Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6ITNG)

• Drug Name: Forskolin Drug Info
• Synonyms: forskolin; Colforsin; 66575-29-9; Coleonol; colforsina; colforsinum; colforsine; Boforsin; Colforsinum [Latin]; Colforsine [French]; Colforsina [Spanish]; Coleonolk; Colforsin [USAN:INN]; UNII-1F7A44V6OU; 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one; EINECS 266-410-9; HL 362; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate; NSC 357088; NSC 375489; Forskolin, Coleus forskohlii; CHEMBL52606; 1F7A44V6OU; L 75 1362B

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 47936
  ChEBI ID: CHEMBL52606
  CAS Number: CAS 66575-29-9
  TTD Drug ID: DM6ITNG

Molecule-Related Drug Atlas

Drug(s) Targeting Adenylate cyclase type 2 (ADCY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	DM5OYWF	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[11]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[12]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[13]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[14]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[15]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[17]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[18]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[19]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[17]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Methysergide	DM1EF73	Migraine	8A80	Approved	[22]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[28]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[36]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[37]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[38]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Ecotropic viral integration site 5 protein homolog (EVI5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[62]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[67]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[68]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[69]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]

Drug(s) Affected By Transmembrane protein 50A (TMEM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[84]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[85]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[86]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[92]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[94]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[97]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[98]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[107]

Drug(s) Affected By Signal peptidase complex subunit 3 (SPCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[111]

Drug(s) Affected By Translation initiation factor eIF2B subunit epsilon (EIF2B5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]

Drug(s) Affected By Ensconsin (MAP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[117]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[118]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[121]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[62]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]

Drug(s) Affected By Transcription termination factor 4, mitochondrial (MTERF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[130]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Zinc transporter 7 (SLC30A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[62]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]

Drug(s) Affected By Neuron navigator 1 (NAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]

Drug(s) Affected By Amyloid protein-binding protein 2 (APPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[136]

Drug(s) Affected By Dynein light chain 2, cytoplasmic (DYNLL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[84]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[139]

Drug(s) Affected By Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]

Drug(s) Affected By Trimethylguanosine synthase (TGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Indomethacin	DMSC4A7	Bursitis		Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[127]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[127]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[130]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[143]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 28 (MED28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[150]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[136]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[151]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Cardiolipin synthase (CRLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[3]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[159]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[160]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[162]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[164]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[163]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[165]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[166]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 1 (NR0B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[168]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[169]

Drug(s) Affected By Adrenocorticotropic hormone receptor (MC2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[179]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[180]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[181]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[181]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[184]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[184]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[185]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[187]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[184]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[184]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[189]

Drug(s) Affected By Choriogonadotropin subunit beta variant 1 (CGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[165]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[194]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]

Drug(s) Affected By Nuclear receptor subfamily 5 group A member 2 (NR5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[139]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[199]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[200]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[200]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[207]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[210]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[223]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[229]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[230]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[231]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[232]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[233]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[234]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[236]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[237]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[238]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[239]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[240]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[242]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[246]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[251]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[254]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]

Drug(s) Affected By Alkaline phosphatase, placental type (ALPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[257]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[260]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[261]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[262]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[263]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[264]
Terbutaline	DMD4381	Asthma	CA23	Approved	[265]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[266]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[269]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[270]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[271]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[275]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[276]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[277]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[276]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]

Drug(s) Affected By Chorionic somatomammotropin hormone 1 (CSH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[282]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[283]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[58]

Drug(s) Affected By Chorionic somatomammotropin hormone 2 (CSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[284]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[58]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[286]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[190]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[286]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[287]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[288]

Drug(s) Affected By Choriogonadotropin subunit beta 7 (CGB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[289]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[290]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]

Drug(s) Affected By Pulmonary surfactant-associated protein C (SFTPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[293]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[295]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[296]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]

Drug(s) Affected By cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[113]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[300]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[257]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[302]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Haloperidol	DM96SE0	Delirium		Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[84]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[305]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[306]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[308]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[62]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[307]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[190]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[311]
Methamphetamine	DMPM4SK	Anxiety		Approved	[312]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[316]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[318]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[320]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[319]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[257]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[5]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[324]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[325]

Drug(s) Affected By Protein Tob1 (TOB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Syncytin-2 (ERVFRD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[319]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[328]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[327]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[85]
Anandamide	DMCKH3P	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[333]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[336]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[339]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[340]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[84]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[342]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[94]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[165]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[343]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[345]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]

Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[347]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[349]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[346]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[350]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[351]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[346]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[118]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[319]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[319]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]

Drug(s) Affected By Kynurenine--oxoglutarate transaminase 1 (KYAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[290]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[136]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[130]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[25]
L-methionine	DME8G1U	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Choriogonadotropin subunit beta variant 2 (CGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[353]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
norfluoxetine	DMKNUP3	Discovery agent	N.A.	Investigative	[354]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[356]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[358]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]

Drug(s) Affected By Mucin-4 (MUC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[360]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[361]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[360]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[362]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A2 (SLC30A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[364]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[136]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[364]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-2 (EIF5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[366]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[341]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[130]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[367]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Fructose	DM43AN2	Vomiting	MD90	Approved	[369]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[370]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[372]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[373]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[76]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[373]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[374]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[250]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[376]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[377]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[94]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]

Drug(s) Affected By Membrane-associated transporter protein (SLC45A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[290]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[136]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[378]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[379]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[379]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[380]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[257]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[381]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[383]

Drug(s) Affected By Syncytin-1 (ERVW-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[384]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[327]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[85]
Anandamide	DMCKH3P	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[385]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[388]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[389]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[83]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase type 2 (ADCY2)	TTBQ9IM	ADCY2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[3]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[3]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[4]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[4]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[6]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[7]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Gene/Protein Processing	[8]
Adrenocorticotropic hormone receptor (MC2R)	OT6V19Y9	ACTHR_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[10]

References

• [1] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [2] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [3] The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305.
• [4] Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells. Biochem Biophys Res Commun. 2005 Aug 5;333(3):935-43. doi: 10.1016/j.bbrc.2005.04.177.
• [5] Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. J Invest Dermatol. 2007 Sep;127(9):2216-27. doi: 10.1038/sj.jid.5700840. Epub 2007 Apr 26.
• [6] Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis. Biochem Pharmacol. 2004 Sep 15;68(6):989-96. doi: 10.1016/j.bcp.2004.05.027.
• [7] The 2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts. Naunyn Schmiedebergs Arch Pharmacol. 2011 Aug;384(2):133-45. doi: 10.1007/s00210-011-0655-5. Epub 2011 May 21.
• [8] Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
• [9] The effect of valproate and levetiracetam on steroidogenesis in forskolin-stimulated H295R cells. Epilepsia. 2010 Nov;51(11):2280-8.
• [10] Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
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