leukaemia 2A85 Discontinued in Phase 1 [77]
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3 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethylmorphine DM0YROF Discovery agent N.A. Investigative [20]
Levoverbenone DMV3P89 N. A. N. A. Investigative [78]
Phenazone DMCE985 Discovery agent N.A. Investigative [79]
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