DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Repaglinide |
DM5SXUV
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Repaglinide mediated induction of CYP450 enzyme. |
Acute diabete complication [5A2Y]
|
[12] |
Midostaurin |
DMI6E0R
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Midostaurin mediated induction of CYP450 enzyme. |
Acute myeloid leukaemia [2A60]
|
[13] |
Gilteritinib |
DMTI0ZO
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Gilteritinib mediated induction of CYP450 enzyme. |
Acute myeloid leukaemia [2A60]
|
[14] |
Oliceridine |
DM6MDCF
|
Major |
Increased metabolism of Methylphenobarbital caused by Oliceridine mediated induction of CYP450 enzyme. |
Acute pain [MG31]
|
[15] |
Emapalumab |
DMZG5WL
|
Moderate |
Altered metabolism of Methylphenobarbital due to Emapalumab alters the formation of CYP450 enzymes. |
Adaptive immunity immunodeficiency [4A01]
|
[16] |
Metronidazole |
DMTIVEN
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Metronidazole mediated induction of CYP450 enzyme. |
Amoebiasis [1A36]
|
[17] |
Siltuximab |
DMGEATB
|
Moderate |
Altered metabolism of Methylphenobarbital due to Siltuximab alters the formation of CYP450 enzymes. |
Anemia [3A00-3A9Z]
|
[16] |
Ivabradine |
DM0L594
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ivabradine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[18] |
Dronedarone |
DMA8FS5
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Dronedarone mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[19] |
Nifedipine |
DMSVOZT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Nifedipine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[20] |
Bedaquiline |
DM3906J
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Bedaquiline mediated induction of CYP450 enzyme. |
Antimicrobial drug resistance [MG50-MG52]
|
[21] |
Aminophylline |
DML2NIB
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Aminophylline mediated induction of CYP450 enzyme. |
Asthma [CA23]
|
[22] |
Tindamax |
DM3OWT4
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tindamax mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[17] |
Telithromycin |
DMZ4P3A
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Telithromycin mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[14] |
Cariprazine |
DMJYDVK
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Cariprazine mediated induction of CYP450 enzyme. |
Bipolar disorder [6A60]
|
[18] |
Ixabepilone |
DM2OZ3G
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ixabepilone mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[23] |
Lapatinib |
DM3BH1Y
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Lapatinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[14] |
LY2835219 |
DM93VBZ
|
Moderate |
Increased metabolism of Methylphenobarbital caused by LY2835219 mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[24] |
Exemestane |
DM9HPW3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Exemestane mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[25] |
Esterified estrogens |
DM9KZDO
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Esterified estrogens mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[26] |
Tucatinib |
DMBESUA
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tucatinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[14] |
Palbociclib |
DMD7L94
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Palbociclib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[27] |
Alpelisib |
DMEXMYK
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Alpelisib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[28] |
Quinestrol |
DMJ6H1Z
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Quinestrol mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[26] |
Cabazitaxel |
DMPAZHC
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Cabazitaxel mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[29] |
Bosutinib |
DMTI8YE
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Bosutinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[30] |
Atorvastatin |
DMF28YC
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Atorvastatin mediated induction of CYP450 enzyme. |
Cardiovascular disease [BA00-BE2Z]
|
[31] |
Macitentan |
DMP79A1
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Macitentan mediated induction of CYP450 enzyme. |
Cardiovascular disease [BA00-BE2Z]
|
[32] |
Doxercalciferol |
DM6FG1P
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Doxercalciferol mediated induction of CYP450 enzyme. |
Chronic kidney disease [GB61]
|
[33] |
Corticotropin |
DMP9TWZ
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Corticotropin mediated induction of CYP450 enzyme. |
Chronic kidney disease [GB61]
|
[34] |
PF-04449913 |
DMSB068
|
Moderate |
Increased metabolism of Methylphenobarbital caused by PF-04449913 mediated induction of CYP450 enzyme. |
Chronic myelomonocytic leukaemia [2A40]
|
[35] |
Dihydrocodeine |
DMB0FWL
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Dihydrocodeine. |
Chronic pain [MG30]
|
[36] |
Levomilnacipran |
DMV26S8
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Levomilnacipran. |
Chronic pain [MG30]
|
[37] |
Anisindione |
DM2C48U
|
Major |
Increased metabolism of Methylphenobarbital caused by Anisindione mediated induction of CYP450 enzyme. |
Coagulation defect [3B10]
|
[38] |
Drospirenone |
DM1A9W3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Drospirenone mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[26] |
Levonorgestrel |
DM1DP7T
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Levonorgestrel mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[26] |
Ulipristal |
DMBNI20
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ulipristal mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[18] |
Levobupivacaine |
DM783CH
|
Minor |
Increased metabolism of Methylphenobarbital caused by Levobupivacaine mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[39] |
Methoxyflurane |
DML0RAE
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Methoxyflurane mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[40] |
Remifentanil |
DMZTXCH
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Remifentanil. |
Corneal disease [9A76-9A78]
|
[36] |
Oxtriphylline |
DMLHSE3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Oxtriphylline mediated induction of CYP450 enzyme. |
Cough [MD12]
|
[22] |
Osilodrostat |
DMIJC9X
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Osilodrostat mediated induction of CYP450 enzyme. |
Cushing syndrome [5A70]
|
[14] |
Ivacaftor |
DMZC1HS
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ivacaftor mediated induction of CYP450 enzyme. |
Cystic fibrosis [CA25]
|
[41] |
Ethanol |
DMDRQZU
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Ethanol. |
Cystitis [GC00]
|
[42] |
MK-8228 |
DMOB58Q
|
Moderate |
Increased metabolism of Methylphenobarbital caused by MK-8228 mediated induction of CYP450 enzyme. |
Cytomegaloviral disease [1D82]
|
[14] |
Rivaroxaban |
DMQMBZ1
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Rivaroxaban mediated induction of CYP450 enzyme. |
Deep vein thrombosis [BD71]
|
[43] |
Sertraline |
DM0FB1J
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Sertraline. |
Depression [6A70-6A7Z]
|
[44] |
Vilazodone |
DM4LECQ
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Vilazodone. |
Depression [6A70-6A7Z]
|
[44] |
Vortioxetine |
DM6F1PU
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Vortioxetine. |
Depression [6A70-6A7Z]
|
[37] |
Milnacipran |
DMBFE74
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Milnacipran. |
Depression [6A70-6A7Z]
|
[44] |
Escitalopram |
DMFK9HG
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Escitalopram. |
Depression [6A70-6A7Z]
|
[44] |
Desvenlafaxine |
DMHD4PE
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Desvenlafaxine. |
Depression [6A70-6A7Z]
|
[44] |
Esketamine |
DMVU687
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Esketamine. |
Depression [6A70-6A7Z]
|
[45] |
[3H]estrone-3-sulphate |
DMGPF0N
|
Moderate |
Increased metabolism of Methylphenobarbital caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. |
Discovery agent [N.A.]
|
[26] |
Zonisamide |
DM0DTF7
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Zonisamide mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[46] |
Cenobamate |
DM8KLU9
|
Moderate |
Decreased metabolism of Methylphenobarbital caused by Cenobamate mediated inhibition of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[47] |
Fosphenytoin |
DMOX3LB
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Fosphenytoin mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[48] |
Praziquantel |
DMOU1PK
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Praziquantel mediated induction of CYP450 enzyme. |
Flatworm infection [1F70-1F86]
|
[49] |
Bay 80-6946 |
DMLOS5R
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Bay 80-6946 mediated induction of CYP450 enzyme. |
Follicular lymphoma [2A80]
|
[50] |
Tazemetostat |
DMWP1BH
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tazemetostat mediated induction of CYP450 enzyme. |
Follicular lymphoma [2A80]
|
[51] |
Solifenacin |
DMG592Q
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Solifenacin mediated induction of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[14] |
Mirabegron |
DMS1GYT
|
Minor |
Increased metabolism of Methylphenobarbital caused by Mirabegron mediated induction of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[52] |
Ripretinib |
DM958QB
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ripretinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[27] |
Sunitinib |
DMCBJSR
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Sunitinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[27] |
Avapritinib |
DMK2GZX
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Avapritinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[18] |
Carvedilol |
DMHTEAO
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Carvedilol mediated induction of CYP450 enzyme. |
Heart failure [BD10-BD1Z]
|
[53] |
Digitoxin |
DMWVIGP
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Digitoxin mediated induction of CYP450 enzyme. |
Heart failure [BD10-BD1Z]
|
[54] |
Boceprevir |
DMBSHMF
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Boceprevir mediated induction of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[55] |
Telaprevir |
DMMRV29
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Telaprevir mediated induction of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[55] |
Rifampin |
DMA8J1G
|
Minor |
Increased metabolism of Methylphenobarbital caused by Rifampin mediated induction of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[56] |
MK-1439 |
DM215WE
|
Moderate |
Increased metabolism of Methylphenobarbital caused by MK-1439 mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[57] |
Fosamprenavir |
DM4W9B3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Fosamprenavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[58] |
Fostemsavir |
DM50ILT
|
Minor |
Increased metabolism of Methylphenobarbital caused by Fostemsavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[14] |
Tipranavir |
DM8HJX6
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tipranavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[58] |
Dolutegravir |
DMCZGRE
|
Minor |
Increased metabolism of Methylphenobarbital caused by Dolutegravir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[59] |
Saquinavir |
DMG814N
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Saquinavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[58] |
Etravirine |
DMGV8QU
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Etravirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[60] |
Rilpivirine |
DMJ0QOW
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Rilpivirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[61] |
Darunavir |
DMN3GCH
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Darunavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[58] |
Atazanavir |
DMSYRBX
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Atazanavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[58] |
Maraviroc |
DMTL94F
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Maraviroc mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[27] |
Fenofibrate |
DMFKXDY
|
Moderate |
Decreased metabolism of Methylphenobarbital caused by Fenofibrate mediated inhibition of CYP450 enzyme. |
Hyper-lipoproteinaemia [5C80]
|
[27] |
Paricalcitol |
DMYBV3G
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Paricalcitol mediated induction of CYP450 enzyme. |
Hyper-parathyroidism [5A51]
|
[33] |
Acebutolol |
DM0TI4U
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Acebutolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[53] |
Penbutolol |
DM4ES8F
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Penbutolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[53] |
Nebivolol |
DM7F1PA
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Nebivolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[53] |
Levamlodipine |
DM92S6N
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Levamlodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[20] |
Felodipine |
DMOSW35
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Felodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[62] |
Tolvaptan |
DMIWFRL
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tolvaptan mediated induction of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[18] |
Lesinurad |
DMUR64T
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Lesinurad mediated induction of CYP450 enzyme. |
Inborn purine/pyrimidine/nucleotide metabolism error [5C55]
|
[39] |
Suvorexant |
DM0E6S3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Suvorexant mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[63] |
Tasimelteon |
DMLOQ1V
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tasimelteon mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[14] |
ITI-007 |
DMUQ1DO
|
Major |
Increased metabolism of Methylphenobarbital caused by ITI-007 mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[64] |
Naloxegol |
DML0B41
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Naloxegol mediated induction of CYP450 enzyme. |
Large intestine motility disorder [DB32]
|
[65] |
Pemigatinib |
DM819JF
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Pemigatinib mediated induction of CYP450 enzyme. |
Liver cancer [2C12]
|
[66] |
Crizotinib |
DM4F29C
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Crizotinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[61] |
Brigatinib |
DM7W94S
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Brigatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[27] |
Ceritinib |
DMB920Z
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ceritinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[67] |
Lurbinectedin |
DMEFRTZ
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Lurbinectedin mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[68] |
Osimertinib |
DMRJLAT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Osimertinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[14] |
Capmatinib |
DMYCXKL
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Capmatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[30] |
Selpercatinib |
DMZR15V
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Selpercatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[14] |
Artemether |
DM48QOT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Artemether mediated induction of CYP450 enzyme. |
Malaria [1F40-1F45]
|
[27] |
Hydroxychloroquine |
DMSIVND
|
Moderate |
Antagonize the effect of Methylphenobarbital when combined with Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[27] |
Idelalisib |
DM602WT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Idelalisib mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[69] |
GDC-0199 |
DMH0QKA
|
Moderate |
Increased metabolism of Methylphenobarbital caused by GDC-0199 mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[14] |
IPI-145 |
DMWA24P
|
Moderate |
Increased metabolism of Methylphenobarbital caused by IPI-145 mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[70] |
Acalabrutinib |
DM7GCVW
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Acalabrutinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[71] |
Ibrutinib |
DMHZCPO
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ibrutinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[18] |
Ponatinib |
DMYGJQO
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ponatinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[27] |
Vemurafenib |
DM62UG5
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Vemurafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[14] |
Selumetinib |
DMC7W6R
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Selumetinib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[72] |
LGX818 |
DMNQXV8
|
Moderate |
Increased metabolism of Methylphenobarbital caused by LGX818 mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[73] |
Ethinyl estradiol |
DMODJ40
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ethinyl estradiol mediated induction of CYP450 enzyme. |
Menopausal disorder [GA30]
|
[26] |
Allopregnanolone |
DMNLHAC
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Allopregnanolone. |
Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]
|
[74] |
Ubrogepant |
DM749I3
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ubrogepant mediated induction of CYP450 enzyme. |
Migraine [8A80]
|
[75] |
Lasmiditan |
DMXLVDT
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Lasmiditan. |
Migraine [8A80]
|
[45] |
Dihydrotachysterol |
DMFB97P
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Dihydrotachysterol mediated induction of CYP450 enzyme. |
Mineral deficiency [5B5K]
|
[33] |
Flibanserin |
DM70DTN
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Flibanserin. |
Mood disorder [6A60-6E23]
|
[45] |
Panobinostat |
DM58WKG
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Panobinostat mediated induction of CYP450 enzyme. |
Multiple myeloma [2A83]
|
[14] |
Thalidomide |
DM70BU5
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Thalidomide. |
Multiple myeloma [2A83]
|
[45] |
Nilotinib |
DM7HXWT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Nilotinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[14] |
Ruxolitinib |
DM7Q98D
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ruxolitinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[76] |
Dasatinib |
DMJV2EK
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Dasatinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[27] |
Rolapitant |
DM8XP26
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Rolapitant mediated induction of CYP450 enzyme. |
Nausea/vomiting [MD90]
|
[77] |
Bupropion |
DM5PCS7
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Bupropion mediated induction of CYP450 enzyme. |
Nicotine use disorder [6C4A]
|
[78] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Entrectinib mediated induction of CYP450 enzyme. |
Non-small cell lung cancer [2C25]
|
[18] |
Levomethadyl Acetate |
DM06HG5
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[36] |
Apraclonidine |
DMO4PVE
|
Moderate |
Additive CNS depression effects by the combination of Methylphenobarbital and Apraclonidine. |
Optic nerve disorder [9C40]
|
[79] |
Olaparib |
DM8QB1D
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Olaparib mediated induction of CYP450 enzyme. |
Ovarian cancer [2C73]
|
[27] |
Oxymorphone |
DM65AGJ
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Oxymorphone. |
Pain [MG30-MG3Z]
|
[36] |
Dezocine |
DMJDB0Y
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Dezocine. |
Pain [MG30-MG3Z]
|
[36] |
Buprenorphine |
DMPRI8G
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Buprenorphine. |
Pain [MG30-MG3Z]
|
[80] |
Hydrocodone |
DMQ2JO5
|
Major |
Additive CNS depression effects by the combination of Methylphenobarbital and Hydrocodone. |
Pain [MG30-MG3Z]
|
[15] |
Pimavanserin |
DMR7IVC
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Pimavanserin mediated induction of CYP450 enzyme. |
Parkinsonism [8A00]
|
[14] |
Macimorelin |
DMQYJIR
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Macimorelin mediated induction of CYP450 enzyme. |
Pituitary gland disorder [5A60-5A61]
|
[14] |
Lefamulin |
DME6G97
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Lefamulin mediated induction of CYP450 enzyme. |
Pneumonia [CA40]
|
[14] |
Ergonovine |
DM0VEC1
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Ergonovine mediated induction of CYP450 enzyme. |
Postpartum haemorrhage [JA43]
|
[27] |
Lonafarnib |
DMGM2Z6
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Lonafarnib mediated induction of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[81] |
Enzalutamide |
DMGL19D
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Enzalutamide mediated induction of CYP450 enzyme. |
Prostate cancer [2C82]
|
[14] |
Darolutamide |
DMV7YFT
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Darolutamide mediated induction of CYP450 enzyme. |
Prostate cancer [2C82]
|
[30] |
Silodosin |
DMJSBT6
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Silodosin mediated induction of CYP450 enzyme. |
Prostate hyperplasia [GA90]
|
[27] |
Ustekinumab |
DMHTYK3
|
Moderate |
Altered metabolism of Methylphenobarbital due to Ustekinumab alters the formation of CYP450 enzymes. |
Psoriasis [EA90]
|
[16] |
Apremilast |
DMTWS9E
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Apremilast mediated induction of CYP450 enzyme. |
Psoriasis [EA90]
|
[82] |
Ixekizumab |
DMXW92T
|
Moderate |
Altered metabolism of Methylphenobarbital due to Ixekizumab alters the formation of CYP450 enzymes. |
Psoriasis [EA90]
|
[16] |
Riociguat |
DMXBLMP
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Riociguat mediated induction of CYP450 enzyme. |
Pulmonary hypertension [BB01]
|
[83] |
Everolimus |
DM8X2EH
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Everolimus mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[27] |
Axitinib |
DMGVH6N
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Axitinib mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[84] |
Temsirolimus |
DMS104F
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Temsirolimus mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[27] |
Tocilizumab |
DM7J6OR
|
Moderate |
Altered metabolism of Methylphenobarbital due to Tocilizumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[16] |
Canakinumab |
DM8HLO5
|
Moderate |
Altered metabolism of Methylphenobarbital due to Canakinumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[16] |
Tofacitinib |
DMBS370
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tofacitinib mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[27] |
Rilonacept |
DMGLUQS
|
Moderate |
Altered metabolism of Methylphenobarbital due to Rilonacept alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[16] |
Golimumab |
DMHZV7X
|
Moderate |
Altered metabolism of Methylphenobarbital due to Golimumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[16] |
Dexamethasone |
DMMWZET
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Dexamethasone mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[34] |
Sarilumab |
DMOGNXY
|
Moderate |
Altered metabolism of Methylphenobarbital due to Sarilumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[16] |
Quetiapine |
DM1N62C
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Quetiapine mediated induction of CYP450 enzyme. |
Schizophrenia [6A20]
|
[27] |
Aripiprazole |
DM3NUMH
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Aripiprazole mediated induction of CYP450 enzyme. |
Schizophrenia [6A20]
|
[85] |
Avanafil |
DM75CXN
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Avanafil mediated induction of CYP450 enzyme. |
Sexual dysfunction [HA00-HA01]
|
[86] |
LDE225 |
DMM9F25
|
Moderate |
Increased metabolism of Methylphenobarbital caused by LDE225 mediated induction of CYP450 enzyme. |
Skin cancer [2C30-2C37]
|
[87] |
Larotrectinib |
DM26CQR
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Larotrectinib mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[27] |
Methylprednisolone |
DM4BDON
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Methylprednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[34] |
Docetaxel |
DMDI269
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Docetaxel mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[88] |
Trabectedin |
DMG3Y89
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Trabectedin mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[18] |
Armodafinil |
DMGB035
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Armodafinil mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[89] |
LEE011 |
DMMX75K
|
Moderate |
Increased metabolism of Methylphenobarbital caused by LEE011 mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[27] |
Prednisolone |
DMQ8FR2
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Prednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[34] |
Taxol |
DMUOT9V
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Taxol mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[90] |
Doxorubicin |
DMVP5YE
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Doxorubicin mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[91] |
Fostamatinib |
DM6AUHV
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Fostamatinib mediated induction of CYP450 enzyme. |
Thrombocytopenia [3B64]
|
[14] |
Apixaban |
DM89JLN
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Apixaban mediated induction of CYP450 enzyme. |
Thrombosis [DB61-GB90]
|
[14] |
Brilinta |
DMBR01X
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Brilinta mediated induction of CYP450 enzyme. |
Thrombosis [DB61-GB90]
|
[18] |
Cabozantinib |
DMIYDT4
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Cabozantinib mediated induction of CYP450 enzyme. |
Thyroid cancer [2D10]
|
[92] |
Sirolimus |
DMGW1ID
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Sirolimus mediated induction of CYP450 enzyme. |
Transplant rejection [NE84]
|
[27] |
Tacrolimus |
DMZ7XNQ
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Tacrolimus mediated induction of CYP450 enzyme. |
Transplant rejection [NE84]
|
[27] |
Canagliflozin |
DMFRM1I
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Canagliflozin mediated induction of UGT. |
Type 2 diabetes mellitus [5A11]
|
[27] |
Saxagliptin |
DMGXENV
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Saxagliptin mediated induction of CYP450 enzyme. |
Type 2 diabetes mellitus [5A11]
|
[30] |
Linagliptin |
DMWFJTR
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Linagliptin mediated induction of CYP450 enzyme. |
Type 2 diabetes mellitus [5A11]
|
[14] |
Elagolix |
DMB2C0E
|
Moderate |
Increased metabolism of Methylphenobarbital caused by Elagolix mediated induction of CYP450 enzyme. |
Uterine fibroid [2E86]
|
[93] |
Propafenone |
DMPIBJK
|
Minor |
Increased metabolism of Methylphenobarbital caused by Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[94] |
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