Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM39BF)

• Drug Name: Mitoxantrone Drug Info
• Synonyms: DHAD; DHAQ; Dihydroxyanthraquinone; MIX; Misostol; Mitoxanthrone; Mitoxantron; Mitoxantrona; Mitoxantronum; Mitozantrone; DHAQ HCl; Mitoxantrone [INN]; Mitozantrone hydrochloride; Mitoxantrone 2HCl; Liposome Encapsulated Mitoxantrone (LEM); Misostol (TN); Mitoxantrona [INN-Spanish]; Mitoxantrone (INN); Mitoxantrone (free base); Mitoxantronum [INN-Latin]; Novantrone (TN); AN-584/42007670; Novantrone(R) (mitoxantrone for injection concentrate); DHAQ (*Diacetate salt*); MITOXANTRONE, Mitoxantrone Hydrochloride, Mitoxantrone dihydrochloride, MITOXANTHRONE HYDROCHLORIDE; MITOXANTRONE, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)ANTHRA-9,10-QUINONE; 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone; 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE; 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione; 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon; 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra-9,10-quinone; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione; 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-(9CI)

Indication

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[1]
Adult acute monocytic leukemia		Approved	[1]
Leukemia		Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Non-hodgkin lymphoma	2B33.5	Phase 1/2	[3]
Metastatic prostate carcinoma		Investigative	[1]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 4212
  ChEBI ID: CHEBI:50729
  CAS Number: CAS 65271-80-9
  TTD Drug ID: DMM39BF
  VARIDT Drug ID: DR00269
  INTEDE Drug ID: DR1102

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[12]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[13]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[12]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[12]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[14]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[12]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[15]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[16]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[17]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[24]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[25]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[26]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[27]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[35]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[41]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[42]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[45]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[50]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[51]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[56]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[57]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[58]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[59]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[61]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[62]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[63]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[64]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[65]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[70]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[71]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[72]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[73]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[74]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[75]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[77]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[78]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[79]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[77]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Fructose	DM43AN2	Vomiting	MD90	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]

Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
Mibefradil	DMU9VDS	Glioblastoma multiforme	2A00.0	Phase 1	[96]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[102]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[105]

Drug(s) Affected By Sodium channel subunit beta-2 (SCN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[110]

Drug(s) Affected By LIM domain-binding protein 3 (LDB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Creatine kinase M-type (CKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[120]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Carbimazole	DMULAI4	Hyperthyroidism	5A02	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[133]

Drug(s) Affected By Glycogen phosphorylase, muscle form (PYGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[134]
Haloperidol	DM96SE0	Delirium		Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[136]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Dystrophin (DMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[142]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]

Drug(s) Affected By Myosin-7 (MYH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[145]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[146]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[146]

Drug(s) Affected By Myosin-6 (MYH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[147]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[145]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By Troponin T, slow skeletal muscle (TNNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[161]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]

Drug(s) Affected By Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Fructose	DM43AN2	Vomiting	MD90	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[174]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]

Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[177]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[177]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Mepivacaine	DMH2NMY	Analgesia	MB40.8	Approved	[178]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Ropivacaine	DMSPJG2	Anaesthesia	9A78.6	Approved	[178]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Myomesin-2 (MYOM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[185]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[186]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By Inward rectifier potassium channel 2 (KCNJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]

Drug(s) Affected By Actin, alpha skeletal muscle (ACTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-4 (IRX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[192]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]

Drug(s) Affected By Ankyrin-2 (ANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[195]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[198]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[199]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[202]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[203]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[204]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[205]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[206]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[207]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[207]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[208]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[209]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[210]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[211]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[207]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[64]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[213]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[214]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[218]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[220]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3A (PPP1R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Caveolae-associated protein 4 (CAVIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[222]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By Nebulin-related-anchoring protein (NRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[136]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Ryanodine receptor 2 (RYR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[224]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[225]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[113]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[224]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[224]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[227]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]

Drug(s) Affected By Histone-lysine N-methyltransferase PRDM16 (PRDM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[236]

Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Atrial natriuretic peptide-converting enzyme (CORIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[242]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[243]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Selenium	DM25CGV	N. A.	N. A.	Approved	[255]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[256]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[257]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[264]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[269]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[270]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[274]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[275]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[276]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[277]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[281]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[282]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[283]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[284]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[284]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[287]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[195]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[290]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[198]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[292]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[293]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[294]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[287]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[297]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[166]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[147]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[312]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[313]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[314]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[315]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[316]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[317]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[196]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[323]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[324]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[327]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[328]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[331]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[324]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[332]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[334]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[335]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[336]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[339]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[344]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[346]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[349]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[352]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[355]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[357]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[359]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[360]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[361]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[363]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[369]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[370]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[372]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[373]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[374]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[150]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[377]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[378]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[379]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[380]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[381]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[382]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[383]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[385]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[386]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[369]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[387]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]

Drug(s) Affected By Mitochondrial pyruvate carrier 2 (MPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[392]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By Molybdenum cofactor sulfurase (MOCOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[394]

Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]

Drug(s) Affected By LEM domain-containing protein 2 (LEMD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-1 (IRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[94]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[110]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[397]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]

Drug(s) Affected By Methylosome subunit pICln (CLNS1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[117]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[400]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]

Drug(s) Affected By TBC1 domain family member 8 (TBC1D8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Protein FAM117A (FAM117A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[403]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[403]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]

Drug(s) Affected By Protein transport protein Sec31A (SEC31A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[135]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[406]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By DNA-binding protein SATB2 (SATB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Haloperidol	DM96SE0	Delirium		Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[407]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[409]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[98]

Drug(s) Affected By Very long chain fatty acid elongase 5 (ELOVL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[417]

Drug(s) Affected By Solute carrier organic anion transporter family member 4A1 (SLCO4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[420]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[421]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[422]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[423]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[425]

Drug(s) Affected By ELAV-like protein 4 (ELAVL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]

Drug(s) Affected By Angiomotin-like protein 1 (AMOTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[426]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[428]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[429]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[239]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[284]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[284]

Drug(s) Affected By PRELI domain containing protein 3B (PRELID3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[430]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[429]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[431]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Centrosomal protein 15 (CEP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[434]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[136]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[436]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[234]

Drug(s) Affected By cAMP-responsive element-binding protein-like 2 (CREBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Indomethacin	DMSC4A7	Bursitis		Approved	[439]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By PACRG-like protein (PACRGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[440]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[441]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[444]
Bortezomib	DMNO38U	Leukemia		Approved	[445]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[445]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[446]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]

Drug(s) Affected By Melanoma-associated antigen D1 (MAGED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[447]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[448]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[407]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[449]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[453]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[447]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[455]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[440]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[456]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[284]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Homeobox protein engrailed-2 (EN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[457]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[458]

Drug(s) Affected By Exosome complex exonuclease RRP44 (DIS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[459]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[460]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[461]

Drug(s) Affected By Protein LBH (LBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[462]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[425]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[463]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[293]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[465]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[466]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[467]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[256]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[468]

Drug(s) Affected By Secreted frizzled-related protein 4 (SFRP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[469]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[392]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[469]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[471]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[446]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[472]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[472]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[473]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[472]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]

Drug(s) Affected By Exostosin-like 2 (EXTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[474]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[475]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[476]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[420]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[477]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[478]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[480]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[481]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[483]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[485]

Drug(s) Affected By Pyridoxal phosphate homeostasis protein (PLPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Haloperidol	DM96SE0	Delirium		Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Splicing factor 45 (RBM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[486]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[487]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[487]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[488]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[488]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[490]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[261]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[491]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[492]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[491]

Drug(s) Affected By POM121 and ZP3 fusion protein (POMZP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[494]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[427]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[495]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Transmembrane protein 47 (TMEM47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]

Drug(s) Affected By RCC1 and BTB domain-containing protein 1 (RCBTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[307]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[407]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[497]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[498]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[498]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[307]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[498]
Fructose	DM43AN2	Vomiting	MD90	Approved	[499]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[498]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[500]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By Cochlin (COCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[284]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[284]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[501]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[485]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[502]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[503]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]

Drug(s) Affected By Spondin-1 (SPON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[505]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[462]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[509]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[510]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[511]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[512]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[513]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[514]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[516]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[518]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]

Drug(s) Affected By KRR1 small subunit processome component homolog (KRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[446]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[520]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[427]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[521]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[280]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[462]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[527]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Bortezomib	DMNO38U	Leukemia		Approved	[528]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[530]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]

Drug(s) Affected By Syndecan-2 (SDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[531]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]

Drug(s) Affected By Schwannomin-interacting protein 1 (SCHIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Bortezomib	DMNO38U	Leukemia		Approved	[528]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[532]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 5 (NDUFS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[533]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[534]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[535]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[536]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By G antigen 7 (GAGE7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[537]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[538]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[539]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[540]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[541]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[542]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[545]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[218]

Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[546]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[547]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[548]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[549]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[550]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]

Drug(s) Affected By Double-stranded RNA-specific editase 1 (ADARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[551]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[552]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Chordin-like protein 1 (CHRDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[94]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[552]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[494]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[159]

Drug(s) Affected By Cytotoxic granule associated RNA binding protein TIA1 (TIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]

Drug(s) Affected By Voltage-gated potassium channel subunit beta-2 (KCNAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[554]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[554]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Nidogen-2 (NID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]

Drug(s) Affected By Endothelial lipase (LIPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[287]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[462]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[425]

Drug(s) Affected By Chemokine-like factor (CKLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[555]

Drug(s) Affected By E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[430]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[434]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[557]

Drug(s) Affected By Basal cell adhesion molecule (BCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Melanoma-associated antigen 6 (MAGEA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[559]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[441]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Indomethacin	DMSC4A7	Bursitis		Approved	[561]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[446]

Drug(s) Affected By Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Haloperidol	DM96SE0	Delirium		Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[135]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[562]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[562]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[563]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[562]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[564]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[562]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]

Drug(s) Affected By Lymphocyte function-associated antigen 3 (CD58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[565]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[566]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[568]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[569]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[570]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[571]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[572]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[573]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[574]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[575]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[576]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[227]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[485]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[546]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[578]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[579]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[580]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[581]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[582]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[583]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[581]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[10]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[407]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[587]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[588]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[482]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[589]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[437]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[590]

Drug(s) Affected By CUGBP Elav-like family member 2 (CELF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[591]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By Protein CASC3 (CASC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[165]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[592]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[594]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[462]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[563]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[595]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[596]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[597]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Homeobox protein Hox-A5 (HOXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[600]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[601]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[602]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[603]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[604]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[605]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Mestranol	DMG3F94	Contraception	QA21	Approved	[98]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[606]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[607]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[608]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[609]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[610]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[611]

Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[613]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[614]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[426]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[616]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[617]

Drug(s) Affected By Protein phosphatase inhibitor 2 (PPP1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[618]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[619]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[620]

Drug(s) Affected By HMG box transcription factor BBX (BBX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[605]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[528]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[451]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[436]

Drug(s) Affected By Melanoma-associated antigen D4 (MAGED4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[10]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[10]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[621]

Drug(s) Affected By Beta-secretase 2 (BACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[622]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[623]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[624]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[625]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase epsilon (PTPRE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[397]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[462]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Probable serine carboxypeptidase CPVL (CPVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[494]

Drug(s) Affected By Caveolae-associated protein 3 (CAVIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[626]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]

Drug(s) Affected By Ecotropic viral integration site 5 protein homolog (EVI5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[421]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[425]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[446]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[627]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[627]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[266]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[347]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[630]

Drug(s) Affected By GTP cyclohydrolase 1 (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[631]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[632]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[261]
Sphingosine-1-phosphate	DMJCQKA	Acne vulgaris	ED80	Phase 1	[633]

Drug(s) Affected By G antigen 4 (GAGE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[537]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[546]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[407]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[634]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[635]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[636]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[637]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[638]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[639]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[526]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[626]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[640]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Bortezomib	DMNO38U	Leukemia		Approved	[528]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[641]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[640]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[642]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[642]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[643]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[642]

Drug(s) Affected By Histone deacetylase 4 (HDAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[644]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[645]
Bortezomib	DMNO38U	Leukemia		Approved	[646]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[647]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[648]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[649]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[651]
Fructose	DM43AN2	Vomiting	MD90	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[653]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[654]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[655]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[656]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[654]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Sal-like protein 2 (SALL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Mestranol	DMG3F94	Contraception	QA21	Approved	[98]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 2 (CSRNP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[657]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[523]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[626]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By Guanylate cyclase soluble subunit beta-1 (GUCY1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[658]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[568]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Glyceryl trinitrate	DMF72W3	N. A.	N. A.	Phase 4	[659]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[401]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]

Drug(s) Affected By Synaptotagmin-like protein 2 (SYTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[660]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[661]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[284]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[403]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[425]

Drug(s) Affected By Fibronectin type-III domain-containing protein 3A (FNDC3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[662]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[565]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[662]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[663]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[664]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[665]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[284]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]

Drug(s) Affected By Forkhead box protein F2 (FOXF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[554]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[554]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[666]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[667]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[284]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]

Drug(s) Affected By Poly polymerase tankyrase-1 (TNKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[668]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]

Drug(s) Affected By ADP-ribose glycohydrolase MACROD1 (MACROD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[669]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[670]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[141]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[634]

Drug(s) Affected By S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[671]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[430]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[672]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[673]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[541]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[674]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[605]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[284]

Drug(s) Affected By Ras-related GTP-binding protein D (RRAGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[675]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[676]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[669]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[677]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[670]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[109]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[678]

Drug(s) Affected By Bone morphogenetic protein 7 (BMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[563]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[679]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[680]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Glutamine synthetase (GLUL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[622]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[681]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[682]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[163]

Drug(s) Affected By BTB/POZ domain-containing protein 3 (BTBD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[122]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[406]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[520]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[683]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[684]

Drug(s) Affected By Zinc finger protein PLAGL1 (PLAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[685]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[563]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[686]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[94]

Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[687]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[406]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[688]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[689]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[527]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[154]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
ATP-binding cassette sub-family A member 3 (ABCA3)	DT2T6VQ	ABCA3_HUMAN	Substrate	[5]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[6]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[7]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[8]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1) Main DME	DEVDYN7	CP2E1_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Drug Response	[10]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)	OTPA0QHW	PLCB4_HUMAN	Drug Response	[10]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Drug Response	[10]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Drug Response	[10]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Drug Response	[10]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Gene/Protein Processing	[11]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Drug Response	[10]
ADP-ribose glycohydrolase MACROD1 (MACROD1)	OTWFEVRW	MACD1_HUMAN	Drug Response	[10]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Drug Response	[10]
AN1-type zinc finger protein 1	OTGZ9X6J	ZFAN1_HUMAN	Drug Response	[10]

References

• [1] Mitoxantrone FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7242).
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
• [5] A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33.
• [6] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [7] Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505.
• [8] Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7.
• [9] FDA label of Mitoxantrone. The 2020 official website of the U.S. Food and Drug Administration.
• [10] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [11] Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
• [12] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [13] Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
• [14] Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
• [15] Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
• [16] Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.
• [17] Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21.
• [18] The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97.
• [19] Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
• [20] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [21] Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14.
• [22] Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
• [23] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [24] ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
• [25] Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
• [26] Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32.
• [27] Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
• [28] Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
• [29] Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
• [30] Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
• [31] Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
• [32] Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
• [33] Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
• [34] Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
• [35] Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
• [36] Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
• [37] Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
• [38] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [39] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [40] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [41] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [42] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [43] Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
• [44] Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
• [45] The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
• [46] Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
• [47] Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
• [48] Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
• [49] The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
• [50] Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
• [51] Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
• [52] Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
• [53] Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96.
• [54] Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9.
• [55] Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55.
• [56] A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300.
• [57] The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
• [58] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [59] Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. Drug Metab Dispos. 2000 Feb;28(2):110-2.
• [60] Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6.
• [61] CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
• [62] Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
• [63] Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
• [64] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [65] ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
• [66] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [67] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [68] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [69] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [70] Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
• [71] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [72] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [73] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [74] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [75] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [76] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [77] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [78] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [79] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [80] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [81] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [82] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [83] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [84] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [85] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [86] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [87] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [88] Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney Int. 2003 Jun;63(6):2065-74. doi: 10.1046/j.1523-1755.2003.t01-2-00004.x.
• [89] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [90] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [91] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [92] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [93] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [94] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [95] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [96] The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol. 2002 Aug;62(2):210-9. doi: 10.1124/mol.62.2.210.
• [97] The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother. 2016 Aug;82:595-605. doi: 10.1016/j.biopha.2016.05.029. Epub 2016 Jun 9.
• [98] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [99] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [100] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [101] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [102] Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22464. doi: 10.1002/jbt.22464. Epub 2020 Feb 5.
• [103] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [104] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [105] Amlodipine inhibits cell proliferation via PKD1-related pathway. Biochem Biophys Res Commun. 2008 May 2;369(2):376-81. doi: 10.1016/j.bbrc.2008.02.075. Epub 2008 Feb 25.
• [106] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [107] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [108] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [109] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [110] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [111] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [112] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [113] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [114] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [115] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [116] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [117] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [118] [Muscular damage during isotretinoin treatment]. Ann Dermatol Venereol. 1998 Feb;125(2):94-7.
• [119] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [120] Elevation of creatine kinase from skeletal muscle associated with inhaled albuterol. Ann Allergy Asthma Immunol. 1996 Dec;77(6):488-90. doi: 10.1016/S1081-1206(10)63356-X.
• [121] Myopathy and hypersensitivity to phenytoin. Neurology. 1983 Jun;33(6):790-1. doi: 10.1212/wnl.33.6.790.
• [122] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [123] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [124] Myositis in association with carbimazole therapy. Lancet. 1989 Apr 29;1(8644):964. doi: 10.1016/s0140-6736(89)92550-6.
• [125] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [126] Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017 Sep 15;130(18):3009-3022. doi: 10.1242/jcs.198176. Epub 2017 Jul 25.
• [127] Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
• [128] Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. PLoS One. 2014 Oct 20;9(10):e107299. doi: 10.1371/journal.pone.0107299. eCollection 2014.
• [129] A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53.
• [130] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [131] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [132] Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
• [133] Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res. 2007 Jun;116(3):329-48.
• [134] Muscle glycogen of steroid myopathy patients. J Neurol Sci. 1996 Mar;136(1-2):192-5. doi: 10.1016/0022-510x(95)00331-u.
• [135] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [136] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [137] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [138] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [139] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [140] The effect of 6-thioguanine on alternative splicing and antisense-mediated exon skipping treatment for duchenne muscular dystrophy. PLoS Curr. 2012 Dec 12;4:ecurrents.md.597d700f92eaa70de261ea0d91821377. doi: 10.1371/currents.md.597d700f92eaa70de261ea0d91821377.
• [141] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [142] Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results. Acta Myol. 2003 May;22(1):15-21.
• [143] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [144] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [145] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [146] CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249.
• [147] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [148] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [149] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [150] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [151] Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. Br J Pharmacol. 2019 May;176(10):1568-1584. doi: 10.1111/bph.14460. Epub 2018 Sep 9.
• [152] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [153] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [154] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [155] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [156] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [157] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [158] Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin Cancer Res. 2009 Jun 15;15(12):4147-56. doi: 10.1158/1078-0432.CCR-08-2814. Epub 2009 Jun 9.
• [159] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [160] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [161] The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol Cell Biochem. 2004 May;260(1-2):129-35. doi: 10.1023/b:mcbi.0000026063.96267.98.
• [162] Sulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor. Cancer Prev Res (Phila). 2010 Apr;3(4):560-72. doi: 10.1158/1940-6207.CAPR-09-0159. Epub 2010 Mar 23.
• [163] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [164] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [165] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [166] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [167] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [168] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [169] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [170] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [171] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [172] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [173] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [174] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [175] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [176] Response of sodium pump to ouabain challenge in human glioblastoma cells in culture. World J Biol Psychiatry. 2009;10(4 Pt 3):884-92. doi: 10.1080/15622970902995620.
• [177] Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome. J Cardiovasc Electrophysiol. 2004 Feb;15(2):190-9. doi: 10.1046/j.1540-8167.2004.03212.x.
• [178] Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current. Anesthesiology. 2006 Sep;105(3):511-20. doi: 10.1097/00000542-200609000-00015.
• [179] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [180] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [181] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [182] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [183] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [184] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [185] Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
• [186] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [187] Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1367-75. doi: 10.1158/1055-9965.EPI-06-0106.
• [188] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [189] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [190] Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
• [191] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [192] A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
• [193] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [194] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [195] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [196] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [197] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [198] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [199] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [200] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [201] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [202] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [203] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [204] Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
• [205] Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
• [206] Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
• [207] Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
• [208] Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
• [209] Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
• [210] Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
• [211] Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
• [212] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [213] Ethnic-Related Sodium Voltage-Gated Channel Subunit 5 Polymorphisms Shape the In Vitro Pharmacological Action of Amiodarone upon Na(v)1.5. Mol Pharmacol. 2021 Jun;99(6):448-459. doi: 10.1124/molpharm.120.000176. Epub 2021 Apr 6.
• [214] Flecainide test in Brugada syndrome: a reproducible but risky tool. Pacing Clin Electrophysiol. 2003 Jan;26(1P2):338-41. doi: 10.1046/j.1460-9592.2003.00045.x.
• [215] Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
• [216] Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1. Chem Biol Interact. 2021 Apr 1;338:109425. doi: 10.1016/j.cbi.2021.109425. Epub 2021 Feb 19.
• [217] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [218] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [219] Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2016 Apr 1;296:42-53. doi: 10.1016/j.taap.2016.01.015. Epub 2016 Jan 25.
• [220] Modulation of the heart's electrical properties by the anticonvulsant drug retigabine. Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317. doi: 10.1016/j.taap.2017.06.018. Epub 2017 Jun 20.
• [221] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [222] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [223] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [224] Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20;107(19):2459-66. doi: 10.1161/01.CIR.0000068316.53218.49. Epub 2003 May 12.
• [225] Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.
• [226] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [227] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [228] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [229] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [230] Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
• [231] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [232] Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
• [233] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [234] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [235] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [236] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [237] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [238] Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes. J Membr Biol. 2001 Nov 1;184(1):35-43. doi: 10.1007/s00232-001-0072-7.
• [239] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [240] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [241] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [242] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [243] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [244] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [245] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [246] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [247] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [248] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [249] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [250] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [251] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [252] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [253] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [254] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [255] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [256] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [257] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [258] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [259] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [260] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [261] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [262] Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells. Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.
• [263] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [264] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [265] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [266] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [267] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [268] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [269] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [270] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [271] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [272] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [273] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [274] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
• [275] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [276] Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
• [277] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
• [278] Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
• [279] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [280] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [281] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [282] Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
• [283] Factors associated with the therapeutic efficacy of retinoic acids on malignant lymphomas. J Formos Med Assoc. 1997 Jul;96(7):525-34.
• [284] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [285] Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 2010 Mar 15;23(3):578-90. doi: 10.1021/tx900325g.
• [286] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [287] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [288] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [289] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [290] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [291] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [292] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [293] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [294] Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
• [295] Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000 Feb;14(2):262-70. doi: 10.1038/sj.leu.2401650.
• [296] Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer. Biochem Biophys Res Commun. 2013 Jan 11;430(2):623-8. doi: 10.1016/j.bbrc.2012.11.103. Epub 2012 Dec 3.
• [297] The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Int J Oncol. 2004 Aug;25(2):493-502.
• [298] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [299] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [300] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [301] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [302] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [303] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [304] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [305] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [306] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [307] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [308] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [309] Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2.
• [310] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [311] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [312] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [313] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [314] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [315] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [316] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [317] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [318] Carbamylation and oxidation of proteins lead to apoptotic death of lymphocytes. Chem Biol Interact. 2017 May 25;270:24-32. doi: 10.1016/j.cbi.2017.04.007. Epub 2017 Apr 8.
• [319] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [320] Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol. 2000;45(2):149-56. doi: 10.1007/s002800050023.
• [321] Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep. 2012 Jul;39(7):7785-93. doi: 10.1007/s11033-012-1621-0. Epub 2012 May 4.
• [322] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [323] Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
• [324] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [325] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [326] A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
• [327] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [328] Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
• [329] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [330] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [331] Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
• [332] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [333] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [334] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [335] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [336] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [337] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [338] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [339] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [340] Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. Biochem J. 2001 Nov 1;359(Pt 3):537-46. doi: 10.1042/0264-6021:3590537.
• [341] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [342] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [343] Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
• [344] Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
• [345] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [346] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [347] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [348] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [349] Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
• [350] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [351] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [352] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [353] The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
• [354] Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 Nov;116:105615. doi: 10.1016/j.biocel.2019.105615. Epub 2019 Sep 17.
• [355] The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
• [356] Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. Eur J Haematol. 2005 Sep;75(3):212-20. doi: 10.1111/j.1600-0609.2005.00498.x.
• [357] Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
• [358] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [359] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [360] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [361] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [362] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [363] Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011 Apr;131(4):990-3. doi: 10.1038/jid.2010.423. Epub 2011 Jan 13.
• [364] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [365] Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
• [366] The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.
• [367] Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25.
• [368] Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9. doi: 10.3109/15376516.2012.686534. Epub 2012 May 22.
• [369] Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
• [370] Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
• [371] Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
• [372] Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
• [373] Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
• [374] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
• [375] Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
• [376] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [377] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [378] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [379] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [380] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [381] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [382] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [383] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [384] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [385] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [386] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [387] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [388] Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
• [389] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [390] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [391] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [392] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [393] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [394] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
• [395] Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
• [396] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [397] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [398] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [399] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [400] Proteomic analysis reveals multiple patterns of response in cells exposed to a toxin mixture. Chem Res Toxicol. 2009 Jun;22(6):1077-85.
• [401] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [402] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [403] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [404] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [405] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [406] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [407] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [408] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [409] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [410] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [411] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [412] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [413] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [414] Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
• [415] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [416] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [417] Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
• [418] Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
• [419] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [420] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [421] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [422] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [423] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [424] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [425] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [426] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [427] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [428] Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Br J Nutr. 2013 Dec;110(12):2150-5.
• [429] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [430] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [431] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [432] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [433] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [434] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [435] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [436] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [437] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [438] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [439] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [440] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [441] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [442] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [443] The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit in AFB1 induced liver lesion. Toxicol Lett. 2014 Jan 30;224(3):371-9. doi: 10.1016/j.toxlet.2013.10.037. Epub 2013 Nov 5.
• [444] Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
• [445] Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays. Molecules. 2019 Feb 27;24(5):841. doi: 10.3390/molecules24050841.
• [446] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [447] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [448] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [449] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [450] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [451] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [452] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [453] Plasma glutathione peroxidase and its relationship to renal proximal tubule function. Mol Genet Metab. 1998 Nov;65(3):238-45. doi: 10.1006/mgme.1998.2760.
• [454] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [455] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [456] Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
• [457] Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21. doi: 10.1073/pnas.0610299104. Epub 2007 Apr 23.
• [458] Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.
• [459] "Minimalist" cyclopropene-containing photo-cross-linkers suitable for live-cell imaging and affinity-based protein labeling. J Am Chem Soc. 2014 Jul 16;136(28):9990-8. doi: 10.1021/ja502780z. Epub 2014 Jul 3.
• [460] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [461] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [462] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [463] The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
• [464] Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
• [465] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [466] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [467] Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
• [468] Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
• [469] Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus. Molecules. 2014 Jul 11;19(7):10129-36. doi: 10.3390/molecules190710129.
• [470] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [471] The effect of folic acid deficiency on Mest/Peg1 in neural tube defects. Int J Neurosci. 2021 May;131(5):468-477. doi: 10.1080/00207454.2020.1750386. Epub 2020 Apr 16.
• [472] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [473] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [474] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [475] Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
• [476] Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res. 2009 May 1;15(9):3076-83. doi: 10.1158/1078-0432.CCR-08-3004. Epub 2009 Apr 21.
• [477] Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
• [478] Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6. doi: 10.1016/j.bcp.2009.12.018. Epub 2010 Jan 8.
• [479] Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
• [480] Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
• [481] Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
• [482] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [483] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [484] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [485] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [486] Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.
• [487] Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
• [488] Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells. J Gen Virol. 2010 Aug;91(Pt 8):1959-1970. doi: 10.1099/vir.0.020065-0. Epub 2010 Apr 14.
• [489] Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of Np63 protein. J Biol Chem. 2013 Feb 1;288(5):2907-13. doi: 10.1074/jbc.M112.428607. Epub 2012 Dec 27.
• [490] E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Genes Cancer. 2016 Nov;7(11-12):383-393. doi: 10.18632/genesandcancer.123.
• [491] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [492] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [493] Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
• [494] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [495] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [496] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [497] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [498] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [499] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [500] Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions. Environ Toxicol. 2022 Aug;37(8):1831-1839. doi: 10.1002/tox.23530. Epub 2022 Apr 1.
• [501] Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
• [502] Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
• [503] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [504] Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15;536(1):135-44. doi: 10.1016/j.gene.2013.11.053. Epub 2013 Dec 4.
• [505] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [506] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [507] Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition. Acta Pharm Sin B. 2020 Jun;10(6):1061-1072. doi: 10.1016/j.apsb.2020.01.016. Epub 2020 Jan 31.
• [508] Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
• [509] Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
• [510] Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
• [511] Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther. 1999 Jul;290(1):314-8.
• [512] Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors. Chem Biol Interact. 2013 Mar 25;203(1):226-30.
• [513] Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007 Jan;95(1):13-22.
• [514] Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches. Toxicol Lett. 2020 Oct 15;333:49-61. doi: 10.1016/j.toxlet.2020.07.024. Epub 2020 Jul 26.
• [515] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [516] Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
• [517] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [518] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [519] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [520] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [521] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [522] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [523] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [524] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [525] Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
• [526] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [527] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [528] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [529] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [530] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [531] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [532] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [533] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [534] Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
• [535] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [536] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [537] Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Clin Cancer Res. 2009 May 15;15(10):3406-15. doi: 10.1158/1078-0432.CCR-08-2099. Epub 2009 Apr 28.
• [538] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [539] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [540] Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
• [541] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [542] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [543] Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
• [544] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [545] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [546] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [547] Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
• [548] Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
• [549] Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Biochem Pharmacol. 1993 Jun 9;45(11):2203-8.
• [550] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [551] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [552] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [553] Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
• [554] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [555] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [556] Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
• [557] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [558] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [559] The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma. Int J Cancer. 2008 Jun 1;122(11):2542-53. doi: 10.1002/ijc.23407.
• [560] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [561] The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. Exp Cell Res. 2005 Jan 15;302(2):244-52. doi: 10.1016/j.yexcr.2004.09.021.
• [562] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [563] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [564] Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma. Cancer Invest. 2007 Dec;25(8):685-90. doi: 10.1080/07357900701561131.
• [565] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [566] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [567] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [568] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [569] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [570] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [571] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [572] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [573] Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29. doi: 10.1074/jbc.M115.643015. Epub 2015 Apr 25.
• [574] S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk Res. 2005 Oct;29(10):1181-90. doi: 10.1016/j.leukres.2005.03.012.
• [575] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [576] Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
• [577] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [578] Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
• [579] Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
• [580] Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
• [581] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [582] Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
• [583] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [584] Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols. Toxicol Appl Pharmacol. 2022 May 1;442:115949. doi: 10.1016/j.taap.2022.115949. Epub 2022 Feb 25.
• [585] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [586] The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact. 2012 Jan 5;195(1):52-60.
• [587] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [588] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [589] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [590] Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
• [591] Discovery of a novel compound: insight into mechanisms for acrylamide-induced axonopathy and colchicine-induced apoptotic neuronal cell death. Brain Res. 2001 Aug 3;909(1-2):8-19. doi: 10.1016/s0006-8993(01)02608-7.
• [592] Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach. BMC Genomics. 2006 Sep 29;7:246. doi: 10.1186/1471-2164-7-246.
• [593] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [594] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [595] Characterization of antioxidant properties of natural killer-enhancing factor-B and induction of its expression by hydrogen peroxide. Toxicol Appl Pharmacol. 1997 Nov;147(1):135-42. doi: 10.1006/taap.1997.8270.
• [596] Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
• [597] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [598] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [599] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [600] Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem. 2014 Aug 1;289(31):21386-400. doi: 10.1074/jbc.M113.528463. Epub 2014 Jun 18.
• [601] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [602] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [603] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [604] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [605] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [606] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [607] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [608] Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
• [609] Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J. 2007 Mar 1;402(2):241-50. doi: 10.1042/BJ20061099.
• [610] Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
• [611] Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC). J Transl Med. 2012 Feb 3;10:21. doi: 10.1186/1479-5876-10-21.
• [612] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [613] Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. Chem Biol Interact. 2013 Apr 25;203(2):512-21. doi: 10.1016/j.cbi.2013.03.001. Epub 2013 Mar 13.
• [614] Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One. 2011;6(11):e27265. doi: 10.1371/journal.pone.0027265. Epub 2011 Nov 11.
• [615] Arsenic metabolites affect expression of the neurofilament and tau genes: an in-vitro study into the mechanism of arsenic neurotoxicity. Toxicol In Vitro. 2007 Sep;21(6):1104-12. doi: 10.1016/j.tiv.2007.04.007. Epub 2007 Apr 27.
• [616] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [617] Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
• [618] Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
• [619] Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr. 2007 Apr;137(4):964-72.
• [620] Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
• [621] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [622] Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
• [623] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [624] Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
• [625] Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
• [626] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [627] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [628] In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
• [629] HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
• [630] Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
• [631] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [632] The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
• [633] A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. Chem Biol Interact. 2015 Jul 25;237:58-65. doi: 10.1016/j.cbi.2015.05.006. Epub 2015 May 14.
• [634] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [635] Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
• [636] Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
• [637] Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
• [638] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [639] Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate. Chem Res Toxicol. 2019 Dec 16;32(12):2526-2537. doi: 10.1021/acs.chemrestox.9b00358. Epub 2019 Nov 11.
• [640] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [641] Morphine induces DNA damage and P53 activation in CD3+ T cells. Biochim Biophys Acta. 2009 Aug;1790(8):793-9. doi: 10.1016/j.bbagen.2009.04.011. Epub 2009 May 3.
• [642] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [643] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [644] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [645] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [646] Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
• [647] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [648] Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. Eur J Biochem. 1995 Sep 1;232(2):425-32.
• [649] Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation. J Heart Lung Transplant. 1999 Jul;18(7):693-700. doi: 10.1016/s1053-2498(99)00021-2.
• [650] Simvastatin increases fibrinolytic activity in human peritoneal mesothelial cells independent of cholesterol lowering. Kidney Int. 2002 Nov;62(5):1611-9. doi: 10.1046/j.1523-1755.2002.00601.x.
• [651] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [652] Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
• [653] Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):176-86.
• [654] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [655] Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
• [656] Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):129-40.
• [657] Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74. doi: 10.1073/pnas.1108190108. Epub 2011 Sep 26.
• [658] Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
• [659] Glyceryl trinitrate treatment up-regulates soluble guanylyl cyclase in rat dura mater. Neuroreport. 2001 Dec 21;12(18):3993-6. doi: 10.1097/00001756-200112210-00028.
• [660] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [661] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [662] A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet. 2010 Aug;42(8):711-4. doi: 10.1038/ng.632. Epub 2010 Jul 18.
• [663] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [664] Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
• [665] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [666] Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther. 2005 Feb;4(2):233-41.
• [667] Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma. Toxicol Appl Pharmacol. 2017 Sep 15;331:54-61. doi: 10.1016/j.taap.2017.05.008. Epub 2017 May 10.
• [668] Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
• [669] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [670] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [671] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [672] Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
• [673] Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
• [674] Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
• [675] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [676] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [677] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [678] Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
• [679] BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens. J Biochem Mol Toxicol. 2004;18(1):1-11. doi: 10.1002/jbt.20004.
• [680] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. Hum Reprod. 2010 Mar;25(3):751-6. doi: 10.1093/humrep/dep455. Epub 2010 Jan 18.
• [681] Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Ann Rheum Dis. 2016 Feb;75(2):439-48. doi: 10.1136/annrheumdis-2014-206305. Epub 2015 Jan 9.
• [682] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [683] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [684] Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
• [685] Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J Nutr Biochem. 2006 Apr;17(4):250-6. doi: 10.1016/j.jnutbio.2005.05.004. Epub 2005 Jun 13.
• [686] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [687] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [688] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [689] Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.