General Information of Drug (ID: DM8VCBE)

Drug Name
Ibuprofen Drug Info
Synonyms
ibuprofen; 15687-27-1; 2-(4-Isobutylphenyl)propanoic acid; Motrin; Brufen; Advil; Nurofen; Dolgit; Nuprin; Liptan; Ibuprocin; Buburone; Medipren; Butylenin; Ibumetin; Anflagen; Lamidon; Ebufac; Mynosedin; Trendar; Roidenin; Apsifen; Haltran; Epobron; Nobgen; Adran; Nobfen; Rufen; PediaProfen; Andran; Bluton; Nobfelon; Pantrop; Brufort; Suspren; Rebugen; Tabalon; Inabrin; (RS)-Ibuprofen; Urem; Anco; 2-[4-(2-methylpropyl)phenyl]propanoic acid; Ibu-slo; Napacetin; Brufanic; Ibuprohm; Ibufen; Ibren; 4-Isobutylhydratropic acid; p-Isobutylhydratropic acid; Actiprofen; Alaxan; Algofen; Amelior; Amersol; Amibufen; Anafen; Antagil; Antalfene; Antarene; Antiflam; Artofen; Artril; Balkaprofen; Betaprofen; Bloom; Brofen; Bruflam; Bufeno; Bufigen; Bukrefen; Bupron; Buracaps; Burana; Carol;Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; Daiprophen; Dalsy; Dansida; Dentigoa; Dibufen; Dignoflex; Dolgirid; Dolibu; Dolmaral; Dolocyl; Dolofen; Dolofin; Dolofort; Dologel; Dolomax; Doloren; Dolormin; Doltibil; Dolven; Dorival; Drin; Duafen; Duobrus; Dysdolen; Easifon; Emflam; Eputex; Ergix; Esprenit; Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid;Fendol; Fenspan; Fibraflex; Gelufene; Gofen; Grefen; Gynofug; Ibol; Ibu; Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibuflamar; Ibufug; Ibugel; Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibulgan; Ibumed; Ibumerck; Ibupirac; Ibuprin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprophen; Ibusal; Ibutid; Ifen; Inflam; Inoven; Ipren; Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Lebrufen; Librofem; Lidifen; Lopane; Malafene; Manypren; Melfen; Mensoton; Midol; Moment; Narfen; Neobrufen; Nerofen; Noalgil; Nobafon; Noritis; Norton; Novadol; Novogent; Novoprofen; Nuprilan; Optifen; Opturem; Oralfene; Ostarin; Ostofen; Ozonol; Paduden; Panafen; Paxofen; Perofen; Proartinal; Profen; Proflex; Provon; Quadrax; Rafen; Ranofen; Relcofen; Rhinadvil; Rofen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solufen; Stelar; Sugafen; Suprafen; Syntofene; Tatanal; Tempil; Tofen; Tonal; Unipron; Upfen; Uprofen; Zafen; Zofen; DOLO PUREN; Deep Relief; Donjust B; Motrin IB; Novogent N; Togal N; Adex 200; Artril 300; Brufen 400; I 4883; IP 82; IP82; Midol 200; RD 13621; Tabalon 400; U 18573; UCB 79171; VUFB 9649; Act-3; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan (TN); Algoflex (TN); Alivium (TN); Am-Fam 400; Apsifen-F; Arthrofen (TN); Bonifen (TN); Brufen (TN); Bugesic (TN); Burana (TN); Caldolor (TN); Calprofen (TN); Cap-Profen; Dalsy (TN); Dismenol (TN); Diverin (TN); Dolgit (TN); Dolo-Dolgit; Dolofen-F; Dolofort (TN); Doloraz (TN); Dolormin (TN); Dorival (TN); Dura-Ibu; Ebufac (TN); Emflam-200; EmuProfen (TN); Espidifen (TN); Eve (TN); Fenbid (TN); Fenpaed (TN); Finalflex (TN); Galprofen (TN); Hedex (TN); Herron Blue (TN); IB-100; IBUFEN (TN); IP-82; Ibalgin (TN); Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-slow; IbuHEXAL (TN); Ibugel (TN); Ibuleve (TN); Ibum (TN); Ibumax (TN); Ibumetin (TN); Ibuprom (TN); Ibuprosyn (TN); Ibux (TN); Ibuxin (TN); Ipren (TN); Kratalgin (TN); Medicol (TN); Moment (TN); Motrin (TN); Nagifen-D; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen (TN); Neofen (TN); Norvectan (TN); Novo-Profen; Nuprin (TN); Nureflex (TN); Nurofen (TN); Orbifen (TN); Panafen (TN); Pedia-Profen; Perifar (TN); Profin (TN); Ratiodolor (TN); Retard (TN); Rimafen (TN); Salvarina (TN); Solpaflex (TN); Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Tab-Profen; U-18573; Upfen (TN); ACHES-N-PAIN; Act-3 (TN); Dolo-Spedifen (TN); I-profen (TN); IBU-Ratiopharm (TN); Ibu-Vivimed (TN); U-18,573; IBUPROPHEN
Indication
Disease Entry ICD 11 Status REF
Dysmenorrhea GA34.3 Approved [1]
Fever MG26 Approved [1]
Headache 8A80-8A84 Approved [1]
Osteoarthritis FA00-FA05 Approved [1]
Pain MG30-MG3Z Approved [2]
Patent ductus arteriosus Approved [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
3672
ChEBI ID
CHEMBL521
CAS Number
CAS 15687-27-1
TTD Drug ID
DM8VCBE
VARIDT Drug ID
DR00663
INTEDE Drug ID
DR0844
ACDINA Drug ID
D00320

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [3]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [18]
SX-682 DMHMG6X Melanoma 2C30 Phase 1 [19]
INDOPROFEN DM5QSKN Gout FA25 Withdrawn from market [3]
R-ketoprofen DMHSUQ1 N. A. N. A. Discontinued in Phase 2 [3]
2-(3-Isopropyl-phenyl)-propionic acid DMUOWNE Discovery agent N.A. Investigative [3]
2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid DMWIUR0 Discovery agent N.A. Investigative [3]
(R)-2-(4-Isobutyl-phenyl)-propionamide DMBQ0PR Discovery agent N.A. Investigative [3]
(R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide DMWRIQG Discovery agent N.A. Investigative [3]
2-[3-(2-Methyl-butyl)-phenyl]-propionic acid DMKSDT4 Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Interleukin-8 (IL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABX-IL8 DMCZFMS Melanoma 2C30 Phase 2 [20]
BMS-986253 DM42B0C Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [21]
MDX-018 DML5FX2 Autoimmune diabetes 5A10 Phase 1 [22]
R-ketoprofen DMHSUQ1 N. A. N. A. Discontinued in Phase 2 [4]
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid DM54M6C Discovery agent N.A. Investigative [4]
2-(2-(2-chlorophenylamino)phenyl)acetic acid DMPLV3A Discovery agent N.A. Investigative [4]
2-(2-(2-fluorophenylamino)phenyl)acetic acid DMVQ68F Discovery agent N.A. Investigative [4]
2-(2-(2-chlorophenoxy)phenyl)acetic acid DMBP1TQ Discovery agent N.A. Investigative [4]
2-(2-(2-fluorophenoxy)phenyl)acetic acid DMDSUR2 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [23]
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [3]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [24]
SB-265610 DM8TKG5 Asthma CA23 Phase 2 [25]
AZD-5069 DM3JSFK Asthma CA23 Phase 2 [26]
PS-938285 DMHZIFJ Chronic obstructive pulmonary disease CA22 Phase 2 [27]
GSK1325756 DMA6RBF Chronic obstructive pulmonary disease CA22 Phase 2 [28]
SB-656933 DMCY785 Chronic obstructive pulmonary disease CA22 Phase 2 [29]
RIST4721 DMA3DKO Hidradenitis suppurativa ED92.0 Phase 2 [30]
SX-682 DMHMG6X Melanoma 2C30 Phase 1 [19]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Naproxen DMZ5RGV Bursitis Approved [31]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [32]
Indomethacin DMSC4A7 Bursitis Approved [33]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [34]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [35]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [36]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [37]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [38]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [33]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [7]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [7]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Propicillin DMWDHUZ Bacterial infection 1A00-1C4Z Approved [7]
Milchsaure DM462BT Pruritus EC90 Investigative [41]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [6]
Phosphate DMUXQG7 Constipation DD91.1 Approved [6]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [6]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [6]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [47]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [52]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [53]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [54]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [51]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [55]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [9]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [60]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [62]
Estrone DM5T6US Acne vulgaris ED80 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [65]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [68]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [70]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [71]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [55]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [76]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [80]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [81]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [11]
Naproxen DMZ5RGV Bursitis Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [84]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [78]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [86]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [87]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [11]
Haloperidol DM96SE0 Delirium Approved [11]
Naproxen DMZ5RGV Bursitis Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [88]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [89]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [90]
Trospium chloride DM32XZT Discovery agent N.A. Approved [91]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [92]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [101]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [94]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [102]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [94]
Ketoprofen DMRKXPT Bursitis Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [105]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [95]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [107]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [94]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [108]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [94]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [109]
Ketoprofen DMRKXPT Bursitis Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Paclitaxel DMLB81S Breast carcinoma Approved [111]
Allopurinol DMLPAOB Gout FA25 Approved [111]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [111]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [111]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [111]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [111]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [119]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A9 (ANXA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [123]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Urethane DM7NSI0 N. A. N. A. Phase 4 [125]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [118]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [126]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [129]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [113]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [131]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [132]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [133]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Folic Acid DMEMBJC Colorectal carcinoma Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [140]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [146]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [150]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [151]
Epinephrine DM3KJBC Acute asthma CA23 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [153]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptide YY (PYY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Orlistat DMRJSP8 Obesity 5B81 Approved [158]
Arsenic DMTL2Y1 N. A. N. A. Approved [159]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [118]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [131]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [164]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [166]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [167]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A3 (ANXA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [171]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [172]
Gefitinib DM15F0X Colon adenocarcinoma Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [175]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [176]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [179]
Quercetin DM3NC4M Obesity 5B81 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [186]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [190]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [191]
Capsaicin DMGMF6V Back pain ME84.Z Approved [192]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [195]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [196]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [197]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [198]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [200]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-3 (CDH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [114]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Folic Acid DMEMBJC Colorectal carcinoma Approved [205]
Menthol DMG2KW7 Back pain ME84.Z Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein PML (PML)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [207]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Menthol DMG2KW7 Back pain ME84.Z Approved [206]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [208]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Menthol DMG2KW7 Back pain ME84.Z Approved [206]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [211]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [212]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [213]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [213]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [214]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [216]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [217]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [218]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [221]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [183]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [222]
paraquat DMR8O3X Discovery agent N.A. Investigative [223]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [226]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [183]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Desmocollin-1 (DSC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [228]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [166]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [228]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [229]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Corneodesmosin (CDSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [123]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [231]
Milchsaure DM462BT Pruritus EC90 Investigative [232]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Urethane DM7NSI0 N. A. N. A. Phase 4 [125]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [233]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [234]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [236]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [237]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [133]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [235]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [222]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Folic Acid DMEMBJC Colorectal carcinoma Approved [138]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [239]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [241]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
Milchsaure DM462BT Pruritus EC90 Investigative [232]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [201]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [243]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [201]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [140]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [244]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [17]
Diazepam DM08E9O Alcohol withdrawal Approved [245]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [246]
Desogestrel DM27U4Y Contraception QA21 Approved [246]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [247]
Quercetin DM3NC4M Obesity 5B81 Approved [248]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [17]
Diazepam DM08E9O Alcohol withdrawal Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [250]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [251]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [252]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [17]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [253]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [254]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [17]
Diazepam DM08E9O Alcohol withdrawal Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [255]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [256]
Ethacrynic acid DM60QMR Edema MG29 Approved [255]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [14]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [225]
Haloperidol DM96SE0 Delirium Approved [257]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [260]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [261]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Fluoxetine DM3PD2C Bipolar depression Approved [263]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [264]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [265]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [216]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cochlin (COCH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [14]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [268]
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [217]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [270]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [183]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [105]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [271]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Ethanol DMDRQZU Chronic pain MG30 Approved [272]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [273]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [275]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [252]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [276]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein AMBP (AMBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [279]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [280]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [118]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
Quercetin DM3NC4M Obesity 5B81 Approved [283]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [216]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [284]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [285]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
Quercetin DM3NC4M Obesity 5B81 Approved [283]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [260]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [253]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [287]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [288]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [289]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [291]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [292]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [292]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.2 (H1-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [294]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [183]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [267]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [296]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [297]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [298]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E3 (TFE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [216]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [301]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [303]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [250]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [304]
Methotrexate DM2TEOL Anterior urethra cancer Approved [305]
Epinephrine DM3KJBC Acute asthma CA23 Approved [306]
Quercetin DM3NC4M Obesity 5B81 Approved [289]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [307]
Fructose DM43AN2 Vomiting MD90 Approved [308]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [309]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [288]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Folic Acid DMEMBJC Colorectal carcinoma Approved [311]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Folic Acid DMEMBJC Colorectal carcinoma Approved [138]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 14-3-3 protein sigma (SFN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [313]
Gefitinib DM15F0X Colon adenocarcinoma Approved [314]
Methotrexate DM2TEOL Anterior urethra cancer Approved [315]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [316]
Quercetin DM3NC4M Obesity 5B81 Approved [317]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [316]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [318]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [320]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [321]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [259]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [286]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [260]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [260]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [164]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ataxin-1 (ATXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [294]
Selenium DM25CGV N. A. N. A. Approved [114]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [322]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [323]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [14]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [324]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [318]
Estrone DM5T6US Acne vulgaris ED80 Approved [325]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [328]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [329]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [268]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [330]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [228]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein D53 (TPD52L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Testosterone enanthate DMB6871 N. A. N. A. Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RRP12-like protein (RRP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [333]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [335]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [241]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [164]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [301]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pantothenate kinase 1 (PANK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [95]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [236]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [338]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [339]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM89A (FAM89A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [340]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [340]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Perilipin-2 (PLIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [315]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [341]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [216]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [145]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
Bortezomib DMNO38U Leukemia Approved [342]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [344]
Ethacrynic acid DM60QMR Edema MG29 Approved [345]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [346]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [348]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [349]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [183]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [350]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [351]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [352]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Arsenic DMTL2Y1 N. A. N. A. Approved [159]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [348]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein piccolo (PCLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [165]
Arsenic DMTL2Y1 N. A. N. A. Approved [159]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [194]
Urethane DM7NSI0 N. A. N. A. Phase 4 [125]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [242]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [348]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [353]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [354]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [356]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [357]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [359]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [313]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [360]
Etretinate DM2CZFA Keratosis ED56 Approved [361]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [362]
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [364]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [365]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [366]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [367]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [369]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [318]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [370]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [371]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [372]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [373]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [374]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [375]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [376]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [377]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [378]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [379]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [380]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [381]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [382]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromelysin-1 (MMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [383]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [383]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [383]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [383]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [385]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [362]
Methotrexate DM2TEOL Anterior urethra cancer Approved [386]
Quercetin DM3NC4M Obesity 5B81 Approved [387]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [388]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [389]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [391]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [377]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [321]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [15]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
Quercetin DM3NC4M Obesity 5B81 Approved [283]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [393]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [394]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [395]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [396]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-6 (PRDX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Ethanol DMDRQZU Chronic pain MG30 Approved [399]
Capsaicin DMGMF6V Back pain ME84.Z Approved [400]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [185]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [401]
Arsenic DMTL2Y1 N. A. N. A. Approved [402]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-2 (PRDX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [403]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Quercetin DM3NC4M Obesity 5B81 Approved [404]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [405]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [114]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [378]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Clozapine DMFC71L Schizophrenia 6A20 Approved [257]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [211]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [406]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [346]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [407]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Etretinate DM2CZFA Keratosis ED56 Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [408]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [378]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [409]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [410]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [410]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [411]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [412]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [410]
Ethacrynic acid DM60QMR Edema MG29 Approved [410]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [413]
Quercetin DM3NC4M Obesity 5B81 Approved [414]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [415]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [416]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [417]
Testosterone DM7HUNW Hot flushes GA30 Approved [418]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [357]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [419]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [420]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [420]
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [228]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [420]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [420]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plectin (PLEC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [294]
Selenium DM25CGV N. A. N. A. Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [14]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [249]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [421]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [118]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [422]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [423]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [196]
Arsenic DMTL2Y1 N. A. N. A. Approved [159]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [424]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [425]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [301]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [324]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [426]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [427]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [113]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [428]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [395]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [429]
Milchsaure DM462BT Pruritus EC90 Investigative [232]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Methotrexate DM2TEOL Anterior urethra cancer Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [430]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [264]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ketorolac DMI4EL5 Postoperative inflammation 1A00-CA43.1 Approved [431]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA (DNMT3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [432]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [433]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [434]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [435]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [436]
Ethanol DMDRQZU Chronic pain MG30 Approved [437]
Folic Acid DMEMBJC Colorectal carcinoma Approved [438]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [439]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [440]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [441]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [442]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [443]
Quercetin DM3NC4M Obesity 5B81 Approved [444]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [3]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [3]
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Inhibitor [4]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [6]
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [8]
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [9]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [9]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [10]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [11]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [11]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Substrate [11]
Acyl-CoA thioesterase 2 (ACOT2) DEMEPVJ ACOT2_HUMAN Substrate [12]
Alpha-methylacyl-CoA racemase (AMACR) DEGKWJB AMACR_HUMAN Substrate [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Gene/Protein Processing [14]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Gene/Protein Processing [14]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [14]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Gene/Protein Processing [15]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Gene/Protein Processing [14]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8) OT2KFY1S ATS8_HUMAN Gene/Protein Processing [16]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Gene/Protein Processing [14]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [17]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [17]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [17]

References

1 Ibuprofen FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2713).
3 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
4 Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
5 Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
6 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
7 Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB.
8 PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb;25(2):96-106.
9 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
10 Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87.
11 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
12 A study on the chiral inversion of mandelic acid in humans. Org Biomol Chem. 2014 Sep 14;12(34):6737-44.
13 Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 2009 Dec;17(6):275-342.
14 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
15 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
16 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
17 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
18 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
19 Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.
20 Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.
21 Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240.
22 Company report (Genmab)
23 Mode of action of clotrimazole: implications for therapy. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):939-44.
24 CXCR2 Antagonist MK-7123.A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2015 May 1;191(9):1001-11.
25 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
26 Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015 May;353(2):340-50.
27 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
28 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
29 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
30 A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.
31 Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20.
32 Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Intern Med. 2007;46(13):1055-8.
33 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
34 Pfizer. Product Development Pipeline. March 31 2009.
35 Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo. Exp Nephrol. 2001;9(6):387-96.
36 Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
37 Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35.
38 Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
39 Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice. Eur Respir J. 2009 Jul;34(1):200-8.
40 Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy. Clin Transl Sci. 2018 Jul;11(4):352-364.
41 Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35.
42 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
43 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
44 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
45 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
46 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
47 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
48 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
49 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
50 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
51 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
52 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
53 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
54 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
55 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
56 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
57 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
58 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
59 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
60 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
61 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
62 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
63 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
64 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
65 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
66 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
67 CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6.
68 Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21.
69 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
70 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
71 Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22.
72 Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 1;870(1):84-90.
73 Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600.
74 Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168.
75 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.
76 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
77 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.
78 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
79 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
80 UGT1A1*28 is associated with decreased systemic exposure of atorvastatin lactone. Mol Diagn Ther. 2013 Aug;17(4):233-7.
81 Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May;21(5):280-8.
82 Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8.
83 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
84 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
85 Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
86 The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
87 The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83.
88 Alpha-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. Prog Lipid Res. 2013 Apr;52(2):220-30.
89 Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
90 Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicol Lett. 2020 Mar 15;321:114-121. doi: 10.1016/j.toxlet.2019.12.012. Epub 2019 Dec 9.
91 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
92 Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005 Dec;315(3):1288-97.
93 Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13.
94 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
95 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
96 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
97 The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8.
98 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
99 P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
100 Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291. doi: 10.1093/toxsci/kfaa033.
101 Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicol Lett. 2023 Apr 15;379:48-55. doi: 10.1016/j.toxlet.2023.03.007. Epub 2023 Mar 22.
102 Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. Toxicol In Vitro. 2017 Oct;44:27-35.
103 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
104 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
105 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
106 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
107 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
108 Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.
109 Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884. doi: 10.1007/s00204-017-2008-8. Epub 2017 Jun 9.
110 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
111 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
112 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
113 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
114 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
115 Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75.
116 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
117 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
118 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
119 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
120 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
121 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
122 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
123 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
124 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
125 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
126 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
127 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
128 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
129 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
130 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
131 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
132 BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
133 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
134 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
135 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
136 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
137 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
138 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
139 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
140 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
141 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
142 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
143 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
144 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
145 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
146 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
147 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
148 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
149 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
150 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
151 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
152 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
153 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
154 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
155 Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
156 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
157 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
158 Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab. 2008 Oct;93(10):3995-8. doi: 10.1210/jc.2008-0924. Epub 2008 Jul 22.
159 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
160 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
161 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
162 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
163 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
164 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
165 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
166 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
167 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
168 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
169 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
170 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
171 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
172 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
173 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
174 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
175 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
176 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
177 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
178 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
179 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
180 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
181 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
182 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
183 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
184 Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
185 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
186 Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms. Neoplasia. 2008 Mar;10(3):279-86. doi: 10.1593/neo.07965.
187 Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
188 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
189 Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
190 Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. PLoS One. 2013 Dec 3;8(12):e82086. doi: 10.1371/journal.pone.0082086. eCollection 2013.
191 Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
192 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
193 Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands. J Pharmacol Exp Ther. 2004 Nov;311(2):467-75. doi: 10.1124/jpet.104.068254. Epub 2004 Jul 23.
194 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
195 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
196 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
197 Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res. 2009 Feb;7(2):199-209. doi: 10.1158/1541-7786.MCR-08-0314. Epub 2009 Feb 10.
198 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
199 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
200 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
201 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
202 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
203 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
204 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
205 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
206 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
207 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
208 Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2.
209 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
210 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
211 Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
212 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
213 Estrogen regulation of apoptosis in osteoblasts. Physiol Behav. 2010 Feb 9;99(2):181-5. doi: 10.1016/j.physbeh.2009.04.025. Epub 2009 May 5.
214 Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
215 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
216 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
217 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
218 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
219 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
220 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
221 Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
222 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
223 An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun;81:105333. doi: 10.1016/j.tiv.2022.105333. Epub 2022 Feb 16.
224 Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
225 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
226 Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
227 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
228 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
229 Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
230 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
231 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
232 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
233 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
234 The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells. Ecotoxicol Environ Saf. 2013 Jun;92:303-11. doi: 10.1016/j.ecoenv.2013.03.009. Epub 2013 Apr 3.
235 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
236 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
237 Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
238 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
239 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
240 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
241 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
242 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
243 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
244 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
245 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
246 Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
247 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
248 AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
249 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
250 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
251 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
252 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
253 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
254 Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
255 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
256 Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
257 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
258 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
259 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
260 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
261 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
262 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
263 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
264 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
265 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
266 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
267 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
268 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
269 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
270 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
271 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
272 Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. Toxicology. 2021 Jun 30;458:152848. doi: 10.1016/j.tox.2021.152848. Epub 2021 Jul 2.
273 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
274 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
275 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
276 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
277 Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta. 2006 Feb;1764(2):161-73. doi: 10.1016/j.bbapap.2005.12.006. Epub 2006 Jan 6.
278 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
279 Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
280 Low-dose dual blockade of the renin-angiotensin system improves tubular status in non-diabetic proteinuric patients. Scand J Urol Nephrol. 2005;39(6):511-7. doi: 10.1080/00365590510031264.
281 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
282 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
283 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
284 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
285 Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011 Oct;26(5):459-71. doi: 10.1002/tox.20572. Epub 2010 Mar 1.
286 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
287 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
288 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
289 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
290 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
291 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
292 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
293 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
294 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
295 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
296 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
297 NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
298 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
299 Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
300 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
301 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
302 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
303 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
304 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
305 Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
306 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
307 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
308 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
309 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
310 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
311 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
312 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
313 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
314 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
315 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
316 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
317 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
318 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
319 Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
320 Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
321 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
322 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
323 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
324 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
325 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
326 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
327 The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res. 2006 Sep;38(9):614-6. doi: 10.1055/s-2006-951310.
328 Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta. 2006 Mar-Apr;1759(3-4):141-51. doi: 10.1016/j.bbaexp.2006.04.005. Epub 2006 Apr 27.
329 Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
330 Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
331 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
332 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
333 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
334 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
335 Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
336 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
337 Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1):17-26.
338 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
339 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
340 Gene expression changes associated with cytotoxicity identified using cDNA arrays. Funct Integr Genomics. 2000 Sep;1(2):114-26.
341 Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models. Arch Toxicol. 2015 Dec;89(12):2325-37. doi: 10.1007/s00204-014-1365-9. Epub 2014 Sep 17.
342 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
343 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
344 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
345 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
346 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
347 Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. J Occup Environ Med. 2012 Jul;54(7):774-80. doi: 10.1097/JOM.0b013e31825296bc.
348 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
349 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
350 Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
351 Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
352 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
353 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
354 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
355 A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
356 Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
357 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
358 IKK inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line. Chem Biol Interact. 2017 Jan 25;262:19-28. doi: 10.1016/j.cbi.2016.12.005. Epub 2016 Dec 6.
359 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
360 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
361 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
362 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
363 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
364 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
365 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
366 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
367 Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
368 Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
369 Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
370 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
371 Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5. Toxicol Appl Pharmacol. 2022 Jan 15;435:115829. doi: 10.1016/j.taap.2021.115829. Epub 2021 Dec 14.
372 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
373 Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation. Mol Cancer Res. 2018 Jan;16(1):32-46. doi: 10.1158/1541-7786.MCR-17-0397. Epub 2017 Oct 17.
374 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
375 The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother. 2016 Aug;82:595-605. doi: 10.1016/j.biopha.2016.05.029. Epub 2016 Jun 9.
376 The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
377 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
378 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
379 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
380 TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4.
381 A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol. 2008 Feb;61(2):203-14. doi: 10.1007/s00280-007-0462-3. Epub 2007 Apr 20.
382 The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res. 2007 Apr 1;67(7):3254-62.
383 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
384 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
385 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
386 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
387 Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
388 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
389 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
390 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
391 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
392 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
393 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
394 Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation. Cancer Detect Prev. 2004;28(6):443-52. doi: 10.1016/j.cdp.2004.08.009.
395 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
396 Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011 Oct 10;206(2):178-88.
397 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
398 Variants of peroxiredoxins expression in response to hydroperoxide stress. Free Radic Biol Med. 2001 Mar 15;30(6):625-35. doi: 10.1016/s0891-5849(00)00503-7.
399 Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
400 A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008 Nov;8(22):4748-67. doi: 10.1002/pmic.200800094.
401 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
402 Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
403 Characterization of antioxidant properties of natural killer-enhancing factor-B and induction of its expression by hydrogen peroxide. Toxicol Appl Pharmacol. 1997 Nov;147(1):135-42. doi: 10.1006/taap.1997.8270.
404 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
405 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
406 Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
407 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
408 Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
409 NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
410 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
411 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
412 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
413 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
414 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
415 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
416 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
417 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
418 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
419 Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
420 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
421 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
422 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
423 The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol Cell Biochem. 2004 May;260(1-2):129-35. doi: 10.1023/b:mcbi.0000026063.96267.98.
424 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan;22(1):65-77. doi: 10.1210/me.2007-0383. Epub 2007 Sep 13.
425 Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells. J Toxicol Sci. 2023;48(5):273-283. doi: 10.2131/jts.48.273.
426 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
427 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
428 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
429 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
430 Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. J Cell Biochem. 2008 Apr 15;103(6):1989-98. doi: 10.1002/jcb.21588.
431 Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003 Aug 1;9(8):3150-7.
432 Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
433 The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol. 2007 Mar;30(3):641-50.
434 [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]. Zhonghua Xue Ye Xue Za Zhi. 2002 Dec;23(12):638-41.
435 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
436 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
437 Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
438 Folate deficiency induces cell-specific changes in the steady-state transcript levels of genes involved in folate metabolism and 1-carbon transfer reactions in human colonic epithelial cells. J Nutr. 2007 Mar;137(3):607-13. doi: 10.1093/jn/137.3.607.
439 Interindividual variability in 5-Fluorouracil metabolism and procainamide N-acetylation in human liver cytosol. Biol Pharm Bull. 2005 Jun;28(6):1071-4. doi: 10.1248/bpb.28.1071.
440 Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol. 2005 Jan 15;69(2):347-59. doi: 10.1016/j.bcp.2004.09.014. Epub 2004 Nov 24.
441 Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010 Jul;11(7):951-8. doi: 10.2217/pgs.10.65.
442 Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity. Pharmacogenomics J. 2007 Apr;7(2):144-52. doi: 10.1038/sj.tpj.6500407. Epub 2006 Jul 18.
443 The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
444 Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clin Exp Pharmacol Physiol. 2009 Aug;36(8):828-33.