Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8G6O4)

• Drug Name: AHPN Drug Info
• Synonyms: Ro 47-2077; 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid; CD437; CD 437

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135411
  ChEBI ID: CHEBI:88334
  CAS Number: CAS 125316-60-1
  TTD Drug ID: DM8G6O4

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Trifarotene	DMOL793	Acne vulgaris	ED80	Approved	[6]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[7]
Palovarotene	DMAD2OZ	Fibrodysplasia ossificans progressiva	FB31.1	Approved	[8]
PMID27336223-Compound-13	DMSZLYD	N. A.	N. A.	Patented	[9]
PMID27336223-Compound-12	DMT4P7K	N. A.	N. A.	Patented	[9]
PMID27336223-Compound-14	DMC41MA	N. A.	N. A.	Patented	[9]
PMID27336223-Compound-11	DMBN6KU	N. A.	N. A.	Patented	[9]
PMID27336223-Compound-15	DMIYCFE	N. A.	N. A.	Patented	[9]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[10]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[15]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[10]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[16]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[17]

Drug(s) Affected By Menin (MEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[33]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]

Drug(s) Affected By Histone deacetylase complex subunit SAP18 (SAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[45]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[49]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 2 (ARPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[54]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[55]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 3 (ARPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[55]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit D (EIF3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 3 (PSMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Asparagine--tRNA ligase, cytoplasmic (NARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 5 (NDUFS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[77]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]

Drug(s) Affected By Selenoprotein F (SELENOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[81]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Barrier-to-autointegration factor (BANF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit G (EIF3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By ATP synthase subunit g, mitochondrial (ATP5MG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By Cystatin-F (CST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[90]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[17]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[94]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]

Drug(s) Affected By Adenomatous polyposis coli protein 2 (APC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[96]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[98]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]
Haloperidol	DM96SE0	Delirium		Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[111]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]

Drug(s) Affected By Muellerian-inhibiting factor (AMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[54]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By ADP/ATP translocase 2 (SLC25A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[101]

Drug(s) Affected By Large ribosomal subunit protein P1 (RPLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]

Drug(s) Affected By Large ribosomal subunit protein P2 (RPLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[88]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[138]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[128]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[151]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Small ribosomal subunit protein eS17 (RPS17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[167]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[168]

Drug(s) Affected By Cytochrome c oxidase subunit 6C (COX6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[172]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[173]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[180]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[179]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[182]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[193]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[196]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[209]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[211]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[212]

Drug(s) Affected By Polyadenylate-binding protein 1 (PABPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By ADP/ATP translocase 3 (SLC25A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[219]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[222]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[222]

Drug(s) Affected By Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[193]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[191]

Drug(s) Affected By Arylsulfatase A (ARSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]

Drug(s) Affected By Small ribosomal subunit protein uS5 (RPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[187]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Cytochrome c oxidase subunit 7C, mitochondrial (COX7C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[172]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[239]

Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[241]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[242]

Drug(s) Affected By ATP synthase-coupling factor 6, mitochondrial (ATP5PF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[172]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[244]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[39]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[39]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[187]

Drug(s) Affected By Cytochrome c oxidase subunit 7B, mitochondrial (COX7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[252]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[253]

Drug(s) Affected By Proteasome subunit alpha type-4 (PSMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[254]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[39]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[259]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[260]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]

Drug(s) Affected By Large ribosomal subunit protein eL13 (RPL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[213]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[264]

Drug(s) Affected By V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By Large ribosomal subunit protein uL16 (RPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]

Drug(s) Affected By Coronin-1A (CORO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[187]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Transcription factor SOX-11 (SOX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[274]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[275]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[239]

Drug(s) Affected By ADP-ribosylation factor-like protein 2 (ARL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[277]

Drug(s) Affected By ATP synthase subunit gamma, mitochondrial (ATP5F1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By RNA-binding motif protein, X chromosome (RBMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[280]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[283]

Drug(s) Affected By Large ribosomal subunit protein uL13 (RPL13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[287]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[288]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]

Drug(s) Affected By Small ribosomal subunit protein eS27 (RPS27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[289]

Drug(s) Affected By Large ribosomal subunit protein uL29 (RPL35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[290]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Translocon-associated protein subunit beta (SSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]

Drug(s) Affected By G-protein coupled receptor 6 (GPR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By Small ribosomal subunit protein eS10 (RPS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[90]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[294]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[253]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[295]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By ATP synthase subunit O, mitochondrial (ATP5PO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[296]

Drug(s) Affected By ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By T-complex protein 1 subunit gamma (CCT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[61]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By Fms-related tyrosine kinase 3 ligand (FLT3LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[297]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[298]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[298]

Drug(s) Affected By Hsc70-interacting protein (ST13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[299]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[300]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[213]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[303]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[304]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[305]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[306]

Drug(s) Affected By Homeobox protein Nkx-2.5 (NKX2-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[307]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[309]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By AP-2 complex subunit sigma (AP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[294]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[284]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[311]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]

Drug(s) Affected By Adenylate kinase 2, mitochondrial (AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]

Drug(s) Affected By 26S proteasome complex subunit SEM1 (SEM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[316]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[317]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[318]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Transmembrane protein 258 (TMEM258)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[319]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Small ribosomal subunit protein uS9 (RPS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[320]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[290]

Drug(s) Affected By Small nuclear ribonucleoprotein F (SNRPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By Small nuclear ribonucleoprotein G (SNRPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm3 (LSM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[323]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D2 (SNRPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB7 (POLR2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[324]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]

Drug(s) Affected By Small ribosomal subunit protein uS19 (RPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[230]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[325]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]

Drug(s) Affected By Large ribosomal subunit protein eL39 (RPL39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Large ribosomal subunit protein uL5 (RPL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[328]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[329]

Drug(s) Affected By Large ribosomal subunit protein uL2 (RPL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[329]

Drug(s) Affected By Small ubiquitin-related modifier 1 (SUMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[331]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[332]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[335]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[336]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Thymosin beta-10 (TMSB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[337]

Drug(s) Affected By T-complex protein 1 subunit beta (CCT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[287]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Large ribosomal subunit protein eL24 (RPL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[339]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Large ribosomal subunit protein eL42 (RPL36A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[213]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Enhancer of rudimentary homolog (ERH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[342]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Large ribosomal subunit protein eL19 (RPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[343]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[187]

Drug(s) Affected By Solute carrier family 25 member 3 (SLC25A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[344]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[345]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Protein SET (SET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[346]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[288]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By POU domain, class 3, transcription factor 1 (POU3F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[306]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[347]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[309]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[348]

Drug(s) Affected By Proteolipid protein 2 (PLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[349]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]

Drug(s) Affected By Interleukin enhancer-binding factor 2 (ILF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[213]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[350]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[324]

Drug(s) Affected By Peroxiredoxin-4 (PRDX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]

Drug(s) Affected By Serine/threonine-protein kinase 3 (STK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[347]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit I (EIF3I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[355]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[355]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[359]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[360]

Drug(s) Affected By Nascent polypeptide-associated complex subunit alpha (NACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[362]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[306]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[288]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]

Drug(s) Affected By Hypermethylated in cancer 1 protein (HIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[363]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[365]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[367]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[304]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]

Drug(s) Affected By Lysine--tRNA ligase (KARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Poly(rC)-binding protein 1 (PCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[369]

Drug(s) Affected By Poly(rC)-binding protein 2 (PCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]

Drug(s) Affected By Septin-7 (SEPTIN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[370]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[290]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Fascin (FSCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]

Drug(s) Affected By Prickle-like protein 4 (PRICKLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[373]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]

Drug(s) Affected By RING1 and YY1-binding protein (RYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[34]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A5 (SLC30A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[374]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]

Drug(s) Affected By Roundabout homolog 4 (ROBO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[375]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[376]

Drug(s) Affected By Proteasome inhibitor PI31 subunit (PSMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[315]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[377]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[378]

Drug(s) Affected By Growth hormone secretagogue receptor type 1 (GHSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zithromax	DMN4H2O	Syphilis infection	1A6Z	Approved	[379]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]

Drug(s) Affected By Ribosomal protein eL42-like (RPL36AL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By AP-2 complex subunit mu (AP2M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Transcriptional regulator protein Pur-beta (PURB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[152]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[381]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Ras-like protein family member 10B (RASL10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[382]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[309]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[383]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[384]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[304]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[91]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[386]

Drug(s) Affected By Apoptosis inhibitor 5 (API5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[387]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]

Drug(s) Affected By INO80 complex subunit B (INO80B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[388]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD5 (SETD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[280]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[390]

Drug(s) Affected By SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]

Drug(s) Affected By SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]

Drug(s) Affected By MOB kinase activator 1A (MOB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]

Drug(s) Affected By U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Sodium-coupled neutral amino acid transporter 7 (SLC38A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Mitoferrin-1 (SLC25A37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[393]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[291]

Drug(s) Affected By Transmembrane protein 14C (TMEM14C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Mitochondrial import receptor subunit TOM7 homolog (TOMM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Stomatin-like protein 2, mitochondrial (STOML2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[395]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[396]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[397]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Integrin alpha-11 (ITGA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[398]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[269]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[399]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[309]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]

Drug(s) Affected By Integral membrane protein 2B (ITM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Kinesin-like protein KIF3A (KIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[393]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Mitochondrial carrier homolog 2 (MTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[98]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[404]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[407]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[416]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[417]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[418]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[420]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[422]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[387]
Fructose	DM43AN2	Vomiting	MD90	Approved	[101]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[423]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[428]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[431]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[432]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[433]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[430]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[436]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[439]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[440]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[442]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[443]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[444]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[445]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[444]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[446]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[447]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[448]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[449]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[451]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[367]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]

Drug(s) Affected By ADP/ATP translocase 1 (SLC25A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[161]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[455]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[457]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[458]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[101]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[459]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[461]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[462]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[465]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[466]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[467]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[469]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[470]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[445]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[471]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[472]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[474]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[416]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[475]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[476]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[477]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[478]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[479]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[459]

Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[481]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[483]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[484]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[485]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[486]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[443]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[489]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[490]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[491]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[492]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[493]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[494]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[471]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[495]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[496]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[497]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[498]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[499]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[500]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[501]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[502]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[504]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[443]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]

Drug(s) Affected By Syntaxin-binding protein 5 (STXBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[69]

Drug(s) Affected By ADP/ATP translocase 4 (SLC25A31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC5 (POLR3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[349]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[291]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor gamma (RARG)	TT1Q3IE	RARG_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein zeta/delta	OT2TKG9P	1433Z_HUMAN	Gene/Protein Processing	[3]
26S proteasome complex subunit SEM1 (SEM1)	OTASLBM1	SEM1_HUMAN	Gene/Protein Processing	[3]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3)	OT585WY8	PSMD3_HUMAN	Gene/Protein Processing	[3]
5'-3' exoribonuclease 2	OT7PNO08	XRN2_HUMAN	Gene/Protein Processing	[3]
Actin-related protein 2/3 complex subunit 2 (ARPC2)	OTSOKOMY	ARPC2_HUMAN	Gene/Protein Processing	[3]
Actin-related protein 2/3 complex subunit 3 (ARPC3)	OTKWVF8P	ARPC3_HUMAN	Gene/Protein Processing	[3]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Gene/Protein Processing	[3]
Adenomatous polyposis coli protein 2 (APC2)	OTRH91CX	APCL_HUMAN	Gene/Protein Processing	[3]
Adenylate kinase 2, mitochondrial (AK2)	OTZG3X2H	KAD2_HUMAN	Gene/Protein Processing	[3]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Gene/Protein Processing	[3]

References

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• [3] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [4] Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9.
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• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
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• [8] Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.
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• [17] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
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